cep-26401 and Cognition-Disorders

cep-26401 has been researched along with Cognition-Disorders* in 1 studies

Other Studies

1 other study(ies) available for cep-26401 and Cognition-Disorders

Article	Year
Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity. Bioorganic & medicinal chemistry letters, 2014, Mar-01, Volume: 24, Issue:5 A series of fused cyclopropyl-4,5-dihydropyridazin-3-one (3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one) phenoxypiperidine analogs was designed and synthesized, leading to the identification of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a) as a second-generation pyridazin-3-one H3R antagonist. Compound R,S-4a was a potent H3R functional antagonist in vivo in the rat dipsogenia model, demonstrated potent wake activity in the rat EEG/EMG model, and enhanced short-term memory in the rat social recognition memory model at doses as low as 0.03-0.3 mg/kg po. Topics: Animals; Cognition Disorders; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Drug Inverse Agonism; Half-Life; Haplorhini; Memory, Short-Term; Nootropic Agents; Piperidines; Pyridazines; Rats; Receptors, Histamine H3; Stereoisomerism; Structure-Activity Relationship	2014

Article

Year

Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity.

Bioorganic & medicinal chemistry letters, 2014, Mar-01, Volume: 24, Issue:5

A series of fused cyclopropyl-4,5-dihydropyridazin-3-one (3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one) phenoxypiperidine analogs was designed and synthesized, leading to the identification of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a) as a second-generation pyridazin-3-one H3R antagonist. Compound R,S-4a was a potent H3R functional antagonist in vivo in the rat dipsogenia model, demonstrated potent wake activity in the rat EEG/EMG model, and enhanced short-term memory in the rat social recognition memory model at doses as low as 0.03-0.3 mg/kg po.

Topics: Animals; Cognition Disorders; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Drug Inverse Agonism; Half-Life; Haplorhini; Memory, Short-Term; Nootropic Agents; Piperidines; Pyridazines; Rats; Receptors, Histamine H3; Stereoisomerism; Structure-Activity Relationship

2014