celastrol has been researched along with Invasiveness, Neoplasm in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 13 (61.90) | 24.3611 |
| 2020's | 7 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, Y; Zhu, B | 1 |
| Jiang, Y; Lazarovici, P; Li, S; Liao, R; Peng, T; Silva, M; Yan, F; Zheng, W | 1 |
| Cao, Y; Chen, Y; Cheng, J; Chu, F; Ding, X; Du, S; Durojaye, OA; Gao, X; Li, Y; Liu, X; Shi, X; Song, X; Su, Z; Wang, D; Wang, F; Wang, J; Wang, T; Zeng, W | 1 |
| Li, Z; Liu, L; Wu, Z; Yan, F | 1 |
| A Kim, S; Jeong, Y; Kim, S; Kim, SW; Lee, JE; Nam, SJ; Yoon, SY; You, D | 1 |
| Cheng, L; Wang, R; Xu, H; Zhang, J | 1 |
| Li, Q; Qian, Y; Shen, Q; Xu, R; Zhang, J; Zhu, G | 1 |
| Ding, M; Li, J; Mao, N; Miao, X; Shi, Z; Wang, C; Wu, J; Wu, Y; Yuan, J | 1 |
| Pan, J; Tan, F; Tu, Y; Zhou, J | 1 |
| Jang, SW; Kang, H; Lee, M | 1 |
| Li, H; Li, Y; Liu, D; Liu, J; Sun, H | 1 |
| Han, LZ; Jin, X; Lee, JJ; Liang, H; Ma, J; Mi, C; Shi, H | 1 |
| Han, LZ; Jin, X; Lee, JJ; Ma, J; Mi, C; Shi, H | 1 |
| Guo, Y; He, P; Huang, S; Li, J; Li, S; Peng, X; Tang, Y; Wa, Q; Xu, D; Zhang, X; Zuo, J | 1 |
| Guerram, M; Hamdi, AM; Hassan, HM; Jiang, ZZ; Wang, B; Yousef, BA; Zhang, LY | 1 |
| Huang, S; Kuchta, K; Li, J; Lin, Z; Pan, T; Peng, X; Tang, Y; Wang, X; Xiang, Y; Xu, J; Zhu, Y | 1 |
| Aggarwal, BB; Chaturvedi, MM; Cho, SG; Kannappan, R; Liu, M; Prasad, S; Sung, B; Yadav, VR | 1 |
| Huang, L; Li, Q; Ren, J; Wu, G; Zeng, H; Zhang, R; Zhang, S; Zhang, Z | 1 |
| Jang, SW; Kang, H; Kim, Y; Ko, J | 1 |
| Jiang, ZZ; Li, H; Mu, XM; Shi, W; Sun, LX; Wang, YR; Zhang, LY | 1 |
| Aggarwal, BB; Ahn, KS; Pandey, MK; Sethi, G | 1 |
21 other study(ies) available for celastrol and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bile Duct Neoplasms; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Cholangiocarcinoma; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Prognosis; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Triterpenes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
Pristimerin-induced uveal melanoma cell death via inhibiting PI3K/Akt/FoxO3a signalling pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Nucleus; Forkhead Box Protein O3; Humans; Melanoma; Neoplasm Invasiveness; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Uveal Neoplasms | 2020 |
Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells.
Topics: Biotin; Carcinoma, Hepatocellular; Catalytic Domain; Cell Movement; Cytoskeletal Proteins; Disease Progression; HEK293 Cells; Hep G2 Cells; Humans; Liver Neoplasms; Medicine, Chinese Traditional; Molecular Docking Simulation; Neoplasm Invasiveness; Neoplasm Metastasis; Pentacyclic Triterpenes; Phosphorylation; rho-Associated Kinases; Triterpenes; Wound Healing | 2020 |
Celastrol Inhibits Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Interleukin-6 via Downregulating Nuclear Factor-κB (NF-κB).
Topics: Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Humans; Interleukin-6; Neoplasm Invasiveness; NF-kappa B; Pentacyclic Triterpenes; Triple Negative Breast Neoplasms | 2020 |
Celastrol attenuates the inflammatory response by inhibiting IL‑1β expression in triple‑negative breast cancer cells.
Topics: Benzimidazoles; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1beta; MAP Kinase Signaling System; Neoplasm Invasiveness; Pentacyclic Triterpenes; Triple Negative Breast Neoplasms | 2021 |
Celastrol inhibit the proliferation, invasion and migration of human cervical HeLa cancer cells through down-regulation of MMP-2 and MMP-9.
Topics: Apoptosis; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pentacyclic Triterpenes; Uterine Cervical Neoplasms | 2021 |
Nanoparticles based on polymers modified with pH-sensitive molecular switch and low molecular weight heparin carrying Celastrol and ferrocene for breast cancer treatment.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; beta-Cyclodextrins; Cell Line, Tumor; Cell Movement; Cell Survival; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Female; Ferrous Compounds; Heparin, Low-Molecular-Weight; Hydrogen-Ion Concentration; Metallocenes; Mice, Inbred BALB C; Nanoparticles; Neoplasm Invasiveness; Pentacyclic Triterpenes; Polyethyleneimine; Polylactic Acid-Polyglycolic Acid Copolymer; Reactive Oxygen Species; Stimuli Responsive Polymers; Triple Negative Breast Neoplasms; Tumor Burden | 2021 |
Celastrol inhibits chondrosarcoma proliferation, migration and invasion through suppression CIP2A/c-MYC signaling pathway.
Topics: Apoptosis; Autoantigens; bcl-2-Associated X Protein; Caspase 8; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Chondrosarcoma; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Neoplasm Invasiveness; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Triterpenes | 2017 |
Pristimerin targeting NF-κB pathway inhibits proliferation, migration, and invasion in esophageal squamous cell carcinoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Male; Mice; Mice, Nude; Molecular Conformation; Neoplasm Invasiveness; NF-kappa B; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured | 2018 |
Celastrol inhibits TGF-β1-induced epithelial-mesenchymal transition by inhibiting Snail and regulating E-cadherin expression.
Topics: Animals; Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dogs; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Gene Expression Regulation; Humans; Lung Neoplasms; Madin Darby Canine Kidney Cells; Neoplasm Invasiveness; Pentacyclic Triterpenes; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta1; Triterpenes | 2013 |
miR-224 is critical for celastrol-induced inhibition of migration and invasion of hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Movement; Cell Survival; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MicroRNAs; Neoplasm Invasiveness; NF-kappa B; Pentacyclic Triterpenes; Real-Time Polymerase Chain Reaction; Triterpenes | 2013 |
Celastrol inhibits the HIF-1α pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Liver Neoplasms, Experimental; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Pentacyclic Triterpenes; Phosphorylation; Proteolysis; Triterpenes; Xenograft Model Antitumor Assays | 2014 |
Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Movement; Down-Regulation; Drug Screening Assays, Antitumor; Female; Gene Expression; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Pentacyclic Triterpenes; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Inhibitory action of pristimerin on hypoxia‑mediated metastasis involves stem cell characteristics and EMT in PC-3 prostate cancer cells.
Topics: Antineoplastic Agents; Argonaute Proteins; Bone Neoplasms; Cadherins; Cell Hypoxia; Cell Proliferation; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Fibronectins; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Hyaluronan Receptors; Hypoxia-Inducible Factor 1, alpha Subunit; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Male; Neoplasm Invasiveness; Neoplastic Stem Cells; Octamer Transcription Factor-3; Pentacyclic Triterpenes; Prostatic Neoplasms; Spheroids, Cellular; Transcription Factors; Triterpenes; Tumor Cells, Cultured; Vimentin; Zinc Finger E-box-Binding Homeobox 1 | 2015 |
Pristimerin inhibits proliferation, migration and invasion, and induces apoptosis in HCT-116 colorectal cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Female; HCT116 Cells; Humans; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Pentacyclic Triterpenes; Reactive Oxygen Species; Triterpenes; Xenograft Model Antitumor Assays | 2016 |
Celastrol, an active constituent of the TCM plant Tripterygium wilfordii Hook.f., inhibits prostate cancer bone metastasis.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Male; Medicine, Chinese Traditional; Neoplasm Invasiveness; Neoplasm Metastasis; Pentacyclic Triterpenes; Prostatic Neoplasms; Triterpenes; Vascular Endothelial Growth Factor A | 2017 |
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
Topics: Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Colonic Neoplasms; Down-Regulation; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Neoplasm Invasiveness; NF-kappa B; Organ Specificity; Pancreatic Neoplasms; Pentacyclic Triterpenes; Protein Processing, Post-Translational; Receptors, CXCR4; Triterpenes; Tumor Necrosis Factor-alpha | 2010 |
Inhibitory action of Celastrol on hypoxia-mediated angiogenesis and metastasis via the HIF-1α pathway.
Topics: Antineoplastic Agents; Cell Hypoxia; Drug Screening Assays, Antitumor; Hep G2 Cells; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Pentacyclic Triterpenes; Plant Roots; RNA, Messenger; RNA, Neoplasm; Tripterygium; Triterpenes; Vascular Endothelial Growth Factor A | 2011 |
Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Enzymologic; Humans; I-kappa B Kinase; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Medicine, Chinese Traditional; Neoplasm Invasiveness; NF-kappa B; Pentacyclic Triterpenes; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate; Triterpenes | 2011 |
Pristimerin inhibits breast cancer cell migration by up- regulating regulator of G protein signaling 4 expression.
Topics: Actins; Analysis of Variance; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chymases; Dose-Response Relationship, Drug; Female; Humans; Leupeptins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Pentacyclic Triterpenes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Random Allocation; RGS Proteins; RNA Interference; Triterpenes; Tumor Burden; Up-Regulation | 2012 |
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents, Phytogenic; Apoptosis; Base Sequence; Cell Line; Cell Line, Tumor; Cell Proliferation; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; I-kappa B Proteins; MAP Kinase Kinase Kinases; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; NF-kappa B; NF-KappaB Inhibitor alpha; Pentacyclic Triterpenes; Phosphorylation; Triterpenes; Tumor Necrosis Factor-alpha | 2007 |