cetirizine has been researched along with Atopic Hypersensitivity in 40 studies
Cetirizine: A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
cetirizine : A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cetirizine is a non-sedating H1 antihistamine which is effective in the treatment of allergic rhinitis and urticaria." | 6.68 | A comparison of the effects of oral cetirizine and inhaled beclomethasone on early and late asthmatic responses to allergen and the associated increase in airways hyperresponsiveness. ( Bentley, AM; De Vos, C; Durham, SR; Hanotte, F; Walker, S, 1996) |
| "Cetirizine elimination was impaired in patients with hepatic dysfunction." | 5.29 | Cetirizine pharmacokinetics and pharmacodynamics in primary biliary cirrhosis. ( Minuk, GY; Simons, FE; Simons, KJ; Watson, WT, 1993) |
| "To study the effect of long-term treatment with the H1-antihistamine levocetirizine on urticaria in young atopic children." | 5.12 | H1-antihistamine treatment in young atopic children: effect on urticaria. ( Simons, FE, 2007) |
| "This comparative study in mosquito-bite-sensitive adults shows that cetirizine and ebastine decrease significantly whealing and accompanying pruritus, and that cetirizine seems to be the most effective against pruritus." | 5.10 | Comparison of cetirizine, ebastine and loratadine in the treatment of immediate mosquito-bite allergy. ( Burri, P; Karppinen, A; Kautiainen, H; Petman, L; Reunala, T, 2002) |
| " The estimated relative bioavailability was 0." | 2.71 | Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: the ETAC study. ( Aarons, L; de Longueville, M; Hussein, Z; Majid, O; Pitsiu, M; Stockis, A, 2005) |
| " In conclusion, this study shows that, at the end of the conventional dosing interval, ebastine 10 mg and cetirizine 10 mg once daily in repeated doses suppressed the histamine wheal more effectively than did loratadine 10 mg once daily or fexofenadine 60 mg twice daily." | 2.70 | Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state. ( Boyce, M; Carey, W; Luria, X; Warrington, S, 2002) |
| "Levocetirizine (5 mg) is a potent inhibitor of the effects of histamine in human skin with an efficacy that exceeded that of loratadine (10 mg) when single doses of the drugs were administered 4 h before the test." | 2.70 | Comparison of the effects of levocetirizine and loratadine on histamine-induced wheal, flare, and itch in human skin. ( Boutsiouki, P; Church, MK; Clough, GF, 2001) |
| "Erythromycin was started to treat presumed bacterial infection in children with complete radiologic opacification of the maxillary sinus(es)." | 2.69 | Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizole, loratadine, and cetirizine in atopic children. ( Delgado, LF; Naspitz, CK; Pferferman, A; Solé, D, 1998) |
| "Ebastine was no better than placebo until 4 h, but was efficacious thereafter until 24 h." | 2.69 | A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects. ( Danielson, L; DeVos, C; Grant, JA; Rihoux, JP, 1999) |
| "5." | 2.68 | Comparative wheal and flare study of mizolastine vs terfenadine, cetirizine, loratadine and placebo in healthy volunteers. ( Cabanis, MJ; Caplain, H; Chaufour, S; Rosenzweig, P; Thebault, JJ; Ulliac, N, 1995) |
| "Cetirizine is a non-sedating H1 antihistamine which is effective in the treatment of allergic rhinitis and urticaria." | 2.68 | A comparison of the effects of oral cetirizine and inhaled beclomethasone on early and late asthmatic responses to allergen and the associated increase in airways hyperresponsiveness. ( Bentley, AM; De Vos, C; Durham, SR; Hanotte, F; Walker, S, 1996) |
| "Cetirizine treatment had no significant effect on these responses." | 2.68 | Cellular inflammatory responses during immediate, developing, and established late-phase allergic cutaneous reactions: effects of cetirizine. ( Atkins, PC; Ciliberti, M; Grossman, S; Moskovitz, A; von Allmen, C; Zweiman, B, 1997) |
| "Cetirizine, 2." | 2.67 | Compared peripheral H1 inhibiting effects of cetirizine 2 HCl and loratadine. ( Coulie, P; Ghys, L; Rihoux, JP, 1990) |
| "With cetirizine 2 HCl treatment, platelet-activating factor-acether was not detected in chamber media." | 2.66 | Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin. ( Benveniste, J; Burtin, C; De Vos, C; Dubertret, L; Michel, L; Rihoux, JP, 1988) |
| "Histamine is a key mediator of the allergic immediate reaction." | 2.43 | [Oral second generation antihistamines in allergic rhinitis]. ( Riechelmann, H, 2005) |
| "Hexapeptide 95/220 inhibited immediate hypersensitivity reactions such as passive cutaneous anaphylaxis (PCA) and mast cell degranulation in rats, antigen-induced bronchoconstriction in actively sensitized guinea pigs in dose dependent manner like DSCG." | 1.31 | Antiallergic/antiasthmatic effect of novel antiallergic hexapeptide-95/220 in various experimental models. ( Gupta, PP; Khare, SK; Kundu, B; Nath, A; Shukla, M; Singh, R, 2001) |
| "Cetirizine elimination was impaired in patients with hepatic dysfunction." | 1.29 | Cetirizine pharmacokinetics and pharmacodynamics in primary biliary cirrhosis. ( Minuk, GY; Simons, FE; Simons, KJ; Watson, WT, 1993) |
| " The hydroxyzine and cetirizine half-life and AUC0-->infinity values were significantly increased and the systemic clearance rates were significantly decreased in the presence of cimetidine." | 1.29 | Effect of the H2-receptor antagonist cimetidine, on the pharmacokinetics and pharmacodynamics of the H1-receptor antagonists hydroxyzine and cetirizine in rabbits. ( Chen, X; Simons, FE; Simons, KJ, 1994) |
| "Cetirizine also inhibited the immediate hypersensitivity reaction induced by Ascaris extract in dogs." | 1.27 | Inhibition of histamine and allergen skin wheal by cetirizine in four animal species. ( Baltes, E; De Vos, C; Gobert, J; Maleux, MR, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.50) | 18.7374 |
| 1990's | 19 (47.50) | 18.2507 |
| 2000's | 17 (42.50) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knight, E | 1 |
| Fischer, P | 1 |
| Arndt, C | 1 |
| Anim, S | 1 |
| Joshi, A | 1 |
| Carey, W | 1 |
| Warrington, S | 1 |
| Boyce, M | 1 |
| Luria, X | 1 |
| Magnan, A | 1 |
| Hussein, Z | 1 |
| Pitsiu, M | 1 |
| Majid, O | 1 |
| Aarons, L | 1 |
| de Longueville, M | 1 |
| Stockis, A | 1 |
| Riechelmann, H | 1 |
| Morita, E | 1 |
| Matsuo, H | 1 |
| Zhang, Y | 1 |
| Liu, JY | 1 |
| Hu, JH | 1 |
| Zhu, QG | 1 |
| Li, FQ | 1 |
| Sun, HJ | 1 |
| Karppinen, A | 2 |
| Brummer-Korvenkontio, H | 3 |
| Petman, L | 2 |
| Kautiainen, H | 2 |
| Hervé, JP | 1 |
| Reunala, T | 4 |
| Popov, TA | 1 |
| Dumitrascu, D | 1 |
| Bachvarova, A | 1 |
| Bocsan, C | 1 |
| Dimitrov, V | 1 |
| Church, MK | 3 |
| Enomoto, T | 1 |
| Ide, T | 1 |
| Ogino, S | 1 |
| Simons, FE | 3 |
| Watson, WT | 1 |
| Minuk, GY | 1 |
| Simons, KJ | 2 |
| Chen, X | 1 |
| Rihoux, JP | 7 |
| Mariz, S | 1 |
| Rosenzweig, P | 1 |
| Caplain, H | 1 |
| Chaufour, S | 1 |
| Ulliac, N | 1 |
| Cabanis, MJ | 1 |
| Thebault, JJ | 1 |
| Bentley, AM | 1 |
| Walker, S | 1 |
| Hanotte, F | 1 |
| De Vos, C | 4 |
| Durham, SR | 1 |
| Zweiman, B | 1 |
| Atkins, PC | 1 |
| Moskovitz, A | 1 |
| von Allmen, C | 1 |
| Ciliberti, M | 1 |
| Grossman, S | 1 |
| Rolland, Y | 1 |
| Mazières, B | 1 |
| Behar, M | 1 |
| Kahn, MF | 1 |
| Cantagrel, A | 1 |
| Laroche, M | 1 |
| Delgado, LF | 1 |
| Pferferman, A | 1 |
| Solé, D | 1 |
| Naspitz, CK | 1 |
| Lippert, U | 1 |
| Hoer, A | 1 |
| Möller, A | 1 |
| Ramboer, I | 1 |
| Cremer, B | 1 |
| Henz, BM | 1 |
| Grant, JA | 1 |
| Danielson, L | 1 |
| DeVos, C | 1 |
| Knol, K | 1 |
| Frossard, N | 1 |
| Walsh, GM | 2 |
| Clough, GF | 1 |
| Boutsiouki, P | 1 |
| Nielsen, PN | 1 |
| Skov, PS | 1 |
| Poulsen, LK | 1 |
| Schmelz, M | 1 |
| Petersen, LJ | 1 |
| Singh, R | 1 |
| Nath, A | 1 |
| Gupta, PP | 1 |
| Shukla, M | 1 |
| Khare, SK | 1 |
| Kundu, B | 1 |
| Burri, P | 1 |
| Varney, V | 1 |
| Gaga, M | 1 |
| Frew, AJ | 1 |
| Kay, AB | 1 |
| Ghys, L | 2 |
| Mühlethaler, K | 1 |
| Wüthrich, B | 1 |
| Shall, L | 1 |
| Thompson, DA | 1 |
| Barkley, AS | 1 |
| Millard, LG | 1 |
| Lappalainen, P | 2 |
| Coulie, P | 2 |
| Palosuo, T | 2 |
| Henocq, E | 1 |
| Räsänen, L | 1 |
| Van Epps, DE | 1 |
| Kutvirt, SG | 1 |
| Potter, JW | 1 |
| Michel, L | 1 |
| Burtin, C | 1 |
| Benveniste, J | 1 |
| Dubertret, L | 1 |
| Maleux, MR | 1 |
| Baltes, E | 1 |
| Gobert, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Placebo Controlled Trial to Evaluate The Effects of Levocetirizine on Nasal Allergen Challenge And Adenosine Monophosphate Challenge In Patients With Intermittent and Persistent Allergic Rhinitis[NCT00679250] | Phase 4 | 25 participants (Actual) | Interventional | 2005-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for cetirizine and Atopic Hypersensitivity
| Article | Year |
|---|---|
[Oral second generation antihistamines in allergic rhinitis].
Topics: Administration, Oral; Adult; Anti-Allergic Agents; Cetirizine; Child; Conjunctivitis, Allergic; Cont | 2005 |
Cetirizine. An updated review of its pharmacological properties and therapeutic efficacy.
Topics: Animals; Cetirizine; Humans; Hypersensitivity, Immediate; Insect Bites and Stings; Respiratory Hyper | 1993 |
Investigating bradykinin-induced reactions in the skin through microdialysis.
Topics: Animals; Bradykinin; Cetirizine; Dermatitis, Contact; Guinea Pigs; Histamine H1 Antagonists; Humans; | 1997 |
Therapeutic index of H1-antihistamines: example of cetirizine.
Topics: Cetirizine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate | 1999 |
Clinical use of antihistamines in infants and children at risk of asthma development.
Topics: Asthma; Cetirizine; Child, Preschool; Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Hy | 2000 |
Comparing the H1 profile of second-generation antihistamines.
Topics: Cetirizine; Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; | 2000 |
The clinical relevance of the anti-inflammatory properties of antihistamines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cetirizine; Child; Clinical Trials as Topic; Histamine H1 A | 2000 |
Immunology and treatment of mosquito bites.
Topics: Animals; Cetirizine; Culicidae; Histamine H1 Antagonists; Humans; Hydroxyzine; Hypersensitivity, Del | 1990 |
22 trials available for cetirizine and Atopic Hypersensitivity
| Article | Year |
|---|---|
Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state.
Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Hist | 2002 |
Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: the ETAC study.
Topics: Anti-Allergic Agents; Body Weight; Cetirizine; Double-Blind Method; Female; Follow-Up Studies; Hista | 2005 |
Double-blind, crossover comparison of olopatadine and cetirizine versus placebo: suppressive effects on skin response to histamine iontophoresis.
Topics: Administration, Oral; Adult; Cetirizine; Cross-Over Studies; Dibenzoxepins; Double-Blind Method; Fem | 2005 |
Levocetirizine for treatment of immediate and delayed mosquito bite reactions.
Topics: Adult; Aedes; Animals; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Ant | 2006 |
A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo.
Topics: Adult; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Histam | 2006 |
Construction of an environmental exposure unit and investigation of the effects of cetirizine hydrochloride on symptoms of cedar pollinosis in Japan.
Topics: Adult; Cedrus; Cetirizine; Cross-Over Studies; Double-Blind Method; Environmental Exposure; Female; | 2007 |
H1-antihistamine treatment in young atopic children: effect on urticaria.
Topics: Cetirizine; Child, Preschool; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; H | 2007 |
Comparative wheal and flare study of mizolastine vs terfenadine, cetirizine, loratadine and placebo in healthy volunteers.
Topics: Adult; Benzimidazoles; Cetirizine; Cross-Over Studies; Double-Blind Method; Histamine H1 Antagonists | 1995 |
A comparison of the effects of oral cetirizine and inhaled beclomethasone on early and late asthmatic responses to allergen and the associated increase in airways hyperresponsiveness.
Topics: Administration, Inhalation; Administration, Oral; Adult; Allergens; Antigens, Dermatophagoides; Asth | 1996 |
Cellular inflammatory responses during immediate, developing, and established late-phase allergic cutaneous reactions: effects of cetirizine.
Topics: Administration, Cutaneous; Anti-Allergic Agents; Biopsy; Blood Proteins; Cetirizine; Codeine; Eosino | 1997 |
Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizole, loratadine, and cetirizine in atopic children.
Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Astemizole; Cetirizine; Child; Child, Preschool; Drug I | 1998 |
Role of antigen-induced cytokine release in atopic pruritus.
Topics: Adolescent; Adult; Allergens; Animals; Anti-Allergic Agents; Antigens; Cetirizine; Cross-Over Studie | 1998 |
A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects.
Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Histamin | 1999 |
Comparison of the effects of levocetirizine and loratadine on histamine-induced wheal, flare, and itch in human skin.
Topics: Anti-Allergic Agents; Cetirizine; Double-Blind Method; Histamine; Humans; Hypersensitivity, Immediat | 2001 |
Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study.
Topics: Administration, Cutaneous; Adult; Allergens; Antitussive Agents; Cetirizine; Codeine; Cross-Over Stu | 2001 |
Comparison of cetirizine, ebastine and loratadine in the treatment of immediate mosquito-bite allergy.
Topics: Adult; Animals; Butyrophenones; Cetirizine; Conscious Sedation; Cross-Over Studies; Culicidae; Doubl | 2002 |
The effect of a single oral dose of prednisolone or cetirizine on inflammatory cells infiltrating allergen-induced cutaneous late-phase reactions in atopic subjects.
Topics: Administration, Oral; Adolescent; Adult; Allergens; Cetirizine; Double-Blind Method; Histamine H1 An | 1992 |
The skin as a target organ for the investigation of antiallergic drugs: comparison between cetirizine and terfenadine.
Topics: Adolescent; Adult; Antigens; Cetirizine; Dermatitis; Double-Blind Method; Female; Histamine; Histami | 1992 |
Comparative inhibition profiles of three non-sedating antihistamines assessed by an extended Lewis model.
Topics: Adult; Analysis of Variance; Cetirizine; Cyproheptadine; Female; Histamine Antagonists; Histamine H1 | 1992 |
Cutaneous reactivity to mosquito bites: effect of cetirizine and development of anti-mosquito antibodies.
Topics: Adolescent; Adult; Aedes; Animals; Antigens; Cetirizine; Double-Blind Method; Female; Histamine; His | 1991 |
Compared peripheral H1 inhibiting effects of cetirizine 2 HCl and loratadine.
Topics: Adult; Cetirizine; Cyproheptadine; Double-Blind Method; Drug Hypersensitivity; Female; Histamine; Hi | 1990 |
Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin.
Topics: Administration, Oral; Adolescent; Adult; Cetirizine; Eosinophils; Female; Histamine; Histamine H1 An | 1988 |
10 other studies available for cetirizine and Atopic Hypersensitivity
| Article | Year |
|---|---|
Cetirizine-responsive, persistent idiopathic eosinophilia in a nonatopic child.
Topics: Anti-Allergic Agents; Cetirizine; Child, Preschool; Eosinophilia; Humans; Hypersensitivity, Immediat | 2017 |
[Respiratory allergies in the child and the adult].
Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Allergens; Anti-Allergic Ag | 2004 |
[Effect of cetirizine hydrochloride on the expression of substance P in IgE-mediated triphasic cutaneous reaction].
Topics: Animals; Anti-Allergic Agents; Cetirizine; Dose-Response Relationship, Drug; Ear; Edema; Female; Hyp | 2005 |
Cetirizine pharmacokinetics and pharmacodynamics in primary biliary cirrhosis.
Topics: Aged; Cetirizine; Female; Half-Life; Histamine Release; Humans; Hypersensitivity, Immediate; Liver C | 1993 |
Effect of the H2-receptor antagonist cimetidine, on the pharmacokinetics and pharmacodynamics of the H1-receptor antagonists hydroxyzine and cetirizine in rabbits.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Cetirizine; Chroma | 1994 |
Does the atopic ("allergic") rheumatism of NERDS really exist? Report of a case.
Topics: Adult; Cetirizine; Cimetidine; Dermatitis; Diagnosis, Differential; Edema; Eosinophilia; Follow-Up S | 1997 |
Antiallergic/antiasthmatic effect of novel antiallergic hexapeptide-95/220 in various experimental models.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Bronchoconstriction; Cetirizine; Cromolyn Sodi | 2001 |
Does reversed-type anaphylaxis in healthy subjects mimic a real allergic reaction?
Topics: Adolescent; Adult; Anaphylaxis; Antigen-Antibody Reactions; Cell Movement; Cetirizine; Double-Blind | 1990 |
In vitro effects of cetirizine and histamine on human neutrophil function.
Topics: Cetirizine; Chemotaxis, Leukocyte; Complement C3; Histamine; Histamine H1 Antagonists; Humans; Hydro | 1987 |
Inhibition of histamine and allergen skin wheal by cetirizine in four animal species.
Topics: Allergens; Animals; Benzhydryl Compounds; Cetirizine; Clemastine; Dogs; Female; Guinea Pigs; Histami | 1987 |