ceruletide and Sjogren-s-Syndrome

ceruletide has been researched along with Sjogren-s-Syndrome* in 2 studies

Other Studies

2 other study(ies) available for ceruletide and Sjogren-s-Syndrome

Article	Year
[Pancreatic duct antibodies and subclinical insufficiency of the exocrine pancreas in Sjögren's syndrome]. Recenti progressi in medicina, 1998, Volume: 89, Issue:10 In previous studies we reported evidence of subclinical exocrine pancreatic insufficiency in primary or secondary Sjögren's syndrome (SSI, SSII) and rheumatoid arthritis (RA). In present study we evaluated the occurrence of pancreatic duct antibodies (PDA), and their relationship to exocrine pancreatic function in 36 women. Of these patients, 12 were classified as SSI, 12 as SSII, and 12 as RA. Exocrine pancreatic function was evaluated using the Secretin-Caerulein test (S.Cae test). The indirect immunofluorescent technique was used to evaluate patient sera for PDA. S.Cae test results, compared to controls, showed a statistically significant decrease in duodenal juice volumes, bicarbonates and enzymes in 58.3% of SSI, in 58.3% of SSI and in 30% of RA, according to our previous trials. PDA were found in two patients, the former with SSI and the latter with SSII, both asymptomatic with regard to pancreatic diseases but with impaired exocrine pancreatic function as evaluated by S.Cae test. We discuss the possible causes of these results. Topics: Adult; Aged; Autoantibodies; Ceruletide; Exocrine Pancreatic Insufficiency; Female; Fluorescent Antibody Technique, Indirect; Humans; Middle Aged; Pancreatic Ducts; Pancreatic Function Tests; Secretin; Sjogren's Syndrome	1998
[Functional reserve of the exocrine pancreas in Sjögren's syndrome]. Recenti progressi in medicina, 1997, Volume: 88, Issue:1 Exocrine pancreatic function was studied in a homogeneous group of 33 female patients aged 42-67 years. Of these patients, 11 were classified as rheumatoid arthritis (RA), 11 as Sjögren's syndrome I (SSI) and 11 as Sjögren's syndrome associated with RA (SSII). Clinical features, laboratory tests and special instrumental techniques excluded gastroenteric-hepatobiliary causes of pancreatic diseases. These patients were subjected to direct pancreatic stimulation with secretin and caerulein (S. Cae test). Test results, compared to control-group (10 voluntary healthy females) showed, in the last 30 m of stimulation, a statistically significant decrease (p < 0.05) in duodenal juice volume, bicarbonates and trypsin in 6 cases (54.5%) of SSI and in 3 cases (27.2%) of RA. SSII S. Cae test showed a decrease of volume and bicarbonates in 6 patients (54.5%) and in only 4 of these (36.4%) it was associated with a concomitant decrease in trypsin levels. Authors discuss the subclinical exocrine pancreatic function in relationship to sicca-syndrome, possible immunological factors and primary disease of pancreatic ducts. Topics: Adult; Aged; Arthritis, Rheumatoid; Bicarbonates; Ceruletide; Exocrine Pancreatic Insufficiency; Female; Humans; Middle Aged; Pancreas; Pancreatic Function Tests; Secretin; Sjogren's Syndrome; Trypsin	1997

Article

Year

[Pancreatic duct antibodies and subclinical insufficiency of the exocrine pancreas in Sjögren's syndrome].

Recenti progressi in medicina, 1998, Volume: 89, Issue:10

In previous studies we reported evidence of subclinical exocrine pancreatic insufficiency in primary or secondary Sjögren's syndrome (SSI, SSII) and rheumatoid arthritis (RA). In present study we evaluated the occurrence of pancreatic duct antibodies (PDA), and their relationship to exocrine pancreatic function in 36 women. Of these patients, 12 were classified as SSI, 12 as SSII, and 12 as RA. Exocrine pancreatic function was evaluated using the Secretin-Caerulein test (S.Cae test). The indirect immunofluorescent technique was used to evaluate patient sera for PDA. S.Cae test results, compared to controls, showed a statistically significant decrease in duodenal juice volumes, bicarbonates and enzymes in 58.3% of SSI, in 58.3% of SSI and in 30% of RA, according to our previous trials. PDA were found in two patients, the former with SSI and the latter with SSII, both asymptomatic with regard to pancreatic diseases but with impaired exocrine pancreatic function as evaluated by S.Cae test. We discuss the possible causes of these results.

Topics: Adult; Aged; Autoantibodies; Ceruletide; Exocrine Pancreatic Insufficiency; Female; Fluorescent Antibody Technique, Indirect; Humans; Middle Aged; Pancreatic Ducts; Pancreatic Function Tests; Secretin; Sjogren's Syndrome

1998

[Functional reserve of the exocrine pancreas in Sjögren's syndrome].

Recenti progressi in medicina, 1997, Volume: 88, Issue:1

Exocrine pancreatic function was studied in a homogeneous group of 33 female patients aged 42-67 years. Of these patients, 11 were classified as rheumatoid arthritis (RA), 11 as Sjögren's syndrome I (SSI) and 11 as Sjögren's syndrome associated with RA (SSII). Clinical features, laboratory tests and special instrumental techniques excluded gastroenteric-hepatobiliary causes of pancreatic diseases. These patients were subjected to direct pancreatic stimulation with secretin and caerulein (S. Cae test). Test results, compared to control-group (10 voluntary healthy females) showed, in the last 30 m of stimulation, a statistically significant decrease (p < 0.05) in duodenal juice volume, bicarbonates and trypsin in 6 cases (54.5%) of SSI and in 3 cases (27.2%) of RA. SSII S. Cae test showed a decrease of volume and bicarbonates in 6 patients (54.5%) and in only 4 of these (36.4%) it was associated with a concomitant decrease in trypsin levels. Authors discuss the subclinical exocrine pancreatic function in relationship to sicca-syndrome, possible immunological factors and primary disease of pancreatic ducts.

Topics: Adult; Aged; Arthritis, Rheumatoid; Bicarbonates; Ceruletide; Exocrine Pancreatic Insufficiency; Female; Humans; Middle Aged; Pancreas; Pancreatic Function Tests; Secretin; Sjogren's Syndrome; Trypsin

1997