celgosivir has been researched along with Dengue in 8 studies
*Dengue: An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Behnam, MA; Boldescu, V; Klein, CD; Nitsche, C | 1 |
| Chan, WK; Cherng, BP; Cheung, YB; Chow, A; Chua, LT; Chung, JS; Connolly, J; Hibberd, ML; Hou, Y; Howe, S; Leo, YS; Low, JG; Lye, DC; Ng, LC; Ooi, EE; Rathore, APS; Sung, C; Tambayah, PA; Tan, BH; Tan, KH; Toh, L; Vasudevan, SG; Watanabe, S; Wei, Y; Wijaya, L | 1 |
| Halstead, SB | 1 |
| Chan, KW; Dow, G; Low, JG; Ooi, EE; Vasudevan, SG; Watanabe, S | 1 |
| Aw, P; Chan, KW; Choy, MM; Connolly, JE; de Sessions, PF; Fan, L; Hibberd, ML; Kamaraj, US; Khoo, YM; Lee, B; Lee, HS; Low, JG; Ooi, EE; Rathore, AP; Sessions, OM; Sung, C; Vasudevan, SG; Vijaykrishna, D; Watanabe, S; Wei, Y; Wijaya, L | 1 |
| Connolly, JE; Low, J; Ooi, EE; Paradkar, PN; Rathore, AP; Sung, C; Tan, KH; Vasudevan, SG; Watanabe, S | 1 |
| Connolly, J; Khoo, YM; Lee, HS; Low, J; Lu, F; Ooi, EE; Rathore, AP; Sung, C; Vasudevan, SG; Watanabe, S | 1 |
| Flamand, M; Liu, W; Schul, W; Vasudevan, SG; Xu, HY | 1 |
1 review(s) available for celgosivir and Dengue
| Article | Year |
|---|---|
The Medicinal Chemistry of Dengue Virus.
Topics: Antiviral Agents; Chemistry, Pharmaceutical; Dengue; Dengue Virus; Humans; Molecular Conformation; Structure-Activity Relationship | 2016 |
2 trial(s) available for celgosivir and Dengue
| Article | Year |
|---|---|
Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial.
Topics: Adult; Aged; Antiviral Agents; Dengue; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Fever; Humans; Indolizines; Male; Middle Aged; Placebos; Singapore; Treatment Outcome; Viral Load; Young Adult | 2014 |
Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients.
Topics: Adult; Antiviral Agents; Cytokines; Dengue; Dengue Virus; Female; Half-Life; High-Throughput Nucleotide Sequencing; Humans; Indolizines; Male; Phylogeny; Th1 Cells; Viral Load; Viremia; Virus Replication | 2016 |
5 other study(ies) available for celgosivir and Dengue
| Article | Year |
|---|---|
Stumbles on the path to dengue control.
Topics: Antiviral Agents; Dengue; Female; Humans; Indolizines; Male | 2014 |
Optimizing celgosivir therapy in mouse models of dengue virus infection of serotypes 1 and 2: The search for a window for potential therapeutic efficacy.
Topics: alpha-Glucosidases; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Cricetinae; Cytokines; Dengue; Dengue Virus; Disease Models, Animal; Enzyme Inhibitors; Humans; In Vitro Techniques; Indolizines; Mice; Real-Time Polymerase Chain Reaction; Serogroup; Vero Cells; Viral Load; Viremia | 2016 |
Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model.
Topics: Animals; Antiviral Agents; Cell Line; Cricetinae; Dengue; Dengue Virus; Disease Models, Animal; Humans; Indolizines; Mice; Mice, 129 Strain; Microbial Sensitivity Tests; Protein Binding; Protein Folding; Signal Transduction; Unfolded Protein Response; Viral Nonstructural Proteins | 2011 |
Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial.
Topics: Animals; Antiviral Agents; Dengue; Dengue Virus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy; Indolizines; Mice; Survival Analysis | 2012 |
A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs.
Topics: 1-Deoxynojirimycin; Animals; Antiviral Agents; Dengue; Disease Models, Animal; Dose-Response Relationship, Drug; Indolizines; Mice; Ribavirin; Time Factors; Tubercidin; Viremia; Virus Replication | 2007 |