cetrorelix and Fetal-Death

To summarize data from completed phase II and III clinical trials on children born after controlled ovarian stimulation using the luteinizing hormone-releasing hormone antagonist cetrorelix.. All children born after ovarian stimulation in patients treated for infertility who were in prospective studies until March 23, 1999.. Academic research center.. Children born after IVF or IVF plus ICSI.. Controlled ovarian stimulation with cetrorelix in a multiple-dose or single/dual-dose protocol.. Outcome of pregnancy and, in deliveries, the date of birth, number and sex of children born, birth weight, body length, and abnormalities were recorded. At approximately 1 year of age and 2 years of age, body weight and length and abnormalities in physical and mental development were recorded.. Two hundred nine and 18 children were born after fresh and frozen embryo transfers, respectively. Of the pregnancies, 76.2% (179 of 234) resulted in live birth and ectopic pregnancy occurred in 3.4% (8 of 231); one heterotopic pregnancy and four induced abortions were recorded. The malformation rate among all live births, stillbirths, and aborted fetuses was 3.1%.. Use of cetrorelix in controlled ovarian stimulation does not harm the subsequently born children.

Topics: Adult; Cohort Studies; Congenital Abnormalities; Embryo Transfer; Europe; Female; Fertility Agents, Female; Fertilization in Vitro; Fetal Death; Follow-Up Studies; Germany; Gonadotropin-Releasing Hormone; Health; Hormone Antagonists; Humans; Infant; Infant, Newborn; Ovary; Pregnancy; Pregnancy Complications; Twins