cetirizine and Rhinitis, Allergic, Perennial studies

Cetirizine: A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
cetirizine : A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.

Rhinitis, Allergic, Perennial: Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.

Research Excerpts

Excerpt	Relevance	Reference
"The aim of this study was to evaluate the efficacy and safety of a fixed-dose combination of montelukast and levocetirizine in patients with perennial allergic rhinitis with mild to moderate asthma compared with the efficacy and safety of montelukast alone."	9.27	A Randomized, Multicenter, Double-blind, Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis. ( Chang, YS; Cho, YJ; Cho, YS; Choi, BW; Chung, JH; Jee, YK; Jo, EJ; Jung, J; Kim, HK; Kim, MK; Kim, SH; Lee, BJ; Lee, JM; Lee, SK; Lee, SY; Park, CS; Park, HS; Park, HW; Park, JW; Yoo, KH; Yoon, HJ, 2018)
"Bilastine is an orally administered, second-generation antihistamine used in the symptomatic treatment of seasonal or perennial allergic rhinoconjunctivitis and urticaria."	8.88	Bilastine: in allergic rhinitis and urticaria. ( Carter, NJ, 2012)
"Levocetirizine (LCZ) is a second-generation antihistamine that was approved in January 2008 for the relief of symptoms of seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR), and chronic idiopathic urticaria (CIU) in adults and children aged > or = 6 years."	8.85	Levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children. ( Borja-Hart, N; Ghin, HL; Perez, A; Robles, GI; Singh-Franco, D, 2009)
"Levocetirizine (Xyzal) is a selective, potent, oral histamine H(1) receptor antagonist of the latest generation that is licensed for the symptomatic treatment of allergic rhinitis (including persistent allergic rhinitis [PER]) and chronic idiopathic urticaria (CIU)."	8.83	Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies. ( Hair, PI; Scott, LJ, 2006)
"Levocetirizine has been shown in observational studies in the west as an effective and satisfactory therapy for patients with allergic respiratory and skin disease."	6.75	An open-label, multicentre study of levocetirizine for the treatment of allergic rhinitis and urticaria in Taiwanese patients. ( Fang, SY; Huangs, CY; Lee, JY; Lin, DY; Perng, DW, 2010)
"Nasal obstruction is the main symptom in patients with perennial allergic rhinitis."	6.71	Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study. ( Allen, M; Barberi, S; Ciprandi, G; Cirillo, I; Civardi, E; Marseglia, GL; Vizzaccaro, A, 2005)
"Nasal obstruction is a difficult-to-treat symptom."	6.43	Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine. ( Bachert, C; De Smedt, H; Patou, J; van Cauwenberge, P, 2006)
"The aim of this study was to evaluate the efficacy and safety of a fixed-dose combination of montelukast and levocetirizine in patients with perennial allergic rhinitis with mild to moderate asthma compared with the efficacy and safety of montelukast alone."	5.27	A Randomized, Multicenter, Double-blind, Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis. ( Chang, YS; Cho, YJ; Cho, YS; Choi, BW; Chung, JH; Jee, YK; Jo, EJ; Jung, J; Kim, HK; Kim, MK; Kim, SH; Lee, BJ; Lee, JM; Lee, SK; Lee, SY; Park, CS; Park, HS; Park, HW; Park, JW; Yoo, KH; Yoon, HJ, 2018)
"To compare the efficacy of an acupuncture regimen for persistent allergic rhinitis (PER), aimed at improving a patient's mind or Shen in Traditional Chinese Medicine, to that of a second-generation Hi-receptor antagonist, cetirizine hydrochloride."	5.19	Comparison of clinical effectiveness of acupuncture and a Western drug on allergic rhinitis: study protocol for a randomized controlled trial. ( Chen, S; Shi, Z; Tan, C; Wang, P; Wang, Y; Zhang, C; Zhao, J, 2014)
"The present open label study in 62 patients indicates that levocetirizine 5 mg reliably controls persistent rhinitis over a period of 6 months, and shows a trend to be more effective in controlling the symptoms of rhinitis, improving QOL and decreasing nasal inflammation, when administered as long-term continuous therapy rather than as on-demand therapy."	5.13	Levocetirizine in persistent allergic rhinitis: continuous or on-demand use? A pilot study. ( Baiardini, I; Canonica, GW; Compalati, E; Fumagalli, F; Gamalero, C; Guerra, L; Massacane, P; Passalacqua, G; Riccio, AM; Rogkakou, A; Scordamaglia, A, 2008)
"Subjects with asthma and perennial allergic rhinitis entered a randomized double blind crossover study comparing montelukast 10 mg and cetirizine 10 mg to extra-fine inhaled beclomethasone 400 mcg/day and intranasal beclomethasone 200 mcg/day, each taken once daily for 2 months, after 2-week placebo washouts."	5.12	Combined mediator blockade or topical steroid for treating the unified allergic airway. ( Barnes, ML; Burns, P; Fardon, TC; Lipworth, BJ; Menzies, D; Wilson, AM, 2007)
"From a comprehensive databank containing data from ten different open-label prospective observational studies including raw data of 140,853 patients with allergic rhinitis, symptomatology variables were analysed and scored to study the effects of treatment with four antihistamines (Desloratadine, Ebastine, Fexofenadine, Levocetirizine) alone or in combination with intranasal corticosteroids."	4.89	The effectiveness of modern antihistamines for treatment of allergic rhinitis - an IPD meta-analysis of 140,853 patients. ( Köberlein, J; König, V; Mösges, R, 2013)
"Bilastine is an orally administered, second-generation antihistamine used in the symptomatic treatment of seasonal or perennial allergic rhinoconjunctivitis and urticaria."	4.88	Bilastine: in allergic rhinitis and urticaria. ( Carter, NJ, 2012)
"Levocetirizine (LCZ) is a second-generation antihistamine that was approved in January 2008 for the relief of symptoms of seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR), and chronic idiopathic urticaria (CIU) in adults and children aged > or = 6 years."	4.85	Levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children. ( Borja-Hart, N; Ghin, HL; Perez, A; Robles, GI; Singh-Franco, D, 2009)
"Levocetirizine (Xyzal) is a selective, potent, oral histamine H(1) receptor antagonist of the latest generation that is licensed for the symptomatic treatment of allergic rhinitis (including persistent allergic rhinitis [PER]) and chronic idiopathic urticaria (CIU)."	4.83	Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies. ( Hair, PI; Scott, LJ, 2006)
"Levocetirizine and desloratadine are newer antihistamines indicated for the treatment of allergic rhinitis and chronic idiopathic urticaria."	4.82	A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis. ( Canonica, GW; Passalacqua, G, 2005)
"It has been demonstrated that cetirizine is able to reduce ICAM-1 expression on nasal epithelial cells and conjunctival nonspecific hyperreactivity in asthmatic asymptomatic children with MPI."	4.80	Minimal persistent inflammation may be controlled by cetirizine. ( Canonica, GW; Ciprandi, G, 1999)
"The second-generation H1-receptor antagonists terfenadine, astemizole, loratadine, and cetirizine are important first-line drugs for the relief of symptoms in patients with allergic rhinoconjunctivitis or chronic urticaria and may eventually supplant the potentially sedating first-generation H1-receptor antagonists in the treatment of these disorders."	4.78	Recent advances in H1-receptor antagonist treatment. ( Simons, FE, 1990)
"Both levocetirizine and desloratadine in monotherapy, or in combination with montelukast, were effective in reducing wheal and flare in SPT."	2.79	Wheal and flare reactions in skin prick tests of patients treated with montelukast alone or in combination with antihistamines. ( Barylski, M; Ciebiada, M; Ciebiada, MG, 2014)
" In addition, bilastine was shown to be safe and well-tolerated over a 1-year treatment period."	2.77	Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo in the treatment of perennial allergic rhinitis. ( Mullol, J; Sastre, J; Valero, A; Valiente, R, 2012)
"Levocetirizine was as effective in control of high and low symptoms except for time to achieve maximum effect (2 days versus 1 week, respectively, p = 0."	2.75	Clinical assessment of levocetirizine and budesonide in treatment of persistent allergic rhinitis regarding to symptom severity. ( Boonkitticharoen, V; Kulapaditharom, B; Pornprasertsuk, K, 2010)
"Levocetirizine has been shown in observational studies in the west as an effective and satisfactory therapy for patients with allergic respiratory and skin disease."	2.75	An open-label, multicentre study of levocetirizine for the treatment of allergic rhinitis and urticaria in Taiwanese patients. ( Fang, SY; Huangs, CY; Lee, JY; Lin, DY; Perng, DW, 2010)
"Cetirizine (Zyrtec) is a potent and long-acting second-generation histamine H1- receptor antagonist for the treatment of allergic disease, such as allergic rhinitis and chronic idiopathic urticaria, in adult and child."	2.74	The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis. ( Ku, MS; Lee, CF; Lu, KH; Lue, KH; Sun, HL, 2009)
" There were 27 adverse events, no serious adverse events in 177 patients during experimental period."	2.73	[Efficacy and safety of Mizolastine in the treatment of perennial allergic rhinitis]. ( Ding, J; Huang, Z; Wang, H; Zheng, C; Zhou, S, 2007)
"01), and the frequency of adverse events did not differ significantly from those seen in the placebo group."	2.71	Efficacy and safety of levocetirizine on symptoms and health-related quality of life of children with perennial allergic rhinitis: a double-blind, placebo-controlled randomized clinical trial. ( Potter, PC, 2005)
"Nasal obstruction is the main symptom in patients with persistent allergic rhinitis."	2.71	Levocetirizine improves nasal symptoms and airflow in patients with persistent allergic rhinitis: a pilot study. ( Ciprandi, G; Cirillo, IG; Tosca, MA; Vizzaccaro, A, 2005)
"Nasal obstruction is the main symptom in patients with perennial allergic rhinitis."	2.71	Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study. ( Allen, M; Barberi, S; Ciprandi, G; Cirillo, I; Civardi, E; Marseglia, GL; Vizzaccaro, A, 2005)
"Levocetirizine was shown to improve quality of life and symptoms and to decrease the overall costs of the disease over the 6-month treatment period."	2.71	Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. ( Bachert, C; Bousquet, J; Canonica, GW; Durham, SR; Klimek, L; Mullol, J; Van Cauwenberge, PB; Van Hammée, G, 2004)
"Levocetirizine was shown to improve symptoms and health-related quality of life of patients with persistent allergic rhinitis in the XPERT study, a 6-month randomized double blind placebo-controlled trial."	2.71	Costs associated with persistent allergic rhinitis are reduced by levocetirizine. ( Bachert, C; Bousquet, J; Demarteau, N; Mullol, J; van den Akker-van Marle, ME; Van Ganse, E, 2005)
"Cetirizine treatment induced a significant decrease of IL4 (p<0."	2.71	Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis. ( Ciprandi, G; Milanese, M; Ricca, V; Tosca, MA, 2004)
"Experimental data demonstrate that mite allergy is characterized by persistent chronic inflammation."	2.71	Long-term cetirizine treatment may reduce new sensitisations in allergic children: a pilot study. ( Ciprandi, G; Frati, F; Marcucci, F; Milanese, M; Sensi, L; Tosca, MA, 2003)
"Cetirizine was significantly more effective at reducing the mean rhinorrhea score compared with oxatomide for both weeks 8 and 12 (P < 0."	2.70	The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis. ( Hsieh, JC; Lai, DS; Lee, HS; Lin, KL; Lue, KH, 2002)
" No clinically relevant adverse events were recorded."	2.70	Efficacy and safety of an oral formulation of cetirizine and prolonged-release pseudoephedrine versus xylometazoline nasal spray in nasal congestion. ( Berger, UE; Burtin, B; Horak, F; Marks, B; Stübner, UP; Toth, J, 2001)
" No serious adverse events occurred, and both regimens were equally well tolerated."	2.69	Efficacy and safety relative to placebo of an oral formulation of cetirizine and sustained-release pseudoephedrine in the management of nasal congestion. ( Berger, UE; Burtin, B; Duby, C; Horak, F; Jäger, S; Marks, B; Stübner, UP; Toth, J, 1998)
" Twenty-four hours after intake, the dose-response curve of nasal obstruction to histamine was significantly lower after treatment with cetirizine compared with placebo (P < 0."	2.69	Nasal effect of cetirizine and loratadine at 24 hours in patients with allergic rhinitis. ( Benabdesselam, O; Frossard, N; Glasser, N; Lacronique, J; Melac, M; Pauli, G, 1998)
"Cetirizine was more effective than loratadine in inhibiting the wheal response to histamine challenge and afforded greater reductions in most individual symptoms assessed daily by the parent."	2.69	Double-blind comparison of cetirizine and loratadine in children ages 2 to 6 years with perennial allergic rhinitis. ( Del Rio-Navarro, B; Gazca-Aguilar, A; Sienra-Monge, JJ, 1999)
" Somnolence scores were similar for both groups at baseline and at the time of dosing (8:00 AM)."	2.69	Loratadine versus cetirizine: assessment of somnolence and motivation during the workday. ( Gates, D; Greiding, L; Heithoff, K; Ramon, F; Salmun, LM; Scharf, M, 2000)
"Cetirizine is an antihistamine used in the treatment of allergic rhinoconjunctivitis, that has antiallergic activity."	2.68	Continuous versus on demand treatment with cetirizine for allergic rhinitis. ( Canonica, GW; Ciprandi, G; Mincarini, M; Passalacqua, G; Ricca, V, 1997)
"Cetirizine was well tolerated, and the frequency of somnolence was not significantly greater in patients receiving this drug than in those given placebo."	2.67	Efficacy and safety of cetirizine therapy in perennial allergic rhinitis. ( Altman, RA; Berman, BA; Buchman, E; Dockhorn, RJ; Leese, PT; Love, SJ; Mansmann, HC; Middleton, E, 1992)
" Adverse events were infrequent and generally mild or moderate in severity."	2.67	Assessment of the efficacy and safety of three dose levels of cetirizine given once daily in children with perennial allergic rhinitis. ( Jobst, S; Schubert, A; van de Venne, H; van den Wijngaart, W, 1994)
"Levocetirizine has several pharmacokinetic properties that are desirable for an antihistamine providing a combination of both potency and safety."	2.47	Pharmacokinetic evaluation of levocetirizine. ( Ferrer, M, 2011)
" No major cytochrome P450 inhibition has been reported with desloratadine, fexofenadine and levocetirizine, and the bioavailability of desloratadine is minimally affected by drugs interfering with transporter molecules."	2.44	Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review. ( Devillier, P; Faisy, C; Roche, N, 2008)
"Nasal obstruction is a difficult-to-treat symptom."	2.43	Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine. ( Bachert, C; De Smedt, H; Patou, J; van Cauwenberge, P, 2006)
"Levocetirizine has a favorable pharmacokinetic profile; it is rapidly and extensively absorbed, minimally metabolized, and has a lower volume of distribution (V(d)) than some other second-generation antihistamines."	2.42	Levocetirizine: a new selective H1 receptor antagonist for use in allergic disorders. ( Day, JH; Ellis, AK; Rafeiro, E, 2004)
"Cetirizine hydrochloride is an orally-active and selective histamine (H(1))-receptor antagonist."	2.42	Review of cetirizine hydrochloride for the treatment of allergic disorders. ( Dinakar, C; Portnoy, JM, 2004)
"Cetirizine is a potent H1-receptor antagonist and has anti-inflammatory properties."	2.40	Impact of cetirizine on the burden of allergic rhinitis. ( Grant, JA; Meltzer, EO, 1999)
" The recommended adult dosage of this agent is 5 or 10 mg/d."	2.38	Cetirizine: a new, nonsedating antihistamine. ( Barnes, CL; McKenzie, CA; Poinsett-Holmes, K; Webster, KD, 1993)
"Cetirizine is a major metabolite of hydroxyzine that has little anticholinergic activity and causes significantly less sedation."	2.38	Perennial allergic rhinitis: clinical efficacy of a new antihistamine. ( Berman, BA, 1990)
" The first-generation H(1)-antihistamines are associated with marked adverse effects such as sedation, sleepiness/drowsiness as well as difficulties in learning and cognitive processing; thus, they are recommended for limited or discontinued use in children with AR or CIU."	1.37	Evidence for clinical safety, efficacy, and parent and physician perceptions of levocetirizine for the treatment of children with allergic disease. ( Kurzawa, R; Pampura, AN; Papadopoulos, NG; Spičák, V, 2011)
" Alternative dosage forms such as liquids or oral disintegrating tablets are available for most agents, allowing ease of administration to most young children and infants; however, limited data are available regarding use in infants for most agents, except desloratadine, cetirizine and montelukast."	1.35	Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. ( Moeller, ML; Nahata, MC; Phan, H, 2009)

Research

Studies (122)

Authors

Clinical Trials (8)

Trial Overview

Trial Outcomes

Likert Score Rating Global Sedation

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (1.64)	18.7374
1990's	32 (26.23)	18.2507
2000's	66 (54.10)	29.6817
2010's	22 (18.03)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Malizia, V	1
Fasola, S	1
Ferrante, G	1
Cilluffo, G	1
Gagliardo, R	1
Landi, M	1
Montalbano, L	1
Marchese, D	1
La Grutta, S	1
Kim, MK	1
Lee, SY	2
Park, HS	1
Yoon, HJ	1
Kim, SH	1
Cho, YJ	1
Yoo, KH	1
Lee, SK	1
Kim, HK	1
Park, JW	1
Park, HW	1
Chung, JH	1
Choi, BW	1
Lee, BJ	1
Chang, YS	1
Jo, EJ	1
Cho, YS	1
Jee, YK	1
Lee, JM	1
Jung, J	1
Park, CS	1
Mösges, R	2
König, V	2
Köberlein, J	2
Hashemi, SM	1
Okhovat, A	1
Amini, S	1
Pourghasemian, M	1
Zhang, L	1
Cheng, L	1
Hong, J	1
Lin, WY	1
Fu, LS	1
Lin, HK	1
Shen, CY	1
Chen, YJ	1
Ciebiada, MG	2
Barylski, M	1
Ciebiada, M	3
Wang, Y	1
Chen, S	1
Wang, P	1
Tan, C	1
Zhang, C	1
Shi, Z	1
Zhao, J	1
Yokota, E	2
Kuyama, S	2
Ogawa, M	2
Kamei, C	2
Fantin, S	1
Maspero, J	1
Bisbal, C	1
Agache, I	1
Donado, E	1
Borja, J	1
Mola, O	1
Izquierdo, I	1
Izumi, N	1
Mizuguchi, H	1
Umehara, H	1
Ogino, S	1
Fukui, H	1
Zhu, WR	1
Zhang, SJ	1
Deng, DH	1
Shen, XH	1
Bukstein, DA	1
Lapine, TJ	1
Canonica, GW	7
Fumagalli, F	1
Guerra, L	2
Baiardini, I	3
Compalati, E	1
Rogkakou, A	3
Massacane, P	2
Gamalero, C	2
Riccio, AM	2
Scordamaglia, A	1
Passalacqua, G	5
Sugimoto, Y	1
Kmiecik, T	1
DuBuske, LM	2
Gorski, P	2
Simoens, S	1
Laekeman, G	1
Lee, CF	1
Sun, HL	3
Lu, KH	3
Ku, MS	2
Lue, KH	4
Vaidyanathan, S	1
Nair, A	1
Barnes, ML	2
Meldrum, K	1
Lipworth, BJ	3
Singh-Franco, D	1
Ghin, HL	1
Robles, GI	1
Borja-Hart, N	1
Perez, A	1
Phan, H	1
Moeller, ML	1
Nahata, MC	1
Rathod, RT	1
Misra, D	2
Konstantinou, GN	1
Ligerou, M	1
Ligeros, MP	1
Kulapaditharom, B	1
Pornprasertsuk, K	1
Boonkitticharoen, V	1
Lopatin, AS	1
Latysheva, EN	1
Adsule, SM	1
Marcucci, F	2
Sensi, LG	1
Abate, P	1
Allocca, G	1
Ugolini, E	1
Di Cara, G	1
Incorvaia, C	1
Pampura, AN	1
Papadopoulos, NG	1
Spičák, V	1
Kurzawa, R	1
Ferrer, M	1
Fang, SY	1
Perng, DW	1
Lee, JY	1
Lin, DY	1
Huangs, CY	1
Sastre, J	1
Mullol, J	4
Valero, A	1
Valiente, R	1
Tzanetos, DB	1
Fahrenholz, JM	1
Scott, T	1
Buchholz, K	1
Zaĭtseva, OV	1
Sheu, JN	1
Chan, CH	1
Wang, YH	1
Carter, NJ	1
Lai, DS	1
Hsieh, JC	1
Lin, KL	1
Lee, HS	1
Tang, JY	1
Simons, FE	2
J Semus, M	1
Goritz, SS	1
Simons, KJ	1
Ciprandi, G	6
Frati, F	1
Sensi, L	1
Milanese, M	2
Tosca, MA	3
Portnoy, JM	1
Dinakar, C	1
Ng, KH	1
Chong, D	1
Wong, CK	1
Ong, HT	1
Lee, CY	1
Lee, BW	1
Shek, LP	1
Lee, DK	2
Gardiner, M	1
Haggart, K	1
Fujihara, S	1
Magnan, A	1
Stübner, P	1
Zieglmayer, R	1
Horak, F	4
Bloebaum, RM	1
Grant, JA	2
Day, JH	2
Ellis, AK	2
Rafeiro, E	1
Ricca, V	2
Bachert, C	4
Bousquet, J	5
Durham, SR	2
Klimek, L	3
Van Cauwenberge, PB	2
Van Hammée, G	2
Currie, GP	1
Shirasaki, H	1
Watanabe, K	1
Kanaizumi, E	1
Sato, J	1
Konno, N	1
Narita, S	1
Himi, T	1
Cirillo, IG	1
Vizzaccaro, A	2
Demarteau, N	1
van den Akker-van Marle, ME	1
Van Ganse, E	1
Holgate, S	1
Powell, R	1
Jenkins, M	1
Ali, O	1
Zieglmayer, UP	1
Toth, J	3
Marks, B	3
Berger, UE	3
Burtin, B	4
Potter, PC	1
Cirillo, I	1
Civardi, E	1
Barberi, S	1
Allen, M	1
Marseglia, GL	1
Chen, ST	1
Chang, WT	1
Chou, MC	1
Baena-Cagnani, R	1
Zanella, Ch	1
Lauriello, M	1
Muzi, P	1
Di Rienzo, L	1
Di Stanislao, C	1
Tirelli, GC	1
Bologna, M	1
Walter Canonica, G	1
Hair, PI	1
Scott, LJ	1
Patou, J	1
De Smedt, H	1
van Cauwenberge, P	1
Pasquali, M	1
Descalzi, D	1
Folli, C	1
Menzies, D	1
Fardon, TC	1
Burns, P	1
Wilson, AM	1
Górska-Ciebiada, M	1
Lehman, JM	1
Blaiss, MS	1
Young, D	1
Zhou, S	1
Ding, J	1
Zheng, C	1
Wang, H	1
Huang, Z	1
Devillier, P	1
Roche, N	1
Faisy, C	1
Braunstein, G	1
Buvry, A	1
Lacronique, J	2
Desjardins, N	1
Frossard, N	2
Cheria-Sammari, S	1
Aloui, R	1
Gormand, F	1
Chabannes, B	1
Gallet, H	1
Grosclaude, M	2
Melac, M	3
Rihoux, JP	3
Perrin-Fayolle, M	1
Lagarde, M	1
Broide, D	1
Jobst, S	1
van den Wijngaart, W	1
Schubert, A	1
van de Venne, H	2
Clement, P	1
Roovers, MH	1
Francillon, C	1
Dodion, P	1
Kaiser, HB	1
Barnes, CL	1
McKenzie, CA	1
Webster, KD	1
Poinsett-Holmes, K	1
Duchateau, J	1
Pignat, JC	1
Fayol, C	1
Marquis, P	1
Mariz, S	1
Ware, JE	1
Valentin, B	1
Gupta, SK	1
Kalayci, O	1
Saraclar, Y	1
Adalioglu, G	1
Sekerel, B	1
Tuncer, A	1
Molkhou, P	2
Billardon, M	3
Jouan, AM	2
Fondarai, J	2
Bertrand, B	2
Jamart, J	1
Marchal, JL	1
Arendt, C	2
Briscoe, MP	1
Clark, RH	1
Gervais, P	1
Mees, K	1
Pinelli, ME	1
Lucas, M	1
Mincarini, M	1
Eloy, P	1
Rombeaux, P	1
Murris-Espin, M	1
Charpentier, JC	1
Didier, A	1
Enzmann, H	1
Mathe, F	1
Stübner, UP	2
Jäger, S	1
Duby, C	1
Benabdesselam, O	1
Glasser, N	1
Pauli, G	1
Pacor, ML	1
Biasi, D	1
Carletto, A	1
Corrocher, R	1
Sienra-Monge, JJ	1
Gazca-Aguilar, A	1
Del Rio-Navarro, B	1
Aubier, M	1
Meltzer, EO	1
Kofler, H	1
Hemmer, W	1
Focke, M	1
Jarisch, R	1
Fadel, R	2
Ramboer, I	2
Chatterjee, N	2
Derde, MP	2
Salmun, LM	1
Gates, D	1
Scharf, M	1
Greiding, L	1
Ramon, F	1
Heithoff, K	1
Uchida, M	1
Nakahara, H	1
Laliberté, F	1
Laliberté, MF	1
Lécart, S	1
Klossec, JM	1
Mounedji, N	1
Fong, DG	1
Angulo, P	1
Burgart, LJ	1
Lindor, KD	1
Larsen, JS	1
Lee, J	1
Cummins, G	2
Okamoto, L	1
Liao, E	1
Leahy, M	1
Rinne, J	1
Simola, M	1
Malmberg, H	1
Haahtela, T	1
Siergiejko, Z	1
Michalska, I	1
Rogalewska, A	1
Chyrek-Borowska, S	1
Mansmann, HC	1
Altman, RA	1
Berman, BA	2
Buchman, E	1
Dockhorn, RJ	1
Leese, PT	1
Love, SJ	1
Middleton, E	1
Lobaton, P	1
Moreno, F	1
Coulie, P	1
Boniver, R	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Efficacy and Safety of HCP1102 Capsule : A Randomized, Double-blind, Active-controlled, Multicenter Phase 3 Clinical Trial[NCT02552667]	Phase 3	228 participants (Actual)	Interventional	2014-09-30	Completed
A Placebo Controlled Trial to Evaluate The Effects of Levocetirizine on Nasal Allergen Challenge And Adenosine Monophosphate Challenge In Patients With Intermittent and Persistent Allergic Rhinitis[NCT00679250]	Phase 4	25 participants (Actual)	Interventional	2005-11-30	Completed
Effectiveness of Montelukast Versus Intranasal Fluticasone Propionate in the Management of Allergic Rhinitis Among Children 02 to 05 Years of Age[NCT04957927]	Phase 4	60 participants (Anticipated)	Interventional	2020-12-12	Recruiting
A Phase III, Comparative Study for the Efficacy and Safety of Bilastine 20 mg Versus Cetirizine 10 mg and Placebo in the Treatment of Perennial Allergic Rhinitis During 4 Weeks, Followed by a Long-term Safety Extension With Bilastine 20 mg[NCT01127620]	Phase 3	650 participants (Actual)	Interventional	2004-05-31	Completed
Quality of Life in Patients With Allergic Rhinitis: a Clinical Trial Comparing the Use of Bilastine Versus Loratadine[NCT02513290]	Phase 4	73 participants (Actual)	Interventional	2013-08-31	Completed
Is Levocetirizine Less Sedating Than Cetirizine? A Randomized, Double-blind, Placebo Controlled Trial.[NCT00826943]	Phase 4	30 participants (Actual)	Interventional	2009-01-31	Completed
A Proof of Concept Study to Evaluate if Concomitant Topical Intranasal Steroid Prevents Tolerance and Rebound Congestion Due to Regular Oxymetazoline in Persistent Allergic Rhinitis.[NCT00846326]	Phase 4	0 participants (Actual)	Interventional		Withdrawn (stopped due to The suppliers were unable to provide the investigational medicinal product (IMP))
A Proof of Concept Study to Evaluate Differential Tachyphylaxis of Alpha 1 and Alpha 2 Adrenoreceptor Mediated Decongestant Response to Oxymetazoline and Its Acute Reversal by Corticosteroid in Healthy Volunteers[NCT00487032]	Phase 4	19 participants (Actual)	Interventional	2008-05-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Likert score range 1 to 9 (no sedation to extreme sedation). Highers scores indicate increased sedation. This was measured on days days 5, 12, 17, 24, 29, and 36 of the study.~This was mean data for all interventions." (NCT00826943)
Timeframe: duration of study (36 days)

Modified Epworth Sleepiness Scale

Intervention	Likert score (Mean)
Placebo	2.80
Levocetirizine	3.07
Cetirizine	3.54

"Epworth Sleepiness Scale ratings (0 to 24); higher scores = increased sedation. This was measured over the 36 days of the study (at the end of each washout period and each intervention period); measured on days 5, 12, 17, 24, 29, and 36.~This was mean data for all interventions." (NCT00826943)
Timeframe: 36 days of the study

Total Four Symptom Scores (Allergy Symptoms)

Intervention	units on a scale (Mean)
Placebo	6.14
Levocetirizine	6.69
Cetirizine	7.48

"Total Four Symptom Scores (TFSS) ranging 0 to 12. Increased scores indicate increased symptoms. This was measured on days 5, 12, 17, 24, 29, and 36 of the study. The mean TFSS for patients receiving placebo, cetirizine, and levocetirizine was then calculated.~This was mean data for all interventions." (NCT00826943)
Timeframe: same as primary outcome measure (obtain on days 5, 12, 17, 24, 29, and 36)

Article	Year
The effectiveness of modern antihistamines for treatment of allergic rhinitis - an IPD meta-analysis of 140,853 patients. Allergology international : official journal of the Japanese Society of Allergology, 2013, Volume: 62, Issue:2 Topics: Anti-Allergic Agents; Cetirizine; Histamine Antagonists; Histamine H1 Antagonists, Non-Sedating; Hum	2013
The clinical use of cetirizine in the treatment of allergic rhinitis. Pharmacology, 2013, Volume: 92, Issue:1-2 Topics: Anti-Allergic Agents; Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Rhinitis, Allergic	2013
Allergic rhinitis in family practice: the role of levocetirizine in clinical care. Postgraduate medicine, 2008, Volume: 120, Issue:2 Topics: Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Rhinitis, Allergic, Perennial; Rhinitis,	2008
Pharmacotherapy of allergic rhinitis: a pharmaco-economic approach. Allergy, 2009, Volume: 64, Issue:1 Topics: Cetirizine; Costs and Cost Analysis; Economics, Pharmaceutical; Humans; Rhinitis, Allergic, Perennia	2009
Levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children. Clinical therapeutics, 2009, Volume: 31, Issue:8 Topics: Adult; Cetirizine; Child; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Quality	2009
[Levocetirizine in therapy for allergic rhinitis]. Vestnik otorinolaringologii, 2010, Issue:4 Topics: Cetirizine; Controlled Clinical Trials as Topic; Histamine H1 Antagonists, Non-Sedating; Humans; Rhi	2010
Long term treatment with montelukast and levocetirizine combination in persistent allergic rhinitis: review of recent evidence. Journal of the Indian Medical Association, 2010, Volume: 108, Issue:6 Topics: Acetates; Cetirizine; Cyclopropanes; Drug Therapy, Combination; Histamine H1 Antagonists, Non-Sedati	2010
Pharmacokinetic evaluation of levocetirizine. Expert opinion on drug metabolism & toxicology, 2011, Volume: 7, Issue:8 Topics: Cetirizine; Chronic Disease; Drug Evaluation; Histamine H1 Antagonists, Non-Sedating; Humans; Random	2011
The effectiveness of levocetirizine in comparison with loratadine in treatment of allergic rhinitis--a meta-analysis. Allergology international : official journal of the Japanese Society of Allergology, 2011, Volume: 60, Issue:4 Topics: Anti-Allergic Agents; Cetirizine; Humans; Loratadine; Rhinitis, Allergic, Perennial; Rhinitis, Aller	2011
[The approaches to diagnostics and therapy of allergic rhinitis]. Vestnik otorinolaringologii, 2011, Issue:5 Topics: Administration, Oral; Adrenal Cortex Hormones; Cetirizine; Combined Modality Therapy; Histamine H1 A	2011
Bilastine: in allergic rhinitis and urticaria. Drugs, 2012, Jun-18, Volume: 72, Issue:9 Topics: Area Under Curve; Benzimidazoles; Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Lorata	2012
Review of cetirizine hydrochloride for the treatment of allergic disorders. Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:1 Topics: Anti-Allergic Agents; Asthma; Cetirizine; Clinical Trials as Topic; Dermatitis, Atopic; Histamine H1	2004
Levocetirizine: a new selective H1 receptor antagonist for use in allergic disorders. Drugs of today (Barcelona, Spain : 1998), 2004, Volume: 40, Issue:5 Topics: Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Nasal Obstruction; Piperazines; Randomiz	2004
Potential of levocetirizine in the relief of nasal congestion. International journal of clinical practice, 2005, Volume: 59, Issue:6 Topics: Administration, Inhalation; Anti-Allergic Agents; Cetirizine; Histamine H1 Antagonists, Non-Sedating	2005
A treatment for allergic rhinitis: a view on the role of levocetirizine. Current medical research and opinion, 2005, Volume: 21, Issue:7 Topics: Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Piperazines; Practice Guidelines as Topi	2005
A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis. Clinical therapeutics, 2005, Volume: 27, Issue:7 Topics: Cetirizine; Histamine Antagonists; Humans; Loratadine; Nose; Piperazines; Quality of Life; Randomize	2005
Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies. Drugs, 2006, Volume: 66, Issue:7 Topics: Cetirizine; Clinical Trials as Topic; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivi	2006
Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006, Volume: 36, Issue:8 Topics: Cetirizine; Eosinophils; Histamine H1 Antagonists, Non-Sedating; Humans; Mast Cells; Nasal Obstructi	2006
Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006, Volume: 36, Issue:8 Topics: Cetirizine; Eosinophils; Histamine H1 Antagonists, Non-Sedating; Humans; Mast Cells; Nasal Obstructi	2006
Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006, Volume: 36, Issue:8 Topics: Cetirizine; Eosinophils; Histamine H1 Antagonists, Non-Sedating; Humans; Mast Cells; Nasal Obstructi	2006
Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006, Volume: 36, Issue:8 Topics: Cetirizine; Eosinophils; Histamine H1 Antagonists, Non-Sedating; Humans; Mast Cells; Nasal Obstructi	2006
Selecting the optimal oral antihistamine for patients with allergic rhinitis. Drugs, 2006, Volume: 66, Issue:18 Topics: Administration, Oral; Cardiovascular System; Central Nervous System; Cetirizine; Drug Interactions;	2006
Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review. Clinical pharmacokinetics, 2008, Volume: 47, Issue:4 Topics: Cetirizine; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis,	2008
Clinical studies with cetirizine in allergic rhinitis and chronic urticaria. Allergy, 1995, Volume: 50, Issue:24 Suppl Topics: Cetirizine; Chronic Disease; Clinical Trials as Topic; Humans; Rhinitis, Allergic, Perennial; Rhinit	1995
Cetirizine in allergic rhinitis. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 1993, Volume: 4, Issue:4 Suppl Topics: Cetirizine; Eosinophils; Humans; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal	1993
Cetirizine: a new, nonsedating antihistamine. The Annals of pharmacotherapy, 1993, Volume: 27, Issue:4 Topics: Asthma; Cetirizine; Humans; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Urticaria	1993
Allergy and sinusitis. Acta oto-rhino-laryngologica Belgica, 1997, Volume: 51, Issue:4 Topics: Allergens; Anti-Allergic Agents; Anti-Inflammatory Agents; Beclomethasone; Blood Proteins; Cetirizin	1997
Linking upper and lower airways. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1999, Volume: 83, Issue:5 Topics: Adrenal Cortex Hormones; Bronchial Hyperreactivity; Cetirizine; Histamine H1 Antagonists; Humans; Rh	1999
Minimal persistent inflammation may be controlled by cetirizine. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1999, Volume: 83, Issue:5 Topics: Animals; Anti-Allergic Agents; Asthma; Cetirizine; Child; Conjunctivitis, Allergic; Humans; Hypersen	1999
Impact of cetirizine on the burden of allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1999, Volume: 83, Issue:5 Topics: Anti-Allergic Agents; Cetirizine; Controlled Clinical Trials as Topic; Cost of Illness; Histamine H1	1999
[Pharmacological and clinical properties of cetirizine hydrochloride]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000, Volume: 115, Issue:4 Topics: Animals; Anti-Allergic Agents; Cetirizine; Chemotaxis; Chronic Disease; Electrocardiography; Eosinop	2000
Do antihistamines have a role in asthma therapy? Pharmacotherapy, 2001, Volume: 21, Issue:3 Pt 2 Topics: Anti-Asthmatic Agents; Asthma; Bronchi; Cetirizine; Histamine; Histamine H1 Antagonists; Humans; Hyp	2001
Perennial allergic rhinitis: clinical efficacy of a new antihistamine. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Benzhydryl Compounds; Cetirizine; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 An	1990
Recent advances in H1-receptor antagonist treatment. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Cyproheptadine; Histamine H1 Antagonis	1990

Article	Year
Comparative Effect of Beclomethasone Dipropionate and Cetirizine on Acoustic Rhinometry Parameters in Children With Perennial Allergic Rhinitis: A Randomized Controlled Trial. Journal of investigational allergology & clinical immunology, 2018, Volume: 28, Issue:6 Topics: Administration, Intranasal; Adolescent; Anti-Inflammatory Agents; Beclomethasone; Cetirizine; Child;	2018
A Randomized, Multicenter, Double-blind, Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis. Clinical therapeutics, 2018, Volume: 40, Issue:7 Topics: Acetates; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Cetirizine; Cyclopropanes; Dou	2018
Comparing the effects of Botulinum Toxin-A and cetirizine on the treatment of allergic rhinitis. Allergology international : official journal of the Japanese Society of Allergology, 2013, Volume: 62, Issue:2 Topics: Administration, Intranasal; Adolescent; Adult; Botulinum Toxins, Type A; Cetirizine; Female; Histami	2013
Evaluation of the effect of Lactobacillus paracasei (HF.A00232) in children (6-13 years old) with perennial allergic rhinitis: a 12-week, double-blind, randomized, placebo-controlled study. Pediatrics and neonatology, 2014, Volume: 55, Issue:3 Topics: Adolescent; Cetirizine; Child; Double-Blind Method; Female; Health Surveys; Histamine H1 Antagonists	2014
Wheal and flare reactions in skin prick tests of patients treated with montelukast alone or in combination with antihistamines. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2014, Volume: 63, Issue:3 Topics: Acetates; Adolescent; Adult; Aged; Antigens; Antigens, Dermatophagoides; Cetirizine; Cross-Over Stud	2014
Comparison of clinical effectiveness of acupuncture and a Western drug on allergic rhinitis: study protocol for a randomized controlled trial. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2014, Volume: 34, Issue:3 Topics: Acupuncture Therapy; Adult; Cetirizine; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male	2014
A 12-week placebo-controlled study of rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis. Allergy, 2008, Volume: 63, Issue:7 Topics: Adolescent; Adult; Anti-Allergic Agents; Cetirizine; Cyproheptadine; Double-Blind Method; Female; Hu	2008
[Dishen Qufeng Decoction for treating allergic rhinitis: a randomized controlled trial]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2008, Volume: 6, Issue:7 Topics: Adolescent; Adult; Aged; Cetirizine; Drugs, Chinese Herbal; Eosinophils; Female; Humans; Leukocyte C	2008
Levocetirizine in persistent allergic rhinitis: continuous or on-demand use? A pilot study. Current medical research and opinion, 2008, Volume: 24, Issue:10 Topics: Adult; Aged; Cetirizine; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Inflammation; Male;	2008
Quality of life in patients with persistent allergic rhinitis treated with montelukast alone or in combination with levocetirizine or desloratadine. Journal of investigational allergology & clinical immunology, 2008, Volume: 18, Issue:5 Topics: Acetates; Adolescent; Adult; Aged; Cetirizine; Chronic Disease; Cross-Over Studies; Cyclopropanes; D	2008
The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2009, Volume: 20, Issue:5 Topics: Cetirizine; Child; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Quality of Life; Rh	2009
Effect of levocetirizine on nasal provocation testing with adenosine monophosphate compared with allergen challenge in allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2009, Volume: 39, Issue:3 Topics: Adenosine Monophosphate; Adult; Aged; Allergens; Area Under Curve; Cetirizine; Cross-Over Studies; D	2009
Clinical assessment of levocetirizine and budesonide in treatment of persistent allergic rhinitis regarding to symptom severity. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2010, Volume: 93, Issue:2 Topics: Adult; Aged; Anti-Inflammatory Agents; Area Under Curve; Budesonide; Cetirizine; Female; Histamine H	2010
Anti-inflammatory activity and clinical efficacy of a 3-month levocetirizine therapy in mite-allergic children. Inflammation & allergy drug targets, 2011, Volume: 10, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchi; Bronchoconstriction; Cetirizine; Child; Double-B	2011
An open-label, multicentre study of levocetirizine for the treatment of allergic rhinitis and urticaria in Taiwanese patients. The Chinese journal of physiology, 2010, Aug-31, Volume: 53, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cetirizine; Child; Female; Histamine H1 Antagonists, Non	2010
Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo in the treatment of perennial allergic rhinitis. Current medical research and opinion, 2012, Volume: 28, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Argentina; Benzimidazoles; Cetirizine; Child; Dosage	2012
Comparison of the sedating effects of levocetirizine and cetirizine: a randomized, double-blind, placebo-controlled trial. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2011, Volume: 107, Issue:6 Topics: Adult; Aged; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists,	2011
A trial of adding Lactobacillus johnsonii EM1 to levocetirizine for treatment of perennial allergic rhinitis in children aged 7-12 years. International journal of pediatric otorhinolaryngology, 2012, Volume: 76, Issue:7 Topics: Cetirizine; Child; Cross-Over Studies; Histamine H1 Antagonists, Non-Sedating; Humans; Lactobacillus	2012
The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:6 Topics: Allergens; Animals; Anti-Allergic Agents; Blood Proteins; Cetirizine; Child; Conjunctivitis, Allergi	2002
[Zrytec drops in the treatment of allergy rhinitis in children]. Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, 2000, Volume: 14, Issue:10 Topics: Cetirizine; Child; Child, Preschool; Drug Administration Schedule; Female; Histamine H1 Antagonists,	2000
H1-antihistaminic activity of cetirizine and fexofenadine in allergic children. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2003, Volume: 14, Issue:3 Topics: Anti-Allergic Agents; Cetirizine; Child; Cross-Over Studies; Double-Blind Method; Female; Histamine	2003
Long-term cetirizine treatment may reduce new sensitisations in allergic children: a pilot study. European annals of allergy and clinical immunology, 2003, Volume: 35, Issue:6 Topics: Animals; Anti-Allergic Agents; Asthma; Cetirizine; Child; Child, Preschool; Double-Blind Method; Dus	2003
Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled comparative study. Pediatrics, 2004, Volume: 113, Issue:2 Topics: Adolescent; Central Nervous System; Cetirizine; Child; Chlorpheniramine; Cross-Over Studies; Double-	2004
Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2004, Volume: 34, Issue:4 Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Cetirizine; Cross-Ove	2004
A direct comparison of the efficacy of antihistamines in SAR and PAR: randomised, placebo-controlled studies with levocetirizine and loratadine using an environmental exposure unit - the Vienna Challenge Chamber (VCC). Current medical research and opinion, 2004, Volume: 20, Issue:6 Topics: Cetirizine; Cross-Over Studies; Double-Blind Method; Environmental Exposure; Female; Histamine H1 An	2004
Levocetirizine: the allergist's arsenal grows larger. Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:7 Topics: Allergy and Immunology; Cetirizine; Chronic Disease; Clinical Trials, Phase III as Topic; Double-Bli	2004
Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis. European annals of allergy and clinical immunology, 2004, Volume: 36, Issue:6 Topics: Adolescent; Animals; Cetirizine; Child; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Eosi	2004
Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. The Journal of allergy and clinical immunology, 2004, Volume: 114, Issue:4 Topics: Adolescent; Adult; Aged; Cetirizine; Conjunctivitis, Allergic; Costs and Cost Analysis; Double-Blind	2004
Effects of cetirizine on substance P release in patients with perennial allergic rhinitis. The Annals of otology, rhinology, and laryngology, 2004, Volume: 113, Issue:12 Topics: Adult; Airway Resistance; Albumins; Anti-Allergic Agents; Cetirizine; Female; Histamine; Histamine H	2004
Levocetirizine improves nasal symptoms and airflow in patients with persistent allergic rhinitis: a pilot study. European annals of allergy and clinical immunology, 2005, Volume: 37, Issue:1 Topics: Adolescent; Adult; Cetirizine; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating;	2005
Costs associated with persistent allergic rhinitis are reduced by levocetirizine. Allergy, 2005, Volume: 60, Issue:6 Topics: Cetirizine; Cost of Illness; Costs and Cost Analysis; Europe; Histamine H1 Antagonists, Non-Sedating	2005
Efficacy and safety of an oral formulation of cetirizine and prolonged-release pseudoephedrine versus budesonide nasal spray in the management of nasal congestion in allergic rhinitis. Treatments in respiratory medicine, 2005, Volume: 4, Issue:4 Topics: Administration, Intranasal; Administration, Oral; Adult; Anti-Allergic Agents; Budesonide; Cetirizin	2005
Efficacy and safety of levocetirizine on symptoms and health-related quality of life of children with perennial allergic rhinitis: a double-blind, placebo-controlled randomized clinical trial. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 95, Issue:2 Topics: Cetirizine; Child; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Male	2005
Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study. International immunopharmacology, 2005, Volume: 5, Issue:13-14 Topics: Adolescent; Adult; Cetirizine; Double-Blind Method; Eosinophils; Female; Histamine H1 Antagonists, N	2005
Randomized placebo-controlled trial comparing montelukast and cetirizine for treating perennial allergic rhinitis in children aged 2-6 yr. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2006, Volume: 17, Issue:1 Topics: Acetates; Anti-Allergic Agents; Cetirizine; Child; Child, Preschool; Cyclopropanes; Double-Blind Met	2006
Effects on symptoms and quality of life of hypertonic saline nasal spray added to antihistamine in persistent allergic rhinitis--a randomized controlled study. European annals of allergy and clinical immunology, 2005, Volume: 37, Issue:9 Topics: Administration, Intranasal; Adult; Cetirizine; Drug Therapy, Combination; Female; Histamine H1 Antag	2005
A two-year course of specific immunotherapy or of continuous antihistamine treatment reverse eosinophilic inflammation in severe persistent allergic rhinitis. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2005, Volume: 25, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Animals; Anti-Allergic Agents; Cetirizine; Data Interpretat	2005
Levocetirizine improves health-related quality of life and health status in persistent allergic rhinitis. Respiratory medicine, 2006, Volume: 100, Issue:10 Topics: Cetirizine; Double-Blind Method; Health Status; Histamine H1 Antagonists, Non-Sedating; Humans; Pipe	2006
Levocetirizine in persistent allergic rhinitis and asthma: effects on symptoms, quality of life and inflammatory parameters. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006, Volume: 36, Issue:9 Topics: Adolescent; Adult; Asthma; Cetirizine; Conjunctivitis, Allergic; Double-Blind Method; Eosinophils; F	2006
Combined mediator blockade or topical steroid for treating the unified allergic airway. Allergy, 2007, Volume: 62, Issue:1 Topics: Acetates; Administration, Topical; Adolescent; Adult; Aged; Anti-Allergic Agents; Anti-Asthmatic Age	2007
Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 97, Issue:5 Topics: Acetates; Adolescent; Adult; Aged; Anti-Asthmatic Agents; Cetirizine; Cross-Over Studies; Cyclopropa	2006
[Efficacy and safety of Mizolastine in the treatment of perennial allergic rhinitis]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2007, Volume: 21, Issue:11 Topics: Adolescent; Adult; Aged; Benzimidazoles; Cetirizine; Child; Double-Blind Method; Female; Histamine H	2007
Do nasal mast cells release histamine on stimulation with substance P in allergic rhinitis? Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1994, Volume: 24, Issue:10 Topics: Adult; Airway Resistance; Cetirizine; Chemotaxis, Leukocyte; Cross-Over Studies; Dose-Response Relat	1994
Assessment of the efficacy and safety of three dose levels of cetirizine given once daily in children with perennial allergic rhinitis. Allergy, 1994, Volume: 49, Issue:8 Topics: Cetirizine; Child; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Rhinitis	1994
Dose-ranging, placebo-controlled study of cetirizine nasal spray in adults with perennial allergic rhinitis. Allergy, 1994, Volume: 49, Issue:8 Topics: Administration, Inhalation; Adolescent; Adult; Aerosols; Aged; Cetirizine; Female; Humans; Male; Mid	1994
Improvement of quality of life by treatment with cetirizine in patients with perennial allergic rhinitis as determined by a French version of the SF-36 questionnaire. The Journal of allergy and clinical immunology, 1996, Volume: 98, Issue:2 Topics: Adolescent; Adult; Belgium; Cetirizine; Double-Blind Method; Follow-Up Studies; France; Health Surve	1996
Reversion and antihistamines. The Journal of the Association of Physicians of India, 1996, Volume: 44, Issue:1 Topics: Anti-Asthmatic Agents; Asthma; Beclomethasone; Cetirizine; Cromolyn Sodium; Glucocorticoids; Histami	1996
The effect of cetirizine on sulfidoleukotriene production by blood leukocytes in children with allergic rhinitis. Allergy, 1995, Volume: 50, Issue:12 Topics: Adolescent; Allergens; Animals; Anti-Allergic Agents; Antigens, Dermatophagoides; Cetirizine; Child;	1995
[Multicenter hospital study on the efficacy of Zyrtec (R) (cetirizine) compared to a placebo, in the treatment of perennial allergic rhinitis in 254 adolescents aged 12-15]. Allergie et immunologie, 1995, Volume: 27, Issue:8 Topics: Adolescent; Cetirizine; Double-Blind Method; Drug Tolerance; Female; Humans; Male; Rhinitis, Allergi	1995
Cetirizine and pseudoephedrine retard alone and in combination in the treatment of perennial allergic rhinitis: a double-blind multicentre study. Rhinology, 1996, Volume: 34, Issue:2 Topics: Adult; Cetirizine; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; D	1996
[Multicenter study on the efficacy of Zyrtec (Cetirizine) in the treatment of perennial allergic rhinitis in 875 adolescents]. Allergie et immunologie, 1996, Volume: 28, Issue:1 Topics: Adolescent; Cetirizine; Female; Humans; Male; Rhinitis, Allergic, Perennial	1996
Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:2 Topics: Adolescent; Adult; Anti-Allergic Agents; Astemizole; Cetirizine; Double-Blind Method; Environmental	1997
Cetirizine and pseudoephedrine retard, given alone or in combination, in patients with seasonal allergic rhinitis. Rhinology, 1997, Volume: 35, Issue:2 Topics: Adolescent; Adult; Analysis of Variance; Bronchodilator Agents; Cetirizine; Child; Delayed-Action Pr	1997
Continuous versus on demand treatment with cetirizine for allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:6 Topics: Adult; Anti-Allergic Agents; Cetirizine; Double-Blind Method; Female; Humans; Male; Middle Aged; Rhi	1997
Comparison of efficacy and safety of cetirizine and ebastine in patients with perennial allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1998, Volume: 80, Issue:5 Topics: Adolescent; Adult; Aged; Butyrophenones; Cetirizine; Double-Blind Method; Female; Histamine H1 Antag	1998
Efficacy and safety relative to placebo of an oral formulation of cetirizine and sustained-release pseudoephedrine in the management of nasal congestion. Allergy, 1998, Volume: 53, Issue:9 Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Adult; Allergens; Animals; Antigens, De	1998
Nasal effect of cetirizine and loratadine at 24 hours in patients with allergic rhinitis. American journal of therapeutics, 1998, Volume: 5, Issue:5 Topics: Adult; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female	1998
[The efficacy of cetirizine in the treatment of perennial allergic rhinitis]. Recenti progressi in medicina, 1999, Volume: 90, Issue:6 Topics: Adult; Anti-Allergic Agents; Cetirizine; Chronic Disease; Female; Histamine H1 Antagonists; Humans;	1999
Double-blind comparison of cetirizine and loratadine in children ages 2 to 6 years with perennial allergic rhinitis. American journal of therapeutics, 1999, Volume: 6, Issue:3 Topics: Cetirizine; Child, Preschool; Double-Blind Method; Eosinophils; Female; Histamine H1 Antagonists; Hu	1999
Cetirizine inhibits bradykinin-induced cutaneous wheal and flare in atopic and healthy subjects. Allergy, 2000, Volume: 55, Issue:4 Topics: Adolescent; Adult; Asthma; Bradykinin; Cetirizine; Cross-Over Studies; Dermatitis, Allergic Contact;	2000
Loratadine versus cetirizine: assessment of somnolence and motivation during the workday. Clinical therapeutics, 2000, Volume: 22, Issue:5 Topics: Adult; Anti-Allergic Agents; Cetirizine; Disorders of Excessive Somnolence; Double-Blind Method; Eff	2000
Clinical and pathologic methods to assess the long-term safety of nasal corticosteroids. French Triamcinolone Acetonide Study Group. Allergy, 2000, Volume: 55, Issue:8 Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Allergic Agents; Anti-Inflammatory Agents; Be	2000
Cetirizine inhibits bradykinin-induced cutaneous wheal and flare in atopic and healthy subjects. Allergy, 2000, Volume: 55, Issue:9 Topics: Adolescent; Adult; Bradykinin; Cetirizine; Cross-Over Studies; Dermatitis, Allergic Contact; Double-	2000
Efficacy and safety of an oral formulation of cetirizine and prolonged-release pseudoephedrine versus xylometazoline nasal spray in nasal congestion. Arzneimittel-Forschung, 2001, Volume: 51, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Blood Pressure; Cetirizine; Cross-Over Stud	2001
Early treatment of perennial rhinitis with budesonide or cetirizine and its effect on long-term outcome. The Journal of allergy and clinical immunology, 2002, Volume: 109, Issue:3 Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents;	2002
Efficacy and safety of cetirizine therapy in perennial allergic rhinitis. Annals of allergy, 1992, Volume: 68, Issue:4 Topics: Adult; Cetirizine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy; Histamine H1	1992
Comparison of cetirizine with astemizole in the treatment of perennial allergic rhinitis and study of the concomitant effect on histamine and allergen-induced wheal responses. Annals of allergy, 1990, Volume: 65, Issue:5 Topics: Adult; Astemizole; Benzimidazoles; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Humans	1990
[Evaluation of cetirizine and of terfenadine in the treatment of perennial allergic rhinitis]. Acta oto-rhino-laryngologica Belgica, 1989, Volume: 43, Issue:1 Topics: Adolescent; Adult; Benzhydryl Compounds; Cetirizine; Clinical Trials as Topic; Double-Blind Method;	1989
[Importance of Zyrtec in the treatment of chronic urticaria and allergic rhinopathies apropos of 1168 cases seen by hospital practitioners]. Allergie et immunologie, 1989, Volume: 21, Issue:8 Topics: Adolescent; Adult; Cetirizine; Chronic Disease; Female; Histamine H1 Antagonists; Humans; Hydroxyzin	1989

Article	Year
Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice. International immunopharmacology, 2008, Volume: 8, Issue:8 Topics: Animals; Capsaicin; Cetirizine; Disease Models, Animal; Female; Histamine; Histamine Agonists; Hista	2008
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale. Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Butyrophenones; Cetirizine; Child; Chlorpheniram	2008
Participation of histamine H3 receptors in experimental allergic rhinitis of mice. Journal of pharmacological sciences, 2008, Volume: 108, Issue:2 Topics: Animals; Anti-Allergic Agents; Cetirizine; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Respo	2008
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. Drugs, 2009, Volume: 69, Issue:18 Topics: Acetates; Administration, Oral; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Astemizole; Ceti	2009
FDC of montelukast with levocetirizine: focus on bilayer technology. Journal of the Indian Medical Association, 2009, Volume: 107, Issue:8 Topics: Acetates; Cetirizine; Cyclopropanes; Drug Combinations; Histamine H1 Antagonists, Non-Sedating; Huma	2009
Levocetirizine-induced iridocyclitis in a patient with allergic rhinitis. Journal of investigational allergology & clinical immunology, 2010, Volume: 20, Issue:1 Topics: Adult; Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Iridocyclitis; Male; Rhinitis, Al	2010
Evidence for clinical safety, efficacy, and parent and physician perceptions of levocetirizine for the treatment of children with allergic disease. International archives of allergy and immunology, 2011, Volume: 155, Issue:4 Topics: Adult; Anti-Allergic Agents; Attitude of Health Personnel; Cetirizine; Child; Child, Preschool; Chro	2011
[In seasonal and perennial rhinitis. Superiority to standard H1 blockers]. MMW Fortschritte der Medizin, 2003, May-29, Volume: 145, Issue:22 Topics: Anti-Allergic Agents; Butyrophenones; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; His	2003
[Antihistaminics. Side effects also after raising dosage at the placebo level]. MMW Fortschritte der Medizin, 2003, May-29, Volume: 145, Issue:22 Topics: Anti-Allergic Agents; Benzimidazoles; Butyrophenones; Cetirizine; Double-Blind Method; Histamine H1	2003
[Respiratory allergies in the child and the adult]. La Revue du praticien, 2004, Jan-31, Volume: 54, Issue:2 Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Allergens; Anti-Allergic Ag	2004
Modern histamine H1-receptor antagonists in the unified airway. The Journal of allergy and clinical immunology, 2004, Volume: 114, Issue:3 Topics: Cetirizine; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Nasal Obstruction; Nasal Pro	2004
[Patient report: allergic rhinitis]. Krankenpflege Journal, 2005, Volume: 43, Issue:7-10 Topics: Absenteeism; Cetirizine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Histamine H1 An	2005
New hay fever, hives treatment approved. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2007, Jul-01, Volume: 64, Issue:13 Topics: Cetirizine; Chronic Disease; Clinical Trials as Topic; Histamine H1 Antagonists, Non-Sedating; Human	2007
Levocetirizine (Xyzal) for allergic rhinitis and urticaria. The Medical letter on drugs and therapeutics, 2007, Dec-03, Volume: 49, Issue:1275 Topics: Cetirizine; Histamine H1 Antagonists; Humans; Piperazines; Rhinitis, Allergic, Perennial; Rhinitis,	2007
Leukotriene B4 production by blood neutrophils in allergic rhinitis--effects of cetirizine. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1995, Volume: 25, Issue:8 Topics: Adult; Anti-Allergic Agents; Asthma; Cetirizine; Female; Granulocyte-Macrophage Colony-Stimulating F	1995
[Acoustic rhinometry for evaluating the effectiveness of antihistaminics]. HNO, 1998, Volume: 46, Issue:5 Topics: Adolescent; Adult; Airway Resistance; Cetirizine; Computer Graphics; Female; Histamine H1 Antagonist	1998
Fern allergy. Allergy, 2000, Volume: 55, Issue:3 Topics: Allergens; Cetirizine; Electrophoresis, Polyacrylamide Gel; Female; Histamine H1 Antagonists; Humans	2000
Cetirizine-induce cholestasis. Journal of clinical gastroenterology, 2000, Volume: 31, Issue:3 Topics: Adult; Cetirizine; Cholestasis, Intrahepatic; Histamine H1 Antagonists; Humans; Liver; Male; Rhiniti	2000
A descriptive analysis of the use and cost of new-generation antihistamines in the treatment of allergic rhinitis: a retrospective database analysis. The American journal of managed care, 2001, Volume: 7, Issue:4 Suppl Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Cetirizine; Child; Databases as Topic; Drug Utilizati	2001
The costs of nonsedating antihistamine therapy for allergic rhinitis in managed care: an updated analysis. The American journal of managed care, 2001, Volume: 7, Issue:15 Suppl Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Cetirizine; Child; Cohort Studies; Drug Costs; Eco	2001
[Effect of cetirizine, selective H1 antagonist of histamine on skin and bronchial reactivity and cellular histamine release in allergic diseases]. Pneumonologia i alergologia polska, 1992, Volume: 60, Issue:11-12 Topics: Asthma; Bronchial Provocation Tests; Cetirizine; Chronic Disease; Histamine; Humans; Neutrophils; Rh	1992
[Cetirizine in allergic symptoms. General practice relevance and a profile of effects. Resume of current studies]. Fortschritte der Medizin. Supplement : die Kongressinformation fur die Praxis, 1990, Volume: 89 Topics: Asthma; Cetirizine; Eosinophils; Histamine H1 Antagonists; Humans; Hydroxyzine; Rhinitis, Allergic,	1990

cetirizine and Rhinitis, Allergic, Perennial