cem-101 has been researched along with Arrhythmias--Cardiac* in 1 studies
1 trial(s) available for cem-101 and Arrhythmias--Cardiac
| Article | Year |
|---|---|
Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way crossover study in healthy subjects.
Macrolide antibiotics may cause QT prolongation.. To study the QT effect of a novel macrolide, solithromycin.. This was a thorough QT study with a three-way crossover design performed in healthy male and female subjects to evaluate the ECG effects of a novel macrolide, solithromycin. Forty-eight subjects were randomized to receive 800 mg of intravenous (iv) solithromycin, 400 mg of oral moxifloxacin and placebo in three separate treatment periods. Continuous 12 lead ECGs were recorded at a pre-dose baseline and serially after drug administration for 24 h.. The study demonstrated that solithromycin, unlike other macrolide antibiotics, does not cause QT prolongation. Topics: Arrhythmias, Cardiac; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Healthy Volunteers; Heart Conduction System; Humans; Macrolides; Male; Moxifloxacin; Placebos; Triazoles | 2017 |