Page last updated: 2024-10-24

celecoxib and Ulcer

celecoxib has been researched along with Ulcer in 23 studies

Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Research Excerpts

ExcerptRelevanceReference
" Amongst all the synthesized derivatives, compound 56 showed the significant anti-inflammatory activity in both rat paw edema models with very less ulcerogenic liability in comparison to standard diclofenac, celecoxib, and zileuton."3.85Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity. ( Bandresh, R; Shrivastava, SK; Srivastava, P; Tripathi, A; Tripathi, PN, 2017)
" All the target compounds showed anti-inflammatory activity and three of them 3b, 3c and 4c surpassed that of indomethacin both locally and systemically in the cotton pellet granuloma and rat paw edema bioassay."3.74Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. ( Abdel Ghany, YS; Ashour, HM; Baraka, A; Bekhit, AA; Bekhit, Ael-D, 2008)
"Treatment with celecoxib significantly delayed esophageal ulcer healing and suppressed ulceration-triggered increases in esophageal epithelial cell proliferation, c-Met mRNA and protein expression, and ERK2 activity."1.31Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation. ( Baatar, D; Jones, MK; Kawanaka, H; Kitano, S; Moon, WS; Pai, R; Szabo, IL; Tarnawski, AS, 2002)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (21.74)29.6817
2010's15 (65.22)24.3611
2020's3 (13.04)2.80

Authors

AuthorsStudies
Bekhit, AA2
Ashour, HM1
Abdel Ghany, YS1
Bekhit, Ael-D1
Baraka, A1
Husain, A1
Ahmad, A1
Alam, MM1
Ajmal, M1
Ahuja, P1
Abbas, SE1
Awadallah, FM1
Ibrahin, NA1
Said, EG1
Kamel, GM3
Hanna, MM1
Abdel-Aziz, HA1
Al-Rashood, KA1
ElTahir, KE1
Suddek, GM1
Abdellatif, KR2
Abdelgawad, MA1
Labib, MB1
Zidan, TH1
Abdellatif, KRA2
Abdelall, EKA4
Fadaly, WAA1
Abdelall, EK1
Banerjee, AG1
Das, N1
Shengule, SA1
Sharma, PA1
Srivastava, RS1
Shrivastava, SK2
Rathore, A1
Sudhakar, R1
Ahsan, MJ1
Ali, A1
Subbarao, N1
Jadav, SS1
Umar, S1
Yar, MS1
Elshemy, HAH2
Azouz, AA4
Moawad, A1
Ali, WAM1
Safwat, NM1
Srivastava, P1
Bandresh, R1
Tripathi, PN1
Tripathi, A1
Abdelhamid, AO1
Felipe, JL1
Cassamale, TB1
Lourenço, LD1
Carvalho, DB1
das Neves, AR1
Duarte, RCF1
Carvalho, MG1
Toffoli-Kadri, MC1
Baroni, ACM1
Philoppes, JN1
Hassanein, EHM1
Kahk, NM1
Shabaan, MA1
Kamal, AM1
Faggal, SI1
Elsahar, AE1
Mohamed, KO1
Onuora, S1
Bakr, RB1
Ghoneim, AA1
Fadaly, WA1
Mohy El-Din, MM1
Senbel, AM1
Bistawroos, AA1
El-Mallah, A1
Nour El-Din, NA1
Abd El Razik, HA1
Lugardon, S1
Lapeyre-Mestre, M1
Montastruc, JL1
Calvo, N1
Iversen, E1
Munck, LK1
Baatar, D1
Jones, MK1
Pai, R1
Kawanaka, H1
Szabo, IL1
Moon, WS1
Kitano, S1
Tarnawski, AS1

Other Studies

23 other studies available for celecoxib and Ulcer

ArticleYear
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cyclooxygenase 1; C

2008
Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Female; Lipid Peroxidation

2009
New quinazolinone-pyrimidine hybrids: synthesis, anti-inflammatory, and ulcerogenicity studies.
    European journal of medicinal chemistry, 2012, Volume: 53

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Edema; Female; Ma

2012
New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies.
    European journal of medicinal chemistry, 2012, Volume: 55

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Cyclooxygenase 1; Cy

2012
Synthesis of N-benzenesulfonamide-1H-pyrazoles bearing arylsulfonyl moiety: novel celecoxib analogs as potent anti-inflammatory agents.
    European journal of medicinal chemistry, 2014, Jun-10, Volume: 80

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemistry Techniques, Synth

2014
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2015, Dec-15, Volume: 25, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 I

2015
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2

    Topics: Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; P

2016
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.
    European journal of medicinal chemistry, 2016, Aug-08, Volume: 118

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 15-Lipoxygenase; Cattle; Celecoxib; C

2016
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.
    Bioorganic chemistry, 2016, Volume: 69

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In

2016
In vivo anti-inflammatory activity and docking study of newly synthesized benzimidazole derivatives bearing oxadiazole and morpholine rings.
    Bioorganic chemistry, 2017, Volume: 70

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Cyclooxygenase 2 Inhibitors; Edema

2017
Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.
    European journal of medicinal chemistry, 2017, Feb-15, Volume: 127

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclization; Cycl

2017
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.
    Bioorganic & medicinal chemistry, 2017, 08-15, Volume: 25, Issue:16

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Cyclooxygenase Inhi

2017
Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids.
    Bioorganic & medicinal chemistry letters, 2017, 09-15, Volume: 27, Issue:18

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationship, Drug; Ede

2017
Anti-inflammatory, ulcerogenic and platelet activation evaluation of novel 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids.
    Bioorganic chemistry, 2022, Volume: 119

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Celecoxib; Dose-Re

2022
Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on celecoxib scaffold supported with in vivo anti-inflammatory activity, ulcerogenic liability, ADME profiling and docking study.
    Bioorganic chemistry, 2022, Volume: 120

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cycl

2022
Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase.
    Archiv der Pharmazie, 2020, Volume: 353, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Celecoxi

2020
Therapy: Celecoxib reduces risk of ulcer bleeding.
    Nature reviews. Rheumatology, 2017, Volume: 13, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Double-Blind Method; Gastrointestinal

2017
Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold.
    Bioorganic chemistry, 2019, Volume: 88

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhi

2019
Synthesis, Cyclooxygenase Inhibition, Anti-Inflammatory Evaluation, and Ulcerogenic Liability of New 1,3,5-Triarylpyrazoline Derivatives Possessing a Methanesulfonyl Pharmacophore.
    Archiv der Pharmazie, 2016, Volume: 349, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Isoenzymes; Pyrazo

2016
A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug.
    Basic & clinical pharmacology & toxicology, 2011, Volume: 108, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzenesulfonamides; Carrageenan; Celecoxib; Chronic

2011
Upper gastrointestinal adverse drug reactions and cyclo-oxygenase-2 inhibitors (celecoxib and rofecoxib): a case/non-case study from the French Pharmacovigilance Database.
    European journal of clinical pharmacology, 2004, Volume: 60, Issue:9

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Celecoxib; Cyclooxygenase 2; Cyclo

2004
[Intestinal side effects of COX-2 inhibitors].
    Ugeskrift for laeger, 2006, Mar-27, Volume: 168, Issue:13

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Colonic Diseases; Colonic Pouches;

2006
Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation.
    The American journal of pathology, 2002, Volume: 160, Issue:3

    Topics: Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Down-R

2002