Page last updated: 2024-10-24

celecoxib and Acute Pain

celecoxib has been researched along with Acute Pain in 7 studies

Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.

Research Excerpts

ExcerptRelevanceReference
"Celecoxib is a selective cyclo-oxygenase-2 (COX-2) inhibitor usually prescribed for the relief of chronic pain in osteoarthritis and rheumatoid arthritis."6.49Single dose oral celecoxib for acute postoperative pain in adults. ( Derry, S; Moore, RA, 2013)
"Celecoxib is a selective cyclo-oxygenase-2 (COX-2) inhibitor usually prescribed for the relief of chronic pain in osteoarthritis and rheumatoid arthritis."6.48Single dose oral celecoxib for acute postoperative pain in adults. ( Derry, S; Moore, RA, 2012)
"Celecoxib (CXB) has a good analgesic effect on postoperative acute pain, but clinically its compliance is compromised because of frequent administration."4.31Comparison of in vivo behaviors of intramuscularly long-acting celecoxib nanosuspensions with different particle sizes for the postoperative pain treatment. ( Fu, Q; He, Z; Li, M; Qin, M; Sui, X; Sun, Y; Xin, J; Ye, G, 2023)
" Although superiority to tramadol was not reached, CTC 200 mg BID exposed patients to lower cumulative opioid (tramadol) doses than tramadol (100 mg QID) alone, with fewer treatment-emergent adverse events."3.11Efficacy and safety of co-crystal of tramadol-celecoxib (CTC) in acute moderate-to-severe pain after abdominal hysterectomy: A randomized, double-blind, phase 3 trial (STARDOM2). ( Adeyemi, S; But-Husaim, L; Cebrecos, J; Fettiplace, J; Gascón, N; Langford, R; Morte, A; Ortiz, E; Plata-Salamán, C; Raba, G; Sust, M; Vaqué, A, 2022)
"Celecoxib is a selective cyclo-oxygenase-2 (COX-2) inhibitor usually prescribed for the relief of chronic pain in osteoarthritis and rheumatoid arthritis."2.49Single dose oral celecoxib for acute postoperative pain in adults. ( Derry, S; Moore, RA, 2013)
"Celecoxib is a selective cyclo-oxygenase-2 (COX-2) inhibitor usually prescribed for the relief of chronic pain in osteoarthritis and rheumatoid arthritis."2.48Single dose oral celecoxib for acute postoperative pain in adults. ( Derry, S; Moore, RA, 2012)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Langford, R1
Morte, A1
Sust, M1
Cebrecos, J1
Vaqué, A1
Ortiz, E1
Fettiplace, J1
Adeyemi, S1
Raba, G1
But-Husaim, L1
Gascón, N1
Plata-Salamán, C1
Qin, M1
Ye, G1
Xin, J1
Li, M1
Sui, X1
Sun, Y1
Fu, Q1
He, Z1
Derry, S2
Moore, RA2
Altman, R1
Daniels, S1
Young, CL1
Thomazeau, J1
Rouquette, A1
Martinez, V1
Rabuel, C1
Prince, N1
Laplanche, JL1
Nizard, R1
Bergmann, JF1
Perrot, S1
Lloret-Linares, C1
Onda, A1
Ogoshi, A1
Itoh, M1
Nakagawa, T1
Kimura, M1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-Blind, Multicenter, Placebo- and Active Comparator-Controlled Study to Evaluate Efficacy and Safety of MR308 in the Treatment of Acute Pain After Abdominal Hysterectomy Surgery Under General Anaesthesia (STARDOM2).[NCT03062644]Phase 31,138 participants (Actual)Interventional2017-04-05Completed
Is There Any Analgesic Benefit From Preoperative vs. Postoperative Etoricoxib Administration in Total Knee Arthroplasty?[NCT02534610]165 participants (Actual)Interventional2014-01-31Completed
Ambulatory Gynecologic Surgery: Finding the Optimal Postoperative Opioid Prescription[NCT03588910]Phase 2120 participants (Actual)Interventional2018-08-08Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Additional Contacts With Provider

By chart review, unscheduled interactions with the healthcare system related to pain will be counted.These will include phone calls related to pain, unscheduled visits to the office or emergency department (NCT03588910)
Timeframe: 1 week post operative

InterventionUnscheduled patient contacts (Number)
Number of Oxycodone Tablets Typically Prescribed1
Half the Number of Oxycodone Tablets Typically Prescribed4

Number of Oxycodone Tablets Used as Reported by Participants 1 Week After Surgery

During the survey phone call on day 7, participants will be asked to report the total number of oxycodone tablets used since the surgery. (NCT03588910)
Timeframe: 7 days post-operative

InterventionOxycodone Tablets (Median)
Number of Oxycodone Tablets Typically Prescribed2.5
Half the Number of Oxycodone Tablets Typically Prescribed2.0

Number of Oxycodone Tablets Used Day 1

During the survey phone call on day 1, participants will be asked to report the total number of oxycodone tablets use since the surgery. (NCT03588910)
Timeframe: 24 hours post-operative

InterventionOxycodone Tablets (Median)
Number of Oxycodone Tablets Typically Prescribed1.0
Half the Number of Oxycodone Tablets Typically Prescribed1.0

Self Reported Pain Score on Post Operative Day 1 (Numeric Pain Reporting Score: NRS)

Participants will be surveyed during the phone call survey to rate pain score on a scale from 0 (no pain), to 10 (severe pain) (NCT03588910)
Timeframe: 1 day post operative

InterventionScore on Numeric Pain Scale (Median)
Number of Oxycodone Tablets Typically Prescribed5.0
Half the Number of Oxycodone Tablets Typically Prescribed5

Self Reported Pain Score on Post Operative Day 7 (Numeric Pain Reporting Score: NRS)

Participants will be surveyed during the phone call survey to rate pain score on a scale from 0 (no pain), to 10 (severe pain) (NCT03588910)
Timeframe: 7 days post operative

InterventionScore on Numeric Pain Scale (Median)
Number of Oxycodone Tablets Typically Prescribed2.0
Half the Number of Oxycodone Tablets Typically Prescribed1.3

Reviews

2 reviews available for celecoxib and Acute Pain

ArticleYear
Single dose oral celecoxib for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2013, Oct-22, Issue:10

    Topics: Acute Pain; Administration, Oral; Adult; Celecoxib; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhi

2013
Single dose oral celecoxib for acute postoperative pain in adults.
    The Cochrane database of systematic reviews, 2012, Mar-14, Issue:3

    Topics: Acute Pain; Administration, Oral; Celecoxib; Cyclooxygenase 2 Inhibitors; Humans; Pain, Postoperativ

2012

Trials

3 trials available for celecoxib and Acute Pain

ArticleYear
Efficacy and safety of co-crystal of tramadol-celecoxib (CTC) in acute moderate-to-severe pain after abdominal hysterectomy: A randomized, double-blind, phase 3 trial (STARDOM2).
    European journal of pain (London, England), 2022, Volume: 26, Issue:10

    Topics: Acute Pain; Analgesics, Opioid; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Co

2022
Indomethacin submicron particle capsules provide effective pain relief in patients with acute pain: a phase 3 study.
    The Physician and sportsmedicine, 2013, Volume: 41, Issue:4

    Topics: Acute Pain; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Celecoxib; C

2013
Comparison of the effects of treatment with celecoxib, loxoprofen, and acetaminophen on postoperative acute pain after arthroscopic knee surgery: A randomized, parallel-group trial.
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2016, Volume: 21, Issue:2

    Topics: Acetaminophen; Acute Pain; Adult; Analgesics, Non-Narcotic; Anterior Cruciate Ligament Injuries; Ant

2016

Other Studies

2 other studies available for celecoxib and Acute Pain

ArticleYear
Comparison of in vivo behaviors of intramuscularly long-acting celecoxib nanosuspensions with different particle sizes for the postoperative pain treatment.
    International journal of pharmaceutics, 2023, Apr-05, Volume: 636

    Topics: Acute Pain; Analgesics; Animals; Celecoxib; Nanoparticles; Pain, Postoperative; Particle Size; Rats

2023
Acute pain Factors predictive of post-operative pain and opioid requirement in multimodal analgesia following knee replacement.
    European journal of pain (London, England), 2016, Volume: 20, Issue:5

    Topics: Acute Pain; Aged; Amides; Analgesics; Analgesics, Opioid; Anesthetics, Local; Anxiety; Arthroplasty,

2016