Page last updated: 2024-10-24

celecoxib and Glioma

celecoxib has been researched along with Glioma in 25 studies

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"In the current study, the authors report a Phase II trial of irinotecan (CPT-11), a topoisomerase I inhibitor active against malignant glioma (MG), with celecoxib, a selective COX-2 inhibitor, among MG patients with recurrent disease."9.11Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma. ( Badruddoja, M; Dowell, JM; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Quinn, JA; Reardon, DA; Rich, JN; Vredenburgh, J, 2005)
"A total of nine patients with malignant glioma, postoperatively presenting with a Karnofsky performance score (KPS) below 70, were treated with standalone metronomic low-dose chemotherapy with temozolomide and celecoxib (cyclo-oxygenase-2 inhibitor)."7.81Dual Anti-angiogenic Chemotherapy with Temozolomide and Celecoxib in Selected Patients with Malignant Glioma Not Eligible for Standard Treatment. ( Brawanski, KR; Freyschlag, CF; Grams, AE; Kerschbaumer, J; Nowosielski, M; Petr, O; Pinggera, D; Schmidt, FA; Seiz, M; Thomé, C; Tuettenberg, J, 2015)
"The purpose of this study was to determine whether a combination treatment of temozolomide with celecoxib is effective in the rat orthotopic glioma model."7.73Combination celecoxib and temozolomide in C6 rat glioma orthotopic model. ( Groves, MD; Kang, SG; Kim, JS; Nam, DH; Park, K, 2006)
" To determine whether oral administration of a COX-2-specific inhibitor can inhibit glial tumors, we analyzed the effect of celecoxib on the growth of 9L rat gliosarcoma cells that were orthotopically transplanted into rat brains."7.72Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib. ( Eoh, W; Hong, SC; Im, YH; Kim, JH; Kim, MH; Lee, S; McDonnell, TJ; Nam, DH; Park, C; Park, K; Shin, HJ, 2004)
"Celecoxib has been utilized with success in the treatment of several types of cancer, including gliomas."5.42Celecoxib and LLW-3-6 Reduce Survival of Human Glioma Cells Independently and Synergistically with Sulfasalazine. ( Winfield, LL; Yerokun, T, 2015)
"Gliomas are highly vascularized tumors, suggesting that the prevention of vessel formation by anti-angiogenic treatment might be effective."5.40Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma. ( Arola, M; Clausen, N; Harila-Saari, A; Holm, S; Kivivuori, SM; Lähteenmäki, P; Lannering, B; Lönnqvist, T; Porkholm, M; Riikonen, P; Saarinen-Pihkala, UM; Schomerus, E; Sehested, A; Thomassen, H; Thorarinsdottir, HK; Valanne, L; Wojcik, D, 2014)
"Malignant gliomas are heavily infiltrated by immature myeloid cells that mediate immunosuppression."5.40Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells. ( Kosaka, A; Ohkuri, T; Okada, H, 2014)
"Malignant gliomas have low survival expectations regardless of current treatments."5.39Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib. ( Grimaldi, M; Hobrath, JV; Johnson, GG; Piazza, GA; White, MC; Zhang, W, 2013)
"In the current study, the authors report a Phase II trial of irinotecan (CPT-11), a topoisomerase I inhibitor active against malignant glioma (MG), with celecoxib, a selective COX-2 inhibitor, among MG patients with recurrent disease."5.11Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma. ( Badruddoja, M; Dowell, JM; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Quinn, JA; Reardon, DA; Rich, JN; Vredenburgh, J, 2005)
"A total of nine patients with malignant glioma, postoperatively presenting with a Karnofsky performance score (KPS) below 70, were treated with standalone metronomic low-dose chemotherapy with temozolomide and celecoxib (cyclo-oxygenase-2 inhibitor)."3.81Dual Anti-angiogenic Chemotherapy with Temozolomide and Celecoxib in Selected Patients with Malignant Glioma Not Eligible for Standard Treatment. ( Brawanski, KR; Freyschlag, CF; Grams, AE; Kerschbaumer, J; Nowosielski, M; Petr, O; Pinggera, D; Schmidt, FA; Seiz, M; Thomé, C; Tuettenberg, J, 2015)
"The selective COX-2 inhibitors NS-398, Celecoxib and Meloxicam and three human glioma cell lines (D384, U251 and U87) were used."3.74Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition: independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration. ( Berg, Jv; Kuipers, GK; Lafleur, MV; Slotman, BJ; Sminia, P; Stoter, TR; Wedekind, LE, 2007)
"The purpose of this study was to determine whether a combination treatment of temozolomide with celecoxib is effective in the rat orthotopic glioma model."3.73Combination celecoxib and temozolomide in C6 rat glioma orthotopic model. ( Groves, MD; Kang, SG; Kim, JS; Nam, DH; Park, K, 2006)
" To determine whether oral administration of a COX-2-specific inhibitor can inhibit glial tumors, we analyzed the effect of celecoxib on the growth of 9L rat gliosarcoma cells that were orthotopically transplanted into rat brains."3.72Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib. ( Eoh, W; Hong, SC; Im, YH; Kim, JH; Kim, MH; Lee, S; McDonnell, TJ; Nam, DH; Park, C; Park, K; Shin, HJ, 2004)
"Celecoxib has been utilized with success in the treatment of several types of cancer, including gliomas."1.42Celecoxib and LLW-3-6 Reduce Survival of Human Glioma Cells Independently and Synergistically with Sulfasalazine. ( Winfield, LL; Yerokun, T, 2015)
"Gliomas are highly vascularized tumors, suggesting that the prevention of vessel formation by anti-angiogenic treatment might be effective."1.40Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma. ( Arola, M; Clausen, N; Harila-Saari, A; Holm, S; Kivivuori, SM; Lähteenmäki, P; Lannering, B; Lönnqvist, T; Porkholm, M; Riikonen, P; Saarinen-Pihkala, UM; Schomerus, E; Sehested, A; Thomassen, H; Thorarinsdottir, HK; Valanne, L; Wojcik, D, 2014)
"Malignant gliomas are heavily infiltrated by immature myeloid cells that mediate immunosuppression."1.40Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells. ( Kosaka, A; Ohkuri, T; Okada, H, 2014)
"Malignant gliomas have low survival expectations regardless of current treatments."1.39Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib. ( Grimaldi, M; Hobrath, JV; Johnson, GG; Piazza, GA; White, MC; Zhang, W, 2013)
"Celecoxib was incorporated into poly DL-lactide-co-glycolide (PLGA) nanoparticles for antitumor drug delivery."1.37Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells. ( Jeong, YI; Jin, SG; Jung, S; Jung, TY; Kang, SS; Kim, IY; Kim, TH; Moon, KS; Pei, J, 2011)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (24.00)29.6817
2010's17 (68.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Tang, B1
Guo, ZS1
Bartlett, DL1
Yan, DZ1
Schane, CP1
Thomas, DL1
Liu, J1
McFadden, G1
Shisler, JL1
Roy, EJ1
Uram, Ł1
Markowicz, J1
Misiorek, M1
Filipowicz-Rachwał, A1
Wołowiec, S1
Wałajtys-Rode, E1
Zhang, H1
Tian, M1
Xiu, C1
Wang, Y1
Tang, G1
Xu, K2
Wang, L1
Shu, HK2
Porkholm, M1
Valanne, L2
Lönnqvist, T2
Holm, S1
Lannering, B1
Riikonen, P2
Wojcik, D1
Sehested, A1
Clausen, N1
Harila-Saari, A1
Schomerus, E1
Thorarinsdottir, HK1
Lähteenmäki, P1
Arola, M1
Thomassen, H1
Saarinen-Pihkala, UM2
Kivivuori, SM2
Kosaka, A1
Ohkuri, T1
Okada, H2
Kerschbaumer, J1
Schmidt, FA1
Grams, AE1
Nowosielski, M1
Pinggera, D1
Brawanski, KR1
Petr, O1
Thomé, C1
Tuettenberg, J1
Seiz, M1
Freyschlag, CF1
Wickström, M1
Dyberg, C1
Milosevic, J1
Einvik, C1
Calero, R1
Sveinbjörnsson, B1
Sandén, E1
Darabi, A1
Siesjö, P1
Kool, M1
Kogner, P1
Baryawno, N1
Johnsen, JI1
Yerokun, T1
Winfield, LL1
Ju, RJ1
Zeng, F1
Liu, L1
Mu, LM1
Xie, HJ1
Zhao, Y1
Yan, Y1
Wu, JS1
Hu, YJ1
Lu, WL1
Sato, A1
Mizobuchi, Y1
Nakajima, K1
Shono, K1
Fujihara, T1
Kageji, T1
Kitazato, K1
Matsuzaki, K1
Mure, H1
Kuwayama, K1
Sumi, A1
Saya, H1
Sampetrean, O1
Nagahirao, S1
Kim, CK1
Joe, YA1
Lee, SK1
Kim, EK1
O, E1
Kim, HK1
Oh, BJ1
Hong, SH1
Hong, YK1
Zhou, R1
Zhang, LZ1
Wang, RZ1
Nakano, I1
Chiocca, EA1
Gao, H1
Fujita, M1
Kohanbash, G1
Fellows-Mayle, W1
Hamilton, RL1
Komohara, Y1
Decker, SA1
Ohlfest, JR1
Kim, TH1
Jeong, YI1
Jin, SG1
Pei, J1
Jung, TY1
Moon, KS1
Kim, IY1
Kang, SS1
Jung, S1
White, MC1
Johnson, GG1
Zhang, W1
Hobrath, JV1
Piazza, GA1
Grimaldi, M1
Nam, DH2
Park, K2
Park, C1
Im, YH1
Kim, MH1
Lee, S1
Hong, SC1
Shin, HJ1
Kim, JH1
Eoh, W1
McDonnell, TJ1
Reardon, DA1
Quinn, JA1
Vredenburgh, J1
Rich, JN1
Gururangan, S1
Badruddoja, M1
Herndon, JE1
Dowell, JM1
Friedman, AH1
Friedman, HS1
Eichele, K1
Weinzierl, U1
Ramer, R1
Brune, K1
Hinz, B1
Kang, SG1
Kim, JS2
Groves, MD1
Kesari, S1
Schiff, D1
Doherty, L1
Gigas, DC1
Batchelor, TT1
Muzikansky, A1
O'Neill, A1
Drappatz, J1
Chen-Plotkin, AS1
Ramakrishna, N1
Weiss, SE1
Levy, B1
Bradshaw, J1
Kracher, J1
Laforme, A1
Black, PM1
Folkman, J1
Kieran, M1
Wen, PY1
Kuipers, GK1
Slotman, BJ1
Wedekind, LE1
Stoter, TR1
Berg, Jv1
Sminia, P1
Lafleur, MV1

Trials

2 trials available for celecoxib and Glioma

ArticleYear
Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma.
    Cancer, 2005, Jan-15, Volume: 103, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Brain Neoplasm

2005
Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults.
    Neuro-oncology, 2007, Volume: 9, Issue:3

    Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasm

2007

Other Studies

23 other studies available for celecoxib and Glioma

ArticleYear
Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 05-01, Volume: 26, Issue:9

    Topics: Animals; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Combined Modality Therapy; Cyclooxygenase 2 I

2020
Celecoxib substituted biotinylated poly(amidoamine) G3 dendrimer as potential treatment for temozolomide resistant glioma therapy and anti-nematode agent.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Sep-01, Volume: 152

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Dendrime

2020
Enhancement of antitumor activity by combination of tumor lysate-pulsed dendritic cells and celecoxib in a rat glioma model.
    Oncology research, 2013, Volume: 20, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cancer Vaccines; Celecoxib; Cell Line, T

2013
COX-2 overexpression increases malignant potential of human glioma cells through Id1.
    Oncotarget, 2014, Mar-15, Volume: 5, Issue:5

    Topics: Animals; Celecoxib; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclooxygenase 2; Cyclooxygen

2014
Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:9

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Stem Neoplasms; Case-Control Studi

2014
Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells.
    Cancer immunology, immunotherapy : CII, 2014, Volume: 63, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; CD40 Antigens; Cele

2014
Dual Anti-angiogenic Chemotherapy with Temozolomide and Celecoxib in Selected Patients with Malignant Glioma Not Eligible for Standard Treatment.
    Anticancer research, 2015, Volume: 35, Issue:9

    Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Che

2015
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance.
    Nature communications, 2015, Nov-25, Volume: 6

    Topics: Animals; Antineoplastic Agents; Benzeneacetamides; beta Catenin; Brain Neoplasms; Camptothecin; Cele

2015
Celecoxib and LLW-3-6 Reduce Survival of Human Glioma Cells Independently and Synergistically with Sulfasalazine.
    Anticancer research, 2015, Volume: 35, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Brain Neoplasms; Celecoxib; Cell Lin

2015
Destruction of vasculogenic mimicry channels by targeting epirubicin plus celecoxib liposomes in treatment of brain glioma.
    International journal of nanomedicine, 2016, Volume: 11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blood-Brain Barrier; Brain Neopl

2016
Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma.
    Journal of neuro-oncology, 2017, Volume: 132, Issue:2

    Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cycloox

2017
Enhancement of anti-tumor activity by low-dose combination of the recombinant urokinase kringle domain and celecoxib in a glioma model.
    Cancer letters, 2010, Feb-28, Volume: 288, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain N

2010
Effect of celecoxib on proliferation, apoptosis, and survivin expression in human glioma cell line U251.
    Chinese journal of cancer, 2010, Volume: 29, Issue:3

    Topics: Apoptosis; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase Inhibito

2010
Antiangiogenic combination therapy after local radiotherapy with topotecan radiosensitizer improved quality of life for children with inoperable brainstem gliomas.
    Acta paediatrica (Oslo, Norway : 1992), 2011, Volume: 100, Issue:1

    Topics: Adolescent; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Brain Stem Neop

2011
Finding drugs against CD133+ glioma subpopulations.
    Journal of neurosurgery, 2011, Volume: 114, Issue:3

    Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents; Brain Neoplasms; Celecoxib; Combined Modality Th

2011
Celecoxib can induce vascular endothelial growth factor expression and tumor angiogenesis.
    Molecular cancer therapeutics, 2011, Volume: 10, Issue:1

    Topics: Animals; Celecoxib; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cyclooxygenase 2 Inhibitors; Endo

2011
COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells.
    Cancer research, 2011, Apr-01, Volume: 71, Issue:7

    Topics: Alleles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; CD8-Positive T-Lymphocytes; Cele

2011
Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells.
    International journal of nanomedicine, 2011, Volume: 6

    Topics: Acetone; Animals; Antineoplastic Agents; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Cell Movement

2011
Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib.
    Journal of neuroscience research, 2013, Volume: 91, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Line, Tumor; Endoplasmic Reticulum Chaperon

2013
Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib.
    Oncology reports, 2004, Volume: 11, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Brain; Brain Neoplasms; Celecoxib; Cell Division; Cycloox

2004
R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cells.
    Pharmaceutical research, 2006, Volume: 23, Issue:1

    Topics: Animals; Apoptosis; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Caspase 3; Caspase 9; Cas

2006
Combination celecoxib and temozolomide in C6 rat glioma orthotopic model.
    Oncology reports, 2006, Volume: 15, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Celecoxib; Cyclooxygenase

2006
Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition: independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration.
    International journal of radiation biology, 2007, Volume: 83, Issue:10

    Topics: Celecoxib; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose

2007