celastrol has been researched along with Lung Neoplasms in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 22 (75.86) | 24.3611 |
| 2020's | 7 (24.14) | 2.80 |
| Authors | Studies |
|---|---|
| Bodle, CR; Doorn, JA; Hayes, MP; Henry, MD; Houtman, JCD; James, MA; Mackie, DI; Miller, MR; Roman, DL; Schamp, JH | 1 |
| Chen, G; Chen, X; Li, J; Liao, W; Lu, L; Ma, L; Qin, X; Wang, J; Wang, X; Wu, W; Wu, Z; Yu, H; Zhang, R; Zhang, Y; Zhu, X | 1 |
| Gong, Y; Huang, X; Li, J; Wang, L; Wang, X; Wang, Y; Yang, L; Zhang, L; Zhao, C; Zhao, H; Zhao, Z; Zhu, J | 1 |
| Wu, J; Xu, T; Ye, F | 1 |
| Bai, Y; Gao, J; Hu, D; Liang, C; Liu, Y; Wang, F; Wu, J; Zhou, J | 1 |
| Chen, J; Efferth, T; Guo, JR; Hamdoun, S; Law, BYK; Liu, L; Mok, SWF; Qu, SLQ; Sugimoto, Y; Wong, VKW; Wu, AG; Xia, C; Xu, SW; Zhang, DW; Zhang, W | 1 |
| Chen, YC; Dai, CH; Du, YJ; Li, J; Tang, XP; Wang, Y; Zhu, LR | 1 |
| Cao, P; Chang, Y; Chen, F; Fan, Y; Han, B; Han, Y; Huang, L; Li, D; Liu, M; Liu, T; Meng, Y; Nakai, A; Song, Z; Tan, K | 1 |
| Fan, C; Guo, M; Li, P; Ling, Y; Qu, D; Zhou, T; Zhou, X | 1 |
| Choi, JW; Jun, HY; Kim, TH; Lee, KK; Lee, YH; Yoon, KH | 1 |
| Hong, Y; Hu, F; Huang, X; Liu, X; Meng, T; Tan, Y; Yang, X; Yuan, H; Zhao, Y; Zhu, Y | 1 |
| Chen, W; Hao, RM; Li, YJ; Ma, X; Ma, Y; Sun, YX; Wang, PY; Wu, P; Xie, N; Xie, SY; Zhang, LJ | 1 |
| Cao, F; Chen, H; Chen, Q; Liu, Q; Peng, B; Uzan, G; Wang, Y; Xu, L; You, J; Zhang, D; Zhang, X | 1 |
| Duan, J; Huang, WD; Wang, GZ; Zhan, JC; Zhao, XC; Zhou, GB | 1 |
| Cai, Z; Mu, C; Wang, H; Wang, Q; Zhao, N | 1 |
| Chai, L; Che, S; Hui, B; Li, B; Shi, F; Song, L; Sun, W; Wang, J; Zhang, Y | 1 |
| Cao, X; Tian, X; Zhang, Q | 1 |
| Kim, SY; Lee, C; Lee, YJ | 1 |
| Jang, SW; Kang, H; Lee, M | 1 |
| Hu, Z; Li, W; Liu, J; Liu, Z; Ma, L; Wen, ZS; Wu, FQ; Zhou, GB | 1 |
| Fu, Y; Gai, R; He, Q; Lou, J; Ma, J; Yang, B; Zheng, L; Zhu, H; Zhuang, L | 1 |
| Fan, XX; He, JX; Leung, EL; Li, N; Liu, L; Wu, JL; Zhou, YL | 1 |
| Bracco, E; Gisabella, M; Lo Iacono, M; Monica, V; Novello, S; Papotti, M; Saviozzi, S; Scagliotti, GV; Vavalà, T | 1 |
| Cheng, X; Liu, YQ; Wang, GZ; Zhou, GB | 1 |
| Huang, J; Wu, CL; Xu, J | 1 |
| Agrawal, AK; Aqil, F; Gupta, R; Jeyabalan, J; Kausar, H; Kyakulaga, AH; Munagala, R | 1 |
| Coghi, PS; Fan, XX; Law, BY; Leung, CH; Leung, EL; Liu, L; Ma, DL; Mok, SW; Wong, VK; Xu, SW; Zeng, W | 1 |
| Bae, S; Choi, KJ; Jang, SY; Kang, S; Kim, JY; Kim, M; Lee, BW; Lee, JH; Lee, YS; Park, KH; Seo, WD | 1 |
| Jin, YB; Lee, BW; Lee, YJ; Lee, YS; Park, KH; Pyun, BJ; Seo, EK; Seo, HR; Seo, WD | 1 |
29 other study(ies) available for celastrol and Lung Neoplasms
| Article | Year |
|---|---|
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.
Topics: Benzophenanthridines; Biological Products; Cytostatic Agents; Cytotoxins; GTP-Binding Protein Regulators; Humans; Isoquinolines; Lung Neoplasms; Male; Molecular Structure; Pentacyclic Triterpenes; Prostatic Neoplasms; Triterpenes | 2017 |
Celastrol inhibits lung cancer growth by triggering histone acetylation and acting synergically with HDAC inhibitors.
Topics: Acetylation; Animals; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Lung Neoplasms; Mice | 2022 |
Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer.
Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Mice; Mice, Nude; Reactive Oxygen Species; STAT3 Transcription Factor | 2022 |
Celastrol impairs tumor growth by modulating the CIP2A-GSK3β-MCL-1 axis in gastric cancer cells.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Stomach Neoplasms; Transcription Factors | 2023 |
Development of novel celastrol-ligustrazine hybrids as potent peroxiredoxin 1 inhibitors against lung cancer.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Pentacyclic Triterpenes; Peroxiredoxins; Reactive Oxygen Species; Triterpenes | 2023 |
SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Autophagy; Autophagy-Related Protein 7; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Hepatocytes; Humans; Lung Neoplasms; Mice, Inbred C57BL; Pentacyclic Triterpenes; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Triterpenes; Xenograft Model Antitumor Assays | 2020 |
Celastrol acts synergistically with afatinib to suppress non-small cell lung cancer cell proliferation by inducing paraptosis.
Topics: Afatinib; Animals; Antineoplastic Combined Chemotherapy Protocols; Calcium; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Humans; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Pentacyclic Triterpenes; Reactive Oxygen Species; Unfolded Protein Response; Xenograft Model Antitumor Assays | 2021 |
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Ferroptosis; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mitochondrial Dynamics; Mitophagy; Pentacyclic Triterpenes; Piperazines; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2021 |
Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol-polyethylene glycol-ginsenoside Rh2.
Topics: A549 Cells; Ginsenosides; Humans; Lung Neoplasms; Micelles; Pentacyclic Triterpenes; Polyethylene Glycols; Triterpenes | 2017 |
Evaluation of connectivity map-discovered celastrol as a radiosensitizing agent in a murine lung carcinoma model: Feasibility study of diffusion-weighted magnetic resonance imaging.
Topics: A549 Cells; Animals; Carcinoma, Non-Small-Cell Lung; Cell Survival; Chemoradiotherapy; Diffusion Magnetic Resonance Imaging; Drug Screening Assays, Antitumor; Feasibility Studies; Humans; Lung Neoplasms; Male; Mice, Nude; Neoplasm Transplantation; Pentacyclic Triterpenes; Radiation-Sensitizing Agents; Random Allocation; Triterpenes | 2017 |
Simultaneous targeting therapy for lung metastasis and breast tumor by blocking the NF-κB signaling pathway using Celastrol-loaded micelles.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Integrin alphaVbeta3; Lung Neoplasms; Mice; Mice, Inbred BALB C; Micelles; Neoplasm Metastasis; NF-kappa B; Pentacyclic Triterpenes; Signal Transduction; Thyroxine; Triterpenes | 2018 |
miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Animals; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; MicroRNAs; Middle Aged; Pentacyclic Triterpenes; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes; Xenograft Model Antitumor Assays | 2018 |
Celastrol improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance.
Topics: A549 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Random Allocation; Signal Transduction; Triterpenes; Xenograft Model Antitumor Assays | 2018 |
The red wine component ellagic acid induces autophagy and exhibits anti-lung cancer activity in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Autoantigens; Autophagy; Cell Proliferation; Ellagic Acid; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Membrane Proteins; Mice, Inbred BALB C; Pentacyclic Triterpenes; Polyphenols; Triterpenes; Wine; Xenograft Model Antitumor Assays | 2019 |
[Celastrol inhibits growth and increases apoptosis of human lung cancer A549 cells].
Topics: A549 Cells; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Triterpenes | 2018 |
Pristimerin enhances the effect of cisplatin by inhibiting the miR‑23a/Akt/GSK3β signaling pathway and suppressing autophagy in lung cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Synergism; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Male; Mice; MicroRNAs; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-akt; Triterpenes | 2019 |
Transferrin-functionalised microemulsion co-delivery of β-elemene and celastrol for enhanced anti-lung cancer treatment and reduced systemic toxicity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Drug Synergism; Emulsions; Female; Humans; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Pentacyclic Triterpenes; Sesquiterpenes; Transferrin; Triterpenes | 2019 |
Axl is a novel target of celastrol that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non‑small cell lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Axl Receptor Tyrosine Kinase; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression; Humans; Lung Neoplasms; Mutation; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Triterpenes | 2019 |
Celastrol inhibits TGF-β1-induced epithelial-mesenchymal transition by inhibiting Snail and regulating E-cadherin expression.
Topics: Animals; Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dogs; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Gene Expression Regulation; Humans; Lung Neoplasms; Madin Darby Canine Kidney Cells; Neoplasm Invasiveness; Pentacyclic Triterpenes; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta1; Triterpenes | 2013 |
Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer.
Topics: Animals; Autoantigens; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Membrane Proteins; Mice; Pentacyclic Triterpenes; Proteolysis; Triterpenes; Ubiquitination | 2014 |
Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo.
Topics: Animals; Apoptosis; Blotting, Western; Cadherins; Cell Proliferation; Drug Synergism; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoenzyme Techniques; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Nude; NF-kappa B; Pentacyclic Triterpenes; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tripterygium; Triterpenes; Tumor Cells, Cultured; Vorinostat | 2014 |
Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gefitinib; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mitochondria; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Proteolysis; Quinazolines; Signal Transduction; Triterpenes | 2014 |
ATF2 contributes to cisplatin resistance in non-small cell lung cancer and celastrol induces cisplatin resensitization through inhibition of JNK/ATF2 pathway.
Topics: Activating Transcription Factor 2; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; MAP Kinase Signaling System; Middle Aged; Pentacyclic Triterpenes; Prognosis; Triterpenes | 2015 |
Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Drug Synergism; Fanconi Anemia Complementation Group D2 Protein; Humans; Lung Neoplasms; Pentacyclic Triterpenes; Proteasome Endopeptidase Complex; Protein Stability; Proteolysis; Triterpenes | 2015 |
[Effect of celastrol in inhibiting metastasis of lung cancer cells by influencing Akt signaling pathway and expressing integrins].
Topics: Apoptosis; Cell Line, Tumor; Drugs, Chinese Herbal; Gene Expression Regulation, Neoplastic; Humans; Integrins; Lung Neoplasms; Neoplasm Metastasis; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-akt; Signal Transduction; Triterpenes | 2015 |
Exosomal formulation enhances therapeutic response of celastrol against lung cancer.
Topics: A549 Cells; Animals; Apoptosis; Cattle; Cell Cycle; Cell Proliferation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Exosomes; Female; Lung Neoplasms; Mice, Nude; NF-kappa B; Pentacyclic Triterpenes; Triterpenes; Xenograft Model Antitumor Assays | 2016 |
Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol.
Topics: Antineoplastic Agents; Autophagy; Blotting, Western; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Flow Cytometry; Gefitinib; Humans; Lung Neoplasms; Pentacyclic Triterpenes; Proteolysis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Triterpenes; Tumor Cells, Cultured | 2016 |
Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90.
Topics: Cell Line, Tumor; ErbB Receptors; Gamma Rays; HSP90 Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Microtubule-Associated Proteins; Pentacyclic Triterpenes; Phosphorylation; Radiation Tolerance; Radiation-Sensitizing Agents; Receptor, ErbB-2; Survivin; Triterpenes; Tumor Suppressor Protein p53 | 2011 |
Radiosensitization by celastrol is mediated by modification of antioxidant thiol molecules.
Topics: Animals; Antioxidants; Apoptosis; Cell Line, Tumor; Glutathione; Humans; Lung Neoplasms; Mice; Mice, Nude; Pentacyclic Triterpenes; Radiation-Sensitizing Agents; Radiation, Ionizing; Reactive Oxygen Species; Sulfhydryl Compounds; Thioredoxin-Disulfide Reductase; Transplantation, Heterologous; Triterpenes | 2011 |