cetirizine has been researched along with Allergic Conjunctivitis in 23 studies
Cetirizine: A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
cetirizine : A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pharmacokinetic study of a single oral dose of cetirizine 10mg in 40 patients treated for allergic conjunctivitis." | 5.10 | Pharmacokinetics of cetirizine in tear fluid after a single oral dose. ( Barbato, F; Cennamo, G; Del Prete, A; Grumetto, L; La Rotonda, MI, 2002) |
| "It has been demonstrated that cetirizine is able to reduce ICAM-1 expression on nasal epithelial cells and conjunctival nonspecific hyperreactivity in asthmatic asymptomatic children with MPI." | 4.80 | Minimal persistent inflammation may be controlled by cetirizine. ( Canonica, GW; Ciprandi, G, 1999) |
| "Rupatadine is a better choice for seasonal allergic rhinitis compared with levocetirizine because of its better efficacy and safety profile." | 2.75 | Rupatadine and levocetirizine for seasonal allergic rhinitis: a comparative study of efficacy and safety. ( Allala, U; Jaida, J; Maiti, R; Palani, A; Rahman, J, 2010) |
| "Levocetirizine was shown to improve quality of life and symptoms and to decrease the overall costs of the disease over the 6-month treatment period." | 2.71 | Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. ( Bachert, C; Bousquet, J; Canonica, GW; Durham, SR; Klimek, L; Mullol, J; Van Cauwenberge, PB; Van Hammée, G, 2004) |
| "Cetirizine was significantly more effective at reducing the mean rhinorrhea score compared with oxatomide for both weeks 8 and 12 (P < 0." | 2.70 | The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis. ( Hsieh, JC; Lai, DS; Lee, HS; Lin, KL; Lue, KH, 2002) |
| "Mizolastine is a potent and selective H1-receptor antagonist with additional anti-allergic properties." | 2.69 | Comparison of the efficacy, safety, and onset of action of mizolastine, cetirizine, and placebo in the management of seasonal allergic rhinoconjunctivitis. MIZOCET Study Group. ( Attali, P; Ben-Soussen, P; Daele, J; Sabbah, A; Wade, AG, 1999) |
| " Compliance was checked and found to be less than 80% of the prescribed dosage in 2 cetirizine patients." | 2.67 | A placebo-controlled trial of cetirizine in seasonal allergic rhino-conjunctivitis in children aged 6 to 12 years. ( Candiani, R; Masi, M; van de Venne, H, 1993) |
| "Cetirizine is a new selective H1-antagonist." | 2.67 | Effect of cetirizine in a conjunctival provocation test with allergens. ( Pécoud, AR; Schoeneich, M, 1990) |
| "Histamine is a key mediator of the allergic immediate reaction." | 2.43 | [Oral second generation antihistamines in allergic rhinitis]. ( Riechelmann, H, 2005) |
| "The long QT syndrome is a rare disease." | 1.33 | Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs. ( Codreanu, A; de Chillou, C; Moneret-Vautrin, DA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Kimchi, N | 1 |
| Bielory, L | 2 |
| Weinberger, M | 1 |
| Hendeles, L | 1 |
| Maiti, R | 1 |
| Rahman, J | 1 |
| Jaida, J | 1 |
| Allala, U | 1 |
| Palani, A | 1 |
| Prieto de Paula, JM | 1 |
| Franco Hidalgo, S | 1 |
| Nalotto, L | 1 |
| Ginés Santiago, A | 1 |
| Chen, X | 1 |
| Li, X | 1 |
| Zhou, Y | 1 |
| Wang, X | 1 |
| Zhang, Y | 1 |
| Fan, Y | 1 |
| Huang, Y | 1 |
| Liu, Y | 1 |
| Lai, DS | 1 |
| Lue, KH | 1 |
| Hsieh, JC | 1 |
| Lin, KL | 1 |
| Lee, HS | 1 |
| Minami, K | 1 |
| Fujii, Y | 1 |
| Kamei, C | 1 |
| Bachert, C | 1 |
| Bousquet, J | 1 |
| Canonica, GW | 4 |
| Durham, SR | 1 |
| Klimek, L | 1 |
| Mullol, J | 1 |
| Van Cauwenberge, PB | 1 |
| Van Hammée, G | 1 |
| Riechelmann, H | 1 |
| Giovannini, M | 1 |
| Braccioni, F | 1 |
| Sella, G | 1 |
| Contoli, M | 1 |
| Perri, G | 1 |
| Frati, F | 1 |
| Incorvaia, C | 1 |
| Pasquali, M | 1 |
| Baiardini, I | 1 |
| Rogkakou, A | 1 |
| Riccio, AM | 1 |
| Gamalero, C | 1 |
| Descalzi, D | 1 |
| Folli, C | 1 |
| Passalacqua, G | 2 |
| Moneret-Vautrin, DA | 1 |
| de Chillou, C | 1 |
| Codreanu, A | 1 |
| Ciprandi, G | 2 |
| Buscaglia, S | 1 |
| Pesce, G | 1 |
| Rihoux, JP | 1 |
| Bagnasco, M | 1 |
| Masi, M | 1 |
| Candiani, R | 1 |
| van de Venne, H | 1 |
| Bonini, S | 2 |
| Magrini, L | 1 |
| Rotiroti, G | 1 |
| Lambiase, A | 1 |
| Tomassini, M | 1 |
| Rumi, C | 1 |
| Helbling, A | 1 |
| Reimers, A | 1 |
| Wälti, M | 1 |
| Borgts, R | 1 |
| Brander, KA | 1 |
| Sabbah, A | 1 |
| Daele, J | 1 |
| Wade, AG | 1 |
| Ben-Soussen, P | 1 |
| Attali, P | 1 |
| Grumetto, L | 1 |
| Cennamo, G | 1 |
| Del Prete, A | 1 |
| La Rotonda, MI | 1 |
| Barbato, F | 1 |
| Schoeneich, M | 1 |
| Pécoud, AR | 1 |
| Panayotopoulos, SM | 1 |
| Panayotopoulou, ES | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Is Levocetirizine Less Sedating Than Cetirizine? A Randomized, Double-blind, Placebo Controlled Trial.[NCT00826943] | Phase 4 | 30 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Likert score range 1 to 9 (no sedation to extreme sedation). Highers scores indicate increased sedation. This was measured on days days 5, 12, 17, 24, 29, and 36 of the study.~This was mean data for all interventions." (NCT00826943)
Timeframe: duration of study (36 days)
| Intervention | Likert score (Mean) |
|---|---|
| Placebo | 2.80 |
| Levocetirizine | 3.07 |
| Cetirizine | 3.54 |
"Epworth Sleepiness Scale ratings (0 to 24); higher scores = increased sedation. This was measured over the 36 days of the study (at the end of each washout period and each intervention period); measured on days 5, 12, 17, 24, 29, and 36.~This was mean data for all interventions." (NCT00826943)
Timeframe: 36 days of the study
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 6.14 |
| Levocetirizine | 6.69 |
| Cetirizine | 7.48 |
"Total Four Symptom Scores (TFSS) ranging 0 to 12. Increased scores indicate increased symptoms. This was measured on days 5, 12, 17, 24, 29, and 36 of the study. The mean TFSS for patients receiving placebo, cetirizine, and levocetirizine was then calculated.~This was mean data for all interventions." (NCT00826943)
Timeframe: same as primary outcome measure (obtain on days 5, 12, 17, 24, 29, and 36)
| Intervention | TFSS scores (Mean) |
|---|---|
| Placebo | 4.41 |
| Levocetirizine | 3.14 |
| Cetirizine | 2.67 |
4 reviews available for cetirizine and Allergic Conjunctivitis
| Article | Year |
|---|---|
The allergic eye: recommendations about pharmacotherapy and recent therapeutic agents.
Topics: Administration, Ophthalmic; Anti-Allergic Agents; Cetirizine; Conjunctivitis, Allergic; Drug Deliver | 2020 |
[Oral second generation antihistamines in allergic rhinitis].
Topics: Administration, Oral; Adult; Anti-Allergic Agents; Cetirizine; Child; Conjunctivitis, Allergic; Cont | 2005 |
The eosinophil and the eye.
Topics: Cetirizine; Conjunctivitis, Allergic; Eosinophils; Eye; Histamine H1 Antagonists; Humans; Keratoconj | 1997 |
Minimal persistent inflammation may be controlled by cetirizine.
Topics: Animals; Anti-Allergic Agents; Asthma; Cetirizine; Child; Conjunctivitis, Allergic; Humans; Hypersen | 1999 |
11 trials available for cetirizine and Allergic Conjunctivitis
| Article | Year |
|---|---|
Rupatadine and levocetirizine for seasonal allergic rhinitis: a comparative study of efficacy and safety.
Topics: Adolescent; Adult; Cetirizine; Conjunctivitis, Allergic; Cyproheptadine; Eosinophils; Female; Histam | 2010 |
The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis.
Topics: Allergens; Animals; Anti-Allergic Agents; Blood Proteins; Cetirizine; Child; Conjunctivitis, Allergi | 2002 |
Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis.
Topics: Adolescent; Adult; Aged; Cetirizine; Conjunctivitis, Allergic; Costs and Cost Analysis; Double-Blind | 2004 |
Comparison of allergen immunotherapy and drug treatment in seasonal rhinoconjunctivitis: a 3-years study.
Topics: Administration, Intranasal; Adolescent; Adult; Allergens; Anti-Allergic Agents; Anti-Inflammatory Ag | 2005 |
Levocetirizine in persistent allergic rhinitis and asthma: effects on symptoms, quality of life and inflammatory parameters.
Topics: Adolescent; Adult; Asthma; Cetirizine; Conjunctivitis, Allergic; Double-Blind Method; Eosinophils; F | 2006 |
Cetirizine reduces inflammatory cell recruitment and ICAM-1 (or CD54) expression on conjunctival epithelium in both early- and late-phase reactions after allergen-specific challenge.
Topics: Adolescent; Adult; Allergens; Cetirizine; Conjunctiva; Conjunctivitis, Allergic; Double-Blind Method | 1995 |
A placebo-controlled trial of cetirizine in seasonal allergic rhino-conjunctivitis in children aged 6 to 12 years.
Topics: Cetirizine; Child; Conjunctivitis, Allergic; Double-Blind Method; Female; Humans; Male; Rhinitis, Al | 1993 |
Comparison of the efficacy, safety, and onset of action of mizolastine, cetirizine, and placebo in the management of seasonal allergic rhinoconjunctivitis. MIZOCET Study Group.
Topics: Adolescent; Adult; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Conjunctivitis, Allergic; Doubl | 1999 |
Pharmacokinetics of cetirizine in tear fluid after a single oral dose.
Topics: Administration, Oral; Adult; Cetirizine; Chromatography, High Pressure Liquid; Conjunctivitis, Aller | 2002 |
Effect of cetirizine in a conjunctival provocation test with allergens.
Topics: Adolescent; Adult; Allergens; Cetirizine; Clinical Trials as Topic; Conjunctivitis, Allergic; Double | 1990 |
Efficacy of cetirizine in the treatment of seasonal allergic rhinoconjunctivitis.
Topics: Adult; Cetirizine; Clinical Trials as Topic; Conjunctivitis, Allergic; Double-Blind Method; Histamin | 1990 |
8 other studies available for cetirizine and Allergic Conjunctivitis
| Article | Year |
|---|---|
Allergic inflammation of the anterior surface of the eye.
Topics: Adult; Cetirizine; Child; Conjunctivitis, Allergic; Eye; Histamine H1 Antagonists; Humans; Hypersens | 2020 |
Nonprescription medications for respiratory symptoms: Facts and marketing fictions.
Topics: Adrenal Cortex Hormones; Adult; Cetirizine; Child; Conjunctivitis, Allergic; Drug Utilization; Evide | 2018 |
[Cetirizine hepatotoxicity].
Topics: Adult; Cetirizine; Chemical and Drug Induced Liver Injury; Conjunctivitis, Allergic; Female; Histami | 2011 |
Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization, and in vivo evaluation.
Topics: Animals; Cetirizine; Chitosan; Conjunctivitis, Allergic; Cornea; Delayed-Action Preparations; Female | 2012 |
[Off-season manifestations of pollen hypersensitization].
Topics: Adult; Cetirizine; Conjunctivitis, Allergic; Desensitization, Immunologic; Female; Histamine H1 Anta | 2011 |
Participation of chemical mediators in the development of experimental allergic conjunctivitis in rats.
Topics: Administration, Oral; Animals; Carbazoles; Cetirizine; Conjunctivitis, Allergic; Disease Models, Ani | 2004 |
Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs.
Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Butyrophenones; Cetirizine; Conjunct | 2006 |
Food allergy to Belgian endive (chicory).
Topics: Adult; Angioedema; Cetirizine; Conjunctivitis, Allergic; Female; Food Hypersensitivity; Humans; Immu | 1997 |