Page last updated: 2024-10-24

celecoxib and Stomach Neoplasms

celecoxib has been researched along with Stomach Neoplasms in 65 studies

Stomach Neoplasms: Tumors or cancer of the STOMACH.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study."9.13Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention. ( Feng, GS; Lam, SK; Li, J; Li, JY; Liu, WD; Ma, JL; Pan, KF; Shen, L; Wong, BC; Xia, HH; You, WC; Zhang, L; Zhang, XD, 2008)
"Celecoxib combined with octreotide significantly promoted necrosis in gastric adenocarcinoma through the induction of apoptosis and the reduction of MVD."9.12Preoperative growth inhibition of human gastric adenocarcinoma treated with a combination of celecoxib and octreotide. ( Chen, ZX; Huang, MH; Huang, MT; Liu, R; Tang, CW; Wang, CH; Wei, B; Zhang, B, 2007)
"Celecoxib can enhance apoptosis of GC cell by induction of NAG-1 gene transcription in human."6.74[Celecoxib inhibits gastric adenocarcinoma growth via inducing expression of human nonsteroidal anti-inflammatory drug activated gene]. ( Chen, JP; Ciren, YJ; Tang, CW; Wang, R; Yang, JL; Zhang, B, 2009)
"To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study."5.13Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention. ( Feng, GS; Lam, SK; Li, J; Li, JY; Liu, WD; Ma, JL; Pan, KF; Shen, L; Wong, BC; Xia, HH; You, WC; Zhang, L; Zhang, XD, 2008)
"Celecoxib combined with octreotide significantly promoted necrosis in gastric adenocarcinoma through the induction of apoptosis and the reduction of MVD."5.12Preoperative growth inhibition of human gastric adenocarcinoma treated with a combination of celecoxib and octreotide. ( Chen, ZX; Huang, MH; Huang, MT; Liu, R; Tang, CW; Wang, CH; Wei, B; Zhang, B, 2007)
"To see whether celecoxib prevents gastric cancer occurrence by disrupting the progression of chronic gastritis into gastric carcinoma through its inhibition of the migration of CD133-positive cells, one of the surface markers of bone marrow-derived cells, in Helicobacter pylori-infected gerbils."3.76Celecoxib inhibits CD133-positive cell migration via reduction of CCR2 in Helicobacter pylori-infected Mongolian gerbils. ( Futagami, S; Gudis, K; Hamamoto, T; Horie, A; Kawagoe, T; Nagoya, H; Sakamoto, C; Shimpuku, M; Shindo, T, 2010)
" We recently showed that NSAIDs such as indomethacin and celecoxib have direct cytotoxicity (ability to induce necrosis and apoptosis in gastric mucosal cells) due to their membrane permeabilizing activities, which is involved in NSAID-induced gastric lesions."3.76Low direct cytotoxicity of loxoprofen on gastric mucosal cells. ( Arai, Y; Ishihara, T; Kimoto, A; Mizushima, T; Okamoto, Y; Otsuka, M; Suemasu, S; Tanaka, K; Yamakawa, N; Yokomizo, K, 2010)
"Celecoxib combined with chemotherapy offers more clinical benefits for COX-2 positive advanced gastric cancer patients."2.90A comprehensive evaluation of clinical efficacy and safety of celecoxib in combination with chemotherapy in metastatic or postoperative recurrent gastric cancer patients: A preliminary, three-center, clinical trial study. ( Chen, Z; Guan, Q; Guo, Q; Li, Q; Liu, M; Wang, J; Wang, Y; Ye, Y; Zhou, Y, 2019)
"In total, 240 gastric cancer patients undergoing radical gastrectomy followed by adjuvant chemotherapy were randomly assigned into 2 groups."2.84Comprehensive evaluation of clinical efficacy and safety of celecoxib combined with chemotherapy in management of gastric cancer. ( Chen, Z; Guo, Q; Ji, R; Liu, X; Lu, L; Wang, Y; Yuan, H; Zhou, Y, 2017)
"Celecoxib can enhance apoptosis of GC cell by induction of NAG-1 gene transcription in human."2.74[Celecoxib inhibits gastric adenocarcinoma growth via inducing expression of human nonsteroidal anti-inflammatory drug activated gene]. ( Chen, JP; Ciren, YJ; Tang, CW; Wang, R; Yang, JL; Zhang, B, 2009)
"Fifty nine gastric cancer patients were randomly divided into two groups: Surgery group (n = 22), in which patients underwent surgical resection after diagnosis, and Celecoxib + Surgery group (n = 37), in which patients received oral Celecoxib 200 mg twice daily for 7 days before curative resection."2.73Effect of celecoxib on E-cadherin, VEGF, Microvessel density and apoptosis in gastric cancer. ( Honghua, L; Ning, C; Qiao, L; Ran, J; Tang, C; Wu, J; Xingwen, L; Zhou, Y, 2007)
"Fifty nine gastric cancer patients were randomly divided into 2 groups: celecoxib group (n = 37) and control group (n = 22)."2.73[Celecoxib induces apoptosis and inhibits angiogenesis in gastric cancer]. ( Lu, H; Lu, JR; Ran, JT; Tang, CW; Wu, J; Yang, GD; Zhou, YN, 2008)
"The GC cells from the resected gastric cancer specimens were isolated by immunomagnetic separation."2.72[The inhibitive effects of celecoxib combined with octreotide on the metastasis of human gastric cancer in vivo]. ( Chen, ZX; Huang, MH; Huang, MT; Tang, CW; Wang, CH; Wei, B; Zhang, B, 2006)
"Capecitabine is an oral 5-fluorouracil (5-FU) prodrug that is more convenient than using infusional 5-FU, appears to have a similar therapeutic profile, and can be combined with daily irradiation."2.42COX-2 inhibitors as radiation sensitizers for upper GI tract cancers: esophagus, stomach, and pancreas. ( Rich, TA; Shepard, R, 2003)
"Gastric cancer is the fourth most common cancer in the world."1.43Dimethyl celecoxib sensitizes gastric cancer cells to ABT-737 via AIF nuclear translocation. ( Li, Y; Lin, N; Wang, L; Wang, M; Yan, Y; Zeng, J; Zhang, B; Zhang, D, 2016)
"Celecoxib (COX-2 inhibitor) inhibits gastric cancer cell proliferation, but with low treatment efficacy, limiting its applications."1.42Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study. ( Aziz, F; Wang, X; Yan, Q; Yang, X, 2015)
"Celecoxib was more effective in SGC-7901/DDP cells with a lower inhibitory concentration compared to that in SGC-7901 cells, supporting such a cyclooxygenase-2-dependent drug resistance in SGC-7901/DDP cells."1.42Celecoxib enhanced the cytotoxic effect of cisplatin in drug-resistant human gastric cancer cells by inhibition of cyclooxygenase-2. ( Lv, QZ; Shen, FM; Xu, HB, 2015)
"As4S4 in combination with JQ1, cisplatin, irinotecan or celecoxib showed enhanced cytotoxic effect on gastric and colon cancer cells, indicating the potential application of these novel drug combinations as part of treatment strategy that warrants further investigation."1.42Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth. ( Chen, S; Pan, M; Tong, Y; Zhang, L; Zhang, X, 2015)
"In two gastric cancer cell lines, MGC-803 and SGC-7901, S100P expression was knocked down by a lentiviral short hairpin delivery system."1.40Knockdown of S100P by lentiviral-mediated RNAi promotes apoptosis and suppresses the colony-formation ability of gastric cancer cells. ( Hu, H; Shi, X; Tang, W; Zhang, Q, 2014)
"The HERG mRNA, protein and current in gastric cancer cells transfected with or without COX-2 antisense vector were measured by RT-PCR, Western blot and patch-clamp, respectively."1.40The mechanism of COX-2 regulating HERG channel in gastric cancer cells. ( Guo, XZ; Lin, H; Ren, LN; Shao, XD, 2014)
" In some tumor models, the combination of celecoxib with chemotherapy agents has shown synergistic antitumor effect; however, the effect of celecoxib combination with tegafur/gimeracil/oteracil potassium on the malignant biological behaviors of gastric cancer in nude mice is unclear."1.40Effect of celecoxib combined with chemotherapy drug on malignant biological behaviors of gastric cancer. ( Dai, K; Fang, M; Lu, Z; Luo, J; Luo, Z; Meng, C; Zhang, S; Zhou, X, 2014)
"pylori-induced gastric cancer cell motility and invasion."1.39Celecoxib inhibits Helicobacter pylori-induced invasion of gastric cancer cells through an adenine nucleotide translocator-dependent mechanism. ( Fan, L; Fang, D; Guo, GJ; Lan, C; Wan, S; Wang, J; Wang, R; Yang, L; Yang, S; Zhang, Y, 2013)
"A xenograft tumor model of gastric cancer was established subcutaneously in nude mice."1.39[Inhibitive effect of celecoxib combined with tegafur gimeracil oteracil potassium on the growth of xenograft tumor of gastric cancer in nude mice]. ( Chen, X; Luo, Z; Meng, C, 2013)
"hTERT was depleted in gastric and cervical cancer cells using small interfering RNA (siRNA) and analysed for COX2 expression using quantitative PCR and immunoblotting."1.39Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects. ( Björkholm, M; Jia, J; Li, B; Liang, X; Liu, T; Xu, D, 2013)
"Celecoxib was able to restrain proliferation and induce apoptosis in a dose- and time- dependent manner, inducing G0/G1 cell cycle arrest, release of cytochrome C into the cytosol, and cleavage of pro-caspase-9 into its active form."1.39Effects of celecoxib on cycle kinetics of gastric cancer cells and protein expression of cytochrome C and caspase-9. ( Han, Z; Ma, YJ; Niu, XP; Wang, YJ; Yang, L, 2013)
"Human gastric cancer cell line SGC-7901 was cultured and treated with different concentration of AG1478 and celecoxib, the proliferation of SGC-7901 cells was determined by MTT."1.36[Effects of EGFR inhibitor AG1478 in combination with celecoxib on the growth of gastric cancer cells]. ( Li, RK; Liao, J; Qiang, O; Wang, CH, 2010)
"pylori-infected MGs developed gastric cancer."1.35Short-term celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model. ( Chang, LL; Hu, HM; Jan, CM; Kuo, CH; Tsai, PY; Wang, JY; Wang, WM; Wu, DC; Wu, IC; Yang, SF, 2009)
"Immunohistochemistry on TMAs of 178 gastric cancers showed no correlation between COX-2 and E-cadherin expression in the conventional or early gastric cancer groups."1.35Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines. ( de Leng, WW; Leguit, RJ; Maciejewski, R; Milne, AN; Morsink, FH; Offerhaus, GJ; Polkowski, WP; Sitarz, R, 2009)
"Celecoxib prevented gastric cancer in MNU-pretreated H."1.35Celecoxib inhibits apurinic/apyrimidinic endonuclease-1 expression and prevents gastric cancer in Helicobacter pylori-infected mongolian gerbils. ( Crowe, SE; Futagami, S; Gudis, K; Hamamoto, T; Horie, A; Kawagoe, T; Kusunoki, M; Miyake, K; Sakamoto, C; Shindo, T; Suzuki, K; Tsukui, T, 2008)
"The anti-cancer effects of celecoxib on gastric cancer cells might be partly mediated by downregulation of Akt, GSK3beta, FKHR, and upregulation of caspase-9, in the mitochondrial apoptotic pathway."1.35Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling. ( Ahn, DW; Cho, SJ; Jung, HC; Kim, CH; Kim, JS; Kim, N; Lee, KS; Lee, MK; Park, JH; Song, IS, 2009)
"The anticancer effects of celecoxib on gastric cancer cells appear to be mediated by cell-cycle arrest and apoptosis, and not by COX-2 or PGE(2) suppression alone."1.34The anti-cancer effect of COX-2 inhibitors on gastric cancer cells. ( Cho, SJ; Jung, HC; Kim, JS; Kim, N; Song, IS, 2007)
"To study the effects of two specific cyclooxygenase inhibitors (SCI), rofecoxib and celecoxib, combined with chemotherapeutic drugs 5-Fu, DDP and VP-16 on gastric cancer cell line BGC-823, and to evaluate whether specific cyclooxygenase inhibitors can be used as a synergetic agent in chemotherapy."1.34[Antitumor effects of specific cyclooxygenase inhibitors combined with chemotherapeutic agents on gastric cancer cells in vitro]. ( Chen, XM; Feng, JX; Wang, YJ; Zhang, X; Zhu, FS, 2007)
"With treatment with celecoxib, PGE(2) levels, the gastric mucosal thickness, and the number of total gastric cells per gastric gland of ACT-GAS mice were significantly decreased."1.33Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice. ( Chiba, T; Fukui, H; Kanda, N; Kawada, M; Konda, Y; Nakajima, T; Sawabu, T; Seno, H; Takeuchi, T; Uenoyoma, Y, 2006)
"The incidences of gastric cancer were 0% in group A, 75% in group B, 68."1.32Chemoprevention of gastric cancer by celecoxib in rats. ( Bai, AH; Hu, PJ; Leung, WK; Lin, HL; Sung, JJ; Tang, BD; Yu, J; Zeng, ZR, 2004)
"Celecoxib combined with octreotide may enhance inhibition of growth of multidrug resistant human gastric cancer cells."1.32[Inhibitory effects of celecoxib combined with octreotide on growth of multidrug resistant human gastric cancer cell line SGC7901/ADR]. ( Qiang, O; Tang, CW; Wang, CH; Zheng, WB, 2004)

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's34 (52.31)29.6817
2010's30 (46.15)24.3611
2020's1 (1.54)2.80

Authors

AuthorsStudies
Jin, G1
Zhang, J1
Cao, T1
Zhu, H1
Shi, Y1
Lin, XM1
Li, S1
Zhou, C1
Li, RZ1
Wang, H1
Luo, W1
Huang, YS1
Chen, LK1
Cai, JL1
Wang, TX1
Zhang, QH1
Cao, H1
Wu, XP1
Guo, Q2
Liu, X1
Lu, L1
Yuan, H1
Wang, Y2
Chen, Z2
Ji, R2
Zhou, Y3
Li, Q3
Wang, J3
Liu, M2
Ye, Y1
Guan, Q1
Lan, C1
Yang, L2
Fan, L1
Zhang, Y3
Guo, GJ1
Wan, S1
Yang, S1
Wang, R2
Fang, D1
Meng, C2
Chen, X1
Luo, Z2
Liu, T1
Liang, X1
Li, B1
Björkholm, M1
Jia, J1
Xu, D1
Wang, YJ2
Niu, XP1
Han, Z1
Ma, YJ1
Nakamura, M1
Takahashi, T1
Matsui, H1
Takahashi, S1
Murayama, SY1
Suzuki, H2
Tsuchimoto, K1
Li, CM1
Chen, ZF1
Guo, QH1
Zhang, HL1
Zhou, YN3
Zhang, Q1
Hu, H1
Shi, X1
Tang, W1
Xiang, HG1
Xie, X1
Hu, FQ1
Xiao, HB1
Zhang, WJ1
Chen, L1
Shao, XD1
Guo, XZ1
Ren, LN1
Lin, H1
Zhang, XQ1
Sun, XE1
Liu, WD3
Feng, YG1
Zhang, HM1
Shi, LH1
Sun, XN1
Li, YQ1
Gao, ZX1
Aziz, F1
Yang, X1
Wang, X1
Yan, Q1
Lu, Z1
Fang, M1
Zhou, X1
Dai, K1
Zhang, S1
Luo, J1
Cao, Y1
Qu, J1
Li, C1
Yang, D1
Hou, K1
Zheng, H1
Liu, Y1
Qu, X1
Xu, HB2
Shen, FM2
Lv, QZ2
Pan, KF4
Zhang, L5
Ma, JL4
Zhou, T1
Li, JY4
Shen, L3
You, WC4
Tong, Y1
Zhang, X2
Pan, M1
Chen, S1
Zeng, HM1
Nie, XR1
Zhang, B4
Yan, Y1
Li, Y1
Zhang, D1
Zeng, J1
Wang, L1
Wang, M1
Lin, N1
Feng, GS2
Wong, BC2
Zhang, XD2
Li, J2
Xia, HH2
Lam, SK1
Kim, N2
Kim, CH1
Ahn, DW1
Lee, KS1
Cho, SJ2
Park, JH1
Lee, MK1
Kim, JS2
Jung, HC2
Song, IS2
Liu, H1
Huang, P1
Xu, X1
Liu, J1
Guo, C1
Futagami, S4
Kawagoe, T2
Horie, A2
Shindo, T4
Hamamoto, T4
Suzuki, K4
Kusunoki, M3
Miyake, K3
Gudis, K4
Tsukui, T3
Crowe, SE1
Sakamoto, C4
Ran, JT2
Tang, CW7
Lu, JR1
Wu, J2
Lu, H2
Yang, GD1
Namba, T3
Homan, T1
Nishimura, T1
Mima, S3
Hoshino, T3
Mizushima, T4
Peng, J1
Zhang, GY1
Wang, CH5
Zheng, WB2
Qiang, O3
Zhang, LJ1
Wang, SY1
Huo, XH1
Zhu, ZL1
Chu, JK1
Ma, JC1
Cui, DS1
Gu, P1
Zhao, ZR1
Wang, MW1
Yu, J4
Li, HH1
Li, XW1
Kuo, CH1
Hu, HM1
Tsai, PY1
Wu, IC1
Yang, SF1
Chang, LL1
Wang, JY1
Jan, CM1
Wang, WM1
Wu, DC1
Sitarz, R1
Leguit, RJ1
de Leng, WW1
Morsink, FH1
Polkowski, WP1
Maciejewski, R1
Offerhaus, GJ1
Milne, AN1
Ciren, YJ1
Yang, JL1
Chen, JP1
Shimpuku, M1
Nagoya, H1
Yamakawa, N1
Suemasu, S1
Kimoto, A1
Arai, Y2
Ishihara, T3
Yokomizo, K1
Okamoto, Y1
Otsuka, M1
Tanaka, K2
Li, RK1
Liao, J1
Oshima, H1
Hioki, K1
Popivanova, BK1
Oguma, K1
Van Rooijen, N1
Ishikawa, TO1
Oshima, M1
Lu, AP1
Lam, S1
Thiel, A1
Narko, K2
Heinonen, M1
Hemmes, A1
Tomasetto, C2
Rio, MC2
Haglund, C1
Mäkelä, TP1
Ristimäki, A2
Fang, L1
Wu, HB1
Chen, XG1
Saito, Y1
Imaeda, H1
Matsuzaki, J1
Hirata, K1
Tsugawa, H1
Hibino, S1
Kanai, Y1
Saito, H1
Hibi, T1
Saukkonen, K1
Rich, TA1
Shepard, R1
Hu, PJ4
Zeng, ZR4
Leung, WK2
Lin, HL1
Tang, BD3
Bai, AH2
Sung, JJ2
Fu, SL1
Wu, YL1
Zhang, YP1
Qiao, MM1
Chen, Y2
To, KF1
Ma, PK1
Go, MY1
Tsutsumi, S2
Tanaka, KI1
Aburaya, M1
Kanda, N1
Seno, H1
Kawada, M1
Sawabu, T1
Uenoyoma, Y1
Nakajima, T1
Konda, Y1
Fukui, H1
Takeuchi, T1
Chiba, T1
Wu, K1
Bai, F1
Zhai, H1
Xie, H1
Du, Y1
Liang, J1
Han, S1
Lin, T1
Fan, D1
Ogawa, S1
Ran, J1
Tang, C2
Honghua, L1
Xingwen, L1
Ning, C1
Qiao, L1
Pang, RP1
Zhou, JG1
Li, XY1
Chen, W1
Chen, MH1
Huang, MT2
Chen, ZX2
Wei, B2
Huang, MH2
Hiratsuka, T2
Ueki, N2
Tatsuguchi, A1
Shinji, Y1
Wada, K1
Zhu, FS1
Chen, XM1
Feng, JX1
Huang, L1
Wang, C1
Zheng, W1
Liu, R2
Yang, J1
Zhao, Q1
Yang, Y1
You, QD1
Zeng, S1
Gu, HY1
Lu, N1
Qi, Q1
Liu, W1
Wang, XT1
Guo, QL1

Reviews

2 reviews available for celecoxib and Stomach Neoplasms

ArticleYear
COX-2 inhibitors as radiation sensitizers for upper GI tract cancers: esophagus, stomach, and pancreas.
    American journal of clinical oncology, 2003, Volume: 26, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy

2003
Chemopreventive effect of celecoxib in gastric cancer.
    Inflammopharmacology, 2007, Volume: 15, Issue:1

    Topics: Animals; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Gastric

2007

Trials

13 trials available for celecoxib and Stomach Neoplasms

ArticleYear
Comprehensive evaluation of clinical efficacy and safety of celecoxib combined with chemotherapy in management of gastric cancer.
    Medicine, 2017, Volume: 96, Issue:51

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Celecoxib;

2017
A comprehensive evaluation of clinical efficacy and safety of celecoxib in combination with chemotherapy in metastatic or postoperative recurrent gastric cancer patients: A preliminary, three-center, clinical trial study.
    Medicine, 2019, Volume: 98, Issue:27

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Capecitabine; Celecoxib; Chemotherapy, Adjuvant; Dis

2019
Helicobacter pylori, cyclooxygenase-2 and evolution of gastric lesions: results from an intervention trial in China.
    Carcinogenesis, 2015, Volume: 36, Issue:12

    Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Celecoxib; China; Clarithromycin; Cyclooxygenase 2; Cyclo

2015
Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent Gastric Cancer in a Chinese Population.
    Cancer prevention research (Philadelphia, Pa.), 2016, Volume: 9, Issue:6

    Topics: Adult; Anti-Bacterial Agents; Asian People; Celecoxib; Chromatography, High Pressure Liquid; Cycloox

2016
Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention.
    World journal of gastroenterology, 2008, Jul-28, Volume: 14, Issue:28

    Topics: Adult; Cardiovascular Diseases; Celecoxib; China; Cyclooxygenase 2 Inhibitors; Dose-Response Relatio

2008
[Celecoxib induces apoptosis and inhibits angiogenesis in gastric cancer].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2008, Volume: 30, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Apoptosis; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Fe

2008
Anti-Helicobacter pylori therapy followed by celecoxib on progression of gastric precancerous lesions.
    World journal of gastroenterology, 2009, Jun-14, Volume: 15, Issue:22

    Topics: Adult; Aged; Apoptosis; Celecoxib; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors

2009
[Short-term preoperative treatment of celecoxib, a selective cyclooxygenase-2 inhibitor, on E-cadherin expression in gastric carcinoma tissues].
    Ai zheng = Aizheng = Chinese journal of cancer, 2009, Volume: 28, Issue:4

    Topics: Adenocarcinoma; Adult; Cadherins; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female;

2009
[Celecoxib inhibits gastric adenocarcinoma growth via inducing expression of human nonsteroidal anti-inflammatory drug activated gene].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2009, Volume: 40, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Apoptosis; Celecoxib; Cell Proliferation; Cyclooxygenase 2 Inhibitors;

2009
Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions.
    Gut, 2012, Volume: 61, Issue:6

    Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Celecoxib; Clarithromycin; Cyclooxygenase 2 Inhibitors; D

2012
Effect of celecoxib on E-cadherin, VEGF, Microvessel density and apoptosis in gastric cancer.
    Cancer biology & therapy, 2007, Volume: 6, Issue:2

    Topics: Adult; Aged; Apoptosis; Cadherins; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; H

2007
[The inhibitive effects of celecoxib combined with octreotide on the metastasis of human gastric cancer in vivo].
    Zhonghua yi xue za zhi, 2006, Dec-12, Volume: 86, Issue:46

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Female; Humans; Male; Matrix Metal

2006
Preoperative growth inhibition of human gastric adenocarcinoma treated with a combination of celecoxib and octreotide.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Apop

2007

Other Studies

50 other studies available for celecoxib and Stomach Neoplasms

ArticleYear
Celecoxib Reverse Invasion and Metastasis of Gastric Cancer through Lnc_AC006548.28-miR-223-LAMC2 Pathway.
    Computational intelligence and neuroscience, 2022, Volume: 2022

    Topics: Animals; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; Mice; MicroRNAs; Stomach Neoplasm

2022
Cisplatin induces chemoresistance through the PTGS2-mediated anti-apoptosis in gastric cancer.
    The international journal of biochemistry & cell biology, 2019, Volume: 116

    Topics: Animals; Antineoplastic Agents; Celecoxib; Cell Line, Tumor; Cisplatin; Cyclooxygenase 2; Dinoprosto

2019
Celecoxib inhibits Helicobacter pylori-induced invasion of gastric cancer cells through an adenine nucleotide translocator-dependent mechanism.
    Anti-cancer agents in medicinal chemistry, 2013, Volume: 13, Issue:8

    Topics: Anoikis; Celecoxib; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2 Inhibitors;

2013
[Inhibitive effect of celecoxib combined with tegafur gimeracil oteracil potassium on the growth of xenograft tumor of gastric cancer in nude mice].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2013, Volume: 29, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2

2013
Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects.
    British journal of cancer, 2013, Jun-11, Volume: 108, Issue:11

    Topics: Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Synergism; Female; Gene Knoc

2013
Effects of celecoxib on cycle kinetics of gastric cancer cells and protein expression of cytochrome C and caspase-9.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:4

    Topics: Apoptosis; Blotting, Western; Caspase 9; Celecoxib; Cell Cycle; Cell Proliferation; Cyclooxygenase 2

2013
New pharmaceutical treatment of gastric MALT lymphoma: anti-angiogenesis treatment using VEGF receptor antibodies and celecoxib.
    Current pharmaceutical design, 2014, Volume: 20, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Antibodies; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models

2014
Celecoxib regulates apoptosis and autophagy via the PI3K/Akt signaling pathway in SGC-7901 gastric cancer cells.
    International journal of molecular medicine, 2014, Volume: 33, Issue:6

    Topics: Apoptosis; Autophagy; Blotting, Western; Caspase 8; Caspase 9; Celecoxib; Cell Line, Tumor; Cell Pro

2014
Knockdown of S100P by lentiviral-mediated RNAi promotes apoptosis and suppresses the colony-formation ability of gastric cancer cells.
    Oncology reports, 2014, Volume: 31, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Apoptosis; beta Catenin; Calcium-Binding Proteins; Caspase 2; Celeco

2014
Cyclooxygenase-2 inhibition as a strategy for treating gastric adenocarcinoma.
    Oncology reports, 2014, Volume: 32, Issue:3

    Topics: Adenocarcinoma; Animals; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxy

2014
The mechanism of COX-2 regulating HERG channel in gastric cancer cells.
    Bratislavske lekarske listy, 2014, Volume: 115, Issue:8

    Topics: Celecoxib; Cell Culture Techniques; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors;

2014
Synergic effect between 5‑fluorouracil and celecoxib on hypoxic gastric cancer cells.
    Molecular medicine reports, 2015, Volume: 11, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Bindi

2015
Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.
    Journal of cancer research and clinical oncology, 2015, Volume: 141, Issue:7

    Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Cycl

2015
Effect of celecoxib combined with chemotherapy drug on malignant biological behaviors of gastric cancer.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cyclooxy

2014
Celecoxib sensitizes gastric cancer to rapamycin via inhibition of the Cbl-b-regulated PI3K/Akt pathway.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Celecoxib; Cell Line, Tumor; Cyclooxygenas

2015
Celecoxib enhanced the cytotoxic effect of cisplatin in drug-resistant human gastric cancer cells by inhibition of cyclooxygenase-2.
    European journal of pharmacology, 2015, Dec-15, Volume: 769

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Caspase 3; Celecoxi

2015
Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenicals; Azepines; Camptothecin; Celec

2015
Celecoxib enhanced the cytotoxic effect of cisplatin in chemo-resistant gastric cancer xenograft mouse models through a cyclooxygenase-2-dependent manner.
    European journal of pharmacology, 2016, Apr-05, Volume: 776

    Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Celecoxib;

2016
Dimethyl celecoxib sensitizes gastric cancer cells to ABT-737 via AIF nuclear translocation.
    Journal of cellular and molecular medicine, 2016, Volume: 20, Issue:11

    Topics: Apoptosis; Apoptosis Inducing Factor; Biphenyl Compounds; Celecoxib; Cell Line, Tumor; Cell Lineage;

2016
Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.
    Journal of gastroenterology and hepatology, 2009, Volume: 24, Issue:3

    Topics: Antineoplastic Agents; Blotting, Western; Caspase 9; Celecoxib; Cell Death; Cell Line, Tumor; Chromo

2009
Anticancer effect of celecoxib via COX-2 dependent and independent mechanisms in human gastric cancers cells.
    Digestive diseases and sciences, 2009, Volume: 54, Issue:7

    Topics: Blotting, Western; Celecoxib; Cell Proliferation; Chemoprevention; Colony-Forming Units Assay; Cycli

2009
Celecoxib inhibits apurinic/apyrimidinic endonuclease-1 expression and prevents gastric cancer in Helicobacter pylori-infected mongolian gerbils.
    Digestion, 2008, Volume: 78, Issue:2-3

    Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Disease Progression; DNA-(Apurinic or Apyrimidinic Si

2008
Up-regulation of S100P expression by non-steroidal anti-inflammatory drugs and its role in anti-tumorigenic effects.
    The Journal of biological chemistry, 2009, Feb-13, Volume: 284, Issue:7

    Topics: Activating Transcription Factor 4; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Ste

2009
[Effect of a selective COX-2 inhibitor on cell proliferation and apoptosis in human gastric cancer cell line BGC-823].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2008, Volume: 33, Issue:12

    Topics: Apoptosis; Celecoxib; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhi

2008
Effects of non-cytotoxic drugs on the growth of multidrug-resistance human gastric carcinoma cell line.
    Journal of digestive diseases, 2009, Volume: 10, Issue:2

    Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Celecoxib; Cell Line, Tumor; Cel

2009
Short-term celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model.
    World journal of gastroenterology, 2009, Oct-21, Volume: 15, Issue:39

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Celecoxib; Cell Proliferation; Cyclooxygenase 2; C

2009
Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines.
    Cellular oncology : the official journal of the International Society for Cellular Oncology, 2009, Volume: 31, Issue:6

    Topics: Adult; Age of Onset; Blotting, Western; Cadherins; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2; Cy

2009
Celecoxib inhibits CD133-positive cell migration via reduction of CCR2 in Helicobacter pylori-infected Mongolian gerbils.
    Digestion, 2010, Volume: 81, Issue:3

    Topics: AC133 Antigen; Adenocarcinoma; Animals; Antigens, CD; Blotting, Western; Celecoxib; Cell Count; Cell

2010
Low direct cytotoxicity of loxoprofen on gastric mucosal cells.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:3

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis;

2010
[Effects of EGFR inhibitor AG1478 in combination with celecoxib on the growth of gastric cancer cells].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2010, Volume: 41, Issue:4

    Topics: Celecoxib; Cell Line, Tumor; Cell Proliferation; Drug Synergism; ErbB Receptors; Humans; Mitogen-Act

2010
Prostaglandin E₂ signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors.
    Gastroenterology, 2011, Volume: 140, Issue:2

    Topics: Animals; Antibodies, Neutralizing; Benzamides; Celecoxib; Cell Line; Cell Transformation, Neoplastic

2011
Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice.
    International journal of cancer, 2012, Sep-01, Volume: 131, Issue:5

    Topics: Adenoma; Animals; Apoptosis; Blotting, Western; Celecoxib; Cell Proliferation; Cyclooxygenase 2; Cyc

2012
[Survivin gene silencing inhibits the proliferation of human gastric cancer MGC-803 cells and enhances their sensitivity to celecoxib].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011, Volume: 31, Issue:11

    Topics: Celecoxib; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Gene Silencing; Humans;

2011
The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells.
    International journal of cancer, 2013, Apr-15, Volume: 132, Issue:8

    Topics: Base Sequence; Blotting, Western; Celecoxib; Cell Line, Tumor; Chromatin Immunoprecipitation; Cycloo

2013
Cyclooxygenase-2 expression and effect of celecoxib in gastric adenomas of trefoil factor 1-deficient mice.
    Cancer research, 2003, Jun-15, Volume: 63, Issue:12

    Topics: Adenoma; Angiogenesis Inhibitors; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors;

2003
Chemoprevention of gastric cancer by celecoxib in rats.
    Gut, 2004, Volume: 53, Issue:2

    Topics: Analysis of Variance; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen

2004
Anti-cancer effects of COX-2 inhibitors and their correlation with angiogenesis and invasion in gastric cancer.
    World journal of gastroenterology, 2004, Jul-01, Volume: 10, Issue:13

    Topics: Animals; Apoptosis; Celecoxib; Cell Division; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 I

2004
[Inhibitory effects of celecoxib combined with octreotide on growth of multidrug resistant human gastric cancer cell line SGC7901/ADR].
    Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:12

    Topics: Antineoplastic Agents, Hormonal; Apoptosis; Celecoxib; Cell Line, Tumor; Cyclooxygenase Inhibitors;

2004
Different cell kinetic changes in rat stomach cancer after treatment with celecoxib or indomethacin: implications on chemoprevention.
    World journal of gastroenterology, 2005, Jan-07, Volume: 11, Issue:1

    Topics: Adenocarcinoma; Animals; Apoptosis; Celecoxib; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inh

2005
Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells.
    Oncogene, 2006, Feb-16, Volume: 25, Issue:7

    Topics: Activating Transcription Factor 4; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calc

2006
Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice.
    American journal of physiology. Gastrointestinal and liver physiology, 2006, Volume: 290, Issue:3

    Topics: Animals; Apoptosis; Celecoxib; Cyclooxygenase 2; Dinoprostone; Gastric Mucosa; Gastrins; Gene Expres

2006
Celecoxib could reverse the hypoxia-induced Angiopoietin-2 upregulation in gastric cancer.
    Cancer letters, 2006, Oct-08, Volume: 242, Issue:1

    Topics: Angiopoietin-2; Angiopoietins; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Line, Tumor;

2006
[Prophylactic effect of a selective COX-2 inhibitor celecoxib on carcinogen-induced gastric premalignant lesions in rats].
    Ai zheng = Aizheng = Chinese journal of cancer, 2006, Volume: 25, Issue:10

    Topics: Animals; Atrophy; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinopr

2006
Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells.
    Molecular pharmacology, 2007, Volume: 71, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Calcium; Celecoxib; Cell Line, Tumor

2007
Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway.
    Cancer letters, 2007, Jun-28, Volume: 251, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Celecoxib; Cell Line, Tumor; Collagen

2007
Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolian gerbils.
    Digestion, 2006, Volume: 74, Issue:3-4

    Topics: Animals; Biomarkers, Tumor; Biopsy, Needle; CDX2 Transcription Factor; Celecoxib; Disease Models, An

2006
The anti-cancer effect of COX-2 inhibitors on gastric cancer cells.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:7

    Topics: Adenocarcinoma; Apoptosis; Celecoxib; Cell Cycle; Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; Din

2007
[Antitumor effects of specific cyclooxygenase inhibitors combined with chemotherapeutic agents on gastric cancer cells in vitro].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2007, Volume: 29, Issue:3

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents; Celecoxib; Cell Line, Tumor;

2007
Effects of celecoxib on the reversal of multidrug resistance in human gastric carcinoma by downregulation of the expression and activity of P-glycoprotein.
    Anti-cancer drugs, 2007, Volume: 18, Issue:9

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport

2007
Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells.
    Cancer letters, 2008, Apr-18, Volume: 262, Issue:2

    Topics: Celecoxib; Cell Line, Tumor; Genes, myc; Humans; Oncogene Protein v-akt; Pyrazoles; RNA Processing,

2008