celecoxib has been researched along with Ectopic Ossification in 25 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, the role of inflammation in traumatic heterotopic ossification around temporomandibular joint (THO-TMJ), as well as the preventive and treatment effect of celecoxib in THO-TMJ both in vivo and in vitro were explored." | 3.96 | The effect of celecoxib in traumatic heterotopic ossification around temporomandibular joint in mice. ( Chen, L; Chen, Q; Dai, J; Fang, B; Ouyang, N; Shen, G; Zhao, Y, 2020) |
| "Celecoxib was more effective than ibuprofen in preventing heterotopic bone formation after total hip replacement." | 2.73 | Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement: a prospective randomised trial. ( Hoffmeyer, P; Keller, A; Perneger, T; Riand, N; Saudan, M; Saudan, P, 2007) |
| " However, clinical data suggest that chronic use of celecoxib, may impair normal skeletal function leading to decreased bone mineral density in older male patients." | 2.44 | Celecoxib, NSAIDs and the skeleton. ( Lysz, T; O'Connor, JP, 2008) |
| "Heterotopic ossification is a common complication following total hip arthroplasty and surgery following acetabular trauma." | 2.44 | Pharmacological treatment of heterotopic ossification following hip and acetabular surgery. ( El Masry, MA; Gamie, Z; Macfarlane, RJ; Ng, BH; Schizas, C; Tsiridis, E; Velonis, S, 2008) |
| "Ten weeks after surgery, ectopic ossification at the tenotomy site was detected by 3D micro-CT." | 1.91 | TNFα-dependent mTOR activity is required for tenotomy-induced ectopic ossification in mice. ( Fukuma, Y; Iwamoto, T; Kobayashi, T; Kushima, Y; Matsumoto, M; Miyamoto, T; Nakamura, M; Sato, Y, 2023) |
| "Traumatic heterotopic ossification (THO) is a serious and common clinical post-traumatic complication for which there is no effective and safe drug treatment." | 1.72 | Poly(lactic acid-co-glycolic acid)-based celecoxib extended-release microspheres for the local treatment of traumatic heterotopic ossification. ( Huang, J; Li, C; Lin, J; Tang, B; Wu, J; Xiao, H, 2022) |
| "The pharmacological prophylaxis of heterotopic ossification (HO) following total hip arthroplasty (THA) is debated." | 1.72 | A comprehensive update on the pharmacological management of heterotopic ossification following hip arthroplasty: a level I evidenced based expert opinion. ( Asparago, G; Cuozzo, F; Maffulli, N; Migliorini, F; Oliva, F, 2022) |
| "Celecoxib did not inhibit the progression of initiated HO in the patients in whom HO was diagnosed, whereas those who received celecoxib after surgery had lower morbidity." | 1.51 | Celecoxib cannot inhibit the progression of initiated traumatic heterotopic ossification. ( Li, F; Mao, D; Mi, J; Pan, X; Rui, Y; Zhang, X, 2019) |
| "Imaging examinations showed widespread heterotopic ossification." | 1.48 | Difficult diagnosis and genetic analysis of fibrodysplasia ossificans progressiva: a case report. ( Lu, Y; Tian, S; Zhu, J, 2018) |
| "Celecoxib was an independent predictor of decreased heterotopic ossification (odds ratio, 0." | 1.48 | Prophylactic Celecoxib Administration Is Associated With Decreased Incidence and Severity of Heterotopic Ossification After Hip Resurfacing by Direct Lateral Approach in Male Patients. ( Bigart, K; Brigati, D; Brooks, P; Khlopas, A; Mont, MA; Ng, M; Sultan, AA; Wagner, TC, 2018) |
| "Background Heterotopic ossification (HO) after joint surgery is always a disturbing problem for patients and surgeons." | 1.46 | The efficacy of a multimodal analgesia protocol in preventing heterotopic ossification after acetabular fractures surgery. ( Cheng, L; Long, HT; Sun, BH; Zhao, SS; Zhu, Y, 2017) |
| "Heterotopic ossification (HO) recurrence after joint surgery is always a disturbing problem for patients and surgeons." | 1.42 | The efficacy of celecoxib in preventing heterotopic ossification recurrence after open arthrolysis for post-traumatic elbow stiffness in adults. ( Cai, J; Fan, C; Li, F; Liu, S; Ruan, H; Sun, Y, 2015) |
| "Based on X-ray and histological results, heterotopic ossification was assessed." | 1.40 | [Effects of selective and non-selective cyclooxygenase 2 inhibitors on heterotopic ossification in rat model with Achilles tenotomy]. ( Shi, W; Wu, J; Xiao, H; Xue, F; Zhao, H, 2014) |
| "However, the effects of celecoxib on heterotopic ossification at other locations remain unclear." | 1.39 | Celecoxib inhibits the heterotopic ossification in the rat model with Achilles tenotomy. ( Bai, X; Cui, Z; Jin, D; Liu, F; Wang, L; Yu, B; Zhang, K; Zhang, S, 2013) |
| "The overall incidence of heterotopic ossification in the celecoxib-treated patients was 23% (no cases of Brooker grade 3 or 4 ossifications), compared to 55% in the untreated patients (Brooker grade 3 and 4: 8." | 1.38 | Adherence to routine use of pharmacological prophylaxis of heterotopic ossification after total hip arthroplasty: results from an Italian multicenter, prospective, observational survey. ( Barbato, M; Cavasinni, L; D'Angelo, E; Di Francesco, A; Di Loreto, G; La Floresta, P; Menna, A; Romanò, CL; Salini, V; Zoppi, U, 2012) |
| "Traumatic heterotopic ossification (HO) is a common clinical condition associated with various orthopedic procedures that involve injury to soft tissues near bone." | 1.35 | The effects of COX-1 and COX-2 inhibitors on prostaglandin synthesis and the formation of heterotopic bone in a rat model. ( Boursiquot, R; Helfet, DL; Lane, JM; Macdonald, DE; Maddula, S; Raghavan, D; Rapuano, BE; Tomin, E, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 11 (44.00) | 24.3611 |
| 2020's | 8 (32.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yim, CR | 1 |
| Uhrich, RM | 1 |
| Perez, L | 1 |
| Lin, J | 1 |
| Huang, J | 1 |
| Wu, J | 2 |
| Tang, B | 1 |
| Li, C | 1 |
| Xiao, H | 2 |
| Migliorini, F | 1 |
| Asparago, G | 1 |
| Oliva, F | 1 |
| Cuozzo, F | 1 |
| Maffulli, N | 1 |
| Kushima, Y | 1 |
| Sato, Y | 1 |
| Kobayashi, T | 1 |
| Fukuma, Y | 1 |
| Matsumoto, M | 1 |
| Nakamura, M | 1 |
| Iwamoto, T | 1 |
| Miyamoto, T | 1 |
| Dow, T | 1 |
| King, JP | 1 |
| Wong, IH | 1 |
| Li, F | 2 |
| Mao, D | 1 |
| Pan, X | 1 |
| Zhang, X | 1 |
| Mi, J | 1 |
| Rui, Y | 1 |
| Ochiai, D | 1 |
| Adib, F | 1 |
| Ouyang, N | 1 |
| Zhao, Y | 1 |
| Chen, Q | 1 |
| Chen, L | 1 |
| Fang, B | 1 |
| Dai, J | 1 |
| Shen, G | 1 |
| Naylor, BH | 1 |
| Iturriaga, CR | 1 |
| Bisen, YB | 1 |
| Caid, MJ | 1 |
| Reinhardt, KR | 1 |
| Cheng, L | 1 |
| Long, HT | 1 |
| Sun, BH | 1 |
| Zhao, SS | 1 |
| Zhu, Y | 1 |
| White, PB | 1 |
| Ramkumar, PN | 1 |
| Meftah, M | 1 |
| Ghazi, N | 1 |
| Ranawat, AS | 1 |
| Ranawat, CS | 1 |
| Tian, S | 1 |
| Zhu, J | 1 |
| Lu, Y | 1 |
| Ng, M | 1 |
| Brigati, D | 1 |
| Wagner, TC | 1 |
| Bigart, K | 1 |
| Khlopas, A | 1 |
| Sultan, AA | 1 |
| Mont, MA | 1 |
| Brooks, P | 1 |
| Zhang, K | 1 |
| Wang, L | 1 |
| Zhang, S | 1 |
| Yu, B | 1 |
| Liu, F | 1 |
| Cui, Z | 1 |
| Jin, D | 1 |
| Bai, X | 1 |
| Lavernia, CJ | 1 |
| Contreras, JS | 1 |
| Villa, JM | 1 |
| Rossi, MD | 1 |
| Xue, F | 1 |
| Shi, W | 1 |
| Zhao, H | 1 |
| Sun, Y | 1 |
| Cai, J | 1 |
| Liu, S | 1 |
| Ruan, H | 1 |
| Fan, C | 1 |
| O'Connor, JP | 1 |
| Lysz, T | 1 |
| Kruser, TJ | 1 |
| Kozak, KR | 1 |
| Cannon, DM | 1 |
| Platta, CS | 1 |
| Heiner, JP | 1 |
| Illgen, RL | 1 |
| Barbato, M | 1 |
| D'Angelo, E | 1 |
| Di Loreto, G | 1 |
| Menna, A | 1 |
| Di Francesco, A | 1 |
| Salini, V | 1 |
| Zoppi, U | 1 |
| Cavasinni, L | 1 |
| La Floresta, P | 1 |
| Romanò, CL | 2 |
| Duci, D | 1 |
| Romanò, D | 1 |
| Mazza, M | 1 |
| Meani, E | 1 |
| Vastel, L | 1 |
| Rosencher, N | 1 |
| Siney, H | 1 |
| Courpied, JP | 1 |
| Saudan, M | 1 |
| Saudan, P | 1 |
| Perneger, T | 1 |
| Riand, N | 1 |
| Keller, A | 1 |
| Hoffmeyer, P | 1 |
| Rapuano, BE | 1 |
| Boursiquot, R | 1 |
| Tomin, E | 1 |
| Macdonald, DE | 1 |
| Maddula, S | 1 |
| Raghavan, D | 1 |
| Lane, JM | 1 |
| Helfet, DL | 1 |
| Macfarlane, RJ | 1 |
| Ng, BH | 1 |
| Gamie, Z | 1 |
| El Masry, MA | 1 |
| Velonis, S | 1 |
| Schizas, C | 1 |
| Tsiridis, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Celecoxib on Heterotopic Bone Formation Following Cementless Total Hip Arthroplasty[NCT05648916] | 200 participants (Anticipated) | Observational | 2022-08-02 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for celecoxib and Ectopic Ossification
| Article | Year |
|---|---|
Treatment of Temporomandibular Joint Heterotopic Ossification: A Novel Protocol With Multimodal Therapy Based on Literature Review and Presentation of a Unique Case Report.
Topics: Celecoxib; Combined Modality Therapy; Etidronic Acid; Humans; Joint Prosthesis; Ossification, Hetero | 2022 |
Incidence of Heterotopic Ossification Following a Multimodal Pain Protocol in Total Hip Arthroplasty With the Posterior Approach.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, | 2018 |
Celecoxib, NSAIDs and the skeleton.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone and Bones; Bone Regeneration; Cele | 2008 |
Pharmacological treatment of heterotopic ossification following hip and acetabular surgery.
Topics: Acetabulum; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Celecoxib; Dicl | 2008 |
3 trials available for celecoxib and Ectopic Ossification
| Article | Year |
|---|---|
Celecoxib versus indomethacin in the prevention of heterotopic ossification after total hip arthroplasty.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Celecoxib; Cyclooxygenase I | 2004 |
[Prevention of heterotopic ossifications in hip arthroplasty: effectiveness of selective Cox-2 inhibitors (celecoxib) versus ketoprofen].
Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Celecoxib; Cyclooxygenase Inhibitors; Femal | 2005 |
Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement: a prospective randomised trial.
Topics: Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Celecoxib; Cyclooxygenase 2 Inhibito | 2007 |
18 other studies available for celecoxib and Ectopic Ossification
| Article | Year |
|---|---|
Poly(lactic acid-co-glycolic acid)-based celecoxib extended-release microspheres for the local treatment of traumatic heterotopic ossification.
Topics: Animals; Celecoxib; Glycolates; Lactic Acid; Microspheres; Ossification, Heterotopic; Osteogenesis; | 2022 |
A comprehensive update on the pharmacological management of heterotopic ossification following hip arthroplasty: a level I evidenced based expert opinion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Celecoxib; Diclofenac; Expe | 2022 |
TNFα-dependent mTOR activity is required for tenotomy-induced ectopic ossification in mice.
Topics: Achilles Tendon; Activities of Daily Living; Animals; Celecoxib; Cimetidine; Female; Humans; Male; M | 2023 |
The Reduction of Heterotopic Ossification Incidence After Hip Arthroscopy in Patients Treated With Selective Cyclooxygenase 2 Inhibitor (Celecoxib).
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Celecoxib; Cyclooxygenase 2 Inhibitors; | 2020 |
Celecoxib cannot inhibit the progression of initiated traumatic heterotopic ossification.
Topics: Achilles Tendon; Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease M | 2019 |
Editorial Commentary: The Curious Incident of the Bone in the Soft Tissue: Is Heterotopic Ossification After Hip Arthroscopy an Interesting Finding or Is It a Complication?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Arthroscopy; Celecoxib; Cyc | 2020 |
The effect of celecoxib in traumatic heterotopic ossification around temporomandibular joint in mice.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type I; Cartilage, Articular; Celecoxib; Cell Differe | 2020 |
Heterotopic Ossification Following Direct Anterior Total Hip Arthroplasty With and Without Postoperative Analgesic Nonsteroidal Anti-inflammatories.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Celecoxib; Humans; Ossifica | 2021 |
The efficacy of a multimodal analgesia protocol in preventing heterotopic ossification after acetabular fractures surgery.
Topics: Acetabulum; Adult; Aged; Analgesia; Celecoxib; Combined Modality Therapy; Cyclooxygenase 2 Inhibitor | 2017 |
Difficult diagnosis and genetic analysis of fibrodysplasia ossificans progressiva: a case report.
Topics: Activin Receptors, Type I; Adolescent; Amino Acid Sequence; Celecoxib; Fingers; Genetic Testing; Glu | 2018 |
Prophylactic Celecoxib Administration Is Associated With Decreased Incidence and Severity of Heterotopic Ossification After Hip Resurfacing by Direct Lateral Approach in Male Patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty; Celecoxib; Follow-Up Studies; Hip Joint; Huma | 2018 |
Celecoxib inhibits the heterotopic ossification in the rat model with Achilles tenotomy.
Topics: Achilles Tendon; Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Male; Ossi | 2013 |
Celecoxib and heterotopic bone formation after total hip arthroplasty.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, R | 2014 |
[Effects of selective and non-selective cyclooxygenase 2 inhibitors on heterotopic ossification in rat model with Achilles tenotomy].
Topics: Achilles Tendon; Animals; Bone Morphogenetic Protein 2; Celecoxib; Cyclooxygenase 2; Cyclooxygenase | 2014 |
The efficacy of celecoxib in preventing heterotopic ossification recurrence after open arthrolysis for post-traumatic elbow stiffness in adults.
Topics: Adolescent; Adult; Celecoxib; Cohort Studies; Cyclooxygenase 2 Inhibitors; Elbow Injuries; Elbow Joi | 2015 |
Low rates of heterotopic ossification after resurfacing hip arthroplasty with use of prophylactic radiotherapy in select patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Arthroplasty, Replacement, H | 2012 |
Adherence to routine use of pharmacological prophylaxis of heterotopic ossification after total hip arthroplasty: results from an Italian multicenter, prospective, observational survey.
Topics: Arthroplasty, Replacement, Hip; Celecoxib; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, | 2012 |
The effects of COX-1 and COX-2 inhibitors on prostaglandin synthesis and the formation of heterotopic bone in a rat model.
Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase | 2008 |