celecoxib has been researched along with Cardiotoxicity in 6 studies
Cardiotoxicity: Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Celecoxib (CLX), a poorly soluble anti-inflammatory drug, requires administration in higher concentrations to produce therapeutic effects, oftentimes resulting in cardiac toxicity." | 8.31 | Attenuation of celecoxib cardiac toxicity using Poly(δ-decalactone) based nanoemulsion via oral route. ( Bansal, KK; Maru, S; Rosenholm, JM; Verma, J; Wilen, CE, 2023) |
| "Celecoxib cardiotoxicity was manifested by significant increases in the LDH, Tn-T, TNF-α, CK-MB, SBP, HR (p < 0." | 7.85 | Folic acid ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model. ( Ahmad, S; Dubey, K; Fahim, M; Kohli, K; Panda, BP, 2017) |
| "Celecoxib (CLX), a poorly soluble anti-inflammatory drug, requires administration in higher concentrations to produce therapeutic effects, oftentimes resulting in cardiac toxicity." | 4.31 | Attenuation of celecoxib cardiac toxicity using Poly(δ-decalactone) based nanoemulsion via oral route. ( Bansal, KK; Maru, S; Rosenholm, JM; Verma, J; Wilen, CE, 2023) |
| "Celecoxib cardiotoxicity was manifested by significant increases in the LDH, Tn-T, TNF-α, CK-MB, SBP, HR (p < 0." | 3.85 | Folic acid ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model. ( Ahmad, S; Dubey, K; Fahim, M; Kohli, K; Panda, BP, 2017) |
| " Since then, many coxibs have been discontinued one by one due to adverse cardiovascular events." | 2.66 | Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review. ( Arora, M; Choudhary, S; Sapra, B; Silakari, O; Singh, PK, 2020) |
| " In this study, we focused on an analysis of celecoxib toxic effects on isolated mitochondria." | 1.72 | Celecoxib decreases mitochondrial complex IV activity and induces oxidative stress in isolated rat heart mitochondria: An analysis for its cardiotoxic adverse effect. ( Atashbar, S; Jamali, Z; Khezri, S; Salimi, A, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 4 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Atashbar, S | 2 |
| Jamali, Z | 1 |
| Khezri, S | 1 |
| Salimi, A | 2 |
| Maru, S | 1 |
| Verma, J | 1 |
| Wilen, CE | 1 |
| Rosenholm, JM | 1 |
| Bansal, KK | 1 |
| Arora, M | 1 |
| Choudhary, S | 1 |
| Singh, PK | 1 |
| Sapra, B | 1 |
| Silakari, O | 1 |
| Sabzalipour, T | 1 |
| Antman, EM | 1 |
| Ahmad, S | 1 |
| Panda, BP | 1 |
| Kohli, K | 1 |
| Fahim, M | 1 |
| Dubey, K | 1 |
2 reviews available for celecoxib and Cardiotoxicity
| Article | Year |
|---|---|
Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review.
Topics: Cardiotoxicity; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Labeling; Humans | 2020 |
Evaluating the Cardiovascular Safety of Nonsteroidal Anti-Inflammatory Drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiotoxicity; Cardiovascular Diseases; Celecox | 2017 |
4 other studies available for celecoxib and Cardiotoxicity
| Article | Year |
|---|---|
Celecoxib decreases mitochondrial complex IV activity and induces oxidative stress in isolated rat heart mitochondria: An analysis for its cardiotoxic adverse effect.
Topics: Animals; Cardiotoxicity; Celecoxib; Electron Transport Complex IV; Male; Mitochondria, Heart; Oxidat | 2022 |
Attenuation of celecoxib cardiac toxicity using Poly(δ-decalactone) based nanoemulsion via oral route.
Topics: Administration, Oral; Cardiotoxicity; Celecoxib; Drug Liberation; Emulsions; Humans; Solubility | 2023 |
Stabilization of Mitochondrial Function by Ellagic Acid Prevents Celecoxib-induced Toxicity in Rat Cardiomyocytes and Isolated Mitochondria.
Topics: Animals; Cardiotoxicity; Celecoxib; Cell Fractionation; Cells, Cultured; Ellagic Acid; Lipid Peroxid | 2021 |
Folic acid ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model.
Topics: Animals; Cardiotoxicity; Celecoxib; Disease Models, Animal; Folic Acid; Heart Failure; Male; Random | 2017 |