celecoxib has been researched along with Ulcer in 23 studies
Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
Excerpt | Relevance | Reference |
---|---|---|
" Amongst all the synthesized derivatives, compound 56 showed the significant anti-inflammatory activity in both rat paw edema models with very less ulcerogenic liability in comparison to standard diclofenac, celecoxib, and zileuton." | 3.85 | Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity. ( Bandresh, R; Shrivastava, SK; Srivastava, P; Tripathi, A; Tripathi, PN, 2017) |
" All the target compounds showed anti-inflammatory activity and three of them 3b, 3c and 4c surpassed that of indomethacin both locally and systemically in the cotton pellet granuloma and rat paw edema bioassay." | 3.74 | Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. ( Abdel Ghany, YS; Ashour, HM; Baraka, A; Bekhit, AA; Bekhit, Ael-D, 2008) |
"Treatment with celecoxib significantly delayed esophageal ulcer healing and suppressed ulceration-triggered increases in esophageal epithelial cell proliferation, c-Met mRNA and protein expression, and ERK2 activity." | 1.31 | Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation. ( Baatar, D; Jones, MK; Kawanaka, H; Kitano, S; Moon, WS; Pai, R; Szabo, IL; Tarnawski, AS, 2002) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (21.74) | 29.6817 |
2010's | 15 (65.22) | 24.3611 |
2020's | 3 (13.04) | 2.80 |
Authors | Studies |
---|---|
Bekhit, AA | 2 |
Ashour, HM | 1 |
Abdel Ghany, YS | 1 |
Bekhit, Ael-D | 1 |
Baraka, A | 1 |
Husain, A | 1 |
Ahmad, A | 1 |
Alam, MM | 1 |
Ajmal, M | 1 |
Ahuja, P | 1 |
Abbas, SE | 1 |
Awadallah, FM | 1 |
Ibrahin, NA | 1 |
Said, EG | 1 |
Kamel, GM | 3 |
Hanna, MM | 1 |
Abdel-Aziz, HA | 1 |
Al-Rashood, KA | 1 |
ElTahir, KE | 1 |
Suddek, GM | 1 |
Abdellatif, KR | 2 |
Abdelgawad, MA | 1 |
Labib, MB | 1 |
Zidan, TH | 1 |
Abdellatif, KRA | 2 |
Abdelall, EKA | 4 |
Fadaly, WAA | 1 |
Abdelall, EK | 1 |
Banerjee, AG | 1 |
Das, N | 1 |
Shengule, SA | 1 |
Sharma, PA | 1 |
Srivastava, RS | 1 |
Shrivastava, SK | 2 |
Rathore, A | 1 |
Sudhakar, R | 1 |
Ahsan, MJ | 1 |
Ali, A | 1 |
Subbarao, N | 1 |
Jadav, SS | 1 |
Umar, S | 1 |
Yar, MS | 1 |
Elshemy, HAH | 2 |
Azouz, AA | 4 |
Moawad, A | 1 |
Ali, WAM | 1 |
Safwat, NM | 1 |
Srivastava, P | 1 |
Bandresh, R | 1 |
Tripathi, PN | 1 |
Tripathi, A | 1 |
Abdelhamid, AO | 1 |
Felipe, JL | 1 |
Cassamale, TB | 1 |
Lourenço, LD | 1 |
Carvalho, DB | 1 |
das Neves, AR | 1 |
Duarte, RCF | 1 |
Carvalho, MG | 1 |
Toffoli-Kadri, MC | 1 |
Baroni, ACM | 1 |
Philoppes, JN | 1 |
Hassanein, EHM | 1 |
Kahk, NM | 1 |
Shabaan, MA | 1 |
Kamal, AM | 1 |
Faggal, SI | 1 |
Elsahar, AE | 1 |
Mohamed, KO | 1 |
Onuora, S | 1 |
Bakr, RB | 1 |
Ghoneim, AA | 1 |
Fadaly, WA | 1 |
Mohy El-Din, MM | 1 |
Senbel, AM | 1 |
Bistawroos, AA | 1 |
El-Mallah, A | 1 |
Nour El-Din, NA | 1 |
Abd El Razik, HA | 1 |
Lugardon, S | 1 |
Lapeyre-Mestre, M | 1 |
Montastruc, JL | 1 |
Calvo, N | 1 |
Iversen, E | 1 |
Munck, LK | 1 |
Baatar, D | 1 |
Jones, MK | 1 |
Pai, R | 1 |
Kawanaka, H | 1 |
Szabo, IL | 1 |
Moon, WS | 1 |
Kitano, S | 1 |
Tarnawski, AS | 1 |
23 other studies available for celecoxib and Ulcer
Article | Year |
---|---|
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cyclooxygenase 1; C | 2008 |
Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Female; Lipid Peroxidation | 2009 |
New quinazolinone-pyrimidine hybrids: synthesis, anti-inflammatory, and ulcerogenicity studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Edema; Female; Ma | 2012 |
New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Cyclooxygenase 1; Cy | 2012 |
Synthesis of N-benzenesulfonamide-1H-pyrazoles bearing arylsulfonyl moiety: novel celecoxib analogs as potent anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemistry Techniques, Synth | 2014 |
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 I | 2015 |
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.
Topics: Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; P | 2016 |
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 15-Lipoxygenase; Cattle; Celecoxib; C | 2016 |
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2016 |
In vivo anti-inflammatory activity and docking study of newly synthesized benzimidazole derivatives bearing oxadiazole and morpholine rings.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Cyclooxygenase 2 Inhibitors; Edema | 2017 |
Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclization; Cycl | 2017 |
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Cyclooxygenase Inhi | 2017 |
Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationship, Drug; Ede | 2017 |
Anti-inflammatory, ulcerogenic and platelet activation evaluation of novel 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Celecoxib; Dose-Re | 2022 |
Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on celecoxib scaffold supported with in vivo anti-inflammatory activity, ulcerogenic liability, ADME profiling and docking study.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cycl | 2022 |
Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Celecoxi | 2020 |
Therapy: Celecoxib reduces risk of ulcer bleeding.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Double-Blind Method; Gastrointestinal | 2017 |
Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhi | 2019 |
Synthesis, Cyclooxygenase Inhibition, Anti-Inflammatory Evaluation, and Ulcerogenic Liability of New 1,3,5-Triarylpyrazoline Derivatives Possessing a Methanesulfonyl Pharmacophore.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Isoenzymes; Pyrazo | 2016 |
A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzenesulfonamides; Carrageenan; Celecoxib; Chronic | 2011 |
Upper gastrointestinal adverse drug reactions and cyclo-oxygenase-2 inhibitors (celecoxib and rofecoxib): a case/non-case study from the French Pharmacovigilance Database.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Celecoxib; Cyclooxygenase 2; Cyclo | 2004 |
[Intestinal side effects of COX-2 inhibitors].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Colonic Diseases; Colonic Pouches; | 2006 |
Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation.
Topics: Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Down-R | 2002 |