celecoxib and Adjuvant Arthritis studies

Research Excerpts

Excerpt	Relevance	Reference
"BACKGROUND Literature shows that serum selenium concentration is low in rheumatoid arthritis (RA) patients."	7.91	Selenium Nanoparticles Dispersed in Phytochemical Exert Anti-Inflammatory Activity by Modulating Catalase, GPx1, and COX-2 Gene Expression in a Rheumatoid Arthritis Rat Model. ( Lin, Y; Ma, DS; Ren, SX; Yan, H; Zhan, B, 2019)
" Herein, we report the effect of both inflammation and NSAIDs (rofecoxib, celecoxib, and meloxicam) on the physiologically active cytochrome P450 metabolites of arachidonic acid (ArA) in the rat with adjuvant arthritis."	7.88	Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid. ( Aghazadeh-Habashi, A; Asghar, W; Jamali, F, 2018)
"Celecoxib (CXB), a COX-2 inhibitor, is primarily indicated for long-term treatment of rheumatoid arthritis (RA)."	7.88	Preclinical Explorative Assessment of Celecoxib-Based Biocompatible Lipidic Nanocarriers for the Management of CFA-Induced Rheumatoid Arthritis in Wistar Rats. ( Goni, VG; Katare, OP; Khuller, GK; Nirbhavane, P; Patil, AB; Sharma, G; Singh, B, 2018)
" Compared with celecoxib controls, both oral and IA, ropivacaine IA treatment resulted in a significant reduction of pain upon successive PGPS reactivation, as demonstrated in two different pain models, gait analysis and incapacitance testing."	7.81	Intra-articular (IA) ropivacaine microparticle suspensions reduce pain, inflammation, cytokine, and substance p levels significantly more than oral or IA celecoxib in a rat model of arthritis. ( Balla, K; Bendele, A; Bogseth, R; Gass, J; Graham, S; Hutchcraft, A; Rabinow, B; Valaitis, P; Werling, J, 2015)
" Thus, the current study aimed at evaluating the effects of two testosterone boosting agents; chrysin, a natural flavone and celecoxib, a selective COX-2 inhibitor, in testicular impairment in rats with adjuvant arthritis, an experimental model of RA."	7.80	Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: comparison with celecoxib. ( Abdelsalam, RM; Arab, HH; Darwish, HA, 2014)
"Lornoxicam exhibits strong analgesic but weak antipyretic effects in rats with paw inflammation."	7.75	The importance of brain PGE2 inhibition versus paw PGE2 inhibition as a mechanism for the separation of analgesic and antipyretic effects of lornoxicam in rats with paw inflammation. ( Arai, I; Futaki, N; Harada, M; Hashimoto, Y; Honma, Y; Hoshi, K; Nakaike, S; Sugimoto, M, 2009)
"Metformin was administered orally every day to rats with OA."	5.62	Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy-Lysosomal Pathway. ( Cho, KH; Cho, ML; Choi, JW; Jung, K; Kim, SJ; Kwon, JY; Lee, AR; Lee, DH; Lee, SH; Lee, SY; Min, HK; Na, HS; Park, SH; Woo, JS, 2021)
" The relative bioavailability (BA) of the M3 and SD6 formulations was also significantly improved as oral bioavailability (167."	5.56	Therapeutic effects of celecoxib polymeric systems in rat models of inflammation and adjuvant-induced rheumatoid arthritis. ( Ahn, JB; Choi, JS; Heo, KS; Lee, DH; Myung, CS; Park, JS; Sim, S, 2020)
"Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms."	5.40	Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. ( El-Azab, MF; El-Sayed, RM; Moustafa, YM, 2014)
"Celecoxib was administered at the rate of 3 mg/kg per day, loxoprofen at 3 mg/kg per day, and SC-58560 at 10 mg/kg per day."	5.35	Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats. ( Kimoto, A; Miyata, K; Noguchi, M; Sasamata, M, 2008)
"BACKGROUND Literature shows that serum selenium concentration is low in rheumatoid arthritis (RA) patients."	3.91	Selenium Nanoparticles Dispersed in Phytochemical Exert Anti-Inflammatory Activity by Modulating Catalase, GPx1, and COX-2 Gene Expression in a Rheumatoid Arthritis Rat Model. ( Lin, Y; Ma, DS; Ren, SX; Yan, H; Zhan, B, 2019)
" Herein, we report the effect of both inflammation and NSAIDs (rofecoxib, celecoxib, and meloxicam) on the physiologically active cytochrome P450 metabolites of arachidonic acid (ArA) in the rat with adjuvant arthritis."	3.88	Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid. ( Aghazadeh-Habashi, A; Asghar, W; Jamali, F, 2018)
"Celecoxib (CXB), a COX-2 inhibitor, is primarily indicated for long-term treatment of rheumatoid arthritis (RA)."	3.88	Preclinical Explorative Assessment of Celecoxib-Based Biocompatible Lipidic Nanocarriers for the Management of CFA-Induced Rheumatoid Arthritis in Wistar Rats. ( Goni, VG; Katare, OP; Khuller, GK; Nirbhavane, P; Patil, AB; Sharma, G; Singh, B, 2018)
" Compared with celecoxib controls, both oral and IA, ropivacaine IA treatment resulted in a significant reduction of pain upon successive PGPS reactivation, as demonstrated in two different pain models, gait analysis and incapacitance testing."	3.81	Intra-articular (IA) ropivacaine microparticle suspensions reduce pain, inflammation, cytokine, and substance p levels significantly more than oral or IA celecoxib in a rat model of arthritis. ( Balla, K; Bendele, A; Bogseth, R; Gass, J; Graham, S; Hutchcraft, A; Rabinow, B; Valaitis, P; Werling, J, 2015)
" Thus, the current study aimed at evaluating the effects of two testosterone boosting agents; chrysin, a natural flavone and celecoxib, a selective COX-2 inhibitor, in testicular impairment in rats with adjuvant arthritis, an experimental model of RA."	3.80	Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: comparison with celecoxib. ( Abdelsalam, RM; Arab, HH; Darwish, HA, 2014)
"Lornoxicam exhibits strong analgesic but weak antipyretic effects in rats with paw inflammation."	3.75	The importance of brain PGE2 inhibition versus paw PGE2 inhibition as a mechanism for the separation of analgesic and antipyretic effects of lornoxicam in rats with paw inflammation. ( Arai, I; Futaki, N; Harada, M; Hashimoto, Y; Honma, Y; Hoshi, K; Nakaike, S; Sugimoto, M, 2009)
" This work led to the identification of 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis."	3.69	Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). ( Bertenshaw, SR; Burton, EG; Carter, JS; Cogburn, JN; Collins, PW; Docter, S; Graneto, MJ; Gregory, SA; Isakson, PC; Koboldt, CM; Lee, LF; Malecha, JW; Miyashiro, JM; Penning, TD; Perkins, WE; Rogers, RS; Rogier, DJ; Seibert, K; Talley, JJ; Veenhuizen, AW; Yu, SS; Zhang, YY, 1997)
"Mechanical hyperalgesia, joint edema, leukocyte recruitment to the joint and damage to cartilage in experimental arthritis and cytotoxicity, spread of disease, phagocytic activity and nitric oxide (NO) and hydrogen peroxide production by macrophages were evaluated."	1.91	1,4-Diaryl-1,2,3-triazole neolignan-celecoxib hybrids inhibit experimental arthritis induced by zymosan. ( B Carvalho, D; Baroni, ACM; Bonfá, IS; Candeloro, L; das Neves, AR; Felipe, JL; Ferreira, GIS; Lencina, JS; Lossavaro, PKMB; Silva-Filho, SE; Souza, MIL; Toffoli-Kadri, MC, 2023)
"Metformin was administered orally every day to rats with OA."	1.62	Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy-Lysosomal Pathway. ( Cho, KH; Cho, ML; Choi, JW; Jung, K; Kim, SJ; Kwon, JY; Lee, AR; Lee, DH; Lee, SH; Lee, SY; Min, HK; Na, HS; Park, SH; Woo, JS, 2021)
" The relative bioavailability (BA) of the M3 and SD6 formulations was also significantly improved as oral bioavailability (167."	1.56	Therapeutic effects of celecoxib polymeric systems in rat models of inflammation and adjuvant-induced rheumatoid arthritis. ( Ahn, JB; Choi, JS; Heo, KS; Lee, DH; Myung, CS; Park, JS; Sim, S, 2020)
"Naproxen was the only treatment to be more effective on all different radiographic subscores than etanercept."	1.51	Structural efficacy of NSAIDs, COX-2 inhibitor and glucocorticoid compared with TNFα blocker: a study in adjuvant-induced arthritis rats. ( Bordy, R; Demougeot, C; Prati, C; Totoson, P; Verhoeven, F; Wendling, D, 2019)
" Linear regression of the celecoxib dose-response showed 0."	1.46	A Comparison of the Anti-Inflammatory Effects of Cis-9, Trans-11 Conjugated Linoleic Acid to Celecoxib in the Collagen-Induced Arthritis Model. ( Cook, ME; Haas, AW; Lor, J; McKee, HS; Olson, JM, 2017)
"Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms."	1.40	Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. ( El-Azab, MF; El-Sayed, RM; Moustafa, YM, 2014)
"The sites of secondary metastasis and the associated inflammatory microenvironment were evaluated."	1.37	Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer. ( Ghosh, S; Gruber, HE; Mukherjee, P; Pathangey, LB; Roy, LD; Tinder, TL, 2011)
"Treatment with celecoxib in a dose of 5 mg/kg was effective in decreasing the elevated levels of IL-6, IL-1β, TNF-α, PGE₂ whereas it lacked any effect on TXB₂ level since it had hardly any effect on COX-1 enzyme."	1.36	Effect of selective COX-2 inhibitor, celecoxib on adjuvant-induced arthritis model in irradiated rats. ( El-Ghazaly, MA; El-Hazek, RM; Khayyal, MT; Nada, AS, 2010)
" Finally, these compounds have shown efficacy when dosed orally in multiple acute and chronic prostaglandin and leukotriene dependent in vivo models."	1.35	Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib. ( Abraham, WM; Albert, L; Behnke, ML; Chen, L; Clark, JD; Donahue, F; Foley, MA; Goodwin, DG; Hegen, M; Hu, B; Hu, Y; Ipek, M; Keith, J; Kirincich, SJ; Ku, MS; Lee, KL; McKew, JC; Michalak, R; Murphy, EA; Nickerson-Nutter, CL; Ramarao, MK; Shen, MW; Sum, FW; Tam, S; Thakker, P; Thomason, J; Williams, C; Wooder, L; Wu, K; Xu, X, 2008)
"Celecoxib was administered at the rate of 3 mg/kg per day, loxoprofen at 3 mg/kg per day, and SC-58560 at 10 mg/kg per day."	1.35	Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats. ( Kimoto, A; Miyata, K; Noguchi, M; Sasamata, M, 2008)
"Juxta-articular osteopenia and growth plate destruction adjacent to inflamed joints were also assessed using plain radiography, bone mineral density measurement, histology, and histomorphometry."	1.34	Celecoxib prevents juxta-articular osteopenia and growth plate destruction adjacent to inflamed joints in rats with collagen-induced arthritis. ( Hashimoto, J; Kawai, S; Matsui, Y; Nampei, A; Ochi, T; Tsuboi, H; Yoshikawa, H, 2007)
"Free celecoxib was found to have been extensively distributed to organs of the reticuloendothelial system such as the liver, lungs and spleen."	1.34	Enhanced retention of celecoxib-loaded solid lipid nanoparticles after intra-articular administration. ( Kumar Sharma, R; Murthy, RS; Thakkar, H, 2007)
"Paw edema and hyperalgesia were monitored from day zero to day 21 after induction as signs of arthritis development."	1.32	Role of endogenous glucocorticoids in hyperalgesia and edema in old arthritic rats. ( Alves, DL; Francischi, JN; Pereira, LS; Tatsuo, MA; Yokoro, CM, 2003)
"Celecoxib was studied in the kainate-induced seizure model in the rat, a model of direct central prostaglandin induction, to determine whether it can act directly in the CNS."	1.31	Pharmacology of celecoxib in rat brain after kainate administration. ( Ciceri, P; Isakson, PC; Leahy, KM; Seibert, K; Shaffer, AF; Smith, WG; Woerner, MB; Zhang, Y, 2002)
" Both exhibit good oral bioavailability and are potent in standard models of pain, fever, and inflammation yet have a much reduced effect on the GI integrity of rats compared to standard nonsteroidal antiflammatory drugs."	1.30	2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors. ( Black, WC; Brideau, C; Chan, CC; Charleson, S; Chauret, N; Claveau, D; Ethier, D; Gordon, R; Greig, G; Guay, J; Hughes, G; Jolicoeur, P; Leblanc, Y; Nicoll-Griffith, D; Ouimet, N; Prasit, P; Riendeau, D; Visco, D; Wang, Z; Xu, L, 1999)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (7.81)	18.2507
2000's	30 (46.88)	29.6817
2010's	24 (37.50)	24.3611
2020's	5 (7.81)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
In Vivo Selectivity of Cyclooxygenase Inhibitors in the Oral Surgery Model[NCT00006299]	Phase 2	120 participants	Interventional	1999-12-31	Completed
Clinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus[NCT04066348]	Phase 2	310 participants (Anticipated)	Interventional	2022-07-01	Recruiting
Cytokine Responses to Acute Inflammation in the Oral Surgery Model[NCT00006175]		160 participants	Observational	2000-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood. Journal of immunology (Baltimore, Md. : 1950), 2010, Sep-15, Volume: 185, Issue:6 Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Experiment	2010
Outcome of specific COX-2 inhibition in rheumatoid arthritis. The Journal of rheumatology. Supplement, 1997, Volume: 49 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Ce	1997

Article	Year
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). Journal of medicinal chemistry, 1997, Apr-25, Volume: 40, Issue:9 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Carrageenan; Celecoxib; Cyclooxygenase 1; C	1997
2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors. Journal of medicinal chemistry, 1999, Apr-08, Volume: 42, Issue:7 Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Biological Availability; Carrageenan; Ce	1999
Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors. Journal of medicinal chemistry, 2000, Jan-27, Volume: 43, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase Inhibitors	2000
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. Journal of medicinal chemistry, 2000, Mar-09, Volume: 43, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 2; Edema;	2000
Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase. Journal of medicinal chemistry, 2000, May-18, Volume: 43, Issue:10 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Blood Platelet	2000
1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite. Journal of medicinal chemistry, 2000, Nov-30, Volume: 43, Issue:24 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyc	2000
2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors. Bioorganic & medicinal chemistry letters, 2001, Jan-22, Volume: 11, Issue:2 Topics: Animals; Arthritis, Experimental; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygena	2001
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility. Bioorganic & medicinal chemistry letters, 2003, Mar-24, Volume: 13, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Phenomena; Chemi	2003
Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles. Journal of medicinal chemistry, 2003, Jul-31, Volume: 46, Issue:16 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Binding Sites	2003
In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives. Journal of medicinal chemistry, 2004, Feb-12, Volume: 47, Issue:4 Topics: Adult; Animals; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge	2004
Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors. Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21 Topics: Administration, Oral; Animals; Arthritis, Experimental; Biological Availability; Brain; Cyclooxygena	2004
Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. Journal of medicinal chemistry, 2007, Jan-11, Volume: 50, Issue:1 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Art	2007
Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib. Journal of medicinal chemistry, 2008, Jun-26, Volume: 51, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoates; Biological Ava	2008
Synthesis and anti-inflammatory activity of paeonol analogues in the murine model of complete Freund's adjuvant induced arthritis. Bioorganic & medicinal chemistry letters, 2016, 11-01, Volume: 26, Issue:21 Topics: Acetophenones; Animals; Arthritis, Experimental; Cyclooxygenase 2; Drug Evaluation, Preclinical; Fre	2016
1,4-Diaryl-1,2,3-triazole neolignan-celecoxib hybrids inhibit experimental arthritis induced by zymosan. Inflammopharmacology, 2023, Volume: 31, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Celecoxib; Edema;	2023
Intra-articular multifunctional celecoxib loaded hyaluronan nanocapsules for the suppression of inflammation in an osteoarthritic rat model. International journal of pharmaceutics, 2020, Jun-15, Volume: 583 Topics: Animals; Arthritis, Experimental; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Carriers; Drug Compou	2020
Therapeutic effects of celecoxib polymeric systems in rat models of inflammation and adjuvant-induced rheumatoid arthritis. Materials science & engineering. C, Materials for biological applications, 2020, Volume: 114 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Celecoxib; Freund's Adjuvant; Inflammation;	2020
A hybrid platform featuring nanomagnetic ligand fishing for discovering COX-2 selective inhibitors from aerial part of Saussurea laniceps Hand.-Mazz. Journal of ethnopharmacology, 2021, May-10, Volume: 271 Topics: Animals; Arthritis, Experimental; Celecoxib; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor	2021
Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy-Lysosomal Pathway. Cells, 2021, 03-19, Volume: 10, Issue:3 Topics: Animals; Arthritis, Experimental; Celecoxib; Chondrocytes; Diabetes Mellitus, Type 2; Disease Models	2021
p-Coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat model. BioFactors (Oxford, England), 2017, Sep-10, Volume: 43, Issue:5 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Resorption; Cartilage; Celecoxib; Coum	2017
Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid. Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Celecox	2018
Diclofenac but not celecoxib improves endothelial function in rheumatoid arthritis: A study in adjuvant-induced arthritis. Atherosclerosis, 2017, Volume: 266 Topics: Animals; Aorta, Thoracic; Arginase; Arginine; Arthritis, Experimental; Biological Factors; Blood Pre	2017
L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels. BMC musculoskeletal disorders, 2017, Nov-16, Volume: 18, Issue:1 Topics: Animals; Ankle Joint; Arthritis, Experimental; Arthritis, Rheumatoid; Celecoxib; Cell Differentiatio	2017
Preclinical Explorative Assessment of Celecoxib-Based Biocompatible Lipidic Nanocarriers for the Management of CFA-Induced Rheumatoid Arthritis in Wistar Rats. AAPS PharmSciTech, 2018, Volume: 19, Issue:7 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase 2 Inhibitors; Dru	2018
Caffeic acid and ellagic acid ameliorate adjuvant-induced arthritis in rats via targeting inflammatory signals, chitinase-3-like protein-1 and angiogenesis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 110 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Caffeic Acids; Celecoxib; Chitinase-3-Li	2019
Structural efficacy of NSAIDs, COX-2 inhibitor and glucocorticoid compared with TNFα blocker: a study in adjuvant-induced arthritis rats. Rheumatology (Oxford, England), 2019, 06-01, Volume: 58, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Experimental; Cel	2019
Selenium Nanoparticles Dispersed in Phytochemical Exert Anti-Inflammatory Activity by Modulating Catalase, GPx1, and COX-2 Gene Expression in a Rheumatoid Arthritis Rat Model. Medical science monitor : international medical journal of experimental and clinical research, 2019, Feb-05, Volume: 25 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Cat	2019
Multitarget-based cotreatment with cilostazol and celecoxib synergistically suppresses collagen-induced arthritis in mice by enhancing interleukin-10 expression. International immunopharmacology, 2019, Volume: 73 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bone Marrow Cells; Cathep	2019
Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. Inflammopharmacology, 2014, Volume: 22, Issue:5 Topics: Administration, Oral; Angiopoietin-1; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Ex	2014
Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: comparison with celecoxib. Toxicology and applied pharmacology, 2014, Sep-01, Volume: 279, Issue:2 Topics: Administration, Oral; Animals; Apoptosis; Arthritis, Experimental; Caspase 3; Celecoxib; Cyclooxygen	2014
Intra-articular (IA) ropivacaine microparticle suspensions reduce pain, inflammation, cytokine, and substance p levels significantly more than oral or IA celecoxib in a rat model of arthritis. Inflammation, 2015, Volume: 38, Issue:1 Topics: Administration, Oral; Amides; Animals; Arthritis, Experimental; Celecoxib; Cytokines; Inflammation;	2015
A Comparison of the Anti-Inflammatory Effects of Cis-9, Trans-11 Conjugated Linoleic Acid to Celecoxib in the Collagen-Induced Arthritis Model. Lipids, 2017, Volume: 52, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Celecoxib; Dietary Supplements; Gene Exp	2017
Synergistic anti-hyperalgesia of electroacupuncture and low dose of celecoxib in monoarthritic rats: involvement of the cyclooxygenase activity in the spinal cord. Brain research bulletin, 2008, Sep-30, Volume: 77, Issue:2-3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Behavior, Animal; Celecox	2008
Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats. Journal of bone and mineral metabolism, 2008, Volume: 26, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bone Diseases; Celecoxib;	2008
Combination therapies that inhibit cyclooxygenase-2 and leukotriene synthesis prevent disease in murine collagen induced arthritis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009, Volume: 58, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arthritis, Experiment	2009
Characterization and pharmacological evaluation of febrile response on zymosan-induced arthritis in rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:5 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Body Temperature; Celecox	2009
The importance of brain PGE2 inhibition versus paw PGE2 inhibition as a mechanism for the separation of analgesic and antipyretic effects of lornoxicam in rats with paw inflammation. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:5 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cel	2009
Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis. Arthritis research & therapy, 2010, Volume: 12, Issue:3 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Cathepsins; Celecoxib; Cyclooxygenase Inhibi	2010
Pharmacological modulation by celecoxib of cachexia associated with experimental arthritis and atherosclerosis in rabbits. British journal of pharmacology, 2010, Volume: 161, Issue:5 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Atherosclerosis; Cachexia; Celecoxib; Cyclo	2010
Effect of selective COX-2 inhibitor, celecoxib on adjuvant-induced arthritis model in irradiated rats. International journal of radiation biology, 2010, Volume: 86, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Celecoxib; Cyclooxygenase	2010
Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer. BMC cancer, 2011, Aug-22, Volume: 11 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Bone Neoplasms; Celecoxib; Collagen Type	2011
Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice. Arthritis and rheumatism, 2012, Volume: 64, Issue:1 Topics: Administration, Oral; Animals; Arthritis, Experimental; Arthroplasty, Replacement, Knee; Cartilage,	2012
Changing the outcome of osteoarthritis: still a challenge for cyclooxygenase 2 inhibitors. Arthritis and rheumatism, 2012, Volume: 64, Issue:1 Topics: Animals; Arthritis, Experimental; Celecoxib; Cyclooxygenase 2 Inhibitors; Female; Humans; Male; Oste	2012
A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation. Arthritis research & therapy, 2012, Jan-17, Volume: 14, Issue:1 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Celecoxib; Collagen Type II; Cytokines; Endo	2012
Intra-articular delivery of liposomal celecoxib-hyaluronate combination for the treatment of osteoarthritis in rabbit model. International journal of pharmaceutics, 2013, Jan-30, Volume: 441, Issue:1-2 Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Celecoxib; Cyclooxygenase 2 Inhibitors; Gels	2013
Augmented chondroprotective effect of coadministration of celecoxib and rebamipide in the monosodium iodoacetate rat model of osteoarthritis. Archives of pharmacal research, 2013, Volume: 36, Issue:1 Topics: Administration, Oral; Alanine; Animals; Arthritis, Experimental; Behavior, Animal; Cartilage; Celeco	2013
Pharmacology of celecoxib in rat brain after kainate administration. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental;	2002
Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2 Topics: Animals; Arthritis, Experimental; Capillary Permeability; Celecoxib; Cyclooxygenase 1; Cyclooxygenas	2002
Role of endogenous glucocorticoids in hyperalgesia and edema in old arthritic rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2003, Volume: 36, Issue:1 Topics: Adrenalectomy; Age Factors; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal;	2003
Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Celecoxib; Cyclooxygenase 1; Cy	2004
Efficacy of chitosan microspheres for controlled intra-articular delivery of celecoxib in inflamed joints. The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:9 Topics: Animals; Arthritis, Experimental; Celecoxib; Chitosan; Delayed-Action Preparations; Drug Delivery Sy	2004
Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat. European journal of pharmacology, 2005, Apr-25, Volume: 513, Issue:3 Topics: Animals; Arthritis, Experimental; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy	2005
Prostanoids as friends, not foes: further evidence from the interference by cycloxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats. Inflammopharmacology, 2005, Volume: 12, Issue:5-6 Topics: Administration, Oral; Animals; Arthritis, Experimental; Aspirin; Celecoxib; Cyclooxygenase 2; Cycloo	2005
Albumin microspheres as carriers for the antiarthritic drug celecoxib. AAPS PharmSciTech, 2005, Sep-20, Volume: 6, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cattle; Celecoxib; Drug C	2005
Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Arzneimittel-Forschung, 2005, Volume: 55, Issue:11 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Celecoxib; Cyclooxygenase 1; Cy	2005
[Three-dimensional trabecular bone microarchitecture in inflammatory bone destruction]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2006, Volume: 127, Issue:4 Topics: Animals; Arthritis, Experimental; Bone and Bones; Celecoxib; Cyclooxygenase 2 Inhibitors; Imaging, T	2006
Celecoxib prevents juxta-articular osteopenia and growth plate destruction adjacent to inflamed joints in rats with collagen-induced arthritis. Modern rheumatology, 2007, Volume: 17, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bone Density; Bone Diseas	2007
Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. Journal of immunology (Baltimore, Md. : 1950), 2007, Jul-01, Volume: 179, Issue:1 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bon	2007
Enhanced retention of celecoxib-loaded solid lipid nanoparticles after intra-articular administration. Drugs in R&D, 2007, Volume: 8, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biocompatible Materials;	2007
Pharmacological analysis of cyclooxygenase-1 in inflammation. Proceedings of the National Academy of Sciences of the United States of America, 1998, Oct-27, Volume: 95, Issue:22 Topics: Animals; Arthritis, Experimental; Blood Platelets; Carrageenan; Celecoxib; Cyclooxygenase 1; Cycloox	1998
COX-2 inhibitors--is there cause for concern? Nature medicine, 1999, Volume: 5, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Celecoxib; Cyclooxygenase	1999
Cyclooxygenase-1 vs. cyclooxygenase-2 inhibitors in the induction of antinociception in rodent withdrawal reflexes. Neuropharmacology, 2001, Volume: 40, Issue:7 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Celecoxib; Cy	2001

celecoxib and Adjuvant Arthritis

Research Excerpts

Research

Studies (64)

Authors

Clinical Trials (3)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Penning, TD	1
Talley, JJ	3
Bertenshaw, SR	1
Carter, JS	2
Collins, PW	1
Docter, S	1
Graneto, MJ	2
Lee, LF	1
Malecha, JW	1
Miyashiro, JM	1
Rogers, RS	2
Rogier, DJ	1
Yu, SS	1
Burton, EG	1
Cogburn, JN	1
Gregory, SA	1
Koboldt, CM	3
Perkins, WE	2
Seibert, K	5
Veenhuizen, AW	1
Zhang, YY	2
Isakson, PC	4
Black, WC	2
Brideau, C	2
Chan, CC	2
Charleson, S	2
Chauret, N	1
Claveau, D	1
Ethier, D	1
Gordon, R	2
Greig, G	1
Guay, J	1
Hughes, G	2
Jolicoeur, P	1
Leblanc, Y	1
Nicoll-Griffith, D	1
Ouimet, N	1
Riendeau, D	2
Visco, D	1
Wang, Z	4
Xu, L	1
Prasit, P	2
Puig, C	1
Crespo, MI	1
Godessart, N	1
Feixas, J	1
Ibarzo, J	1
Jiménez, JM	1
Soca, L	1
Cardelús, I	1
Heredia, A	1
Miralpeix, M	1
Puig, J	1
Beleta, J	1
Huerta, JM	1
López, M	1
Segarra, V	1
Ryder, H	1
Palacios, JM	1
Brown, DL	1
Masferrer, JL	3
Shaffer, AF	2
Zweifel, BS	2
Inagaki, M	1
Tsuri, T	1
Jyoyama, H	1
Ono, T	1
Yamada, K	1
Kobayashi, M	1
Hori, Y	1
Arimura, A	1
Yasui, K	1
Ohno, K	1
Kakudo, S	1
Koizumi, K	1
Suzuki, R	1
Kawai, S	2
Kato, M	1
Matsumoto, S	1
Portevin, B	1
Tordjman, C	1
Pastoureau, P	1
Bonnet, J	1
Shin, SS	2
Noh, MS	2
Byun, YJ	1
Choi, JK	2
Kim, JY	2
Lim, KM	2
Ha, JY	1
Kim, JK	2
Lee, CH	1
Chung, S	2
Cromlish, W	1
Grimm, EL	1
Leger, S	1
Li, CS	1
Thérien, M	1
Xu, LJ	1
Almansa, C	1
Alfón, J	1
de Arriba, AF	1
Cavalcanti, FL	1
Escamilla, I	1
Gómez, LA	1
Miralles, A	1
Soliva, R	1
Bartrolí, J	1
Carceller, E	1
Merlos, M	1
García-Rafanell, J	1
Byun, Y	1
Lee, KW	1
Moh, JH	1
Jeong, YS	1
Choi, YH	1
Koh, HJ	1
Park, YH	1
Oh, YI	1
Beswick, P	1
Bingham, S	1
Bountra, C	1
Brown, T	1
Browning, K	1
Campbell, I	1
Chessell, I	1
Clayton, N	1
Collins, S	1
Corfield, J	1
Guntrip, S	1
Haslam, C	1
Lambeth, P	1
Lucas, F	1
Mathews, N	1
Murkit, G	1
Naylor, A	1
Pegg, N	1
Pickup, E	1
Player, H	1
Price, H	1
Stevens, A	1
Stratton, S	1
Wiseman, J	1
Kaila, N	1
Janz, K	1
DeBernardo, S	1
Bedard, PW	1
Camphausen, RT	1
Tam, S	2
Tsao, DH	1
Keith, JC	1
Nickerson-Nutter, C	1
Shilling, A	1
Young-Sciame, R	1
Wang, Q	1
McKew, JC	1
Lee, KL	1
Shen, MW	1
Thakker, P	1
Foley, MA	1
Behnke, ML	1
Hu, B	1
Sum, FW	1
Hu, Y	1
Chen, L	2
Kirincich, SJ	1
Michalak, R	1
Thomason, J	1
Ipek, M	1
Wu, K	1
Wooder, L	1
Ramarao, MK	1
Murphy, EA	1
Goodwin, DG	1
Albert, L	1
Xu, X	1
Donahue, F	1
Ku, MS	1
Keith, J	1
Nickerson-Nutter, CL	1
Abraham, WM	1
Williams, C	1
Hegen, M	1
Clark, JD	1
Huang, L	2
Zhang, B	1
Yang, Y	1
Gong, X	1
Chen, Z	1
Zhang, P	1
Zhang, Q	1
Felipe, JL	1
Bonfá, IS	1
Lossavaro, PKMB	1
Lencina, JS	1
B Carvalho, D	1
Candeloro, L	1
Ferreira, GIS	1
das Neves, AR	1
Souza, MIL	1
Silva-Filho, SE	1
Baroni, ACM	1
Toffoli-Kadri, MC	1
El-Gogary, RI	1
Khattab, MA	1
Abd-Allah, H	1
Choi, JS	1
Lee, DH	2
Ahn, JB	1
Sim, S	1
Heo, KS	1
Myung, CS	1
Park, JS	2
Chen, Q	1
Zhu, L	1
Yip, KM	1
Tang, Y	1
Liu, Y	1
Jiang, T	1
Zhang, J	1
Zhao, Z	1
Yi, T	1
Chen, H	1
Na, HS	1
Kwon, JY	1
Lee, SY	2
Lee, SH	1
Lee, AR	1
Woo, JS	1
Jung, K	1
Cho, KH	1
Choi, JW	1
Min, HK	1
Park, SH	2
Kim, SJ	1
Cho, ML	2
Neog, MK	1
Joshua Pragasam, S	1
Krishnan, M	1
Rasool, M	1
Aghazadeh-Habashi, A	1
Asghar, W	1
Jamali, F	1
Verhoeven, F	2
Totoson, P	2
Marie, C	1
Prigent-Tessier, A	1
Wendling, D	2
Tournier-Nappey, M	1
Prati, C	2
Demougeot, C	2
Wu, X	1
Zhong, J	1
Li, D	1
Nirbhavane, P	1
Sharma, G	1
Singh, B	1
Khuller, GK	1
Goni, VG	1
Patil, AB	1
Katare, OP	1
Fikry, EM	1
Gad, AM	1
Eid, AH	1
Arab, HH	2
Bordy, R	1
Ren, SX	1
Zhan, B	1
Lin, Y	1
Ma, DS	1
Yan, H	1
Park, SY	1
Lee, YS	1
Lee, SW	1
Hong, KW	1
Kim, CD	1
El-Sayed, RM	1
Moustafa, YM	1
El-Azab, MF	1
Darwish, HA	1
Abdelsalam, RM	1
Rabinow, B	1
Werling, J	1
Bendele, A	1
Gass, J	1
Bogseth, R	1
Balla, K	1
Valaitis, P	1
Hutchcraft, A	1
Graham, S	1
Olson, JM	1
Haas, AW	1
Lor, J	1
McKee, HS	1
Cook, ME	1
Mi, WL	1
Mao-Ying, QL	1
Liu, Q	1
Wang, XW	1
Wang, YQ	1
Wu, GC	1
Noguchi, M	2
Kimoto, A	3
Sasamata, M	2
Miyata, K	2
Anderson, GD	1
Keys, KL	1
De Ciechi, PA	1
Kanashiro, A	1
Pessini, AC	1
Machado, RR	1
Malvar, Ddo C	1
Aguiar, FA	1
Soares, DM	1
do Vale, ML	1
de Souza, GE	1
Futaki, N	1
Harada, M	1
Sugimoto, M	1
Hashimoto, Y	1
Honma, Y	1
Arai, I	1
Nakaike, S	1
Hoshi, K	1
Peterson, JD	1
Labranche, TP	1
Vasquez, KO	1
Kossodo, S	1
Melton, M	1
Rader, R	1
Listello, JT	1
Abrams, MA	1
Misko, TP	1
Romero, FI	1
Martínez-Calatrava, MJ	1
Sánchez-Pernaute, O	1
Gualillo, O	1
Largo, R	1
Herrero-Beaumont, G	1
El-Ghazaly, MA	2
Nada, AS	1
El-Hazek, RM	1
Khayyal, MT	2
Page, TH	1
Turner, JJ	1
Brown, AC	1
Timms, EM	1
Inglis, JJ	1
Brennan, FM	1
Foxwell, BM	1
Ray, KP	1
Feldmann, M	1
Roy, LD	1
Ghosh, S	1
Pathangey, LB	1
Tinder, TL	1
Gruber, HE	1
Mukherjee, P	1
Fukai, A	1
Kamekura, S	1
Chikazu, D	1
Nakagawa, T	1
Hirata, M	1
Saito, T	1
Hosaka, Y	1
Ikeda, T	1
Nakamura, K	1
Chung, UI	1
Kawaguchi, H	1
Lories, RJ	1
Chiba, A	1
Mizuno, M	1
Tomi, C	1
Tajima, R	1
Alloza, I	1
di Penta, A	1
Yamamura, T	1
Vandenbroeck, K	1
Miyake, S	1
Dong, J	1
Jiang, D	1
Wu, G	1
Miao, L	1
Moon, SJ	1
Jeong, JH	1
Yang, EJ	1
Park, MK	1
Kim, EK	1
Kim, HY	1
Min, JK	1
Ciceri, P	1
Zhang, Y	2
Leahy, KM	1
Woerner, MB	1
Smith, WG	1
Kato, S	1
Ogawa, Y	1
Kanatsu, K	1
Okayama, M	1
Watanabe, T	1
Arakawa, T	1
Takeuchi, K	1
Yokoro, CM	1
Tatsuo, MA	1
Pereira, LS	1
Alves, DL	1
Francischi, JN	1
Fiorucci, S	1
Di Lorenzo, A	1
Renga, B	1
Farneti, S	1
Morelli, A	1
Cirino, G	1
Thakkar, H	3
Sharma, RK	2
Mishra, AK	2
Chuttani, K	2
Murthy, RS	2
Kobayashi, S	1
Yoshino, T	1
Whitehouse, MW	1
Murthy, RR	1
Abdallah, DM	1
Okpanyi, SN	1
Kelber, O	1
Weiser, D	1
Tsuboi, H	1
Nampei, A	1
Matsui, Y	1
Hashimoto, J	1
Ochi, T	1
Yoshikawa, H	1
Niki, Y	1
Takaishi, H	1
Takito, J	1
Miyamoto, T	1
Kosaki, N	1
Matsumoto, H	1
Toyama, Y	1
Tada, N	1
Kumar Sharma, R	1
Lipsky, PE	1
Smith, CJ	1
Muhammad, J	1
Shaffer, A	1
Lefkowith, J	1
Tripp, C	1
Isakson, P	1
Needleman, P	1
Mazario, J	1
Gaitan, G	1
Herrero, JF	1