celastrol has been researched along with Prostatic Neoplasms in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 19 (73.08) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Bodle, CR; Doorn, JA; Hayes, MP; Henry, MD; Houtman, JCD; James, MA; Mackie, DI; Miller, MR; Roman, DL; Schamp, JH | 1 |
| Chen, J; Gao, X; Guo, H; Hu, R; Huang, S; Li, Z; Liang, L; Liu, Z; Qiu, X; Tan, Q; Wang, Y; Wu, D; Zhou, B | 1 |
| Dai, S; Fu, K; Gong, L; Li, Y; Ma, C; Peng, C; Wang, C; Zhang, Y; Zhao, X | 1 |
| Hou, Y; Song, X; Wang, P; Yin, J; Yin, Y | 1 |
| Bai, Y; Cai, Y; Castro, P; Dakhov, O; Ji, H; Shao, L; Shen, W; Shi, P; Wang, J; Zhou, Z | 1 |
| Chen, Y; Liu, C; Qu, D; Yuan, L; Zhang, Z; Zhou, L | 1 |
| Boom, K; Borsoi, C; Celia, C; Ferrari, M; Fresta, M; Huang, Y; Molinaro, R; Paolino, D; Scott, B; Shen, H; Suri, K; Wang, J; Wolfram, J | 1 |
| Chang, PL; Chen, WT; Chiang, KC; Chung, LC; Juang, HH; Tsui, KH; Yeh, CN | 1 |
| Brigolin, C; Deeb, D; Gao, X; Gautam, SC; Liu, YB; Pindolia, K; Shaw, J; Zhang, Y | 1 |
| Guo, Y; He, P; Huang, S; Li, J; Li, S; Peng, X; Tang, Y; Wa, Q; Xu, D; Zhang, X; Zuo, J | 1 |
| Chen, X; Deng, Y; Ji, N; Jin, H; Kong, F; Li, J; Li, Y; Wei, Z | 1 |
| Deeb, D; Gao, X; Gautam, SC; Liu, YB; Pindolia, K | 1 |
| He, P; Huang, S; Li, J; Peng, X; Tang, Y; Xu, D | 1 |
| Guo, J; Huang, X; Wang, H; Yang, H | 1 |
| Cao, F; Cao, L; Peng, B; Shen, Y; Uzan, G; Wang, Y; Yang, C; Zhang, D; Zhang, X | 1 |
| Chamcheu, JC; Mukhtar, H; Pala, N; Sanna, V; Sechi, M; Siddiqui, IA | 1 |
| Kim, JS; Lee, HJ; Lee, MS; Lee, SO | 1 |
| Huang, S; Kuchta, K; Li, J; Lin, Z; Pan, T; Peng, X; Tang, Y; Wang, X; Xiang, Y; Xu, J; Zhu, Y | 1 |
| Dou, QP; Murthy, S; Reddy, GP; Sarkar, FH; Sheng, S; Yang, H | 1 |
| Dai, Y; DeSano, JT; Ji, Q; Lawrence, TS; Ljungman, M; Meng, Y; Xu, L | 1 |
| Aggarwal, BB; Liu, M; Lu, B; Pang, X; Qu, W; Sung, B; Yi, Z; Zhang, J | 1 |
| Burstein, E; Dai, Y; Desano, J; Lawrence, TS; Meng, X; Meng, Y; Tang, W; Xu, L | 1 |
| Bevan, CL; Cano, LQ; Lavery, DN | 1 |
| Chen, D; Cui, QC; Dou, QP; Yang, H; Yuan, X | 1 |
| Chiosis, G; Clardy, J; Clement, C; Du, J; Golub, TR; Hahn, WC; Hieronymus, H; Lamb, J; Maloney, KN; Nieto, M; Peng, XP; Raj, SM; Rodina, A; Ross, KN; Stegmaier, K | 1 |
| Dou, QP; Landis-Piwowar, KR; Li, L; Lu, D; Reddy, GP; Yang, H; Yuan, P; Yuan, X | 1 |
2 review(s) available for celastrol and Prostatic Neoplasms
| Article | Year |
|---|---|
Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Male; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; Signal Transduction; Triterpenes | 2023 |
Mini-review: Foldosome regulation of androgen receptor action in prostate cancer.
Topics: Binding Sites; Cell Nucleus; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Intramolecular Oxidoreductases; Male; Models, Biological; Molecular Chaperones; Pentacyclic Triterpenes; Prostaglandin-E Synthases; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Triterpenes | 2013 |
24 other study(ies) available for celastrol and Prostatic Neoplasms
| Article | Year |
|---|---|
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.
Topics: Benzophenanthridines; Biological Products; Cytostatic Agents; Cytotoxins; GTP-Binding Protein Regulators; Humans; Isoquinolines; Lung Neoplasms; Male; Molecular Structure; Pentacyclic Triterpenes; Prostatic Neoplasms; Triterpenes | 2017 |
Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors.
Topics: Animals; DNA; Humans; Ligases; Male; Mice; Pentacyclic Triterpenes; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Protein Isoforms; Receptors, Androgen; Receptors, Glucocorticoid; Ubiquitin-Protein Ligases; Ubiquitins | 2022 |
Optimization on biodistribution and antitumor activity of tripterine using polymeric nanoparticles through RES saturation.
Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Male; Mice; Mice, Inbred BALB C; Mononuclear Phagocyte System; Nanoparticles; Particle Size; Pentacyclic Triterpenes; Polymers; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Tissue Distribution; Triterpenes | 2017 |
Celastrol suppresses tumor cell growth through targeting an AR-ERG-NF-κB pathway in TMPRSS2/ERG fusion gene expressing prostate cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Oncogene Proteins, Fusion; Pentacyclic Triterpenes; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Trans-Activators; Transcription Factor RelA; Transcriptional Regulator ERG; Triterpenes | 2013 |
Antitumor activity of tripterine via cell-penetrating peptide-coated nanostructured lipid carriers in a prostate cancer model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell-Penetrating Peptides; Drug Carriers; Humans; In Situ Nick-End Labeling; Interleukin-6; Lipids; Male; Mice; Mice, Inbred C57BL; Nanostructures; Pentacyclic Triterpenes; Prostatic Neoplasms; Triterpenes; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2013 |
Evaluation of anticancer activity of celastrol liposomes in prostate cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Liposomes; Male; Pentacyclic Triterpenes; Prostate; Prostatic Neoplasms; Tripterygium; Triterpenes | 2014 |
Celastrol blocks interleukin-6 gene expression via downregulation of NF-κB in prostate carcinoma cells.
Topics: Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Male; Neoplasm Proteins; NF-kappa B; Pentacyclic Triterpenes; Prostatic Neoplasms; Triterpenes | 2014 |
Ubiquitin-proteasomal degradation of antiapoptotic survivin facilitates induction of apoptosis in prostate cancer cells by pristimerin.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Male; Pentacyclic Triterpenes; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Survivin; Triterpenes; Ubiquitin | 2014 |
Inhibitory action of pristimerin on hypoxia‑mediated metastasis involves stem cell characteristics and EMT in PC-3 prostate cancer cells.
Topics: Antineoplastic Agents; Argonaute Proteins; Bone Neoplasms; Cadherins; Cell Hypoxia; Cell Proliferation; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Fibronectins; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Hyaluronan Receptors; Hypoxia-Inducible Factor 1, alpha Subunit; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Male; Neoplasm Invasiveness; Neoplastic Stem Cells; Octamer Transcription Factor-3; Pentacyclic Triterpenes; Prostatic Neoplasms; Spheroids, Cellular; Transcription Factors; Triterpenes; Tumor Cells, Cultured; Vimentin; Zinc Finger E-box-Binding Homeobox 1 | 2015 |
Effect of celastrol on growth inhibition of prostate cancer cells through the regulation of hERG channel in vitro.
Topics: Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Proteins; Pentacyclic Triterpenes; Prostatic Neoplasms; Triterpenes | 2015 |
Role of telomerase in anticancer activity of pristimerin in prostate cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Male; Pentacyclic Triterpenes; Phosphorylation; Prostatic Neoplasms; RNA Interference; RNA, Messenger; Signal Transduction; Telomerase; Transcription, Genetic; Transfection; Triterpenes | 2015 |
Pristimerin Inhibits Prostate Cancer Bone Metastasis by Targeting PC-3 Stem Cell Characteristics and VEGF-Induced Vasculogenesis of BM-EPCs.
Topics: AC133 Antigen; Aged; Animals; Antigens, CD; Bone Marrow Cells; Bone Neoplasms; Cell Line, Tumor; Endothelial Cells; Glycoproteins; Humans; Hyaluronan Receptors; Male; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Middle Aged; Neoplastic Stem Cells; Neovascularization, Pathologic; Nitric Oxide Synthase Type III; Pentacyclic Triterpenes; Peptides; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Triterpenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
Celastrol Induces Autophagy by Targeting AR/miR-101 in Prostate Cancer Cells.
Topics: Autophagy; Cell Line, Tumor; Drug Delivery Systems; Gene Expression Regulation, Neoplastic; Humans; Male; MicroRNAs; Neoplasm Proteins; Pentacyclic Triterpenes; Prostatic Neoplasms; Receptors, Androgen; RNA, Neoplasm; Triterpenes | 2015 |
Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol.
Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MCF-7 Cells; MicroRNAs; NF-kappa B; Pentacyclic Triterpenes; Prostatic Neoplasms; Signal Transduction; Triterpenes | 2015 |
Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment.
Topics: Apoptosis; Calorimetry, Differential Scanning; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Endocytosis; Humans; Male; Microscopy, Confocal; Nanoparticles; Neovascularization, Pathologic; Particle Size; Pentacyclic Triterpenes; Prostatic Neoplasms; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity; Triterpenes | 2015 |
Anti-cancer effect of pristimerin by inhibition of HIF-1α involves the SPHK-1 pathway in hypoxic prostate cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Pentacyclic Triterpenes; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Signal Transduction; Triterpenes | 2016 |
Celastrol, an active constituent of the TCM plant Tripterygium wilfordii Hook.f., inhibits prostate cancer bone metastasis.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Male; Medicine, Chinese Traditional; Neoplasm Invasiveness; Neoplasm Metastasis; Pentacyclic Triterpenes; Prostatic Neoplasms; Triterpenes; Vascular Endothelial Growth Factor A | 2017 |
Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells.
Topics: Apoptosis; Calmodulin; Calpain; Cell Line, Tumor; Cell-Free System; Cytosol; Gene Expression Regulation, Neoplastic; Herpes Simplex Virus Protein Vmw65; Humans; Male; Molecular Weight; Pentacyclic Triterpenes; Peptide Fragments; Prostatic Neoplasms; Protease Inhibitors; Protein Binding; Protein Processing, Post-Translational; Receptors, Androgen; Triterpenes | 2008 |
Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer.
Topics: Animals; Apoptosis; Caspase 3; Cell Line, Tumor; DNA Damage; Dose-Response Relationship, Radiation; Enzyme Activation; Female; Flow Cytometry; Histones; Humans; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Pentacyclic Triterpenes; Prostatic Neoplasms; Radiation-Sensitizing Agents; Random Allocation; Triterpenes; Xenograft Model Antitumor Assays | 2009 |
Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Growth Processes; Cell Line, Tumor; Chemotaxis; Endothelial Cells; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Pentacyclic Triterpenes; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Specific Pathogen-Free Organisms; TOR Serine-Threonine Kinases; Triterpenes; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2010 |
Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB.
Topics: Androgens; Animals; Apoptosis; Cell Line, Tumor; Disease Progression; Enzyme Inhibitors; Female; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; NF-kappa B; Pentacyclic Triterpenes; Prostatic Neoplasms; Protease Inhibitors; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Triterpenes | 2010 |
Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.
Topics: Androgen Receptor Antagonists; Animals; Apoptosis; Cell Growth Processes; Cell Line, Tumor; Chymotrypsin; Diterpenes; Diterpenes, Kaurane; Humans; Male; Mice; Mice, Nude; Pentacyclic Triterpenes; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rabbits; Receptors, Androgen; Tripterygium; Triterpenes; Xenograft Model Antitumor Assays | 2006 |
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Biomarkers, Tumor; Cell Culture Techniques; Cell Line; Cell Line, Tumor; Cell Survival; ErbB Receptors; fms-Like Tyrosine Kinase 3; Fusion Proteins, bcr-abl; Gene Expression; Gene Expression Profiling; Genome, Human; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Lactams, Macrocyclic; Limonins; Male; Metribolone; Pentacyclic Triterpenes; Prostatic Neoplasms; Receptors, Androgen; Reproducibility of Results; RNA, Messenger; Triterpenes | 2006 |
Pristimerin induces apoptosis by targeting the proteasome in prostate cancer cells.
Topics: Androgens; Animals; Apoptosis; Cell Extracts; Cell Line, Tumor; Computational Biology; Electrons; Humans; Kinetics; Male; Models, Molecular; Molecular Structure; Pentacyclic Triterpenes; Prostatic Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Subunits; Rabbits; Receptors, Androgen; Serine Endopeptidases; Triterpenes | 2008 |