Page last updated: 2024-10-24

celecoxib and Injuries, Tendon

celecoxib has been researched along with Injuries, Tendon in 6 studies

Research Excerpts

ExcerptRelevanceReference
" However, clinical data suggest that chronic use of celecoxib, may impair normal skeletal function leading to decreased bone mineral density in older male patients."2.44Celecoxib, NSAIDs and the skeleton. ( Lysz, T; O'Connor, JP, 2008)
"Lactoferrin has a great potential for the tendon regeneration."1.91Screening for autophagy/hypoxia/ferroptosis/pyroptosis-related genes of tendon injury and repair in a rat model after celecoxib and lactoferrin treatment. ( Min, N; Shi, L; Wang, F; Wang, L; Wen, L; Xue, Q; Zhang, Y, 2023)
"Indomethacin (3 mg/kg) was then compared to celecoxib (4."1.32Indomethacin and celecoxib improve tendon healing in rats. ( Aspenberg, P; Bylander, B; Forslund, C, 2003)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Zhang, Y1
Shi, L1
Wang, F1
Wang, L1
Min, N1
Wen, L1
Xue, Q1
Jiang, S1
Yan, H1
Fan, D1
Song, J1
Fan, C1
Lu, Y1
Li, Y1
Li, FL1
Li, X1
Zhuo, HW1
Jiang, CY1
O'Connor, JP1
Lysz, T1
Forslund, C1
Bylander, B1
Aspenberg, P1
Cohen, DB1
Kawamura, S1
Ehteshami, JR1
Rodeo, SA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Ibuprofen on Postoperative Opiate Medication Use and Shoulder[NCT02588027]100 participants (Anticipated)Interventional2015-10-31Active, not recruiting
Rotator Cuff Tendinopathy: A Randomized and Blinded Comparison of Superficial and Deep Injection Methods[NCT01402011]77 participants (Actual)Interventional2010-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Maximum Pain Score at 9 Months

Participants were asked about pain at rest, at work, doing sports. The maximum pain reported on a scale ranging from 0 (no pain at all) to 10 (extreme pain) was recorded for each participant. Maximum of pain scores rest, work, sport recorded. Calculated as pain at baseline - pain at 9 months. (NCT01402011)
Timeframe: baseline and 9 months

Interventionunits on a scale (Mean)
25% Dextrose in Ligaments and Tendons2.9
.1% Lidocaine in Ligaments and Tendons1.8
.1% Lidocaine Subcutaneous1.3

Change From Baseline of Visual Analog Pain Scale at 3 Months

Subject marks his pain level at rest, at work, doing sports on a 10 cm scale. Maximum of pain scores rest, work, sport recorded. Calculated as pain at baseline - pain at 3 months. VAS scale is from 0 = no pain to 10 = maximum pain (NCT01402011)
Timeframe: baseline and three months

Interventionunits on a scale (Mean)
25% Dextrose in Ligaments and Tendons3.0
.1% Lidocaine in Ligaments and Tendons2.7
.1% Lidocaine Subcutaneous2.7

Nine Month Satisfaction Questionnaire

Phone call asking how satisfied were they with their treatment 10 = extremely satisfied, 0 = extremely dissatisfied ) (NCT01402011)
Timeframe: Nine months after first injection treatment appointment

Interventionunits on a scale (Mean)
25% Dextrose in Ligaments and Tendons6.7
.1% Lidocaine in Ligaments and Tendons4.7
.1% Lidocaine Subcutaneous3.9

Visual Analog Pain Scale 0= no Pain 10 = Maximum Pain

Subject marks his pain level at rest, at work, doing sports on a 10 cm scale. The maximum pain level among the 3 different activities was recorded. (NCT01402011)
Timeframe: 20 minutes before first injection on first day of patient visit

Interventionunits on a scale (Mean)
25% Dextrose in Shoulder Entheses7.3
.1% Lidocaine in Shoulder Entheses6.9
.1% Lidocaine Subcu. Above Shouldr Enth.6.9

Disabilities of the Arm Shoulder and Hand Questionnaire

http://www.dash.iwh.on.ca/assets/images/pdfs/DASH_quest06.pdf 30 questions assessing ability to use shoulder in everyday activities, each question scored 1 to 5, where one is normal, no problem and five is unable to perform. No data was collected at 9 months. The score ranges from 30 to 150. Higher scores represent worse outcomes. (NCT01402011)
Timeframe: 20 minutes before the first injection and at 3 months

,,
Interventionunits on a scale (Mean)
Baseline3 months
.1% Lidocaine in Ligaments and Tendons71.354.7
.1% Lidocaine Subcutaneous69.661
25% Dextrose in Ligaments and Tendons72.461.3

Physical Examination of the Shoulder Scale

From Steven W. Brose, DO, Michael L. Boninger, MD, Bradley Fullerton, MD, Thane McCann, MD, From: Jennifer L. Collinger, BSE, Bradley G. Impink, BSE, Trevor A. Dyson-Hudson, MD Shoulder ultrasound abnormalities, physical examination findings, and pain in manual wheelchair users with spinal cord injury. Arch Phys Med Rehabil 2008 Nov; 89:2086-93, appendix 1 12 parameters of shoulder examination: Biceps tendon/bicipital groove tenderness, Supraspinatus tendon/greater tuberosity tenderness Acromioclavicular joint tenderness Resisted external rotation. Resisted internal rotation. Supraspinatus test. Painful Arc Test. Neer impingement sign. Hawkins-Kennedy impingement sign. O'Brien Active Compression Test for AC Joint Pathology O'Brien Active Compression Test for Labral Pathology impingement sign. each test scored 0 = no pain, 1 = tenderness, 2 = pain. All 12 scores added. Range 0-24. Higher scores = more pathology (NCT01402011)
Timeframe: 20 minutes before first injection on first day of patient visit and at 3 months

,,
Interventionunits on a scale (Mean)
Baseline3 months
.1% Lidocaine in Ligaments and Tendons13.110.7
.1% Lidocaine Subcutaneous1312.9
25% Dextrose in Ligaments and Tendons13.211.4

Rotator Cuff Ultrasound, Ultrasound Shoulder Pathology Rating Scale

"From Brose et al. shoulder ultrasound abnormalities, physical examination findings, and pain in manual wheelchair users with spinal cord injury Arch Phys Med Rehabil 2008 Nov, 89: 2086-93 appendix 2. rates biceps tendinopathy (0-6), supraspinatus tendinopathy (0-5), greater tuberosity the cortical surface (0-3), dynamics supraspinatus impingement (0-3), dynamic subscapularis/ biceps/ coracoid impingement (0-3). The total score ranged from 0 to 20 with higher scores indicating a worse outcome. The change was calculated by taking the final score - the baseline score." (NCT01402011)
Timeframe: 20 minutes before first injection on first day of patient visit and at on average 9.4 months

,,
Interventionunits on a scale (Mean)
Baselinechange at 9.4 +/- 2.2 months
.1% Lidocaine in Ligaments and Tendons4.3-0.6
.1% Lidocaine Subcutaneous4.3-0.6
25% Dextrose in Ligaments and Tendons4.0-0.3

Reviews

1 review available for celecoxib and Injuries, Tendon

ArticleYear
Celecoxib, NSAIDs and the skeleton.
    Drugs of today (Barcelona, Spain : 1998), 2008, Volume: 44, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone and Bones; Bone Regeneration; Cele

2008

Trials

1 trial available for celecoxib and Injuries, Tendon

ArticleYear
Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing.
    The American journal of sports medicine, 2006, Volume: 34, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Indomethacin; Male; New York City; Pyra

2006
Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing.
    The American journal of sports medicine, 2006, Volume: 34, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Indomethacin; Male; New York City; Pyra

2006
Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing.
    The American journal of sports medicine, 2006, Volume: 34, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Indomethacin; Male; New York City; Pyra

2006
Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing.
    The American journal of sports medicine, 2006, Volume: 34, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Indomethacin; Male; New York City; Pyra

2006

Other Studies

4 other studies available for celecoxib and Injuries, Tendon

ArticleYear
Screening for autophagy/hypoxia/ferroptosis/pyroptosis-related genes of tendon injury and repair in a rat model after celecoxib and lactoferrin treatment.
    Journal of orthopaedic surgery and research, 2023, May-25, Volume: 18, Issue:1

    Topics: Animals; Celecoxib; Ferroptosis; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; L

2023
Multi-layer electrospun membrane mimicking tendon sheath for prevention of tendon adhesions.
    International journal of molecular sciences, 2015, Mar-26, Volume: 16, Issue:4

    Topics: Animals; Biomechanical Phenomena; Biomimetic Materials; Celecoxib; Collagen; Hyaluronic Acid; Membra

2015
Do Different Cyclooxygenase Inhibitors Impair Rotator Cuff Healing in a Rabbit Model?
    Chinese medical journal, 2015, Sep-05, Volume: 128, Issue:17

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena; Celecoxib; Cyclooxygenase

2015
Indomethacin and celecoxib improve tendon healing in rats.
    Acta orthopaedica Scandinavica, 2003, Volume: 74, Issue:4

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Sectional S

2003