celecoxib has been researched along with Stomatitis in 2 studies
Stomatitis: INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral mucositis is a severe, dose-limiting side effect of radio(chemo)therapy for head and neck tumors." | 1.35 | Effect of selective inhibitors of inflammation on oral mucositis: preclinical studies. ( Dörr, W; Haagen, J; Krohn, H; Röllig, S; Schmidt, M; Wolfram, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lalla, RV | 1 |
| Choquette, LE | 1 |
| Curley, KF | 1 |
| Dowsett, RJ | 1 |
| Feinn, RS | 1 |
| Hegde, UP | 1 |
| Pilbeam, CC | 1 |
| Salner, AL | 1 |
| Sonis, ST | 1 |
| Peterson, DE | 1 |
| Haagen, J | 1 |
| Krohn, H | 1 |
| Röllig, S | 1 |
| Schmidt, M | 1 |
| Wolfram, K | 1 |
| Dörr, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cyclooxygenase-2 Inhibition in Radiation-Induced Oral Mucositis[NCT00698204] | Phase 2 | 43 participants (Actual) | Interventional | 2003-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Oral Mucositis Assessment Scale (OMAS) was used to assess oral mucosal injury during the period of radiation therapy. This validated scale scores ulceration and erythema independently at nine specified sites in the oral cavity. Ulceration is scored from 0-3 based on size of lesion and erythema is scored from 0-2 based on severity of erythema. The sum of scores is then divided by 9.~The mean OMAS score at a cumulative radiation dose of 5000 cGy (approximately 5 weeks of treatment) was compared between groups." (NCT00698204)
Timeframe: 5 weeks from start of radiation therapy (5000 cGy)
| Intervention | units on a scale (Mean) |
|---|---|
| I- Celecoxib | 1.42 |
| II- Placebo | 1.36 |
Mean worst pain at 5000 cGy on 0-10 scale, 0 = no pain, 10 = worst pain imaginable (NCT00698204)
Timeframe: 5 weeks from start of radiation therapy (cumulative dose of 5000 cGy)
| Intervention | units on a scale (Mean) |
|---|---|
| I- Celecoxib | 4.47 |
| II- Placebo | 3.70 |
1 trial available for celecoxib and Stomatitis
| Article | Year |
|---|---|
Randomized double-blind placebo-controlled trial of celecoxib for oral mucositis in patients receiving radiation therapy for head and neck cancer.
Topics: Adult; Aged; Celecoxib; Double-Blind Method; Female; Head and Neck Neoplasms; Humans; Male; Middle A | 2014 |
1 other study available for celecoxib and Stomatitis
| Article | Year |
|---|---|
Effect of selective inhibitors of inflammation on oral mucositis: preclinical studies.
Topics: Animals; Antibodies, Monoclonal; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dos | 2009 |