ceruletide and Parkinson-Disease

ceruletide has been researched along with Parkinson-Disease* in 4 studies

Trials

3 trial(s) available for ceruletide and Parkinson-Disease

ArticleYear
Reduced cholecystokinin levels in cerebrospinal fluid of parkinsonian and schizophrenic patients. Effect of ceruletide in schizophrenia.
    Annals of the New York Academy of Sciences, 1985, Volume: 448

    Topics: Adult; Aged; Ceruletide; Cholecystokinin; Clinical Trials as Topic; Dopamine; Double-Blind Method; Female; Humans; Male; Middle Aged; Parkinson Disease; Schizophrenia

1985
Cholecystokinin-mediated synaptic function and the treatment of neuropsychiatric disease.
    Annals of the New York Academy of Sciences, 1985, Volume: 448

    Topics: Animals; Ceruletide; Cholecystokinin; Clinical Trials as Topic; Feeding Behavior; Humans; Motor Activity; Parkinson Disease; Receptors, Dopamine; Schizophrenia; Sincalide; Synapses

1985
Caerulein treatment of Parkinson's disease.
    Clinical neuropharmacology, 1985, Volume: 8, Issue:3

    In view of evidence linking cholecystokinin-containing neurons with both dopamine system function and Parkinson's disease pathophysiology, the therapeutic effects of the cholecystokinin analog, caerulein, were evaluated in 10 parkinsonian patients stabilized on L-Dopa therapy. Despite substantially elevated plasma caerulein levels immediately following intramuscular injection of this peptide, no consistent change in neurologic status could be discerned. These negative results may be due to the relatively small amounts of caerulein entering the CNS at dose levels that do not induce gastrointestinal toxicity.

    Topics: Adult; Aged; Carbidopa; Ceruletide; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease

1985

Other Studies

1 other study(ies) available for ceruletide and Parkinson-Disease

ArticleYear
Sweat function in Parkinson's disease.
    Journal of neurology, 1994, Volume: 241, Issue:10

    Sweat function was studied in patients with Parkinson's disease and in normal adults by sympathetic skin response, the bromphenol blue printing method and the silicone mould method. In patients with Parkinson's disease, dysfunction of sweating was classified into two types: one type involved the postganglionic fibres and the other involved the preganglionic fibres or the central nervous system. The latter was observed in patients with milder disease and the former was observed in patients with severe disease. The progressive involvement of sweat function in Parkinson's disease may reflect spread from the central nervous system or preganglionic fibres to postganglionic fibres. In a few patients the results of sweat tests were normal. Ceruletide increased sweating in Parkinson's disease patients, and decreased the prolonged latency of the sympathetic skin response. It is hypothesized that ceruletide facilitates the preserved somatosympathetic reflex of sweating.

    Topics: Aged; Axons; Ceruletide; Galvanic Skin Response; Humans; Parkinson Disease; Skin; Sweat; Sweat Glands; Sweating; Sympathetic Nervous System

1994