Page last updated: 2024-10-24

celecoxib and Cancer, Radiation-Induced

celecoxib has been researched along with Cancer, Radiation-Induced in 9 studies

Research Excerpts

ExcerptRelevanceReference
"Over a million nonmelanoma skin cancer cases will be reported in the United States this year alone."1.32Chemotherapeutic efficacy of topical celecoxib in a murine model of ultraviolet light B-induced skin cancer. ( Koki, AT; Oberyszyn, TM; Rubal, PA; Wilgus, TA; Zweifel, BS, 2003)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's5 (55.56)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Laquer, V1
Dellinger, RW1
Mannering, I1
Garcia, AG1
Abraham, V1
Pavlis, J1
Liu-Smith, F1
De Feraudy, S1
Meyskens, FL1
Kelly, KM1
Wulff, BC1
Thomas-Ahner, JM1
Schick, JS1
Oberyszyn, TM3
Fischer, SM3
Conti, CJ2
Viner, J1
Aldaz, CM1
Lubet, RA2
Wilgus, TA2
Koki, AT2
Zweifel, BS2
Rubal, PA2
Kusewitt, DF1
Won, YK1
Ong, CN1
Shi, X1
Shen, HM1
Riedel, SB1
Sanders, BG1
Kline, K1
Lo, HH1
Gordon, GB1
Seibert, K1
Kelloff, G1
Pentland, AP1
Schoggins, JW1
Scott, GA1
Khan, KN1
Han, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Radiosensitization With a COX-2 Inhibitor (Celecoxib), With Chemoradiation for Cancer of the Head and Neck[NCT00581971]Phase 1/Phase 230 participants (Actual)Interventional2002-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Response as Evaluated by Recurrence of Diseases

Evaluate the response to concurrent celecoxib, carboplatin, paclitaxel, and radiotherapy in the treatment of locally advanced SSC of the head and neck. Response is determined by local control only, local and distant metastasis, distant metastasis only, second primary, and surgical salvage. (NCT00581971)
Timeframe: 2 years from end of treatment (Radiation therapy)

InterventionParticipants (Number)
Local Control OnlyLocal Control and Distant MetastasisDistant Metastatsis OnlySecondary Primary - Site UnknownSurgical Salvage
Recurrence62123

Toxicity of Celecoxib With Concurrent Weekly Chemotherapy and Radiotherapy in the Treatment of Locally Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck.

Particpants experiencing Acute Toxicities > Grade 3 (NCT00581971)
Timeframe: 2 years from radiation therapy

Interventionparticipants (Number)
HematologicDermatitisMucositis/Dysphagia
Acute Toxicity12716

Other Studies

9 other studies available for celecoxib and Cancer, Radiation-Induced

ArticleYear
12-Hydroxyeicosatetraenoic acid levels are increased in actinic keratoses and squamous cell carcinoma.
    Journal of the American Academy of Dermatology, 2018, Volume: 79, Issue:6

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Biopsy; Carcinoma, Squamous Cell; Celecoxib; Chemopreven

2018
Celecoxib reduces the effects of acute and chronic UVB exposure in mice treated with therapeutically relevant immunosuppressive drugs.
    International journal of cancer, 2010, Jan-01, Volume: 126, Issue:1

    Topics: Animals; Blotting, Western; Caspase 3; Celecoxib; Cyclooxygenase Inhibitors; Cyclosporine; Dinoprost

2010
Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice.
    Carcinogenesis, 2003, Volume: 24, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Celecoxib; Cell Division; Cyclooxygenase 2; Disease Progr

2003
Chemotherapeutic efficacy of topical celecoxib in a murine model of ultraviolet light B-induced skin cancer.
    Molecular carcinogenesis, 2003, Volume: 38, Issue:1

    Topics: Administration, Topical; Animals; Celecoxib; Cell Division; Cyclooxygenase 2; Dinoprostone; Disease

2003
Inhibition of cutaneous ultraviolet light B-mediated inflammation and tumor formation with topical celecoxib treatment.
    Molecular carcinogenesis, 2003, Volume: 38, Issue:2

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents;

2003
Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms.
    Carcinogenesis, 2004, Volume: 25, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Blotting, West

2004
Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in mice.
    Anti-cancer drugs, 2008, Volume: 19, Issue:2

    Topics: Acetates; Administration, Inhalation; Animals; Antineoplastic Combined Chemotherapy Protocols; Carci

2008
Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis.
    Molecular carcinogenesis, 1999, Volume: 25, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Celecoxib; Cell Division; Cyclooxygen

1999
Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition.
    Carcinogenesis, 1999, Volume: 20, Issue:10

    Topics: Animals; Carcinoma, Squamous Cell; Celecoxib; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhi

1999