cerivastatin has been researched along with Hypertension--Pulmonary* in 1 studies
1 other study(ies) available for cerivastatin and Hypertension--Pulmonary
| Article | Year |
|---|---|
Cerivastatin Nanoliposome as a Potential Disease Modifying Approach for the Treatment of Pulmonary Arterial Hypertension.
In this study we investigated nanoliposome as an approach to tailoring the pharmacology of cerivastatin as a disease-modifying drug for pulmonary arterial hypertension (PAH). Cerivastatin encapsulated liposomes with an average diameter of 98 ± 27 nm were generated by a thin film and freeze-thaw process. The nanoliposomes demonstrated sustained drug-release kinetics in vitro and inhibited proliferation of pulmonary artery (PA) smooth muscle cells with significantly less cellular cytotoxicity as compared with free cerivastatin. When delivered by inhalation to a rat model of monocrotaline-induced PAH, cerivastatin significantly reduced PA pressure from 55.13 ± 9.82 to 35.56 ± 6.59 mm Hg ( Topics: Animals; Humans; Hypertension, Pulmonary; Lactones; Liposomes; Nanostructures; Pyridines; Rats; Safety | 2018 |