ceruletide and Intestinal-Pseudo-Obstruction

Sequential analysis of a double-blind clinical trial involving 26 patients demonstrated a statistically significant superiority of ceruletide over metroclopramide in restoring peristalsis in intestinal paralysis after abdominal surgery (P less than 0.05).

Topics: Adult; Aged; Ceruletide; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Male; Metoclopramide; Middle Aged; Postoperative Complications

We conducted a controlled clinical trial designed to test caerulein for tolerability and effectiveness in post-operative patients recovering from abdominal surgery. The test product was administered 24 hours after surgery, by intravenous drip infusion, at the rate of 2 nanograms/kg/minute. The results were compared with parallel observations made in a matched group of patients receiving no drugs or manipulation likely to promote intestinal peristalsis with the exception of the application of a nasogastric tube for aspiration and the water and electrolyte replenishment customary in the post-operative period. The results of this study evince a clear-cut difference between the two groups of patients in regard to the restoration of intestinal peristalsis and the passing of flatus and faeces, as confirmed by statistical analysis (Cochran's test) demonstrating the significant (p less than 0.01) superiority of caerulein treatment relative to the untreated control group. Likewise, the study revealed the excellent tolerability of the test drug at the dosage employed.

Topics: Ceruletide; Female; Humans; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Laparotomy; Male; Peristalsis; Postoperative Complications

Three patients had as a side effect of cytostatic treatment severe intestinal atonia which in two cases led to paralytic ileus. With ceruletid (Takus) rapid normalisation of intestinal peristalsis was achieved in all three patients.

Topics: Adult; Bleomycin; Ceruletide; Humans; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Male; Vinblastine; Vincristine

After the failure of other medicamentous treatment attempts for paralytic ileus, Ceruletid (Takus) was used in 20 surgical patients. Ceruletid was applied as an infusion of 40 microgram in 250 ml or 500 ml physiological saline solution over a period of 2-3 hours. During this time the occurrence of bowel sounds, flatulence and defecation was observed. The most important clinical and serological parameters were measured before and after treatment. Treatment was successful in 17 cases, in 3 cases no success was achieved. Severe side effects did not occur. The use of Ceruletid in the described form of administration can be recommended for the treatment of paralytic ileus.

Topics: Ceruletide; Drug Evaluation; Humans; Infusions, Parenteral; Intestinal Obstruction; Intestinal Pseudo-Obstruction

After a short analysis of the pathogenetic causes which can lead to paralytic ileus and the drugs at present available for treatment of this serious morbid form, the paper reports results obtained with Ceruletide, a decapeptide which has proved active on intestinal peristalsis in experimental and clinical trials. The results of this study, carried out on 20 patients subjected to surgical operation on the abdomen, treated with Ceruletide by intramuscular route 24-48 hours after the operation, showed that this drug is capable of leading to a quick recovery of intestinal motor activity without causing the patient unpleasant effects for the patient. The practical utility of Ceruletide is evident since by leading to earlier canalisation of the intestine it also allows the venous hydro-electric delivery to be reduced, nasogastric aspiration to be eliminated early and hence the postoperative course to be made more acceptable to the patient.

Topics: Ceruletide; Female; Humans; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Male; Postoperative Complications