Page last updated: 2024-10-24

celecoxib and Hemorrhage, Peptic Ulcer

celecoxib has been researched along with Hemorrhage, Peptic Ulcer in 14 studies

Research Excerpts

ExcerptRelevanceReference
"For this industry-independent, double-blind, double-dummy, randomised trial done in one academic hospital in Hong Kong, we screened patients with arthritis and cardiothrombotic diseases who were presenting with upper gastrointestinal bleeding, were on NSAIDs, and require concomitant aspirin."9.24Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. ( Au, KWL; Chan, FKL; Chan, H; Cheong, PK; Ching, JYL; Kee, KM; Kyaw, MH; Lam, K; Lee, V; Lo, A; Ng, SC; Suen, BY; Tse, YK; Wong, GLH; Wong, VWS; Wu, JCY, 2017)
"For this industry-independent, double-blind, double-dummy, randomised trial done in one academic hospital in Hong Kong, we screened patients with arthritis and cardiothrombotic diseases who were presenting with upper gastrointestinal bleeding, were on NSAIDs, and require concomitant aspirin."5.24Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. ( Au, KWL; Chan, FKL; Chan, H; Cheong, PK; Ching, JYL; Kee, KM; Kyaw, MH; Lam, K; Lee, V; Lo, A; Ng, SC; Suen, BY; Tse, YK; Wong, GLH; Wong, VWS; Wu, JCY, 2017)
"Patients aged 60 years and over with osteoarthritis or rheumatoid arthritis, free from established CV disease and taking chronic prescribed nsNSAIDs, were randomized to switch to celecoxib or to continue their previous nsNSAID."5.24Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the Standard care vs. Celecoxib Outcome Trial (SCOT). ( Connolly, E; Findlay, E; Ford, I; Greenlaw, N; Grobbee, DE; Hallas, J; Hawkey, CJ; Hobbs, FDR; MacDonald, TM; Mackenzie, IS; McMurray, JJV; Perez-Gutthann, S; Ralston, SH; Reid, DM; Ritchie, LD; Ruschitzka, F; Scheiman, JM; Walters, MR; Webster, J; Wei, L; Wilson, A, 2017)
"Celecoxib was as effective as lansoprazole co-therapy in the prevention of recurrences of ulcer complications in subjects with a history of NSAID-related complicated peptic ulcers."5.11Celecoxib compared with lansoprazole and naproxen to prevent gastrointestinal ulcer complications. ( Chan, AO; Chu, KM; Hu, WH; Hui, WM; Lai, KC; Lam, SK; Wong, BC; Wong, J; Wong, WM, 2005)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (71.43)29.6817
2010's4 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chan, FKL1
Ching, JYL1
Tse, YK1
Lam, K1
Wong, GLH1
Ng, SC1
Lee, V1
Au, KWL1
Cheong, PK1
Suen, BY4
Chan, H1
Kee, KM1
Lo, A1
Wong, VWS1
Wu, JCY1
Kyaw, MH1
MacDonald, TM1
Hawkey, CJ1
Ford, I1
McMurray, JJV1
Scheiman, JM1
Hallas, J1
Findlay, E1
Grobbee, DE1
Hobbs, FDR1
Ralston, SH1
Reid, DM1
Walters, MR1
Webster, J1
Ruschitzka, F1
Ritchie, LD1
Perez-Gutthann, S1
Connolly, E1
Greenlaw, N1
Wilson, A1
Wei, L1
Mackenzie, IS1
Patterson, MK1
Castellsague, J1
Walker, AM1
Rahme, E1
Bernatsky, S1
Chan, FK3
Hung, LC2
Wu, JC2
Lee, KC1
Leung, VK2
Hui, AJ2
To, KF2
Leung, WK2
Wong, VW2
Chung, SC1
Sung, JJ2
Graham, DY1
Zeidler, H1
Lanas, A1
Nurmohamed, MT1
Lems, WF1
Lee, KK1
You, JH1
Ho, JT1
Yung, MY1
Lau, WH1
Lee, VW2
Sung, JY1
Lai, KC1
Chu, KM1
Hui, WM1
Wong, BC1
Hu, WH1
Wong, WM1
Chan, AO1
Wong, J1
Lam, SK1
Ching, JY1
Lai, LH1
Wong, GL1
Chow, DK1
Chiu, PW1
Lee, YT1
Lau, JY1
Chan, HL1
Ng, EK1
Pilotto, A1
Seripa, D1
Franceschi, M1
Scarcelli, C1
Colaizzo, D1
Grandone, E1
Niro, V1
Andriulli, A1
Leandro, G1
Di Mario, F1
Dallapiccola, B1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-blind Randomized Comparison of Celecoxib Plus Esomeprazole Versus Naproxen Plus Esomeprazole for Prevention of Recurrent Ulcer Bleeding in Patients With Arthritis and Cardiothrombotic Diseases (NSAID#8 Study)[NCT00153660]Phase 3514 participants (Actual)Interventional2005-06-30Completed
Phase 4 Study A Large Streamline Safety Study Designed to Compare the Cardiovascular Safety od Celecoxib Versus Traditional Non-selective NSAID's[NCT00447759]Phase 47,297 participants (Actual)Interventional2007-06-30Completed
A Phase 3 Double Blinded, Randomized, Placebo Controlled Trial of Proton Pump Inhibitor for the Prevention of Recurrent Ulcer Bleeding in Patients Receiving a COX-2 Inhibitor[NCT00365313]Phase 3273 participants Interventional2002-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

6 trials available for celecoxib and Hemorrhage, Peptic Ulcer

ArticleYear
Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial.
    Lancet (London, England), 2017, Jun-17, Volume: 389, Issue:10087

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Cardiovascular

2017
Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the Standard care vs. Celecoxib Outcome Trial (SCOT).
    European heart journal, 2017, Jun-14, Volume: 38, Issue:23

    Topics: Acute Coronary Syndrome; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celec

2017
Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis.
    The New England journal of medicine, 2002, Dec-26, Volume: 347, Issue:26

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Celecoxib; Cyclooxygenase 2;

2002
Economic analysis of celecoxib versus diclofenac plus omeprazole for the treatment of arthritis in patients at risk of ulcer disease.
    Alimentary pharmacology & therapeutics, 2003, Jul-15, Volume: 18, Issue:2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Celecoxib;

2003
Celecoxib compared with lansoprazole and naproxen to prevent gastrointestinal ulcer complications.
    The American journal of medicine, 2005, Volume: 118, Issue:11

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-

2005
Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial.
    Lancet (London, England), 2007, May-12, Volume: 369, Issue:9573

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Celecoxib; Cyclooxygenase Inhibito

2007

Other Studies

8 other studies available for celecoxib and Hemorrhage, Peptic Ulcer

ArticleYear
Hospitalization for peptic ulcer and bleeding in users of selective COX-2 inhibitors and nonselective NSAIDs with special reference to celecoxib.
    Pharmacoepidemiology and drug safety, 2008, Volume: 17, Issue:10

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Celecoxib; C

2008
NSAIDs and risk of lower gastrointestinal bleeding.
    Lancet (London, England), 2010, Jul-17, Volume: 376, Issue:9736

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Celecoxib; Coloni

2010
[Inflammation-induced pain. How rheumatism patients profit from the proper NSAID choice].
    MMW Fortschritte der Medizin, 2012, May-03, Volume: 154, Issue:8

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Drug-Related Side E

2012
NSAIDs, Helicobacter pylori, and Pandora's Box.
    The New England journal of medicine, 2002, Dec-26, Volume: 347, Issue:26

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Celecoxib; Cyclooxygenase 2;

2002
[When the cardiac patient with arthritis needs aspirin and NSAID: how to protect the stomach?].
    MMW Fortschritte der Medizin, 2003, Jan-30, Volume: 145, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Celecoxi

2003
Celecoxib versus diclofenac and omeprazole to prevent recurrent ulcer bleeding.
    The New England journal of medicine, 2003, Jun-12, Volume: 348, Issue:24

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Celecoxib; Cyclooxygenase 2; Cyclooxygen

2003
Celecoxib versus diclofenac and omeprazole to prevent recurrent ulcer bleeding.
    The New England journal of medicine, 2003, Jun-12, Volume: 348, Issue:24

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Celecoxib; Contraindications; Cyclooxyge

2003
Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms.
    Gastroenterology, 2007, Volume: 133, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cas

2007