cetyl-myristoleate and Inflammation

Cetylated fatty acids are a group of naturally occurring fats of plant and/or animal origin. Cetyl myristoleate, in particular, was initially involved in osteoarthritis related research as its therapeutic administration prevented experimentally induced arthritis in Swiss Albino mice. In this context, the aim of our study was to investigate the possible mechanisms of Celadrin cetylated fatty acids action at the cellular level inflammation related pain relief and chondrogenesis.. For this, we tested the effects of the cetylated fatty acids mixture from Celadrin on an. The cetylated fatty acids mixture from Celadrin significantly decreased the production of IL-6, MCP-1, and TNF, key regulators of the inflammatory process, in stimulated RAW264.7 mouse macrophage cells. The treatment with cetylated fatty acids mixture initiated and propagated the process of chondrogenesis as demonstrated by the increased expression and deposition of chondrogenic markers by the differentiating mesenchymal cells.. The cetylated fatty acids mixture from Celadrin reduces inflammation

Topics: Acetylation; Animals; Cell Differentiation; Chemokine CCL2; Chondrogenesis; Fatty Acids; Humans; Inflammation; Interleukin-6; Macrophages; Mesenchymal Stem Cells; Mice; Osteoarthritis; RAW 264.7 Cells; Tumor Necrosis Factor-alpha; Waxes