cem-101 and Hyperplasia

cem-101 has been researched along with Hyperplasia* in 1 studies

Other Studies

1 other study(ies) available for cem-101 and Hyperplasia

ArticleYear
Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells.
    PeerJ, 2023, Volume: 11

    Solithromycin is a novel fluoroketolide antibiotic belonging to the class of macrolide antibiotics. Activation of the interleukin (IL)-13 receptor leads to STAT6 activation and subsequent induction of SAM pointed domain containing ETS transcription factor (SPDEF), chloride channel accessory 1 (CLCA1), and anoctamin-1 (ANO1), all of which are associated with the induction of MUC5AC. We examined the effects of solithromycin on mucin production led by IL-13 signaling. Normal human bronchial epithelial cells were grown at the air-liquid interface with IL-13 with/without solithromycin for 14 days. Histochemical analysis was performed using hematoxylin and eosin staining and MUC5AC immunostaining.

    Topics: Anoctamin-1; Chloride Channels; Goblet Cells; Humans; Hyperplasia; Interleukin-13; Macrolides; Mucin 5AC; Neoplasm Proteins; RNA, Messenger

2023