celecoxib has been researched along with Brain Edema in 5 studies
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effect of celecoxib, a selective inhibitor of cyclo-oxygenase 2, in patients with intracerebral hemorrhage (ICH)." | 9.17 | Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: a multicenter randomized controlled trial. ( Bae, HJ; Chung, JW; Han, MK; Jung, KH; Kim, CK; Kwon, HM; Lee, JS; Lee, SH; Lee, YS; Park, ES; Park, HK; Roh, JK; Ryu, WS, 2013) |
| "Celecoxib is a potent anti-inflammatory drug with a safety profile that has been well-demonstrated in several human diseases and is reported to have beneficial effects in a rat model of intracerebral hemorrhage (ICH)." | 7.75 | Effects of celecoxib on volumes of hematoma and edema in patients with primary intracerebral hemorrhage. ( Chu, K; Lee, SH; Park, HK; Roh, JK, 2009) |
| " In this study, the authors examined whether a selective COX-2 inhibitor (celecoxib) reduces cerebral inflammation and edema after intracerebral hemorrhage (ICH), and whether functional recovery is sustained with longer treatment." | 7.72 | Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death. ( Chu, K; Han, SY; Jeong, SW; Jung, KH; Kim, M; Lee, ST; Roh, JK, 2004) |
| "We investigated the effect of celecoxib, a selective inhibitor of cyclo-oxygenase 2, in patients with intracerebral hemorrhage (ICH)." | 5.17 | Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: a multicenter randomized controlled trial. ( Bae, HJ; Chung, JW; Han, MK; Jung, KH; Kim, CK; Kwon, HM; Lee, JS; Lee, SH; Lee, YS; Park, ES; Park, HK; Roh, JK; Ryu, WS, 2013) |
| "These cases revealed that low-dose celecoxib may be an effective management for symptoms caused by perihematomal edema in patients with ICH, particularly those involving the thalamus." | 4.12 | Improvement After Celecoxib Treatment in Patients with Thalamic Hemorrhage - A Case Report. ( Jeng, JS; Lin, YW; Tang, SC; Tsai, LK; Yeh, SJ, 2022) |
| "Celecoxib is a potent anti-inflammatory drug with a safety profile that has been well-demonstrated in several human diseases and is reported to have beneficial effects in a rat model of intracerebral hemorrhage (ICH)." | 3.75 | Effects of celecoxib on volumes of hematoma and edema in patients with primary intracerebral hemorrhage. ( Chu, K; Lee, SH; Park, HK; Roh, JK, 2009) |
| " In this study, the authors examined whether a selective COX-2 inhibitor (celecoxib) reduces cerebral inflammation and edema after intracerebral hemorrhage (ICH), and whether functional recovery is sustained with longer treatment." | 3.72 | Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death. ( Chu, K; Han, SY; Jeong, SW; Jung, KH; Kim, M; Lee, ST; Roh, JK, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, YW | 1 |
| Yeh, SJ | 1 |
| Tang, SC | 1 |
| Tsai, LK | 1 |
| Jeng, JS | 1 |
| Lee, SH | 2 |
| Park, HK | 2 |
| Ryu, WS | 1 |
| Lee, JS | 1 |
| Bae, HJ | 1 |
| Han, MK | 1 |
| Lee, YS | 1 |
| Kwon, HM | 1 |
| Kim, CK | 1 |
| Park, ES | 1 |
| Chung, JW | 1 |
| Jung, KH | 2 |
| Roh, JK | 3 |
| Chu, K | 2 |
| Sangha, N | 1 |
| Gonzales, NR | 1 |
| Jeong, SW | 1 |
| Han, SY | 1 |
| Lee, ST | 1 |
| Kim, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects and Mechanisms of Celecoxib on Intracerebral Hemorrhage[NCT05434065] | Phase 2 | 60 participants (Anticipated) | Interventional | 2023-01-01 | Recruiting | ||
| Multi-center, Prospective Randomized, Comparative Open With Blinded Endpoints (PROBE) Trial to Assess the Safety and Effectiveness of Administration of Celecoxib in Patients With Intracerebral Hemorrhage[NCT00526214] | 44 participants (Actual) | Interventional | 2007-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for celecoxib and Brain Edema
| Article | Year |
|---|---|
Treatment targets in intracerebral hemorrhage.
Topics: Anti-Inflammatory Agents; Blood Pressure; Brain Edema; Celecoxib; Cerebral Amyloid Angiopathy; Cereb | 2011 |
1 trial available for celecoxib and Brain Edema
| Article | Year |
|---|---|
Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: a multicenter randomized controlled trial.
Topics: Aged; Aged, 80 and over; Brain Edema; Celecoxib; Cerebral Hemorrhage; Cyclooxygenase 2 Inhibitors; D | 2013 |
3 other studies available for celecoxib and Brain Edema
| Article | Year |
|---|---|
Improvement After Celecoxib Treatment in Patients with Thalamic Hemorrhage - A Case Report.
Topics: Brain Edema; Celecoxib; Cerebral Hemorrhage; Edema; Hematoma; Humans | 2022 |
Effects of celecoxib on volumes of hematoma and edema in patients with primary intracerebral hemorrhage.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Brain Edema; Celecoxib; Cerebral Hemorrhage; Female; | 2009 |
Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death.
Topics: Animals; Brain Edema; Celecoxib; Cerebral Hemorrhage; Collagenases; Cyclooxygenase Inhibitors; Dinop | 2004 |