celecoxib has been researched along with Depression, Involutional in 12 studies
Depression, Involutional: Form of depression in those MIDDLE AGE with feelings of ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Celecoxib as add-on strategy resulted in a significant reduction of Hamilton Depression Scale scores compared to placebo." | 9.15 | Elevated macrophage migration inhibitory factor and decreased transforming growth factor-beta levels in major depression--no influence of celecoxib treatment. ( Arolt, V; Cerovecki, A; Dehning, S; Müller, N; Musil, R; Riedel, M; Schwarz, MJ; Spellmann, I, 2011) |
| "There was also no evidence that pre-treatment inflammation levels modified the effect of celecoxib augmentation versus placebo." | 7.01 | No evidence for clinical efficacy of adjunctive celecoxib with vortioxetine in the treatment of depression: A 6-week double-blind placebo controlled randomized trial. ( Baune, BT; Clark, SR; Fourrier, C; Hori, H; Louise, J; Mills, NT; Sampson, E; Schubert, KO, 2021) |
| "Celecoxib as add-on strategy resulted in a significant reduction of Hamilton Depression Scale scores compared to placebo." | 5.15 | Elevated macrophage migration inhibitory factor and decreased transforming growth factor-beta levels in major depression--no influence of celecoxib treatment. ( Arolt, V; Cerovecki, A; Dehning, S; Müller, N; Musil, R; Riedel, M; Schwarz, MJ; Spellmann, I, 2011) |
| "There was also no evidence that pre-treatment inflammation levels modified the effect of celecoxib augmentation versus placebo." | 3.01 | No evidence for clinical efficacy of adjunctive celecoxib with vortioxetine in the treatment of depression: A 6-week double-blind placebo controlled randomized trial. ( Baune, BT; Clark, SR; Fourrier, C; Hori, H; Louise, J; Mills, NT; Sampson, E; Schubert, KO, 2021) |
| "In patients with major depressive disorder (MDD), antidepressant response and remission rates are low, highlighting the need for new treatment approaches." | 2.87 | Anti-inflammatory treatment of depression: study protocol for a randomised controlled trial of vortioxetine augmented with celecoxib or placebo. ( Baune, BT; Fourrier, C; Mills, NT; Sampson, E, 2018) |
| "Celecoxib 200 mg bid did not slow the progression of AD in this study, and the occurrence of adverse events was as expected for an elderly population with a complex chronic medical condition." | 2.73 | Long-term efficacy and safety of celecoxib in Alzheimer's disease. ( Niculescu, L; Robbins, J; Soininen, H; West, C, 2007) |
| "Five RCTs (four unipolar depression studies and one bipolar depression study) were included in the systematic review for qualitative data synthesis." | 2.50 | Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta-analysis of randomized placebo-controlled trials. ( Farid, L; Faridhosseini, F; Pourgholami, M; Sadeghi, R, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 5 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sampson, E | 3 |
| Mills, NT | 3 |
| Hori, H | 2 |
| Schwarte, K | 1 |
| Hohoff, C | 1 |
| Schubert, O | 1 |
| Clark, SR | 2 |
| Fourrier, C | 3 |
| Baune, BT | 3 |
| Attwells, S | 1 |
| Setiawan, E | 1 |
| Rusjan, PM | 1 |
| Xu, C | 1 |
| Hutton, C | 1 |
| Rafiei, D | 1 |
| Varughese, B | 1 |
| Kahn, A | 1 |
| Kish, SJ | 1 |
| Vasdev, N | 1 |
| Houle, S | 1 |
| Meyer, JH | 2 |
| Husain, MI | 1 |
| Chaudhry, IB | 1 |
| Khoso, AB | 1 |
| Husain, MO | 1 |
| Hodsoll, J | 1 |
| Ansari, MA | 1 |
| Naqvi, HA | 1 |
| Minhas, FA | 1 |
| Carvalho, AF | 1 |
| Deakin, B | 1 |
| Mulsant, BH | 1 |
| Husain, N | 1 |
| Young, AH | 1 |
| Raison, CL | 1 |
| Louise, J | 1 |
| Schubert, KO | 1 |
| Na, KS | 1 |
| Lee, KJ | 1 |
| Lee, JS | 1 |
| Cho, YS | 1 |
| Jung, HY | 1 |
| Faridhosseini, F | 1 |
| Sadeghi, R | 1 |
| Farid, L | 1 |
| Pourgholami, M | 1 |
| Akhondzadeh, S | 2 |
| Jafari, S | 1 |
| Raisi, F | 1 |
| Nasehi, AA | 1 |
| Ghoreishi, A | 1 |
| Salehi, B | 1 |
| Mohebbi-Rasa, S | 1 |
| Raznahan, M | 1 |
| Kamalipour, A | 1 |
| Musil, R | 1 |
| Schwarz, MJ | 1 |
| Riedel, M | 1 |
| Dehning, S | 1 |
| Cerovecki, A | 1 |
| Spellmann, I | 1 |
| Arolt, V | 1 |
| Müller, N | 1 |
| Abbasi, SH | 1 |
| Hosseini, F | 1 |
| Modabbernia, A | 1 |
| Ashrafi, M | 1 |
| Soininen, H | 1 |
| West, C | 1 |
| Robbins, J | 1 |
| Niculescu, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Minocycline and Celecoxib as Adjunctive Treatments of Bipolar Depression: A Factorial Design Randomised Controlled Trial[NCT02703363] | Phase 3 | 265 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| Precision Psychiatry: Anti-inflammatory Medication in Immuno-metabolic Depression[NCT05415397] | Phase 3 | 140 participants (Anticipated) | Interventional | 2022-09-28 | Recruiting | ||
| Salicylic Augmentation in Depression[NCT03152409] | Phase 2 | 74 participants (Anticipated) | Interventional | 2018-11-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for celecoxib and Depression, Involutional
| Article | Year |
|---|---|
Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: a meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Databases, Bibliographic; Depressive Disorder, M | 2014 |
Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta-analysis of randomized placebo-controlled trials.
Topics: Antidepressive Agents; Bipolar Disorder; Celecoxib; Cyclooxygenase 2 Inhibitors; Depressive Disorder | 2014 |
7 trials available for celecoxib and Depression, Involutional
| Article | Year |
|---|---|
Exploratory Analysis of the Effects of Celecoxib on Cognitive Function in Vortioxetine-Treated Patients With Major Depressive Disorder in the PREDDICT Study: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: C-Reactive Protein; Celecoxib; Cognition; Depressive Disorder, Major; Double-Blind Method; Humans; T | 2023 |
Minocycline and celecoxib as adjunctive treatments for bipolar depression: a multicentre, factorial design randomised controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bipolar Disorder; Case-Contro | 2020 |
No evidence for clinical efficacy of adjunctive celecoxib with vortioxetine in the treatment of depression: A 6-week double-blind placebo controlled randomized trial.
Topics: Antidepressive Agents; Australia; C-Reactive Protein; Celecoxib; Depression; Depressive Disorder, Ma | 2021 |
Anti-inflammatory treatment of depression: study protocol for a randomised controlled trial of vortioxetine augmented with celecoxib or placebo.
Topics: Adolescent; Adult; Affect; Aged; Antidepressive Agents; Biomarkers; C-Reactive Protein; Celecoxib; C | 2018 |
Elevated macrophage migration inhibitory factor and decreased transforming growth factor-beta levels in major depression--no influence of celecoxib treatment.
Topics: Adult; Aged; Antidepressive Agents; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Depres | 2011 |
Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: randomized double-blind placebo-controlled study.
Topics: Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Biomarkers; Celecoxib; | 2012 |
Long-term efficacy and safety of celecoxib in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cognition Disorders; De | 2007 |
3 other studies available for celecoxib and Depression, Involutional
| Article | Year |
|---|---|
Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder.
Topics: Celecoxib; Depressive Disorder, Major; Gyrus Cinguli; Humans; Positron-Emission Tomography; Receptor | 2020 |
Microglial Activation and Response to Anti-inflammatory Treatment in Major Depressive Disorder: Another Piece in the Inflammation-Mood Disorders Puzzle.
Topics: Anti-Inflammatory Agents; Celecoxib; Depressive Disorder, Major; Humans; Inflammation; Mood Disorder | 2020 |
Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial.
Topics: Adult; Celecoxib; Cyclooxygenase 2 Inhibitors; Depressive Disorder, Major; Diagnostic and Statistica | 2009 |