celastrol has been researched along with Obesity in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 16 (51.61) | 24.3611 |
| 2020's | 15 (48.39) | 2.80 |
| Authors | Studies |
|---|---|
| Cowley, MA; De Angelis, M; Dodd, GT; Geerlof, A; Kyriakou, E; Lenhart, D; Messias, AC; Pfluger, PT; Pfuhlmann, K; Plettenburg, O; Sattler, M; Schmidt, S; Schramm, KW; Schriever, SC; Simonds, SE; Tiganis, T; Tschöp, MH | 1 |
| Chang, YH; Hung, HY | 1 |
| Afrin, S; Cao, J; Chau, D; Cheng, B; Dong, Y; Gao, Y; He, Z; Hu, L; Huang, Y; Hwang, ES; Kabahizi, A; Lieu, L; Okolo, J; Wallace, B; Williams, KW; Yao, T | 1 |
| Guo, B; Hu, Z; Liu, J; Qin, L; Su, Z; Wang, B; Yang, X; Zhang, C; Zhang, W; Zhao, M; Zheng, R | 1 |
| Fan, N; Huang, M; Li, D; Luo, D; Ngo, FY; Rong, J; Wang, Y; Zhang, X; Zhao, J; Zhao, W | 1 |
| Abu Bakar, MH; Karunakaran, T; Mohamad Khalid, MSF; Mohamad Rosdi, MN; Mohammad, S; Mohd Salleh, R; Nor Shahril, NS; Shariff, KA | 1 |
| Cifre, M; Oliver, P; Palou, A; Reynés, B | 1 |
| Bian, J; Ding, Y; Jiang, Y; Shao, Y; Si, L; Wang, M; Wang, S; Wei, K; Zhao, X | 1 |
| Feng, Y; Gu, H; Huang, Q; Li, J; Sun, J; Wang, D; Wu, Y; Xian, J; Zhang, C; Zhang, J; Zhong, X | 1 |
| Lin, M; Wang, M; Wang, Z; Wei, P | 1 |
| Liu, YC; Qin, SC; Xue, JL; Zhang, Y | 1 |
| Fan, N; Luo, D; Nie, H; Rong, J; Wang, Y; Zhang, Z; Zhao, J | 1 |
| Auen, T; Choi, JW; Copps, KD; Faruk, F; Feng, X; Guan, D; Ozcan, U; Salazar-Hernandez, MA | 1 |
| Dong, T; Du, G; Guan, Q; Hu, W; Song, L; Wang, L; Wang, X; Xia, Y | 1 |
| Abu Bakar, MH; Lee, LK; Shariff, KA; Tan, JS | 1 |
| Chen, G; Fang, K; Li, J; Li, L; Lu, F; Luo, J; Lynch, EC; Wu, F; Xie, L; Xu, L; Yang, X; Zhao, Y; Zou, X | 1 |
| Feng, Y; He, W; Li, X; Xu, S; Xu, W; Yang, H | 1 |
| Chi, H; Li, J; Lin, N; Liu, Y; Meng, Y; Tian, C; Wang, J; Yang, J; Zhu, C; Zhu, Y | 1 |
| Cheng, Y; Guo, Y; Luo, D; Rong, J; Wang, Y; Zhao, J | 1 |
| Baumann, P; Clemmensen, C; Contreras, RE; Cowley, MA; De Angelis, M; Harrison, L; Jastroch, M; Kabra, DG; Kyriakou, E; Mazibuko-Mbeje, SE; Messias, AC; Pfluger, PT; Pfuhlmann, K; Sattler, M; Schramm, KW; Schriever, SC; Simonds, SE; Tiganis, T; Tschöp, MH; Woods, SC | 1 |
| Bo, P; Fang, P; He, B; Shi, M; Yu, M; Zhang, Z; Zhu, Y | 1 |
| Baur, JA; Chellappa, K; Naidoo, N; Perron, IJ | 1 |
| Auen, T; Choi, JW; Chun, H; Copps, KD; Faruk, F; Feng, X; Guan, D; Herbert, Z; Kaplun, E; Lee, J; Ozcan, U; Salazar Hernández, MA | 1 |
| Berglund, ED; Cui, H; Davis, KC; Grobe, JL; Jiang, J; Morgan, DA; Rahmouni, K; Saito, K; Singh, U; Toth, BA | 1 |
| Shi, C; Sun, H; Wang, C; Yang, M; Yang, X | 1 |
| Lee, J; Liu, J; Mazitschek, R; Ozcan, U; Salazar Hernandez, MA | 1 |
| Alberobello, AT; Bagattin, A; Finkel, T; Gavrilova, O; Liu, J; Ma, X; Mueller, E; Skarulis, M; Xu, L | 1 |
| Aragonès, G; Ardid-Ruiz, A; Bladé, C; Ibars, M; Suárez, M | 1 |
| Leibel, R; Tortoriello, DV; Weisberg, S | 1 |
| Choi, JW; Feng, X; Ibi, D; Lee, J; Liu, J; Mucka, P; Ozcan, U; Salazar Hernández, MA | 1 |
| Chang, Y; Fang, F; Gao, M; Geng, C; Li, M; Liu, X; Zhang, Y | 1 |
4 review(s) available for celastrol and Obesity
| Article | Year |
|---|---|
Recent advances in natural anti-obesity compounds and derivatives based on in vivo evidence: A mini-review.
Topics: Animals; Anti-Obesity Agents; Drug Discovery; Obesity; Phytochemicals | 2022 |
[Research progress of celastrol on the prevention and treatment of metabolic associated fatty liver disease].
Topics: Humans; Liver; Non-alcoholic Fatty Liver Disease; Obesity; Pentacyclic Triterpenes | 2023 |
Celastrol in metabolic diseases: Progress and application prospects.
Topics: Animals; Diabetes Mellitus, Type 2; Energy Metabolism; Humans; Inflammation; Insulin Resistance; Lipid Metabolism; Metabolic Diseases; Obesity; Pentacyclic Triterpenes; Tripterygium | 2021 |
Modulation of leptin resistance by food compounds.
Topics: Agouti-Related Protein; Animals; Blood-Brain Barrier; Caffeine; Eating; Food; Hypothalamus; Leptin; Low Density Lipoprotein Receptor-Related Protein-2; Neurons; Neuropeptide Y; Obesity; Pentacyclic Triterpenes; Pro-Opiomelanocortin; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptors, Leptin; Resveratrol; Saponins; Stilbenes; Taurine; Triterpenes | 2016 |
27 other study(ies) available for celastrol and Obesity
| Article | Year |
|---|---|
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Topics: Allosteric Site; Animals; Anti-Obesity Agents; Catalytic Domain; Diet, High-Fat; Hypothalamus; Magnetic Resonance Spectroscopy; Male; Mice, Transgenic; Obesity; Pentacyclic Triterpenes; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Structure-Activity Relationship; Triterpenes; Weight Loss | 2018 |
PERK in POMC neurons connects celastrol with metabolism.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Diet, High-Fat; Eating; eIF-2 Kinase; Endoplasmic Reticulum Stress; Energy Metabolism; Glucose; Insulin Resistance; Leptin; Male; Mice; Mice, Knockout; Neurons; Obesity; Pentacyclic Triterpenes; Pro-Opiomelanocortin | 2021 |
Celastrol prevents high-fat diet-induced obesity by promoting white adipose tissue browning.
Topics: Adipose Tissue, White; Analysis of Variance; Animals; Diet, High-Fat; Disease Models, Animal; Maillard Reaction; Mice; Mice, Knockout; Obesity; Pentacyclic Triterpenes | 2021 |
Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Inflammation; Insulin Resistance; Lipid Metabolism; Liver; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Pentacyclic Triterpenes; RAW 264.7 Cells | 2022 |
Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex.
Topics: Animals; Diet, High-Fat; Glucose; Insulin Resistance; Male; Mice; Muscle, Skeletal; Obesity; Oxidative Stress; Pentacyclic Triterpenes; Pyruvate Dehydrogenase Complex; Up-Regulation | 2022 |
Perinatal Treatment with Leptin, but Not Celastrol, Protects from Metabolically Obese, Normal-Weight Phenotype in Rats.
Topics: Animals; Body Weight; Diet, High-Fat; Dietary Fats; Female; Insulin; Leptin; Obesity; Pentacyclic Triterpenes; Phenotype; Pregnancy; Rats | 2022 |
Celastrol confers ferroptosis resistance via AKT/GSK3β signaling in high-fat diet-induced cardiac injury.
Topics: Animals; Cardiomyopathies; Diet, High-Fat; Ferroptosis; Glycogen Synthase Kinase 3 beta; Heart Injuries; Mice; Obesity; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species | 2023 |
N-Trimethylated chitosan coating white adipose tissue vascular-targeting oral nano-system for the enhanced anti-obesity effects of celastrol.
Topics: Adipose Tissue, White; Animals; Caco-2 Cells; Chitosan; Humans; Mice; Nanoparticles; Obesity | 2023 |
Tripterine Serves a Dual Role in Palmitate-Induced Pancreatic Beta-Cell Lipotoxicity.
Topics: Apoptosis; Diabetes Mellitus; Humans; Obesity; Palmitates; Pentacyclic Triterpenes; Reactive Oxygen Species | 2023 |
Celastrol-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Ethylene Glycols; Gastrointestinal Tract; Inflammation; Insulin Resistance; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Obesity; Particle Size; Pentacyclic Triterpenes; Polyesters; Triterpenes | 2019 |
Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight.
Topics: Animals; Anti-Obesity Agents; Body Weight; Eating; Female; Gene Expression; Lipocalin-2; Male; Mice, Inbred C57BL; Obesity; Pentacyclic Triterpenes; Triterpenes; Weight Loss | 2019 |
Effects of Microbiota on the Treatment of Obesity with the Natural Product Celastrol in Rats.
Topics: Animals; Biological Products; Male; Mice; Microbiota; Obesity; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; RNA, Ribosomal, 16S | 2020 |
Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Inflammation Mediators; Insulin Resistance; Macrophage Activation; Macrophages; Male; Mitochondria, Muscle; Muscle, Skeletal; Obesity; Organelle Biogenesis; Panniculitis; Pentacyclic Triterpenes; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1 | 2020 |
Celastrol alleviates metabolic disturbance in high-fat diet-induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Cytokines; Diet, High-Fat; Dyslipidemias; Energy Metabolism; Glucose Intolerance; Inflammasomes; Inflammation; Insulin Resistance; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Pentacyclic Triterpenes; Thermogenesis; Triterpenes; Weight Gain | 2021 |
Celastrol alleviates comorbid obesity and depression by directly binding amygdala HnRNPA1 in a mouse model.
Topics: Amygdala; Animals; Comorbidity; Depression; Disease Models, Animal; Heterogeneous Nuclear Ribonucleoprotein A1; Mice; Obesity; Pentacyclic Triterpenes | 2021 |
Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways.
Topics: Animals; Anti-Inflammatory Agents; Diet, High-Fat; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Obesity; Pentacyclic Triterpenes; RAW 264.7 Cells; Signal Transduction; Triterpenes | 2017 |
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.
Topics: Animals; Diet, High-Fat; Eating; Energy Metabolism; Mice, Knockout; Obesity; Pentacyclic Triterpenes; Plant Extracts; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Triterpenes; Uncoupling Protein 1; Weight Loss | 2018 |
Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose consumption.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cyclic AMP Response Element-Binding Protein; Diet, High-Fat; Eating; Galanin; Gene Expression Regulation; Glucose; Glucose Tolerance Test; Glucose Transporter Type 4; Hypoglycemic Agents; Hypothalamus; Male; Mice; Mice, Inbred C57BL; Obesity; p38 Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Proto-Oncogene Proteins c-akt; Receptors, Galanin; Signal Transduction; Triterpenes | 2019 |
The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Circadian Rhythm; Eating; Energy Metabolism; Glucose Tolerance Test; Injections, Intraperitoneal; Leptin; Male; Mice; Obesity; Pentacyclic Triterpenes; Triterpenes; Weight Loss | 2019 |
IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects.
Topics: Animals; Anti-Obesity Agents; Diet; HEK293 Cells; Humans; Interleukin 1 Receptor Antagonist Protein; Leptin; Male; Mice, Inbred C57BL; Mice, Knockout; Obesity; Pentacyclic Triterpenes; Receptors, Interleukin-1 Type I; Triterpenes | 2019 |
Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions.
Topics: Adipose Tissue, Brown; Animals; Arterial Pressure; Basal Metabolism; Body Weight; Cytokines; Diet, High-Fat; Disease Models, Animal; Eating; Endoplasmic Reticulum Stress; Energy Metabolism; Inflammation; Kidney; Mice; Mice, Knockout; Obesity; Pentacyclic Triterpenes; Receptor, Melanocortin, Type 4; Receptors, Leptin; Sympathetic Nervous System; Triterpenes; Weight Loss | 2019 |
Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism.
Topics: Animals; Antioxidants; Apolipoprotein A-I; Apolipoproteins B; ATP Binding Cassette Transporter 1; Diet, High-Fat; Lipid Metabolism; Lipoproteins, HDL; Lipoproteins, LDL; Male; Malondialdehyde; NADP; Obesity; Oxidative Stress; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Triglycerides; Triterpenes | 2014 |
Treatment of obesity with celastrol.
Topics: Animals; Anti-Obesity Agents; Energy Metabolism; Gene Expression Profiling; Glucose; Hypothalamus; Leptin; Mice; Obesity; Pentacyclic Triterpenes; Plant Extracts; Tripterygium; Triterpenes | 2015 |
Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Cells, Cultured; Diet, High-Fat; DNA-Binding Proteins; Energy Metabolism; Fatty Liver; Female; Heat Shock Transcription Factors; Humans; Liver; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Pentacyclic Triterpenes; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Promoter Regions, Genetic; Thermogenesis; Transcription Factors; Triglycerides; Triterpenes | 2015 |
Proteasome inhibitors, including curcumin, improve pancreatic β-cell function and insulin sensitivity in diabetic mice.
Topics: 3T3-L1 Cells; Animals; Body Composition; Cell Survival; Curcumin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Supplements; Glycated Hemoglobin; Homeostasis; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Obesity; Oligopeptides; Pentacyclic Triterpenes; Polyphenols; Proteasome Inhibitors; Receptors, Leptin; Triterpenes | 2016 |
Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Type 2; Diet, High-Fat; Fatty Liver; Fluorescent Antibody Technique; Glucose Tolerance Test; Hypothalamus; Immunohistochemistry; Leptin; Liver; Mice; Mice, Obese; Obesity; Pentacyclic Triterpenes; Real-Time Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; Triterpenes; Withanolides | 2016 |
Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Hepatocytes; Insulin Resistance; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Obesity; Oxidative Stress; Pentacyclic Triterpenes; Sirtuin 1; Triterpenes | 2017 |