celecoxib has been researched along with Bipolar Disorder in 26 studies
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There is little evidence indicating the efficacy of celecoxib adjuvant therapy in treatmenting of manic episodes of bipolar disorder." | 9.69 | Does celecoxib with sodium valproate have an augmentation effect on acute mania in bipolar disorder? A double-blind controlled clinical trial in Iran. ( Ahrari, S; Eslamzadeh, M; Faridhosseini, F; Khadem-Rezaiyan, M; Pourgholami, M; Salimi, Z; Shahini, N; Talaei, A, 2023) |
| "To investigate whether the cox-2 inhibitor celecoxib has antidepressant effects in bipolar disorder (BD) patients during depressive or mixed phases." | 9.13 | Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study. ( Bowden, CL; Fonseca, M; Frey, BN; Hatch, JP; Monkul, ES; Nery, FG; Soares, JC; Zunta-Soares, GB, 2008) |
| "This clinical evidence is consistent with the hypothesis that low-dose chronic aspirin and celecoxib, which can inhibit COX-2 and enter brain, can be repurposed in bipolar disorder to enhance mood stabilizer effects on arachidonic acid metabolism and neurotransmission." | 9.12 | Aspirin and celecoxib may help to rectify a neurotransmission imbalance in bipolar disorder. ( Rapoport, SI, 2021) |
| "We reviewed randomized controlled trials (RCTs) and population studies to examine whether celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, and acetylsalicylate (aspirin), a COX-1 and COX-2 inhibitor and acetylator, were useful in bipolar disorder patients on mood stabilizers." | 9.05 | THERAPEUTIC TARGETING OF BRAIN ARACHIDONIC ACID CASCADE IN BIPOLAR DISORDER BY LOW DOSE ASPIRIN AND CELECOXIB. ( Hibbeln, JR; Rapoport, SI, 2020) |
| " A search strategy was developed using the terms: "Bipolar disorder" or "Bipolar mania" or "Bipolar depression" or "Bipolar mixed" or "Bipolar euthymic" and "Celecoxib" or "Cyclooxygenase-2 inhibitors" or "Cox-2 inhibitors" as text words and Medical Subject Headings (i." | 9.01 | Efficacy of Celecoxib Adjunct Treatment on Bipolar Disorder: Systematic Review and Meta-Analysis. ( Bavaresco, DV; Colom, F; Colonetti, T; da Rosa, MI; Grande, AJ; Quevedo, J; Valvassori, SS, 2019) |
| " There is little evidence indicating the efficacy of celecoxib adjuvant therapy in treatmenting of manic episodes of bipolar disorder." | 5.69 | Does celecoxib with sodium valproate have an augmentation effect on acute mania in bipolar disorder? A double-blind controlled clinical trial in Iran. ( Ahrari, S; Eslamzadeh, M; Faridhosseini, F; Khadem-Rezaiyan, M; Pourgholami, M; Salimi, Z; Shahini, N; Talaei, A, 2023) |
| " This study is the first to analyze blood levels of the pro-inflammatory biomarker C-reactive protein (CRP) in bipolar disorder patients treated with the cyclooxygenase-2 inhibitor, celecoxib (CBX)." | 5.27 | Plasma C-reactive protein levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment. ( Edberg, D; Fareed, J; Halaris, A; Hoppensteadt, D; Sinacore, J; Walborn, A, 2018) |
| "To investigate whether the cox-2 inhibitor celecoxib has antidepressant effects in bipolar disorder (BD) patients during depressive or mixed phases." | 5.13 | Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study. ( Bowden, CL; Fonseca, M; Frey, BN; Hatch, JP; Monkul, ES; Nery, FG; Soares, JC; Zunta-Soares, GB, 2008) |
| "This clinical evidence is consistent with the hypothesis that low-dose chronic aspirin and celecoxib, which can inhibit COX-2 and enter brain, can be repurposed in bipolar disorder to enhance mood stabilizer effects on arachidonic acid metabolism and neurotransmission." | 5.12 | Aspirin and celecoxib may help to rectify a neurotransmission imbalance in bipolar disorder. ( Rapoport, SI, 2021) |
| "We reviewed randomized controlled trials (RCTs) and population studies to examine whether celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, and acetylsalicylate (aspirin), a COX-1 and COX-2 inhibitor and acetylator, were useful in bipolar disorder patients on mood stabilizers." | 5.05 | THERAPEUTIC TARGETING OF BRAIN ARACHIDONIC ACID CASCADE IN BIPOLAR DISORDER BY LOW DOSE ASPIRIN AND CELECOXIB. ( Hibbeln, JR; Rapoport, SI, 2020) |
| " A search strategy was developed using the terms: "Bipolar disorder" or "Bipolar mania" or "Bipolar depression" or "Bipolar mixed" or "Bipolar euthymic" and "Celecoxib" or "Cyclooxygenase-2 inhibitors" or "Cox-2 inhibitors" as text words and Medical Subject Headings (i." | 5.01 | Efficacy of Celecoxib Adjunct Treatment on Bipolar Disorder: Systematic Review and Meta-Analysis. ( Bavaresco, DV; Colom, F; Colonetti, T; da Rosa, MI; Grande, AJ; Quevedo, J; Valvassori, SS, 2019) |
| "The increased VEGF in bipolar depression agrees with similar findings in major depressive disorder." | 2.94 | Vascular endothelial growth factor in bipolar depression: A potential biomarker for diagnosis and treatment outcome prediction. ( Castillo, MFR; Cohen, A; Edberg, D; Fareed, J; Halaris, A; Hoppensteadt, D; Martin, B, 2020) |
| " No serious adverse event was reported." | 2.84 | A Randomized, Double-Blind Placebo-Controlled Trial on Effectiveness and Safety of Celecoxib Adjunctive Therapy in Adolescents with Acute Bipolar Mania. ( Akhondzadeh, S; Gholamian, F; Karkhaneh-Yousefi, MA; Khezri, R; Mohammadi, MR; Mohammadinejad, P; Mousavi, SY; Zeinoddini, A, 2017) |
| "Celecoxib is an effective adjuvant therapy in the treatment of manic episodes (without psychotic features) of bipolar mood disorder." | 2.80 | Celecoxib adjunctive therapy for acute bipolar mania: a randomized, double-blind, placebo-controlled trial. ( Akhondzadeh, S; Ameli, N; Arabzadeh, S; Farokhnia, M; Ghaleiha, A; Mohammadinejad, P; Rezaei, F; Zeinoddini, A, 2015) |
| "Celecoxib was concluded to reduce TNF-α levels significantly in the patients at the end of the study." | 2.79 | Effects of celecoxib on inflammatory markers in bipolar patients undergoing electroconvulsive therapy: a placebo-controlled, double-blind, randomised study. ( Abdollahi, A; Ahmadvand, A; Akhondzadeh, S; Artounian, V; Ghaeli, P; Kargar, M; Mojtahedzadeh, M; Yousefi, A, 2014) |
| "Five RCTs (four unipolar depression studies and one bipolar depression study) were included in the systematic review for qualitative data synthesis." | 2.50 | Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta-analysis of randomized placebo-controlled trials. ( Farid, L; Faridhosseini, F; Pourgholami, M; Sadeghi, R, 2014) |
| "The pharmacologic treatment of schizophrenia and bipolar disorder leaves much to be desired." | 2.48 | Adjunct treatments for schizophrenia and bipolar disorder: what to try when you are out of ideas. ( Davis, JM; Torrey, EF, 2012) |
| "Inflammation is closely linked with behavioral parameters such as exercise, sleep, alcohol abuse, and smoking, as well as with medical comorbidities including coronary artery disease, obesity and insulin resistance, osteoporosis, and pain." | 2.45 | Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. ( Goldstein, BI; Kemp, DE; McIntyre, RS; Soczynska, JK, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (11.54) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 12 (46.15) | 2.80 |
| Authors | Studies |
|---|---|
| Faridhosseini, F | 2 |
| Talaei, A | 1 |
| Shahini, N | 1 |
| Salimi, Z | 1 |
| Eslamzadeh, M | 1 |
| Ahrari, S | 1 |
| Pourgholami, M | 2 |
| Khadem-Rezaiyan, M | 1 |
| Halaris, A | 5 |
| Cantos, A | 1 |
| Johnson, K | 1 |
| Hakimi, M | 1 |
| Sinacore, J | 3 |
| Valvassori, SS | 3 |
| Tonin, PT | 2 |
| Dal-Pont, GC | 2 |
| Varela, RB | 2 |
| Cararo, JH | 1 |
| Garcia, AF | 1 |
| Gava, FF | 2 |
| Menegas, S | 1 |
| Soares, JC | 3 |
| Quevedo, J | 3 |
| Murata, S | 1 |
| Murphy, M | 1 |
| Hoppensteadt, D | 4 |
| Fareed, J | 4 |
| Welborn, A | 1 |
| Castillo, MFR | 1 |
| Cohen, A | 1 |
| Edberg, D | 3 |
| Martin, B | 1 |
| Berk, M | 1 |
| Vieta, E | 1 |
| Dean, OM | 1 |
| Husain, MI | 2 |
| Chaudhry, IB | 2 |
| Khoso, AB | 1 |
| Husain, MO | 1 |
| Hodsoll, J | 1 |
| Ansari, MA | 1 |
| Naqvi, HA | 1 |
| Minhas, FA | 1 |
| Carvalho, AF | 1 |
| Meyer, JH | 1 |
| Deakin, B | 2 |
| Mulsant, BH | 2 |
| Husain, N | 1 |
| Young, AH | 2 |
| Rapoport, SI | 2 |
| Hibbeln, JR | 1 |
| Walborn, A | 2 |
| Miller, AH | 1 |
| Pariante, CM | 1 |
| Sebastian, CS | 1 |
| Mousavi, SY | 1 |
| Khezri, R | 1 |
| Karkhaneh-Yousefi, MA | 1 |
| Mohammadinejad, P | 2 |
| Gholamian, F | 1 |
| Mohammadi, MR | 1 |
| Zeinoddini, A | 2 |
| Akhondzadeh, S | 4 |
| Bavaresco, DV | 1 |
| Colonetti, T | 1 |
| Grande, AJ | 1 |
| Colom, F | 1 |
| da Rosa, MI | 1 |
| Ferreira, CL | 1 |
| Andersen, ML | 1 |
| Kargar, M | 2 |
| Yousefi, A | 1 |
| Mojtahedzadeh, M | 1 |
| Artounian, V | 1 |
| Abdollahi, A | 1 |
| Ahmadvand, A | 1 |
| Ghaeli, P | 2 |
| Sadeghi, R | 1 |
| Farid, L | 1 |
| Gurvich, A | 1 |
| Begemann, M | 1 |
| Dahm, L | 1 |
| Sargin, D | 1 |
| Miskowiak, K | 1 |
| Ehrenreich, H | 1 |
| Arabzadeh, S | 1 |
| Ameli, N | 1 |
| Rezaei, F | 1 |
| Farokhnia, M | 1 |
| Ghaleiha, A | 1 |
| Yoosefi, A | 1 |
| Artonian, V | 1 |
| Ashouri, A | 1 |
| Goldstein, BI | 1 |
| Kemp, DE | 1 |
| Soczynska, JK | 1 |
| McIntyre, RS | 1 |
| Torrey, EF | 1 |
| Davis, JM | 1 |
| Slørdal, L | 1 |
| Samstad, S | 1 |
| Bathen, J | 1 |
| Spigset, O | 1 |
| Nery, FG | 1 |
| Monkul, ES | 1 |
| Hatch, JP | 1 |
| Fonseca, M | 1 |
| Zunta-Soares, GB | 1 |
| Frey, BN | 1 |
| Bowden, CL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cyclooxygenase-2-Inhibitor Combination Treatment for Bipolar Depression: Role of Inflammation and Kynurenine Pathway Biomarkers[NCT01479829] | Phase 4 | 88 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| Minocycline and Celecoxib as Adjunctive Treatments of Bipolar Depression: A Factorial Design Randomised Controlled Trial[NCT02703363] | Phase 3 | 265 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression: a Proof of Concept Randomized Controlled Trial[NCT02155972] | Phase 2 | 16 participants (Actual) | Interventional | 2013-05-31 | Terminated (stopped due to The trial was terminated because of inability to recruit the needed number of participants) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for celecoxib and Bipolar Disorder
| Article | Year |
|---|---|
THERAPEUTIC TARGETING OF BRAIN ARACHIDONIC ACID CASCADE IN BIPOLAR DISORDER BY LOW DOSE ASPIRIN AND CELECOXIB.
Topics: Arachidonic Acid; Aspirin; Bipolar Disorder; Brain; Celecoxib; Humans; Randomized Controlled Trials | 2020 |
Aspirin and celecoxib may help to rectify a neurotransmission imbalance in bipolar disorder.
Topics: Animals; Antimanic Agents; Aspirin; Bipolar Disorder; Celecoxib; Humans; Rats; Synaptic Transmission | 2021 |
Efficacy of Celecoxib Adjunct Treatment on Bipolar Disorder: Systematic Review and Meta-Analysis.
Topics: Bipolar Disorder; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Humans | 2019 |
Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta-analysis of randomized placebo-controlled trials.
Topics: Antidepressive Agents; Bipolar Disorder; Celecoxib; Cyclooxygenase 2 Inhibitors; Depressive Disorder | 2014 |
Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature.
Topics: Anti-Inflammatory Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Brief Psychiatric | 2009 |
Adjunct treatments for schizophrenia and bipolar disorder: what to try when you are out of ideas.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; An | 2012 |
12 trials available for celecoxib and Bipolar Disorder
| Article | Year |
|---|---|
Does celecoxib with sodium valproate have an augmentation effect on acute mania in bipolar disorder? A double-blind controlled clinical trial in Iran.
Topics: Antipsychotic Agents; Bipolar Disorder; Celecoxib; Double-Blind Method; Humans; Iran; Mania; Psychia | 2023 |
Modulation of the inflammatory response benefits treatment-resistant bipolar depression: A randomized clinical trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Bipolar Disorder; Celecoxib; | 2020 |
Effects of adjunctive inflammatory modulation on IL-1β in treatment resistant bipolar depression.
Topics: Bipolar Disorder; Celecoxib; Citalopram; Depressive Disorder, Treatment-Resistant; Humans; Interleuk | 2020 |
Vascular endothelial growth factor in bipolar depression: A potential biomarker for diagnosis and treatment outcome prediction.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Biomarkers; Bipolar Disorder; Celecoxib; Cita | 2020 |
Minocycline and celecoxib as adjunctive treatments for bipolar depression: a multicentre, factorial design randomised controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bipolar Disorder; Case-Contro | 2020 |
Plasma MCP-1 levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bipolar Disorder; Celecoxib; Chemokine CCL2; Cyclooxygenase | 2020 |
A Randomized, Double-Blind Placebo-Controlled Trial on Effectiveness and Safety of Celecoxib Adjunctive Therapy in Adolescents with Acute Bipolar Mania.
Topics: Adolescent; Antimanic Agents; Bipolar Disorder; Celecoxib; Child; Double-Blind Method; Drug Therapy, | 2017 |
Plasma C-reactive protein levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Bipolar Disorder; Body Mass Index; C-Reactive | 2018 |
Effects of celecoxib on inflammatory markers in bipolar patients undergoing electroconvulsive therapy: a placebo-controlled, double-blind, randomised study.
Topics: Adult; Biomarkers; Bipolar Disorder; C-Reactive Protein; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyt | 2014 |
Celecoxib adjunctive therapy for acute bipolar mania: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Bipolar Disorder; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Therapy, | 2015 |
Effect of Adjunctive Celecoxib on BDNF in Manic Patients Undergoing Electroconvulsive Therapy: a Randomized Double Blind Controlled Trial.
Topics: Adolescent; Adult; Aged; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Celecoxib; Combined Mo | 2015 |
Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Celecoxib; Cyclooxygenase Inhibitor | 2008 |
8 other studies available for celecoxib and Bipolar Disorder
| Article | Year |
|---|---|
Coadministration of lithium and celecoxib reverses manic-like behavior and decreases oxidative stress in a dopaminergic model of mania induced in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimanic Agents; Behavior, Animal; Bipolar Disord | 2019 |
Anti-inflammatory treatment of bipolar depression: promise and disappointment.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antirheumatic Agents; Biomarkers; Bipolar Disorder; | 2020 |
Trial failures of anti-inflammatory drugs in depression.
Topics: Anti-Inflammatory Agents; Bipolar Disorder; Celecoxib; Depression; Humans; Minocycline | 2020 |
Trial failures of anti-inflammatory drugs in depression - Authors' reply.
Topics: Anti-Inflammatory Agents; Bipolar Disorder; Celecoxib; Depression; Humans; Minocycline | 2020 |
A Case of Influenza Vaccine-Induced Bipolar Depression Treated With Celecoxib.
Topics: Bipolar Disorder; Celecoxib; Drug Therapy, Combination; Humans; Influenza Vaccines | 2021 |
Coadministration of lithium and celecoxib attenuates the behavioral alterations and inflammatory processes induced by amphetamine in an animal model of mania.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimanic Agents; Behavior, | 2019 |
A role for prostaglandins in rapid cycling suggested by episode-specific gene expression shifts in peripheral blood mononuclear cells: a preliminary report.
Topics: Aged; Antidepressive Agents; Bipolar Disorder; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibit | 2014 |
A life-threatening interaction between lithium and celecoxib.
Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Bipolar Disorder; Celecoxib; Drug Inte | 2003 |