cevine and Coronavirus-Infections

cevine has been researched along with Coronavirus-Infections* in 1 studies

Other Studies

1 other study(ies) available for cevine and Coronavirus-Infections

Article	Year
Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 A novel human coronavirus has been reported to be the causative agent of severe acute respiratory syndrome (SARS). Since replication of HcoVs depends on extensive proteolytic processing, the main proteinase, 3CLpro, is an attractive drug target for anti-SARS agents. We have employed molecular docking of a chemical database into the active site of 3CLpro to search for non-peptidyl inhibitors. One compound was identified to be the natural product sabadinine, isolated from a historical herbal remedy. Topics: Antiviral Agents; Binding Sites; Cells, Cultured; Cevanes; Coronavirus; Coronavirus 3C Proteases; Coronavirus Infections; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Databases, Factual; Humans; Models, Molecular; Murine hepatitis virus	2004

Article

Year

Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design.

Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

A novel human coronavirus has been reported to be the causative agent of severe acute respiratory syndrome (SARS). Since replication of HcoVs depends on extensive proteolytic processing, the main proteinase, 3CLpro, is an attractive drug target for anti-SARS agents. We have employed molecular docking of a chemical database into the active site of 3CLpro to search for non-peptidyl inhibitors. One compound was identified to be the natural product sabadinine, isolated from a historical herbal remedy.

Topics: Antiviral Agents; Binding Sites; Cells, Cultured; Cevanes; Coronavirus; Coronavirus 3C Proteases; Coronavirus Infections; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Databases, Factual; Humans; Models, Molecular; Murine hepatitis virus

2004