ceruletide has been researched along with Nociceptive-Pain* in 1 studies
1 other study(ies) available for ceruletide and Nociceptive-Pain
| Article | Year |
|---|---|
Ximenia americana heteropolysaccharides ameliorate inflammation and visceral hypernociception in murine caerulein-induced acute pancreatitis: Involvement of CB2 receptors.
This study aimed to investigate and characterize the anti-inflammatory and anti-hypernociceptive effects of the total polysaccharides of X. americana (TPL-Xa) bark in a mouse model of acute pancreatitis-induced by caerulein and the potential involvement of cannabinoid receptors.. TPL-Xa, containing a heteropolysaccharide composed of glucose, galactose, arabinose, rhamnose, fucose and galacturonic acid, reduced amylase and lipase levels, MPO activity, acinar cell necrosis, edema and neutrophil infiltration. TPL-Xa increased the threshold of visceral hypernociception, an effect reversed by AM630, an antagonist of cannabinoid receptor type 2 (CB2). In addition, TPL-Xa did not alter the animals' motor coordination.. TPL-Xa contains heteropolysaccharides that inhibit inflammation and hypernociception in the experimental model of caerulein-induced AP, by a mechanism involving type CB2 receptors. Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cannabinoid Receptor Agonists; Carbon-13 Magnetic Resonance Spectroscopy; Ceruletide; Disease Models, Animal; Enzymes; Inflammation Mediators; Male; Mice; Motor Activity; Nociceptive Pain; Olacaceae; Pain Threshold; Pancreas; Pancreatitis; Phytotherapy; Plant Extracts; Plants, Medicinal; Polysaccharides; Proton Magnetic Resonance Spectroscopy; Receptor, Cannabinoid, CB2; Signal Transduction; Time Factors | 2018 |