Compounds > celastrol
Page last updated: 2024-09-03

celastrol and Multiple Myeloma

celastrol has been researched along with Multiple Myeloma in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's6 (75.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Chen, XL; Jiang, PJ; Kang, D; Kong, XT; Ni, HW; Xu, XM; Yu, H; Zhu, XY1
Chang, G; Chen, G; Dai, B; Gao, L; Hou, J; Hu, L; Li, B; Shi, J; Song, D; Sun, X; Tao, Y; Wu, H; Xiao, W; Xie, B; Xu, Z; Yang, G; Yu, D; Zhang, Y; Zhu, W1
An, JL; Huang, S; Liu, J; Xiao, XF; Xu, GJ; Yang, T; Zeng, Y; Zhao, L; Zhong, YL1
Kong, X; Li, H; Ni, H; Ouyang, J; Zhao, W2
Keats, JJ; Mao, X; Palmer, SE; Schimmer, AD; Schmidt, J; Shi, CX; Stewart, AK; Tiedemann, RE; Zhu, YX1
Abbasi, T; Chng, WJ; Hay, HS; Kannaiyan, R; Kapoor, S; Kumar, AP; Li, F; Rajendran, P; Sethi, G; Shanmugam, MK; Sharma, A; Vali, S1
Kizaki, M; Sagawa, M; Tozawa, K1

Other Studies

8 other study(ies) available for celastrol and Multiple Myeloma

ArticleYear
[Effect of Celastrol Based on IRAK4/ERK/p38 Signaling Pathway on Proliferation and Apoptosis of Multiple Myeloma Cells].
    Zhongguo shi yan xue ye xue za zhi, 2022, Volume: 30, Issue:1

    Topics: Apoptosis; Bortezomib; Cell Line, Tumor; Cell Proliferation; Humans; Interleukin-1 Receptor-Associated Kinases; Multiple Myeloma; Pentacyclic Triterpenes; Signal Transduction

2022
Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo.
    Acta biochimica et biophysica Sinica, 2017, May-01, Volume: 49, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Interleukin-6; Male; MAP Kinase Signaling System; Mice; Mice, Nude; Multiple Myeloma; Pentacyclic Triterpenes; STAT3 Transcription Factor; Treatment Outcome; Triterpenes

2017
Celastrol induce apoptosis of human multiple myeloma cells involving inhibition of proteasome activity.
    European journal of pharmacology, 2019, Jun-15, Volume: 853

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Female; G1 Phase Cell Cycle Checkpoints; Humans; Mice; Multiple Myeloma; Pentacyclic Triterpenes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Resting Phase, Cell Cycle; Triterpenes; Xenograft Model Antitumor Assays

2019
Celastrol inhibits lipopolysaccharide-induced angiogenesis by suppressing TLR4-triggered nuclear factor-kappa B activation.
    Acta haematologica, 2014, Volume: 131, Issue:2

    Topics: Active Transport, Cell Nucleus; Angiogenesis Inhibitors; Cell Division; Cell Line, Tumor; Cell Movement; Culture Media, Conditioned; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; I-kappa B Kinase; I-kappa B Proteins; Lipopolysaccharides; Molecular Structure; Multiple Myeloma; Neovascularization, Pathologic; NF-kappa B; NF-KappaB Inhibitor alpha; Pentacyclic Triterpenes; Toll-Like Receptor 4; Transcription Factor RelA; Transcription, Genetic; Triterpenes; Vascular Endothelial Growth Factor A; Wound Healing

2014
NF-kappa B modulation is involved in celastrol induced human multiple myeloma cell apoptosis.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p27; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; Humans; I-kappa B Proteins; Inhibitory Concentration 50; Multiple Myeloma; NF-KappaB Inhibitor alpha; Pentacyclic Triterpenes; Transcription Factor RelA; Triterpenes

2014
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.
    Blood, 2009, Apr-23, Volume: 113, Issue:17

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Products; Bone Marrow Cells; Cell Lineage; Cells, Cultured; Chymases; Coculture Techniques; Combinatorial Chemistry Techniques; Cyclin D; Cyclins; Drug Screening Assays, Antitumor; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Mice; Molecular Structure; Multiple Myeloma; NF-kappa B; Pentacyclic Triterpenes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Transcriptional Activation; Triterpenes; Xenograft Model Antitumor Assays

2009
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.
    British journal of pharmacology, 2011, Volume: 164, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression Regulation; Humans; Immunohistochemistry; Models, Biological; Multiple Myeloma; NF-kappa B; Pentacyclic Triterpenes; Real-Time Polymerase Chain Reaction; STAT3 Transcription Factor; Triterpenes

2011
Quinone methide tripterine, celastrol, induces apoptosis in human myeloma cells via NF-κB pathway.
    International journal of oncology, 2011, Volume: 39, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Humans; Mitochondria; Multiple Myeloma; NF-kappa B; Pentacyclic Triterpenes; Signal Transduction; Triterpenes

2011