Page last updated: 2024-10-24

cetirizine and Erythema

cetirizine has been researched along with Erythema in 18 studies

Cetirizine: A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
cetirizine : A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.

Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.

Research Excerpts

ExcerptRelevanceReference
"Here we studied the development of erythema after histamine iontophoresis in 12 AE patients and 12 healthy volunteers by means of a RGB-camera for recording true colour images."5.08Flare responses of atopic eczema patients analysed with true colour images. ( Forster, C; Handwerker, HO; Heyer, G; Nischik, M; Rukwied, R, 1997)
" The areas of weal and flare induced by intracutaneous injections of histamine were measured using planimetry, weal thickness by A-scan pulsed ultrasound and erythema index by a device which measures the relative reflectance of red and green light."5.07Effects of cetirizine, loratadine and terfenadine on histamine weal and flare reactions. ( Hill, S; Lever, LR; Marks, R; Rosenberg, R; Thompson, D, 1992)
" We herein describe a case of a 13year old male patient with left thalamic mixed germ cell tumour treated by multimodality approach, who developed flagellate erythema after two cycles of combination chemotherapy with bleomycin, etoposide and cisplatin (BEP)."3.83Bleomycin induced flagellate erythema in a patient with thalamic mixed germ cell tumour: Report of a rare adverse effect. ( Biswas, A; Julka, PK, 2016)
"Acute skin inflammation occurs following topical aminolevulinic acid-photodynamic therapy (ALA-PDT), but its nature and mediation are ill defined."3.73Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory response. ( Brooke, RC; Church, MK; Clough, GF; Friedmann, PS; Rhodes, LE; Sidhu, MK; Sinha, A; Watson, RE, 2006)
" The objective of this study was to evaluate the impact of antihistamines upon adverse effects following ALA-PDT."2.84A randomized, double-blind, placebo-controlled clinical trial evaluating the role of systemic antihistamine therapy for the reduction of adverse effects associated with topical 5-aminolevulinic acid photodynamic therapy. ( Goldman, MP; Jones, IT; Vanaman Wilson, MJ; Wu, DC, 2017)
"Levocetirizine was used as a comparator."2.71Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin. ( Boutsiouki, P; Church, MK; Clough, GF; Denham, KJ, 2003)
"Two double-blind clinical pharmacology studies were performed in healthy volunteers to compare the dermal pharmacodynamic profile of epinastine with cetirizine, a well-documented anti-H1 antagonist, after oral administration at the usual recommended dosage, i."2.70Dermal objective pharmacodynamic profile of cetirizine and epinastine: two controlled, randomised, double-blind, crossover studies. ( Leroy, T; van Neste, D, 2002)
"In contrast, controls reported a burning pain after the injection of ACh, whereas AE patients felt predominantly pruritus."2.69Administration of acetylcholine and vasoactive intestinal polypeptide to atopic eczema patients. ( Heyer, G; Rukwied, R, 1999)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's7 (38.89)18.2507
2000's5 (27.78)29.6817
2010's4 (22.22)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Vargas-Mora, P1
Arceu, M1
Cortés, A1
Carreño, L1
Vanaman Wilson, MJ1
Jones, IT1
Wu, DC1
Goldman, MP1
Veraldi, S1
Pontini, P1
Nazzaro, G1
Biswas, A1
Julka, PK1
Bäumer, W1
Stahl, J1
Sander, K1
Petersen, LJ1
Paps, J1
Stark, H1
Kietzmann, M1
Olivry, T1
Inamadar, AC1
Palit, A1
Athanikar, SB1
Sampagavi, VV1
Deshmukh, NS1
Leroy, T1
van Neste, D3
Denham, KJ1
Boutsiouki, P1
Clough, GF2
Church, MK2
Brooke, RC1
Sinha, A1
Sidhu, MK1
Watson, RE1
Friedmann, PS1
Rhodes, LE1
de la Cuadra, J1
Teruel, M1
Teixidó, P1
Roma, J1
Hannuksela, M1
Kalimo, K1
Lammintausta, K1
Mattila, T1
Turjanmaa, K1
Varjonen, E1
Coulie, PJ1
Leroy, DT1
de Brouwer, B1
Rihoux, JP2
Rukwied, R2
Nischik, M1
Forster, C1
Heyer, G2
Handwerker, HO1
Nissen, JB1
Egekvist, H1
Bjerring, P1
Kragballe, K1
Kränke, B1
Kern, T1
Lever, LR1
Hill, S1
Marks, R1
Rosenberg, R1
Thompson, D1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-blind, Placebo-controlled, Prospective Clinical Trial Evaluating the Role of Systemic Antihistamine Therapy in the Reduction of Adverse Effects Associated With Topical 5-aminolevulinic Acid Photodynamic Therapy[NCT02451579]20 participants (Anticipated)Interventional2015-02-28Completed
Management of Pruritus With Xyzal in Atopic Dermatitis in a Randomized, Double-Blind, Placebo Controlled Study[NCT00884325]Phase 440 participants (Actual)Interventional2009-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Dermatology Life Quality Index (DLQI) Questionnaire Scores at Baseline, Week 2 and Week 4

Consented subjects who met inclusion/exclusion criteria were asked to complete a DLQI (Dermatology Life Quality Index)at Baseline, Week 2 and Week 4. The DLQI is a 10 item questionnaire broken down into 6 domains; symptoms and feelings, daily activities, leisure, work and school, personal relationships and treatment with a total score ranging from 0-30 (no effect on subject's life for 0, extremely large effect on subject's life for 30) (NCT00884325)
Timeframe: Baseline - Week 2 - Week 4

,
Interventionunits on a scale (Median)
DLQI - BaselineDLQI - Week 2DLQI - Week 4
Subjects Receiving Placebo8.005.54.00
Subjects Receiving Xyzal7.53.52.00

Pruritus VAS Scores at Baseline, Week 2 and Week 4

Consented subjects who met inclusion/exclusion criteria were assigned either 5mg levocetirizine dihydrochloride (Xyzal) or placebo to be taken daily each evening for 28 days. Subjects were asked to complete a Visual Analog Scale to measure itch at Baseline, Week 2 and Week 4. The scale is an eleven point scale ranging from 0-10 with 0 indicating no itch to 10 indicating itch that frequently interferes with daily activities. (NCT00884325)
Timeframe: Baseline - Week 2-Week 4

,
Interventionunits on a scale (Median)
BaselineWeek 2Week 4
Subjects Receiving Placebo7.55.96.4
Subjects Receiving Xyzal7.86.104.15

Trials

11 trials available for cetirizine and Erythema

ArticleYear
A randomized, double-blind, placebo-controlled clinical trial evaluating the role of systemic antihistamine therapy for the reduction of adverse effects associated with topical 5-aminolevulinic acid photodynamic therapy.
    Lasers in surgery and medicine, 2017, Volume: 49, Issue:8

    Topics: Administration, Cutaneous; Aged; Aminolevulinic Acid; Cetirizine; Double-Blind Method; Drug Eruption

2017
Dermal objective pharmacodynamic profile of cetirizine and epinastine: two controlled, randomised, double-blind, crossover studies.
    International journal of clinical practice, 2002, Volume: 56, Issue:8

    Topics: Administration, Oral; Adult; Cetirizine; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Dr

2002
Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2003, Volume: 52, Issue:10

    Topics: Adult; Anti-Allergic Agents; Cetirizine; Cross-Over Studies; Double-Blind Method; Erythema; Histamin

2003
Assessment of the wheal size and skin blood flow of the erythema induced by histamine and its modification with cetirizine and ebastine: a crossover, double-blind study.
    Dermatology (Basel, Switzerland), 1994, Volume: 188, Issue:2

    Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Double-Blind Method; Erythema; Female; Histamine; His

1994
Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults.
    Annals of allergy, 1993, Volume: 70, Issue:2

    Topics: Administration, Topical; Adult; Alanine Transaminase; Cetirizine; Dermatitis, Atopic; Dose-Response

1993
Histamine-induced skin reactions using iontophoresis and H1-blockade.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45 Suppl 1

    Topics: Adult; Cetirizine; Cross-Over Studies; Double-Blind Method; Erythema; Female; Histamine; Histamine H

1996
Flare responses of atopic eczema patients analysed with true colour images.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46, Issue:9

    Topics: Adult; Cetirizine; Cross-Over Studies; Dermatitis, Atopic; Double-Blind Method; Erythema; Female; Hi

1997
Effect of intradermal injection of methionine-enkephalin on human skin.
    Acta dermato-venereologica, 1999, Volume: 79, Issue:1

    Topics: Adult; Anti-Allergic Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; CD3 Complex; C

1999
Administration of acetylcholine and vasoactive intestinal polypeptide to atopic eczema patients.
    Experimental dermatology, 1999, Volume: 8, Issue:1

    Topics: Acetylcholine; Adult; Cetirizine; Cholinergic Agents; Cross-Over Studies; Dermatitis, Atopic; Double

1999
Effects of cetirizine, loratadine and terfenadine on histamine weal and flare reactions.
    Skin pharmacology : the official journal of the Skin Pharmacology Society, 1992, Volume: 5, Issue:1

    Topics: Administration, Oral; Adult; Cetirizine; Cyproheptadine; Double-Blind Method; Erythema; Female; Hist

1992
Inhibition of the cutaneous response to histamine by H1-blocking agents. Quantitative evaluation of microvascular changes in the skin after histamine challenge and a comparison of the effects of a single intake of cetirizine and terfenadine.
    Skin pharmacology : the official journal of the Skin Pharmacology Society, 1988, Volume: 1, Issue:3

    Topics: Adult; Benzhydryl Compounds; Cetirizine; Dermatitis; Double-Blind Method; Erythema; Female; Histamin

1988

Other Studies

7 other studies available for cetirizine and Erythema

ArticleYear
Multiple annular plaques in an adult woman.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2020, Volume: 18, Issue:9

    Topics: Cetirizine; Dapsone; Eosinophilia; Erythema; Female; Humans; Hydroxychloroquine; Middle Aged; Predni

2020
An Erythematous-squamous Lesion of the Foot: A Quiz.
    Acta dermato-venereologica, 2018, Aug-29, Volume: 98, Issue:8

    Topics: Cetirizine; Erythema; Foot Dermatoses; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Pityria

2018
Bleomycin induced flagellate erythema in a patient with thalamic mixed germ cell tumour: Report of a rare adverse effect.
    Journal of the Egyptian National Cancer Institute, 2016, Volume: 28, Issue:2

    Topics: Adolescent; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Betamethaso

2016
Lack of preventing effect of systemically and topically administered histamine H(1) or H(4) receptor antagonists in a dog model of acute atopic dermatitis.
    Experimental dermatology, 2011, Volume: 20, Issue:7

    Topics: Aging; Animals; Antigens, Dermatophagoides; Cetirizine; Dermatitis, Atopic; Dermatophagoides farinae

2011
Multiple fixed drug eruptions due to cetirizine.
    The British journal of dermatology, 2002, Volume: 147, Issue:5

    Topics: Cetirizine; Drug Eruptions; Erythema; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Middle A

2002
Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory response.
    The Journal of investigative dermatology, 2006, Volume: 126, Issue:10

    Topics: Adult; Aged; Aminolevulinic Acid; Cetirizine; Dose-Response Relationship, Drug; Erythema; Female; Hi

2006
Multilocalized fixed drug eruption to the antihistamine cetirizine.
    The Journal of allergy and clinical immunology, 2000, Volume: 106, Issue:5

    Topics: Adult; Cetirizine; Drug Eruptions; Erythema; Histamine H1 Antagonists; Humans; Male; Skin

2000
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