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celecoxib and Experimental Mammary Neoplasms

celecoxib has been researched along with Experimental Mammary Neoplasms in 34 studies

Research Excerpts

ExcerptRelevanceReference
"The therapeutic benefits of combined MCT with cyclophosphamide plus celecoxib on mammary adenocarcinomas together with its very low toxicity profile warrant further study in an attempt to make the translation into the clinic."7.77Antitumoral and antimetastatic effects of metronomic chemotherapy with cyclophosphamide combined with celecoxib on murine mammary adenocarcinomas. ( Bonfil, RD; Mainetti, LE; Rossa, A; Rozados, VR; Scharovsky, OG, 2011)
"This study showed that in NMU-induced mammary cancer in rats, the combination of resveratrol and celecoxib led to a significant reduction in all tumor parameters."5.40Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats. ( Bojková, B; Ekmekcioglu, C; Fedoročko, P; Jäger, W; Jendželovský, R; Kajo, K; Kassayová, M; Kisková, T; Kokošová, N; Kubatka, P; Maier-Salamon, A; Mikeš, J; Orendáš, P; Papčová, Z; Rentsen, E; Svoboda, M; Thalhammer, T, 2014)
"Celecoxib was administered i."5.31Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts. ( Blumenthal, RD; Burton, J; Flefleh, C; Goldenberg, DM; Lew, W; Waskewich, C, 2001)
"The therapeutic benefits of combined MCT with cyclophosphamide plus celecoxib on mammary adenocarcinomas together with its very low toxicity profile warrant further study in an attempt to make the translation into the clinic."3.77Antitumoral and antimetastatic effects of metronomic chemotherapy with cyclophosphamide combined with celecoxib on murine mammary adenocarcinomas. ( Bonfil, RD; Mainetti, LE; Rossa, A; Rozados, VR; Scharovsky, OG, 2011)
"Chronic inflammation has been directly linked to cancer progression."1.43Celecoxib and fish oil: a combination strategy for decreased inflammatory mediators in early stages of experimental mammary cancer. ( Agnihotri, N; Bhatnagar, A; Negi, AK, 2016)
"Celecoxib (100 µM) was found to induce downregulation of COX-2 protein expression."1.40Usefulness of selective COX-2 inhibitors as therapeutic agents against canine mammary tumors. ( Asano, R; Saito, T; Tamura, D, 2014)
" As long-term use of COX-2 inhibitors (COX-2i) can promote thrombo-embolic events, we tested an alternative target, prostaglandin E2 receptor EP4 subtype (EP4), downstream of COX-2."1.40Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions. ( Girish, GV; Lala, PK; Liu, L; Majumder, M; Xin, X, 2014)
"This study showed that in NMU-induced mammary cancer in rats, the combination of resveratrol and celecoxib led to a significant reduction in all tumor parameters."1.40Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats. ( Bojková, B; Ekmekcioglu, C; Fedoročko, P; Jäger, W; Jendželovský, R; Kajo, K; Kassayová, M; Kisková, T; Kokošová, N; Kubatka, P; Maier-Salamon, A; Mikeš, J; Orendáš, P; Papčová, Z; Rentsen, E; Svoboda, M; Thalhammer, T, 2014)
"Celecoxib and anti-Gr1 treatment may be useful for blockade of these processes, thereby preventing brain metastasis in patients with breast cancer."1.39Premetastatic soil and prevention of breast cancer brain metastasis. ( Fellows-Mayle, W; Ikeura, M; Kohanbash, G; Kosaka, A; Liu, Y; Okada, H; Snyder, LA, 2013)
" Therefore, the present study was designed to investigate the effect of combined dosage of celecoxib and n-3 PUFA-rich fish oil in experimental mammary carcinogenesis."1.39Alteration in apoptosis and cell cycle by celecoxib and/or fish oil in 7,12-dimethyl benzene (α) anthracene-induced mammary carcinogenesis. ( Agnihotri, N; Bhatnagar, A; Kansal, S; Negi, AK, 2013)
"Pretreatment with celecoxib and fish oil in DMBA-treated animals led to normal histology, increase in DNA fragmentation, and decrease in TSA and LASA levels with reduced oxidative stress, and the effect was more pronounced than animals pretreated with either celecoxib/fish oil alone suggesting a synergistic effect of the two regimens."1.37Evaluation of the role of oxidative stress in chemopreventive action of fish oil and celecoxib in the initiation phase of 7,12-dimethyl benz(α)anthracene-induced mammary carcinogenesis. ( Aggarwal, R; Agnihotri, N; Kansal, S; Kaur, R; Negi, AK; Sarotra, P; Sharma, G, 2011)
"The sites of secondary metastasis and the associated inflammatory microenvironment were evaluated."1.37Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer. ( Ghosh, S; Gruber, HE; Mukherjee, P; Pathangey, LB; Roy, LD; Tinder, TL, 2011)
"Celecoxib was administered daily at a concentration of 1."1.35Celecoxib and melatonin in prevention of female rat mammary carcinogenesis. ( Ahlers, I; Ahlersova, E; Bojkova, B; Kajo, K; Kassayova, M; Kubatka, P; Orendas, P; Pec, M, 2009)
"Lung and bone metastasis and the associated inflammatory milieu were evaluated in the arthritic versus the non-arthritic mice."1.35Breast-cancer-associated metastasis is significantly increased in a model of autoimmune arthritis. ( Das Roy, L; Gruber, HE; Mukherjee, P; Pathangey, LB; Schettini, JL; Tinder, TL, 2009)
" This study was to evaluate the chemopreventive effect of tamoxifen combined with celecoxib, a COX-2 selective inhibitor, on 7,12-dimethylbenz anthracene (DMBA)-induced breast cancer in rats."1.33[Chemopreventive effect of tamoxifen combined with celecoxib on DMBA-induced breast cancer in rats]. ( Dai, ZJ; Kang, HF; Liu, XX; Wang, XJ; Xue, FJ; Xue, XH, 2006)
"Celecoxib-treated mice also developed fewer tumors (1."1.32The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice. ( Daskalakis, C; Flynn, J; Gallatig, K; Lanza-Jacoby, S; Masferrer, JL; Miller, S; Russo, IH; Sembhi, H; Zweifel, BS, 2003)
"Celecoxib alone was most effective with a reduction in 98% of the metastases, yet distinctions were observed in the results with respect to the local recurrences, blood levels for the inhibitors and tissue production of prostaglandin E2."1.32Control of pulmonary metastases of rat mammary cancer by inhibition of uPA and COX-2, singly and in combination. ( Evans, DM; Sloan Stakleff, KD, 2004)
"Treatment with celecoxib (500 ppm) significantly reduced the incidence of mammary tumors in MMTV/neu mice (P = 0."1.31Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer. ( Brown, AM; Dannenberg, AJ; Deora, A; Du, B; Howe, LR; Hudis, C; Masferrer, JL; Muller, WJ; Patel, J; Subbaramaiah, K; Thaler, HT, 2002)
"celecoxib-treated group, and 1500 p."1.31Chemopreventive effect of celecoxib and expression of cyclooxygenase-1 and cyclooxygenase-2 on chemically-induced rat mammary tumours. ( Jang, TJ; Jung, HG; Jung, KH; O, MK, 2002)
"Celecoxib was administered i."1.31Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts. ( Blumenthal, RD; Burton, J; Flefleh, C; Goldenberg, DM; Lew, W; Waskewich, C, 2001)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's22 (64.71)29.6817
2010's12 (35.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, Y2
Kosaka, A1
Ikeura, M1
Kohanbash, G1
Fellows-Mayle, W1
Snyder, LA1
Okada, H1
Negi, AK4
Kansal, S2
Bhatnagar, A3
Agnihotri, N4
Saito, T1
Tamura, D1
Asano, R1
Majumder, M1
Xin, X1
Liu, L2
Girish, GV1
Lala, PK1
Kisková, T1
Jendželovský, R1
Rentsen, E1
Maier-Salamon, A1
Kokošová, N1
Papčová, Z1
Mikeš, J1
Orendáš, P2
Bojková, B2
Kubatka, P2
Svoboda, M1
Kajo, K2
Fedoročko, P1
Jäger, W1
Ekmekcioglu, C1
Kassayová, M2
Thalhammer, T1
Booth, L1
Roberts, JL1
Cruickshanks, N1
Tavallai, S1
Webb, T1
Samuel, P1
Conley, A1
Binion, B1
Young, HF1
Poklepovic, A1
Spiegel, S1
Dent, P1
Brown, PH3
Subbaramaiah, K2
Salmon, AP1
Baker, R1
Newman, RA1
Yang, P1
Zhou, XK1
Bissonnette, RP2
Dannenberg, AJ2
Howe, LR2
Medina, D2
Kittrell, F1
Hill, J2
Zhang, Y1
Hilsenbeck, SG1
Bissonette, R1
Abba, MC1
Hu, Y1
Levy, CC1
Gaddis, S1
Kittrell, FS1
Aldaz, CM1
Woditschka, S1
Haag, JD1
Sullivan, R1
Gould, MN1
Ahlers, I1
Pec, M1
Ahlersova, E1
Das Roy, L1
Pathangey, LB2
Tinder, TL2
Schettini, JL1
Gruber, HE2
Mukherjee, P2
Mainetti, LE1
Rozados, VR1
Rossa, A1
Bonfil, RD1
Scharovsky, OG1
Kaur, R1
Sarotra, P1
Sharma, G1
Aggarwal, R1
Roy, LD1
Ghosh, S1
Zhang, B1
Ma, X2
Li, Z1
Gao, X1
Wang, F1
Shen, G1
Sang, Y1
Li, M1
Li, Y1
Zhao, J1
Wei, Y1
Patel, J1
Masferrer, JL2
Deora, A1
Hudis, C1
Thaler, HT1
Muller, WJ1
Du, B1
Brown, AM1
Jang, TJ1
Jung, HG1
Jung, KH1
O, MK1
Lanza-Jacoby, S1
Miller, S1
Flynn, J1
Gallatig, K1
Daskalakis, C1
Zweifel, BS1
Sembhi, H1
Russo, IH1
Badawi, AF2
Eldeen, MB1
Ross, EA1
Badr, MZ1
Awara, WM1
El-Sisi, AE1
El-Sayad, ME1
Goda, AE1
Evans, DM1
Sloan Stakleff, KD1
Kundu, N1
Walser, TC1
Fulton, AM1
Narko, K1
Zweifel, B1
Trifan, O1
Ristimäki, A1
Lane, TF1
Hla, T1
Ferrario, A1
Fisher, AM1
Rucker, N1
Gomer, CJ1
Fenton, BM2
Paoni, SF2
Grimwood, B1
Ding, I2
Kang, HF2
Wang, XJ2
Liu, XX2
Dai, ZJ2
Xue, FJ2
Xue, XH2
Beauchamp, BK1
Okunieff, P1
Blumenthal, RD1
Waskewich, C1
Goldenberg, DM1
Lew, W1
Flefleh, C1
Burton, J1
Medhurst, SJ1
Walker, K1
Bowes, M1
Kidd, BL1
Glatt, M1
Muller, M1
Hattenberger, M1
Vaxelaire, J1
O'Reilly, T1
Wotherspoon, G1
Winter, J1
Green, J1
Urban, L1
Lu, S1
Zhang, X1
El-Sohemy, A1
Archer, MC1

Other Studies

34 other studies available for celecoxib and Experimental Mammary Neoplasms

ArticleYear
Premetastatic soil and prevention of breast cancer brain metastasis.
    Neuro-oncology, 2013, Volume: 15, Issue:7

    Topics: Adenocarcinoma; Animals; Apoptosis; Blotting, Western; Brain Neoplasms; Calgranulin B; CD11b Antigen

2013
Alteration in apoptosis and cell cycle by celecoxib and/or fish oil in 7,12-dimethyl benzene (α) anthracene-induced mammary carcinogenesis.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013, Volume: 34, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis

2013
Usefulness of selective COX-2 inhibitors as therapeutic agents against canine mammary tumors.
    Oncology reports, 2014, Volume: 31, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Celecoxib; Cell Line, Tumor; Cell Prol

2014
Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions.
    Cancer science, 2014, Volume: 105, Issue:9

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Celecoxib; Cell Line, Tumor;

2014
Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2014, Volume: 23, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Carcinogens; Celecoxib; Chemoprevention; Drug Sy

2014
PDE5 inhibitors enhance celecoxib killing in multiple tumor types.
    Journal of cellular physiology, 2015, Volume: 230, Issue:5

    Topics: Animals; Apoptosis; Autophagy; Celecoxib; Cell Line, Tumor; Drug Synergism; Endoplasmic Reticulum St

2015
Celecoxib and fish oil: a combination strategy for decreased inflammatory mediators in early stages of experimental mammary cancer.
    Inflammopharmacology, 2016, Volume: 24, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokin

2016
Fish oil augments celecoxib mediated alteration in apoptotic pathway in the initiation phase of 7,12-dimethylbenz(α)anthracene-induced mammary carcinogenesis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 79

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogenesis; Ca

2016
Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid.
    Cancer prevention research (Philadelphia, Pa.), 2008, Volume: 1, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bexarotene; Carcinoma; Celecoxib; Cell Tran

2008
Prevention of tumorigenesis in p53-null mammary epithelium by rexinoid bexarotene, tyrosine kinase inhibitor gefitinib, and celecoxib.
    Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Bexarotene; Celecoxib; Cyclooxygenase Inhibitors; Disease Models,

2009
Identification of modulated genes by three classes of chemopreventive agents at preneoplastic stages in a p53-null mouse mammary tumor model.
    Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Bexarotene; Biomarkers, Tumor; Celecoxib; Cyclooxygenase Inhibitor

2009
A short-term rat mammary carcinogenesis model for the prevention of hormonally responsive and nonresponsive in situ carcinomas.
    Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Bexarotene; Carcinoma

2009
Celecoxib and melatonin in prevention of female rat mammary carcinogenesis.
    Neoplasma, 2009, Volume: 56, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Celecoxib; Drug Therapy,

2009
Breast-cancer-associated metastasis is significantly increased in a model of autoimmune arthritis.
    Breast cancer research : BCR, 2009, Volume: 11, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis; Autoimmune Dise

2009
Antitumoral and antimetastatic effects of metronomic chemotherapy with cyclophosphamide combined with celecoxib on murine mammary adenocarcinomas.
    Journal of cancer research and clinical oncology, 2011, Volume: 137, Issue:1

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Cyclophosphamide

2011
Evaluation of the role of oxidative stress in chemopreventive action of fish oil and celecoxib in the initiation phase of 7,12-dimethyl benz(α)anthracene-induced mammary carcinogenesis.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2011, Volume: 32, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Celecoxib; Cyclooxygenase 2; Cyclooxygenase

2011
Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer.
    BMC cancer, 2011, Aug-22, Volume: 11

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Bone Neoplasms; Celecoxib; Collagen Type

2011
Celecoxib enhances the efficacy of 15-hydroxyprostaglandin dehydrogenase gene therapy in treating murine breast cancer.
    Journal of cancer research and clinical oncology, 2013, Volume: 139, Issue:5

    Topics: Animals; Apoptosis; Celecoxib; Cell Line, Tumor; Combined Modality Therapy; Cyclooxygenase 2; Cycloo

2013
Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer.
    Cancer research, 2002, Oct-01, Volume: 62, Issue:19

    Topics: Animals; Anticarcinogenic Agents; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy

2002
Chemopreventive effect of celecoxib and expression of cyclooxygenase-1 and cyclooxygenase-2 on chemically-induced rat mammary tumours.
    International journal of experimental pathology, 2002, Volume: 83, Issue:4

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Blotting, Western; Celecoxib; Cycl

2002
The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003, Volume: 12, Issue:12

    Topics: Animals; Biopsy, Needle; Blotting, Western; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, An

2003
Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma.
    Cancer research, 2004, Feb-01, Volume: 64, Issue:3

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Celecoxib; Cell Cycle; Cell Division; Cycl

2004
The potential role of cyclooxygenase-2 inhibitors in the treatment of experimentally-induced mammary tumour: does celecoxib enhance the anti-tumour activity of doxorubicin?
    Pharmacological research, 2004, Volume: 50, Issue:5

    Topics: Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Doxoru

2004
Control of pulmonary metastases of rat mammary cancer by inhibition of uPA and COX-2, singly and in combination.
    Clinical & experimental metastasis, 2004, Volume: 21, Issue:4

    Topics: Amiloride; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibit

2004
Cyclooxygenase inhibitors modulate NK activities that control metastatic disease.
    Cancer immunology, immunotherapy : CII, 2005, Volume: 54, Issue:10

    Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase

2005
COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice.
    Prostaglandins & other lipid mediators, 2005, Volume: 76, Issue:1-4

    Topics: Animals; Base Sequence; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh

2005
Celecoxib and NS-398 enhance photodynamic therapy by increasing in vitro apoptosis and decreasing in vivo inflammatory and angiogenic factors.
    Cancer research, 2005, Oct-15, Volume: 65, Issue:20

    Topics: Animals; Apoptosis; Celecoxib; Cyclooxygenase Inhibitors; Dihematoporphyrin Ether; Dinoprostone; Dru

2005
Varied response of spontaneous tumors to antiangiogenic agents.
    Advances in experimental medicine and biology, 2005, Volume: 566

    Topics: Angiogenesis Inhibitors; Animals; Celecoxib; Endostatins; Female; Hypoxia; Mammary Neoplasms, Experi

2005
[Chemopreventive effect of tamoxifen combined with celecoxib on DMBA-induced breast cancer in rats].
    Ai zheng = Aizheng = Chinese journal of cancer, 2006, Volume: 25, Issue:11

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Celecoxib

2006
[Chemopreventive effect of celecoxib against DMBA-induced breast cancer and its mechanism].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2006, Volume: 26, Issue:11

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; D

2006
Characterization of the effects of antiangiogenic agents on tumor pathophysiology.
    American journal of clinical oncology, 2001, Volume: 24, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Celecoxib; Cell Hypoxia; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi

2001
Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:10

    Topics: Animals; Antineoplastic Agents; Aspartate Aminotransferases; Bilirubin; Blood Urea Nitrogen; Blottin

2001
A rat model of bone cancer pain.
    Pain, 2002, Volume: 96, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Body Tempera

2002
Cyclooxygenase-2 inhibitor celecoxib inhibits promotion of mammary tumorigenesis in rats fed a high fat diet rich in n-6 polyunsaturated fatty acids.
    Cancer letters, 2002, Oct-08, Volume: 184, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy

2002