Page last updated: 2024-10-24

cetylpyridinium and Halitosis

cetylpyridinium has been researched along with Halitosis in 29 studies

Cetylpyridinium: Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.

Halitosis: An offensive, foul breath odor resulting from a variety of causes such as poor oral hygiene, dental or oral infections, or the ingestion of certain foods.

Research Excerpts

ExcerptRelevanceReference
" The aim of this study was to clarify the relationship between periodontal parameters and volatile sulfur compounds and to evaluate the improvement of several halitosis-related outcomes by tongue scraping, nonsurgical periodontal treatment (including oral hygiene instruction) and oral hygiene instruction/chlorhexidine + cetyl pyridinium gargling."9.13The levels of volatile sulfur compounds in mouth air from patients with chronic periodontitis. ( Chou, HH; Ho, KY; Ho, YP; Tsai, CC; Wu, TL; Wu, YM; Yang, YH, 2008)
" Patients were selected on the basis of (1) halitosis of oral origin, (2) full-mouth organoleptic score>1, using an arbitrary 0-5 scale, (3) level of volatile sulfur compounds (VSC)>170 parts per billion (ppb) and (4) Winkel tongue coating index (WTCI)>4 (0-12)."9.10Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study. ( Herrera, D; Roldán, S; Sanz, M; Van Winkelhoff, AJ; Winkel, EG, 2003)
"To investigate the effect of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions."7.80[Effects of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions]. ( Cai, D; Li, S; Liu, CH; Yang, X; Zhang, D; Zhang, J; Zhong, H, 2014)
"To evaluate the effect of lemon essential oil (LEO) on salivary bacteria and volatile sulfur compound (VSC) production of patients with halitosis."5.69Effect of lemon essential oil on halitosis. ( Chen, J; Hui, J; Ma, L; Pang, C; Wang, X; Yan, C; Zhang, X; Zhou, L, 2023)
"Halitosis is a common complaint affecting the majority of the population."5.39Cetylpyridinium chloride suppresses gene expression associated with halitosis. ( Ling, JQ; Liu, J; Wu, CD, 2013)
" The aim of this study was to clarify the relationship between periodontal parameters and volatile sulfur compounds and to evaluate the improvement of several halitosis-related outcomes by tongue scraping, nonsurgical periodontal treatment (including oral hygiene instruction) and oral hygiene instruction/chlorhexidine + cetyl pyridinium gargling."5.13The levels of volatile sulfur compounds in mouth air from patients with chronic periodontitis. ( Chou, HH; Ho, KY; Ho, YP; Tsai, CC; Wu, TL; Wu, YM; Yang, YH, 2008)
" Patients were selected on the basis of (1) halitosis of oral origin, (2) full-mouth organoleptic score>1, using an arbitrary 0-5 scale, (3) level of volatile sulfur compounds (VSC)>170 parts per billion (ppb) and (4) Winkel tongue coating index (WTCI)>4 (0-12)."5.10Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study. ( Herrera, D; Roldán, S; Sanz, M; Van Winkelhoff, AJ; Winkel, EG, 2003)
"To investigate the effect of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions."3.80[Effects of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions]. ( Cai, D; Li, S; Liu, CH; Yang, X; Zhang, D; Zhang, J; Zhong, H, 2014)
"This in vitro observation supports the use of chlorhexidine and cetylpyridinium chloride in the treatment of oral halitosis."3.79In vitro antimicrobial effects of two antihalitosis mouth rinses on oral pathogens and human tongue microbiota. ( Raangs, GC; van Winkelhoff, AJ; Winkel, EG, 2013)
" TC was used in combination with an antibacterial tongue spray (BreathRx, BRx) containing 0."2.82Daily reduction of oral malodor with the use of a sonic tongue brush combined with an antibacterial tongue spray in a randomized cross-over clinical investigation. ( Gomez-Pereira, P; Greenman, J; Hewett, K; Horstman, P; Patel, J; Saad, S, 2016)
"Halitosis was induced by L-cysteine in 11 volunteers, and 4 solutions were compared: a test solution containing 0."1.39The effect of a mouthrinse containing chlorine dioxide in the clinical reduction of volatile sulfur compounds. ( da Silva, DG; Falabella, ME; Guaitolini, RL; Soares, LG; Tinoco, EM; Weyne, Sde C, 2013)
"Halitosis is a common complaint affecting the majority of the population."1.39Cetylpyridinium chloride suppresses gene expression associated with halitosis. ( Ling, JQ; Liu, J; Wu, CD, 2013)
" The objective was to examine the anti-VSC dose-response effects of each of the above agents."1.32Inhibition of orally produced volatile sulfur compounds by zinc, chlorhexidine or cetylpyridinium chloride--effect of concentration. ( Jonski, G; Rölla, G; Young, A, 2003)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (6.90)18.2507
2000's14 (48.28)29.6817
2010's12 (41.38)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Ma, L1
Pang, C1
Yan, C1
Chen, J1
Wang, X1
Hui, J1
Zhou, L1
Zhang, X1
Kang, JH1
Kim, DJ1
Choi, BK1
Park, JW1
Dadamio, J1
Van Tournout, M1
Teughels, W1
Dekeyser, C1
Coucke, W4
Quirynen, M5
Soares, LG1
Guaitolini, RL1
Weyne, Sde C1
Falabella, ME1
Tinoco, EM1
da Silva, DG1
Iha, K1
Suzuki, N1
Yoneda, M1
Takeshita, T1
Hirofuji, T1
Liu, J1
Ling, JQ1
Wu, CD1
Zhang, D1
Liu, CH1
Zhang, J1
Cai, D1
Yang, X1
Li, S1
Zhong, H1
Mendes, L1
Coimbra, J1
Pereira, AL1
Resende, M1
Pinto, MG1
Feres, M1
Figueiredo, LC1
Faveri, M1
Guerra, MC1
Mateo, LR1
Stewart, B1
Williams, M1
Panagakos, F1
Saad, S2
Gomez-Pereira, P1
Hewett, K1
Horstman, P1
Patel, J1
Greenman, J2
Farrell, S1
Barker, ML1
Walanski, A1
Gerlach, RW1
Shaw, H1
Blom, T1
Slot, DE1
Van der Weijden, GA1
Raangs, GC1
Winkel, EG3
van Winkelhoff, AJ3
Avontroodt, P3
Soers, C2
Zhao, H2
Pauwels, M3
van Steenberghe, D3
Roldán, S3
Herrera, D3
Sanz, M3
Borden, LC1
Chaves, ES1
Bowman, JP1
Fath, BM1
Hollar, GL1
Young, A2
Jonski, G2
Rölla, G2
Carvalho, MD1
Tabchoury, CM1
Cury, JA1
Toledo, S1
Nogueira-Filho, GR1
O'Connor, A1
González, I1
Tsai, CC1
Chou, HH1
Wu, TL1
Yang, YH1
Ho, KY1
Wu, YM1
Ho, YP1
Kozlovsky, A1
Goldberg, S1
Natour, I1
Rogatky-Gat, A1
Gelernter, I2
Rosenberg, M2
Silwood, CJ1
Grootveld, MC1
Lynch, E1
Peeters, W1
Lijnen, A1
Kleinberg, I1
Codipilly, DM1
Barki, M1
Bar-Ness, R1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Mouthwash Containing Green Tea With Aloe Vera and Chlorhexidine Mouthwash on Oral Malodour Among a Group of Egyptian Children: Randomized Clinical Trial[NCT03115892]Phase 1/Phase 227 participants (Anticipated)Interventional2017-04-01Enrolling by invitation
"Effect of Single Rinsing With Three Different Types of Mouthwash on VSC Levels in Morning Breath; Randomized Clinical Trial, Double-blind Cross-sectional Study"[NCT04279106]36 participants (Actual)Interventional2018-09-03Completed
Effectiveness of a Pre-procedural Mouthwash in Reducing Bacteria in Dental Aerosols and Splatters: a Randomized Clinical Trial[NCT02875769]Phase 360 participants (Actual)Interventional2015-02-28Completed
Effect Off Full Mouth Disinfection And Scaling Root Planing Per Quadrant In Halitosis in Patients With Advanced Chronic Periodontitis: Randomized Controlled Clinical Trial[NCT02368678]30 participants (Actual)Interventional2013-04-30Completed
Oral Malodour and Periodontal Disease-related Parameters. Clinical and Real-time PCR Findings[NCT01234948]78 participants (Actual)Observational2008-01-31Completed
Evaluation of Nonsurgical Periodontal Treatment in Patients With Social Phobia: a Randomized Controlled Clinical Trial[NCT03241277]45 participants (Anticipated)Interventional2017-10-05Not yet recruiting
Impact of Bracket Design and Oral Hygiene Maintenance on Halitosis in the Orthodontic Patient[NCT01948349]40 participants (Actual)Interventional2012-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for cetylpyridinium and Halitosis

ArticleYear
The effect of mouthrinses on oral malodor: a systematic review.
    International journal of dental hygiene, 2012, Volume: 10, Issue:3

    Topics: Cetylpyridinium; Chlorhexidine; Halitosis; Humans; Mouthwashes; Sulfur Compounds; Tongue; Volatile O

2012

Trials

18 trials available for cetylpyridinium and Halitosis

ArticleYear
Effect of lemon essential oil on halitosis.
    Oral diseases, 2023, Volume: 29, Issue:4

    Topics: Cetylpyridinium; Chlorhexidine; Halitosis; Humans; Mouthwashes; Oils, Volatile; Sulfur Compounds

2023
Efficacy of different mouthrinse formulations in reducing oral malodour: a randomized clinical trial.
    Journal of clinical periodontology, 2013, Volume: 40, Issue:5

    Topics: Amines; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Cetylpyridinium; Chemis

2013
Effect of mouth cleaning with hinokitiol-containing gel on oral malodor: a randomized, open-label pilot study.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2013, Volume: 116, Issue:4

    Topics: Adult; Aged; Anti-Infective Agents; Candida albicans; Cetylpyridinium; Chromatography, Gas; Cupressa

2013
Comparative effect of a new mouthrinse containing chlorhexidine, triclosan and zinc on volatile sulphur compounds: a randomized, crossover, double-blind study.
    International journal of dental hygiene, 2016, Volume: 14, Issue:3

    Topics: Adult; Cetylpyridinium; Chlorhexidine; Cross-Over Studies; Dental Plaque; Double-Blind Method; Femal

2016
Comparative effect of a new mouthrinse containing chlorhexidine, triclosan and zinc on volatile sulphur compounds: a randomized, crossover, double-blind study.
    International journal of dental hygiene, 2016, Volume: 14, Issue:3

    Topics: Adult; Cetylpyridinium; Chlorhexidine; Cross-Over Studies; Dental Plaque; Double-Blind Method; Femal

2016
Comparative effect of a new mouthrinse containing chlorhexidine, triclosan and zinc on volatile sulphur compounds: a randomized, crossover, double-blind study.
    International journal of dental hygiene, 2016, Volume: 14, Issue:3

    Topics: Adult; Cetylpyridinium; Chlorhexidine; Cross-Over Studies; Dental Plaque; Double-Blind Method; Femal

2016
Comparative effect of a new mouthrinse containing chlorhexidine, triclosan and zinc on volatile sulphur compounds: a randomized, crossover, double-blind study.
    International journal of dental hygiene, 2016, Volume: 14, Issue:3

    Topics: Adult; Cetylpyridinium; Chlorhexidine; Cross-Over Studies; Dental Plaque; Double-Blind Method; Femal

2016
The efficacy of two oral hygiene regimens in reducing oral malodour: a randomised clinical trial.
    International dental journal, 2015, Volume: 65, Issue:6

    Topics: Adolescent; Adult; Anti-Infective Agents, Local; Biofilms; Cariostatic Agents; Cetylpyridinium; Chro

2015
Daily reduction of oral malodor with the use of a sonic tongue brush combined with an antibacterial tongue spray in a randomized cross-over clinical investigation.
    Journal of breath research, 2016, Feb-12, Volume: 10, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Breath Tests; Cetylpyridinium; Combined Modality Therapy; Cross-Over S

2016
Short-term effects of a combination product night-time therapeutic regimen on breath malodor.
    The journal of contemporary dental practice, 2008, Sep-01, Volume: 9, Issue:6

    Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Cetylpyridinium; Cross-Over Studies; Dent

2008
Comparative effects of various commercially available mouthrinse formulations on oral malodor.
    Oral diseases, 2011, Volume: 17, Issue:2

    Topics: Adult; Anti-Infective Agents, Local; Benzoic Acid; Betaine; Cetylpyridinium; Chemistry, Pharmaceutic

2011
The efficacy of amine fluoride/stannous fluoride in the suppression of morning breath odour.
    Journal of clinical periodontology, 2002, Volume: 29, Issue:10

    Topics: Adult; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Circadian Rhythm; Cross-Over St

2002
Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study.
    Journal of clinical periodontology, 2003, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Double

2003
Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study.
    Journal of clinical periodontology, 2003, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Double

2003
Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study.
    Journal of clinical periodontology, 2003, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Double

2003
Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study.
    Journal of clinical periodontology, 2003, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Double

2003
Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study.
    Journal of clinical periodontology, 2003, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Double

2003
Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study.
    Journal of clinical periodontology, 2003, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Double

2003
Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study.
    Journal of clinical periodontology, 2003, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Double

2003
Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study.
    Journal of clinical periodontology, 2003, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Double

2003
Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study.
    Journal of clinical periodontology, 2003, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Double

2003
The effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc lactate on the microflora of oral halitosis patients: a dual-centre, double-blind placebo-controlled study.
    Journal of clinical periodontology, 2003, Volume: 30, Issue:5

    Topics: Anti-Infective Agents, Local; Cetylpyridinium; Chi-Square Distribution; Chlorhexidine; Colony Count,

2003
The effect of four mouthrinses on oral malodor.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2002, Volume: 23, Issue:6

    Topics: Adult; Aged; Anti-Infective Agents, Local; Cetylpyridinium; Chlorine Compounds; Double-Blind Method;

2002
A salivary incubation test for evaluation of oral malodor: a pilot study.
    Journal of periodontology, 2003, Volume: 74, Issue:7

    Topics: Adult; Anti-Infective Agents, Local; Cariostatic Agents; Cetylpyridinium; Chlorhexidine; Colony Coun

2003
Impact of mouthrinses on morning bad breath in healthy subjects.
    Journal of clinical periodontology, 2004, Volume: 31, Issue:2

    Topics: Adult; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Cross-Over Studies; Dental Plaq

2004
The levels of volatile sulfur compounds in mouth air from patients with chronic periodontitis.
    Journal of periodontal research, 2008, Volume: 43, Issue:2

    Topics: Adult; Anti-Infective Agents, Local; Breath Tests; Cetylpyridinium; Chlorhexidine; Dental Scaling; F

2008
Efficacy of a 2-phase oil: water mouthrinse in controlling oral malodor, gingivitis, and plaque.
    Journal of periodontology, 1996, Volume: 67, Issue:6

    Topics: Adult; Analysis of Variance; Breath Tests; Cadaverine; Cetylpyridinium; Dental Plaque; Dental Plaque

1996
Effect of different mouthrinses on morning breath.
    Journal of periodontology, 2001, Volume: 72, Issue:9

    Topics: Adult; Anti-Infective Agents, Local; Bacteria, Anaerobic; Breath Tests; Cetylpyridinium; Chlorhexidi

2001
Day-long reduction of oral malodor by a two-phase oil:water mouthrinse as compared to chlorhexidine and placebo rinses.
    Journal of periodontology, 1992, Volume: 63, Issue:1

    Topics: Bacteria; Cetylpyridinium; Chlorhexidine; Colony Count, Microbial; Halitosis; Humans; Hydrogen Sulfi

1992

Other Studies

10 other studies available for cetylpyridinium and Halitosis

ArticleYear
Inhibition of malodorous gas formation by oral bacteria with cetylpyridinium and zinc chloride.
    Archives of oral biology, 2017, Volume: 84

    Topics: Aggregatibacter actinomycetemcomitans; Anti-Infective Agents, Local; Cetylpyridinium; Chlorides; Chr

2017
The effect of a mouthrinse containing chlorine dioxide in the clinical reduction of volatile sulfur compounds.
    General dentistry, 2013, Volume: 61, Issue:4

    Topics: Cetylpyridinium; Halitosis; Humans; Mouthwashes; Sodium Fluoride; Sulfur Compounds

2013
Cetylpyridinium chloride suppresses gene expression associated with halitosis.
    Archives of oral biology, 2013, Volume: 58, Issue:11

    Topics: Analysis of Variance; Cell Culture Techniques; Cetylpyridinium; Dental Plaque; Electrophoresis, Poly

2013
[Effects of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014, Volume: 34, Issue:9

    Topics: Cetylpyridinium; Fusobacterium nucleatum; Halitosis; Humans; Microbial Sensitivity Tests; Porphyromo

2014
In vitro antimicrobial effects of two antihalitosis mouth rinses on oral pathogens and human tongue microbiota.
    International journal of dental hygiene, 2013, Volume: 11, Issue:3

    Topics: Bacteria, Anaerobic; Biofilms; Case-Control Studies; Cetylpyridinium; Chlorhexidine; Drug Combinatio

2013
Combined effect of zinc ions and cationic antibacterial agents on intraoral volatile sulphur compounds (VSC).
    International dental journal, 2003, Volume: 53, Issue:4

    Topics: Adult; Aged; Anti-Infective Agents, Local; Breath Tests; Cetylpyridinium; Chlorhexidine; Chromatogra

2003
Inhibition of orally produced volatile sulfur compounds by zinc, chlorhexidine or cetylpyridinium chloride--effect of concentration.
    European journal of oral sciences, 2003, Volume: 111, Issue:5

    Topics: Adult; Aged; Analysis of Variance; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Chr

2003
A combined therapeutic approach to manage oral halitosis: a 3-month prospective case series.
    Journal of periodontology, 2005, Volume: 76, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cetylpyridinium; Chlorhexidine; Dental

2005
A multifactorial investigation of the ability of oral health care products (OHCPs) to alleviate oral malodour.
    Journal of clinical periodontology, 2001, Volume: 28, Issue:7

    Topics: Adult; Analysis of Variance; Anti-Infective Agents, Local; Bacteria; Capsules; Cetylpyridinium; Chlo

2001
Cysteine challenge testing: a powerful tool for examining oral malodour processes and treatments in vivo.
    International dental journal, 2002, Volume: 52 Suppl 3

    Topics: Anti-Infective Agents, Local; Cetylpyridinium; Chewing Gum; Chlorhexidine; Chlorides; Cysteine; Dent

2002