Compounds > celastrol
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celastrol and Neoplasms

celastrol has been researched along with Neoplasms in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (7.14)29.6817
2010's26 (61.90)24.3611
2020's13 (30.95)2.80

Authors

AuthorsStudies
Brooks, WH; Chen, L; Daniel, KG; Guida, WC; Lawrence, HR; Lawrence, NJ; Scott, LM; Sebti, SM; Wu, J1
Blagg, BS; Halaweish, F; Hall, JA; Kopel, L; Rice, N; Seedarala, S1
Li, J; Liu, XH; Shi, JB; Tang, WJ; Tong, X; Wang, J1
Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L1
Chen, Y; Shan, WG; Wang, HG; Wang, JW; Wen, YT; Wu, R; Ying, YM; Zhan, ZJ; Zhang, LW1
Alho, DPS; Figueiredo, SAC; Gonçalves, BMF; Leal, AS; Mendes, VIS; Salvador, JAR; Silvestre, SM; Valdeira, AS1
Li, L; Wang, L; Xu, XL; You, QD1
Song, Y; Wang, S; Yang, X; Yu, B; Zhao, M1
Gong, T; Li, M; Li, Y; Lin, Q; Sun, X; Xu, X; Yang, L; Zhang, L; Zhang, Y; Zhang, Z1
Akter, R; Bibi, P; Hassan, SSU; Mubin, S; Najda, A; Rahman, MH; Saeeda, S; Shah, M; Wesołowska, S1
Aoki, S; Balachandran, C; Haribabu, J; Naito, K; Tamura, Y; Tobita, S; Tsuchiya, K; Umezawa, M; Yokoi, K; Yoshihara, T1
Anwar, A; Chen, C; Guo, M; Ji, R; Li, X; Liu, J; Liu, X; Mao, J; Wang, Z; Xiao, Y; Yuan, H; Zheng, H1
Dai, W; Guo, D; Liang, J; Song, X; Zhu, R1
Chen, X; Dai, R; Gao, J; Ma, Y; Wang, T; Wu, S; Xing, J; Zhang, R; Zheng, Z1
Li, J; Liu, Y1
Dai, L; He, GN; Song, J1
Lin, R; Wu, Y; Xie, J; Yu, L; Zhang, X; Zhou, M1
Huang, J; Lai, W; Li, G; Liao, J; Liu, W; Wang, F; Xie, D; Xu, R; Zhang, R; Zhang, Z; Zhou, M1
Ansari, MN; Bajaj, A; Dasgupta, U; Jha, SK; Kumar, S; Medatwal, N; Pal, S; Rana, K; Verma, P1
Dai, S; Hu, F; Liu, X; Meng, T; Tan, Y; Wen, L; Yang, X; Yuan, H; Zhao, Y; Zhu, Y1
Choi, HG; Choi, JY; Gupta, B; Jeong, JH; Jin, SG; Kim, JO; Ramasamy, T; Yong, CS1
Das, SK; Garg, VK; Jaswal, V; Kashyap, D; Sharma, A; Srinivas, R; Tuli, HS; Yadav, P1
Bishayee, A; Kashyap, D; Mukherjee, T; Sak, K; Sharma, A; Tuli, HS1
Beck, R; Buc Calderon, P; Glorieux, C1
Dai, E; Du, H; Song, X; Wang, L; Zhang, Y1
Kapoor, S2
Alves, FR; Ramos, CH; Zanphorlin, LM1
Chen, G; Cheng, X; Guan, Y; Han, X; Lin, S; Sun, S; Yu, X; Zhao, M1
Chen, MW; Chen, Y; Cheng, KJ; Jiang, QW; Lv, M; Mei, XL; Qin, WM; Qiu, JG; Shi, Z; Wei, MN; Wei, X; Xue, YQ; Yang, Y; Zhang, WJ; Zhang, X; Zheng, DW1
Arsenian-Henriksson, M; Cosford, ND; Eiseman, J; Holien, T; Hu, A; Lazo, JS; Misund, K; Oliynyk, G; Pendelton, K; Prochownik, EV; Raveendra-Panickar, D; Sundan, A; Teriete, P; Wang, H1
Chen, D; Dou, QP; Landis-Piwowar, KR; Milacic, V; Yang, H1
Ding, WJ; He, QJ; Jin, RJ; Lou, JS; Lu, W; Weng, QJ; Wu, R; Yang, B; Zhu, H1
Dou, QP; Liu, J; Yang, H1
Jin, MM; Kang, S; Kim, JY; Park, S; Veach, AJ; Vedvyas, Y; Zarnegar, R1
Kannaiyan, R; Sethi, G; Shanmugam, MK1
Huang, L; Li, Q; Ren, J; Wu, G; Zeng, H; Zhang, R; Zhang, S; Zhang, Z1
Chen, G; Cheng, X; Du, Z; Wang, D; Wang, Y; Xu, Y; Yu, X; Zhang, X; Zhao, M1
Liu, Z; Ma, L; Zhou, GB1
Chen, L; Kannaiyan, R; Kumar, AP; Lam, P; Li, F; Manu, KA; Rajendran, P; Sethi, G; Subramaniam, A1
Tang, D; Tao, X1
Aggarwal, BB; Ahn, KS; Pandey, MK; Sethi, G1

Reviews

14 review(s) available for celastrol and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction

2015
Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.
    European journal of medicinal chemistry, 2017, Dec-15, Volume: 142

    Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Humans; Indolequinones; Neoplasms; Oleanolic Acid; Structure-Activity Relationship; Triterpenes

2017
Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.
    Journal of medicinal chemistry, 2020, 03-12, Volume: 63, Issue:5

    Topics: Animals; Antineoplastic Agents; Autoimmune Diseases; Benzoquinones; Forecasting; HSP90 Heat-Shock Proteins; Humans; Immunosuppressive Agents; Lactams, Macrocyclic; Molecular Chaperones; Neoplasms; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary

2020
Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy.
    Journal of medicinal chemistry, 2022, 02-24, Volume: 65, Issue:4

    Topics: Animals; Antineoplastic Agents; Drug Design; Drug Discovery; Enzyme Inhibitors; Humans; Neoplasms; Protein Tyrosine Phosphatase, Non-Receptor Type 11

2022
Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives.
    Molecules (Basel, Switzerland), 2021, Oct-02, Volume: 26, Issue:19

    Topics: Berberine; Biological Products; Curcumin; Emodin; Genistein; Humans; Neoplasms; Pentacyclic Triterpenes; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy; Resveratrol; Sesquiterpenes; Triterpenes; Ursolic Acid; Vitamin D; Withanolides

2021
A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 162

    Topics: Diterpenes; Epoxy Compounds; Humans; Neoplasms; Phenanthrenes; Triterpenes

2023
Celastrol as a pentacyclic triterpenoid with chemopreventive properties.
    Pharmaceutical patent analyst, 2018, Volume: 7, Issue:4

    Topics: Animals; Antineoplastic Agents; Humans; Neoplasms; Patents as Topic; Pentacyclic Triterpenes; Triterpenes

2018
Molecular targets of celastrol in cancer: Recent trends and advancements.
    Critical reviews in oncology/hematology, 2018, Volume: 128

    Topics: Animals; Antineoplastic Agents; Humans; Molecular Targeted Therapy; Neoplasms; Pentacyclic Triterpenes; Signal Transduction; Triterpenes

2018
Targeting hsp90 family members: A strategy to improve cancer cell death.
    Biochemical pharmacology, 2019, Volume: 164

    Topics: Animals; Antineoplastic Agents; Cell Death; Drug Delivery Systems; HSP90 Heat-Shock Proteins; Humans; Neoplasms; Oxidative Stress; Pentacyclic Triterpenes; Peptide Fragments; Triterpenes

2019
Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.
    Current protein & peptide science, 2008, Volume: 9, Issue:3

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Boronic Acids; Bortezomib; Clinical Trials as Topic; Curcumin; Humans; Neoplasms; Pentacyclic Triterpenes; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Triterpenes; Ubiquitin

2008
Targeting tumor proteasome with traditional Chinese medicine.
    Current drug discovery technologies, 2010, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Benzyl Compounds; Curcumin; Diterpenes; Drug Delivery Systems; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Epoxy Compounds; Humans; Medicine, Chinese Traditional; Molecular Structure; Naphthoquinones; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Phenols; Proteasome Endopeptidase Complex; Signal Transduction; Triterpenes

2010
Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.
    Cancer letters, 2011, Apr-01, Volume: 303, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Humans; Inflammation; Neoplasms; Pentacyclic Triterpenes; Plant Extracts; Plant Roots; Tripterygium; Triterpenes

2011
The main anticancer bullets of the Chinese medicinal herb, thunder god vine.
    Molecules (Basel, Switzerland), 2011, Jun-23, Volume: 16, Issue:6

    Topics: Animals; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Humans; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Signal Transduction; Tripterygium; Triterpenes

2011
[Advances in the study of tumor angiogenesis and anti-angiogenic Chinese herbal drugs].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2003, Volume: 26, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Bufanolides; Drugs, Chinese Herbal; Ginsenosides; Glucans; Humans; Neoplasms; Neovascularization, Pathologic; Pentacyclic Triterpenes; Phytotherapy; Plants, Medicinal; Polysaccharides; Triterpenes

2003

Other Studies

28 other study(ies) available for celastrol and Neoplasms

ArticleYear
Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.
    Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2

    Topics: Antineoplastic Agents, Hormonal; Estramustine; Humans; Models, Molecular; Neoplasms; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Structure-Activity Relationship; Triterpenes

2011
Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery.
    Journal of natural products, 2015, Apr-24, Volume: 78, Issue:4

    Topics: Benzoquinones; Cucurbitaceae; DNA-Binding Proteins; Heat Shock Transcription Factors; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; MCF-7 Cells; Molecular Chaperones; Molecular Structure; Neoplasms; Transcription Factors; Triterpenes

2015
Design and synthesis of celastrol derivatives as anticancer agents.
    European journal of medicinal chemistry, 2015, May-05, Volume: 95

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Neoplasms; Pentacyclic Triterpenes; Structure-Activity Relationship; Telomerase; Triterpenes; Tumor Cells, Cultured

2015
Synthesis of 3- and 29-substituted celastrol derivatives and structure-activity relationship studies of their cytotoxic activities.
    Bioorganic & medicinal chemistry letters, 2017, 08-01, Volume: 27, Issue:15

    Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Design; Drug Screening Assays, Antitumor; Esterification; Humans; Mice, Nude; Neoplasms; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes

2017
Multifunctional Size-Expandable Nanomedicines Enhance Tumor Accumulation and Penetration for Synergistic Chemo-Photothermal Therapy.
    ACS applied materials & interfaces, 2021, Oct-06, Volume: 13, Issue:39

    Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Combined Modality Therapy; Drug Carriers; Drug Liberation; Drug Therapy; Female; Indocyanine Green; Infrared Rays; Male; Mice, Inbred C57BL; Mice, Nude; Nanoparticles; Neoplasms; Pentacyclic Triterpenes; Photosensitizing Agents; Photothermal Therapy; Polymers; Polymethacrylic Acids

2021
Cyclometalated Iridium(III) Complex-Cationic Peptide Hybrids Trigger Paraptosis in Cancer Cells via an Intracellular Ca
    Molecules (Basel, Switzerland), 2021, Nov-21, Volume: 26, Issue:22

    Topics: A549 Cells; Apoptosis; Calcium; Calmodulin; Cell Death; Cell Line, Tumor; Curcumin; Endoplasmic Reticulum; HeLa Cells; Humans; Iridium; Jurkat Cells; K562 Cells; Membrane Potential, Mitochondrial; Mitochondria; Neoplasms; Pentacyclic Triterpenes; Signal Transduction; Triterpenes; U937 Cells

2021
Reverse anti-breast cancer drug resistance effects by a novel two-step assembled nano-celastrol medicine.
    Nanoscale, 2022, Jun-01, Volume: 14, Issue:21

    Topics: Antineoplastic Agents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Nanoparticles; Neoplasms; Pentacyclic Triterpenes

2022
Celastrol Loaded PEGylated Nanographene Oxide for Highly Efficient Synergistic Chemo/Photothermal Therapy.
    Anti-cancer agents in medicinal chemistry, 2023, Volume: 23, Issue:3

    Topics: Animals; Mice; Neoplasms; Oxides; Phototherapy; Photothermal Therapy; Polyethylene Glycols

2023
Dual H
    Small (Weinheim an der Bergstrasse, Germany), 2022, Volume: 18, Issue:37

    Topics: Cell Line, Tumor; Copper; Glucose Oxidase; Humans; Nanoparticles; Neoplasms; Pentacyclic Triterpenes; Theranostic Nanomedicine; Tumor Microenvironment

2022
Self-assembling nanoarchitectonics of size-controllable celastrol nanoparticles for efficient cancer chemotherapy with reduced systemic toxicity.
    Journal of colloid and interface science, 2023, Apr-15, Volume: 636

    Topics: Animals; Mice; Nanoparticles; Neoplasms; Pentacyclic Triterpenes; Triterpenes

2023
Acid-Responsive Macroporous Silica Nanoparticles for Bcl-2-Functional-Converting Peptide Release and Synergism with Celastrol for Enhanced Therapy against Resistant Cancer.
    ACS applied materials & interfaces, 2023, Jun-28, Volume: 15, Issue:25

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Liberation; Mice; Nanoparticles; Neoplasms; Peptides; Silicon Dioxide

2023
A celastrol-based nanodrug with reduced hepatotoxicity for primary and metastatic cancer treatment.
    EBioMedicine, 2023, Volume: 94

    Topics: Apoptosis; Chemical and Drug Induced Liver Injury; Heparin, Low-Molecular-Weight; Humans; Nanoparticles; Neoplasms; P-Selectin; Phosphatidylinositol 3-Kinases; Triterpenes

2023
Hydrogel-mediated delivery of celastrol and doxorubicin induces a synergistic effect on tumor regression via upregulation of ceramides.
    Nanoscale, 2020, Sep-21, Volume: 12, Issue:35

    Topics: Animals; Ceramides; Chromatography, Liquid; Doxorubicin; Hydrogels; Mice; Neoplasms; Pentacyclic Triterpenes; Tandem Mass Spectrometry; Triterpenes; Up-Regulation

2020
Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy.
    Biomaterials, 2018, Volume: 154

    Topics: Animals; Apoptosis; Cell Death; Cell Line, Tumor; Drug Delivery Systems; Drug Liberation; Glycolipids; Hydrogen-Ion Concentration; Mice, Nude; Micelles; Mitochondria; Neoplasms; Onium Compounds; Organophosphorus Compounds; Particle Size; Pentacyclic Triterpenes; Signal Transduction; Static Electricity; Time Factors; Tissue Distribution; Triterpenes; Xenograft Model Antitumor Assays

2018
PEGylated polyaminoacid-capped mesoporous silica nanoparticles for mitochondria-targeted delivery of celastrol in solid tumors.
    Colloids and surfaces. B, Biointerfaces, 2018, May-01, Volume: 165

    Topics: Amino Acids; Animals; Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Drug Delivery Systems; Drug Liberation; Endocytosis; Female; Glutathione Disulfide; Humans; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Nanoparticles; Neoplasms; Pentacyclic Triterpenes; Polyethylene Glycols; Silicon Dioxide; Triterpenes

2018
Mechanism of action of celastrol against rheumatoid arthritis: A network pharmacology analysis.
    International immunopharmacology, 2019, Volume: 74

    Topics: Arthritis, Rheumatoid; Cell Death; Computational Biology; Connective Tissue Diseases; Drug Discovery; Humans; Macrophages; Molecular Docking Simulation; Neoplasms; Organogenesis; Pentacyclic Triterpenes; Pharmacology; Signal Transduction; Th1 Cells; Th2 Cells; Triterpenes

2019
Celastrol and attenuation of tumor growth in systemic malignancies: a clinical perspective.
    Journal of cellular physiology, 2014, Volume: 229, Issue:2

    Topics: Antineoplastic Agents; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Pentacyclic Triterpenes; Triterpenes

2014
The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90kDa heat shock protein Hsp90α, a chaperone implicated in the stabilization of the tumor phenotype.
    Biochimica et biophysica acta, 2014, Volume: 1840, Issue:10

    Topics: Antineoplastic Agents; HSP90 Heat-Shock Proteins; Humans; Mitochondrial Membrane Transport Proteins; Mitochondrial Precursor Protein Import Complex Proteins; Neoplasm Proteins; Neoplasms; Pentacyclic Triterpenes; Protein Binding; Protein Multimerization; Protein Stability; Protein Structure, Tertiary; Recombinant Proteins; Triterpenes

2014
Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Cell Line; Cell Nucleus; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; HeLa Cells; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Neoplasms; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Triterpenes; Vascular Endothelial Growth Factor A

2014
Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.
    Oncotarget, 2015, Oct-20, Volume: 6, Issue:32

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Epoxy Compounds; G2 Phase Cell Cycle Checkpoints; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Mice, Inbred BALB C; Mice, Nude; Molecular Chaperones; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Phytotherapy; Plant Extracts; Plants, Medicinal; Reactive Oxygen Species; Time Factors; Transfection; Tripterygium; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays

2015
Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.
    Oncotarget, 2015, Oct-20, Volume: 6, Issue:32

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Targeted Therapy; Neoplasms; Pentacyclic Triterpenes; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Proto-Oncogene Proteins c-myc; Signal Transduction; Structure-Activity Relationship; Time Factors; Transfection; Triterpenes; Tumor Cells, Cultured

2015
Tumor growth attenuating effect of celastrol in systemic malignancies.
    International journal of cancer, 2016, 09-15, Volume: 139, Issue:6

    Topics: Animals; Humans; Neoplasms; Pentacyclic Triterpenes; Triterpenes

2016
Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol.
    Cancer investigation, 2010, Volume: 28, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Humans; Mice; Mice, Nude; Neoplasms; Pentacyclic Triterpenes; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays

2010
Self-assembled nanoplatform for targeted delivery of chemotherapy agents via affinity-regulated molecular interactions.
    Biomaterials, 2010, Volume: 31, Issue:30

    Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Drug Carriers; Drug Compounding; Drug Delivery Systems; HeLa Cells; Humans; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Materials Testing; Models, Molecular; Molecular Structure; Nanoparticles; Neoplasms; Pentacyclic Triterpenes; Polymers; Protein Conformation; Triterpenes

2010
Inhibitory action of Celastrol on hypoxia-mediated angiogenesis and metastasis via the HIF-1α pathway.
    International journal of molecular medicine, 2011, Volume: 27, Issue:3

    Topics: Antineoplastic Agents; Cell Hypoxia; Drug Screening Assays, Antitumor; Hep G2 Cells; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Pentacyclic Triterpenes; Plant Roots; RNA, Messenger; RNA, Neoplasm; Tripterygium; Triterpenes; Vascular Endothelial Growth Factor A

2011
Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells.
    BMC cancer, 2011, May-14, Volume: 11

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Electron Transport Complex I; Hep G2 Cells; HSP90 Heat-Shock Proteins; Humans; MAP Kinase Kinase 4; Neoplasms; Pentacyclic Triterpenes; Reactive Oxygen Species; Signal Transduction; Triterpenes

2011
Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways.
    Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:10

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Proliferation; Humans; JNK Mitogen-Activated Protein Kinases; Neoplasms; Pentacyclic Triterpenes; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Triterpenes

2011
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.
    Blood, 2007, Apr-01, Volume: 109, Issue:7

    Topics: Active Transport, Cell Nucleus; Antineoplastic Agents, Phytogenic; Apoptosis; Base Sequence; Cell Line; Cell Line, Tumor; Cell Proliferation; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; I-kappa B Proteins; MAP Kinase Kinase Kinases; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; NF-kappa B; NF-KappaB Inhibitor alpha; Pentacyclic Triterpenes; Phosphorylation; Triterpenes; Tumor Necrosis Factor-alpha

2007