cetirizine has been researched along with Long QT Syndrome in 8 studies
Cetirizine: A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
cetirizine : A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen asymptomatic patients with type 1 (LQT1), 15 patients with type 2 (LQT2) long QT syndrome, and 15 healthy volunteers took a placebo and cetirizine 10 mg." | 9.12 | The effect of antihistamine cetirizine on ventricular repolarization in congenital long QT syndrome. ( Hekkala, AM; Swan, H; Toivonen, L; Väänänen, H; Viitasalo, M, 2007) |
| " We compared cetirizine, another compound of that class, to D-sotalol and to astemizole in a model of acquired long QT syndrome." | 7.70 | Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome. ( Cheymol, G; Jaillon, P; Noyer, M; Weissenburger, J, 1999) |
| "Fifteen asymptomatic patients with type 1 (LQT1), 15 patients with type 2 (LQT2) long QT syndrome, and 15 healthy volunteers took a placebo and cetirizine 10 mg." | 5.12 | The effect of antihistamine cetirizine on ventricular repolarization in congenital long QT syndrome. ( Hekkala, AM; Swan, H; Toivonen, L; Väänänen, H; Viitasalo, M, 2007) |
| " We compared cetirizine, another compound of that class, to D-sotalol and to astemizole in a model of acquired long QT syndrome." | 3.70 | Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome. ( Cheymol, G; Jaillon, P; Noyer, M; Weissenburger, J, 1999) |
| "Cetirizine is a metabolite of hydroxyzine, another antihistamine." | 2.46 | Cetirizine and loratadine: minimal risk of QT prolongation. ( , 2010) |
| "The long QT syndrome is a rare disease." | 1.33 | Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs. ( Codreanu, A; de Chillou, C; Moneret-Vautrin, DA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Darpo, B | 1 |
| Benson, C | 1 |
| Brown, R | 1 |
| Dota, C | 1 |
| Ferber, G | 1 |
| Ferry, J | 1 |
| Jarugula, V | 1 |
| Keirns, J | 1 |
| Ortemann-Renon, C | 1 |
| Pham, T | 1 |
| Riley, S | 1 |
| Sarapa, N | 1 |
| Ticktin, M | 1 |
| Zareba, W | 1 |
| Couderc, JP | 1 |
| Gravel, AE | 1 |
| Arnold, AA | 1 |
| Dufourc, EJ | 1 |
| Marcotte, I | 1 |
| Lehman, JM | 1 |
| Blaiss, MS | 1 |
| Moneret-Vautrin, DA | 1 |
| de Chillou, C | 1 |
| Codreanu, A | 1 |
| Hekkala, AM | 1 |
| Swan, H | 1 |
| Väänänen, H | 1 |
| Viitasalo, M | 1 |
| Toivonen, L | 1 |
| Hulhoven, R | 1 |
| Rosillon, D | 1 |
| Letiexhe, M | 1 |
| Meeus, MA | 1 |
| Daoust, A | 1 |
| Stockis, A | 1 |
| Weissenburger, J | 1 |
| Noyer, M | 1 |
| Cheymol, G | 1 |
| Jaillon, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical ECG Study to Evaluate Electrophysiological Effects of Potential QT Prolonging Drugs With Novel ECG Biomarkers With Exposure-Response Analysis[NCT05716854] | Phase 1 | 44 participants (Actual) | Interventional | 2023-03-21 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cetirizine and Long QT Syndrome
| Article | Year |
|---|---|
Cetirizine and loratadine: minimal risk of QT prolongation.
Topics: Anti-Allergic Agents; Cetirizine; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; | 2010 |
Selecting the optimal oral antihistamine for patients with allergic rhinitis.
Topics: Administration, Oral; Cardiovascular System; Central Nervous System; Cetirizine; Drug Interactions; | 2006 |
3 trials available for cetirizine and Long QT Syndrome
| Article | Year |
|---|---|
Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study.
Topics: Arrhythmias, Cardiac; Biomarkers; Cetirizine; Drug-Related Side Effects and Adverse Reactions; Elect | 2020 |
The effect of antihistamine cetirizine on ventricular repolarization in congenital long QT syndrome.
Topics: Adult; Cetirizine; Female; Heart Defects, Congenital; Heart Rate; Heart Ventricles; Histamine H1 Ant | 2007 |
Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study.
Topics: Adolescent; Adult; Aza Compounds; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; | 2007 |
3 other studies available for cetirizine and Long QT Syndrome
| Article | Year |
|---|---|
An NMR investigation of the structure, function and role of the hERG channel selectivity filter in the long QT syndrome.
Topics: Bepridil; Cetirizine; Dimyristoylphosphatidylcholine; Diphenhydramine; ERG1 Potassium Channel; Ether | 2013 |
Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs.
Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Butyrophenones; Cetirizine; Conjunct | 2006 |
Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Astemizole; Cetirizine; Dogs; Dose-Response Rela | 1999 |