celastrol has been researched along with Innate Inflammatory Response in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.59) | 18.2507 |
| 2000's | 4 (6.35) | 29.6817 |
| 2010's | 36 (57.14) | 24.3611 |
| 2020's | 22 (34.92) | 2.80 |
| Authors | Studies |
|---|---|
| Chan, WK; Chang, MN; He, W; Huang, FC; Moriarty, KJ; Yu, KT; Zhang, DC; Zilberstein, A | 1 |
| He, E; Xiao, R; Zeng, R; Zhang, A; Zhao, J | 1 |
| Abu Bakar, MH; Karunakaran, T; Mohamad Khalid, MSF; Nor Shahril, NS; Shariff, KA | 1 |
| Fan, N; Rong, J; Shen, Y; Shum, HC; Song, Q; Wang, Y; Zhao, J; Zhao, W | 1 |
| Fei, XY; Jiang, JS; Kuai, L; Li, B; Li, YY; Luo, Y; Ru, Y; Song, JK; Yin, SY; Zhou, M; Zhu, CC; Zhu, QG | 1 |
| Fan, N; Huang, M; Li, D; Luo, D; Ngo, FY; Rong, J; Wang, Y; Zhang, X; Zhao, J; Zhao, W | 1 |
| Chen, JY; Dai, LY; Li, ZJ; Liu, JH; Luo, P; Tian, Y; Wang, JG; Yang, F; Zhang, JZ; Zhang, Q; Zheng, LH; Zhong, TY; Zou, C | 1 |
| Chen, Q; Fan, J; Liu, S; Ren, Y; Yan, L; Zhang, X; Zhu, S | 1 |
| Dong, Y; Fan, H; Gui, Y; Guo, W; Hu, D; Jiang, F; Li, J; Li, M; Luo, S; Sarapultsev, A; Tian, C; Wang, H; Wang, W; Xue, K; Yu, T; Zhang, G; Zhang, Z; Zhou, H | 1 |
| Chen, SR; Cheng, YC; Ding, MY; Li, ZQ; Shan, YM; Sun, YW; Wang, Y; Wang, YQ; Xu, J; Zhang, GX | 1 |
| Fan, Y; Gong, F; Jiang, X; Pan, M; Sun, Y; Wang, D; Wang, Y; Wang, Z | 1 |
| Fan, N; Luo, D; Nie, H; Rong, J; Wang, Y; Zhang, Z; Zhao, J | 1 |
| Bi, Y; Jia, J; Liu, Y; Ren, Z; Tan, Y; Yu, M; Yu, X; Zhang, Q; Zhao, Q; Zhong, J | 1 |
| Bi, J; Chen, S; Cheng, B; Guo, D; Wang, Y; Xie, Y; Yang, H; Zhang, W | 1 |
| Chen, C; Duanmu, J; Gu, J; Li, C; Liu, Z; Miao, J; Tao, J; Tu, M; Wang, Y; Xiong, B; Yao, W; Zhao, L | 1 |
| Feng, W; Li, Y; Luo, C; Sun, S; Zhang, X; Zhu, M; Zhu, S | 1 |
| Cao, Y; Li, K; Ma, L; Pan, Y; Yan, L; Zhang, L; Zhu, J | 1 |
| Chen, G; Fang, K; Li, J; Li, L; Lu, F; Luo, J; Lynch, EC; Wu, F; Xie, L; Xu, L; Yang, X; Zhao, Y; Zou, X | 1 |
| An, L; Jin, L; Li, J; Li, Z; Shi, L; Shuai, X; Wang, L; Wang, Y | 1 |
| Fang, G; Tang, B | 1 |
| Feng, Y; He, W; Li, X; Xu, S; Xu, W; Yang, H | 1 |
| Bilancia, R; Börner, F; Chen, X; Fischer, D; Gerstmeier, J; Gilbert, NC; Hofstetter, RK; Jordan, PM; Kretzer, C; Lorkowski, S; Newcomer, ME; Pace, S; Potenza, M; Rossi, A; Wang, W; Werz, O; Zhang, K | 1 |
| Deng, C; Gong, T; He, K; He, P; Lei, G; Sun, X; Zhang, Q; Zhang, Z; Zhou, B | 1 |
| Cai, J; Cai, Y; Chen, G; Chen, J; Chen, T; Gu, C; Hu, X; Jie, L; Li, J; Qin, B; Shen, Y; Sun, J; Wang, C; Wang, L; Xu, D; Xu, H; Ying, G; Yu, M | 1 |
| Cho, I; Cho, YY; Kang, HC; Kim, KB; Kwack, SJ; Lee, HS; Lee, JK; Lee, JY; Seok, JK; Yang, G | 1 |
| Chen, J; Chen, JX; Chen, XB; Chen, Y; Gu, YT; Shi, KS; Wang, XY; Wu, YS; Xie, JJ; Xuan, J; Zhang, XL; Zheng, ZM | 1 |
| Cheng, Y; Guo, Y; Luo, D; Rong, J; Wang, Y; Zhao, J | 1 |
| Hui, B; Hui, L; Zhang, L; Zhou, Q | 1 |
| Cao, FF; Ge, HY; Gu, YJ; Peng, B; Uzan, G; Wang, Y; Yang, CX; Zhang, DH; Zhang, X | 1 |
| Chen, X; Feng, M; Li, J; Wan, L; Yao, W; Zhang, B; Zhang, C; Zhang, Y | 1 |
| Cao, X; He, QH; Li, GQ; Li, SJ; Li, Y; Tang, M; Xu, GL; Zhang, K; Zhang, KQ; Zheng, QY | 1 |
| Li, Y; Xiong, Y; Yan, Y | 1 |
| Chen, LM; Han, LP; Li, CJ; Sun, B; Xie, Y | 1 |
| Huang, C; Huang, Z; Liu, X; Shan, R; Zhang, X; Zhao, W | 1 |
| Chen, Q; Chen, Y; Deng, L; Qiu, P; Wei, X; Xiao, J; Yan, C; Yang, Y; Zhan, X | 1 |
| Dai, W; Li, C; Teng, H; Wang, B; Wang, J; Wang, X | 1 |
| Chan, Y; Chan, YL; Chellappan, DK; Collet, T; Dua, K; Gupta, G; Hansbro, N; Hansbro, PM; Hsu, A; Madheswaran, T; Ng, SW; Oliver, BG; Panneerselvam, J; Wark, P; Zeeshan, F | 1 |
| Li, Z; Shang, F; Zhang, J; Zhang, X; Zhou, K; Zhou, Y | 1 |
| Cao, X; Deng, L; Tu, H; Zhang, ZR; Zhou, X | 1 |
| Berglund, ED; Cui, H; Davis, KC; Grobe, JL; Jiang, J; Morgan, DA; Rahmouni, K; Saito, K; Singh, U; Toth, BA | 1 |
| Hu, C; Liu, Z; Song, Y; Yang, H | 1 |
| Ashamallah, SA; Houssen, ME; Shaker, ME | 1 |
| Hui, B; Sheng, P; Wu, Z; Yao, X; Zhang, L; Zhou, Q | 1 |
| Astry, B; Christensen-Quick, A; Frieman, MB; Garzino-Demo, A; Laurence, A; Moudgil, KD; O'Shea, JJ; Venkatesha, SH | 1 |
| Hearth-Holmes, MP; Klassen, LW; Koehn, CD; Li, S; Mikuls, TR; O'Dell, JR; Su, K; Thiele, GM; Yu, Y; Yue, Y; Zhang, Z | 1 |
| Abu Bakar, MH; Cheng, KK; Huri, HZ; Sarmidi, MR; Yaakob, H | 1 |
| Ampong, B; Benny Klimek, ME; Dillingham, BC; Gallardo, E; Gernapudi, R; Gordish-Dressman, H; Jordan, S; Nagaraju, K; Rayavarapu, S; Spurney, CF; Van der Meulen, JH | 1 |
| Bian, M; Chen, Y; Cui, J; Du, X; Wang, P; Wang, W; Zhang, T; Zhu, W | 1 |
| Astry, B; Dudics, S; Moudgil, KD; Venkatesha, SH | 1 |
| Ge, F; He, Q; Li, H; Wu, C; Xu, R; Yuan, Y; Zhang, Y | 1 |
| Moudgil, KD; Venkatesha, SH | 1 |
| Abu Bakar, MH; Mohamad Rosdi, MN; Sarmidi, MR; Tan, JS | 1 |
| Jiang, F; Li, C; Lin, J; Liu, C; Tao, W; Yu, X | 1 |
| Kannaiyan, R; Sethi, G; Shanmugam, MK | 1 |
| Chen, X; Daniel, S; Dickens, G; Jin, MM; Kang, S; Lee, B; Lu, K; Park, T; Rakhilin, N | 1 |
| Boridy, S; Maysinger, D; Soliman, GM | 1 |
| Dumont, S; Hentsch, D; Kessler, P; Moreira-Tabaka, H; Muller, CD; Peluso, J; Reimund, JM; Vonesch, JL | 1 |
| Moudgil, KD; Nanjundaiah, SM; Stains, JP; Tong, L; Venkatesha, SH; Yu, H | 1 |
| Fang, W; Lam, CW; Peng, F; Wan, C; Xu, H; Yang, X; Yi, T; Zhang, C | 1 |
| Hong, GC; Li, Q; Liu, RL; Liu, ZL; Lü, HJ; Qiu, ZM; Yang, ZM | 1 |
| Arondel, Y; Fiorucci, M; Muller, CD; Pinna, GF; Reimund, JM; Taquet, N | 1 |
| Hong, YS; Jin, HZ; Jung, HS; Koo, TH; Lee, JH; Lee, JJ; Lee, K; Yoon, H | 1 |
| Chung, YS; Jung, HW; Kim, YS; Park, YK | 1 |
6 review(s) available for celastrol and Innate Inflammatory Response
| Article | Year |
|---|---|
Small molecules targeting cGAS-STING pathway for autoimmune disease.
Topics: Autoimmune Diseases; Humans; Inflammation; Membrane Proteins; Nucleotidyltransferases; Signal Transduction | 2022 |
Current advances in the nano-delivery of celastrol for treating inflammation-associated diseases.
Topics: Animals; Drug Delivery Systems; Humans; Inflammation; Inflammation Mediators; Nanoparticles; Pentacyclic Triterpenes; Tripterygium; Triterpenes | 2020 |
Celastrol in metabolic diseases: Progress and application prospects.
Topics: Animals; Diabetes Mellitus, Type 2; Energy Metabolism; Humans; Inflammation; Insulin Resistance; Lipid Metabolism; Metabolic Diseases; Obesity; Pentacyclic Triterpenes; Tripterygium | 2021 |
Molecular modulators of celastrol as the keystones for its diverse pharmacological activities.
Topics: Animals; Arthritis, Rheumatoid; Biological Products; Drug Discovery; Humans; Inflammation; Metabolic Diseases; Pentacyclic Triterpenes; Plants, Medicinal; Tripterygium; Triterpenes | 2019 |
Control of autoimmune inflammation by celastrol, a natural triterpenoid.
Topics: Animals; Autoimmune Diseases; Autoimmunity; Biological Products; Cell Adhesion Molecules; Cell Communication; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Humans; Immunomodulation; Inflammation; Pentacyclic Triterpenes; Signal Transduction; T-Lymphocyte Subsets; Triterpenes | 2016 |
Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Humans; Inflammation; Neoplasms; Pentacyclic Triterpenes; Plant Extracts; Plant Roots; Tripterygium; Triterpenes | 2011 |
57 other study(ies) available for celastrol and Innate Inflammatory Response
| Article | Year |
|---|---|
Novel cytokine release inhibitors. Part I: Triterpenes.
Topics: Animals; Cytokines; Humans; In Vitro Techniques; Inflammation; Molecular Structure; Rats; Triterpenes | 1998 |
Celastrol attenuates high-fructose diet-induced inflammation and insulin resistance via inhibition of 11β-hydroxysteroid dehydrogenase type 1 activity in rat adipose tissues.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Diet; Fructose; Inflammation; Insulin Resistance; Pentacyclic Triterpenes; Rats | 2022 |
Biodegradable celastrol-loaded albumin nanoparticles ameliorate inflammation and lipid accumulation in diet-induced obese mice.
Topics: Animals; Diet; Drug Carriers; Inflammation; Lipids; Mice; Mice, Obese; Nanoparticles; Particle Size; Pentacyclic Triterpenes; Serum Albumin, Bovine | 2022 |
Celastrol Attenuates Psoriasiform Inflammation by Targeting the IRF1/GSTM3 Axis.
Topics: Glutathione Transferase; Humans; Inflammation; Interferon Regulatory Factor-1; Pentacyclic Triterpenes; Psoriasis; Triterpenes | 2022 |
Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Inflammation; Insulin Resistance; Lipid Metabolism; Liver; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Pentacyclic Triterpenes; RAW 264.7 Cells | 2022 |
Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Endotoxemia; HMGB1 Protein; Humans; Inflammation; Lipopolysaccharides; Mice; Pentacyclic Triterpenes; Pyruvate Kinase; Sepsis | 2022 |
Phytosomal tripterine with selenium modification attenuates the cytotoxicity and restrains the inflammatory evolution via inhibiting NLRP3 inflammasome activation and pyroptosis.
Topics: Animals; Caspases; Inflammasomes; Inflammation; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Pentacyclic Triterpenes; Pyroptosis; Selenium | 2022 |
Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Experimental Ulcerative Colitis Mice.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Dextran Sulfate; Gastrointestinal Microbiome; Inflammation; Mice; RNA, Ribosomal, 16S | 2022 |
Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β.
Topics: Animals; Carcinoma, Hepatocellular; Heat-Shock Proteins; Hepacivirus; Hepatitis C; HSP90 Heat-Shock Proteins; Inflammation; Liver Neoplasms; Mice; NLR Family, Pyrin Domain-Containing 3 Protein | 2023 |
Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2/GPX4 pathway.
Topics: Acute Kidney Injury; Animals; Cisplatin; Ferroptosis; Inflammation; Iron; Mice; NF-E2-Related Factor 2 | 2023 |
Celastrol-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Ethylene Glycols; Gastrointestinal Tract; Inflammation; Insulin Resistance; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Obesity; Particle Size; Pentacyclic Triterpenes; Polyesters; Triterpenes | 2019 |
Pristimerin suppresses colorectal cancer through inhibiting inflammatory responses and Wnt/β-catenin signaling.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; HCT116 Cells; HT29 Cells; Humans; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Pentacyclic Triterpenes; Triterpenes; Wnt Signaling Pathway | 2020 |
Celastrol Induces Necroptosis and Ameliorates Inflammation via Targeting Biglycan in Human Gastric Carcinoma.
Topics: Biglycan; Biomarkers; Cell Death; Cell Line, Tumor; Cytokines; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Inflammation Mediators; Necroptosis; Pentacyclic Triterpenes; Protein Kinases; Stomach Neoplasms; Triterpenes | 2019 |
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Gene Expression Regulation; Hepatic Stellate Cells; Inflammation; Liver Cirrhosis; Male; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Sirtuins | 2020 |
Selenium-deposited tripterine phytosomes ameliorate the antiarthritic efficacy of the phytomedicine via a synergistic sensitization.
Topics: Animals; Antirheumatic Agents; Caco-2 Cells; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Drug Synergism; Humans; Inflammation; Liposomes; Male; Nanoparticles; Particle Size; Pentacyclic Triterpenes; Phytotherapy; Rats; Rats, Sprague-Dawley; Selenium; Triterpenes | 2020 |
Celastrol mitigates high glucose-induced inflammation and apoptosis in rat H9c2 cardiomyocytes via miR-345-5p/growth arrest-specific 6.
Topics: Animals; Apoptosis; Glucose; Humans; Inflammation; Intercellular Signaling Peptides and Proteins; MicroRNAs; Myocytes, Cardiac; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction | 2020 |
Celastrol alleviates metabolic disturbance in high-fat diet-induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Cytokines; Diet, High-Fat; Dyslipidemias; Energy Metabolism; Glucose Intolerance; Inflammasomes; Inflammation; Insulin Resistance; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Pentacyclic Triterpenes; Thermogenesis; Triterpenes; Weight Gain | 2021 |
Inflammation-Targeted Celastrol Nanodrug Attenuates Collagen-Induced Arthritis through NF-κB and Notch1 Pathways.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Inflammation; NF-kappa B; Pentacyclic Triterpenes | 2020 |
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Biosynthetic Pathways; Cells, Cultured; Humans; Inflammation; Leukotrienes; Lipid Metabolism; Lipoxygenase Inhibitors; Male; Mice; Molecular Docking Simulation; Pentacyclic Triterpenes; Tripterygium | 2021 |
Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis.
Topics: Animals; Apoptosis; Arthritis, Rheumatoid; Bone and Bones; Endocytosis; Female; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Joints; Lipopolysaccharides; Macrophages; Mice, Inbred C57BL; Nanoparticles; Oligopeptides; Osteoclasts; Pentacyclic Triterpenes; Rats; Synovial Membrane; Tissue Distribution; Triterpenes; X-Ray Microtomography | 2021 |
Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis.
Topics: Albumins; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cerebral Ventricles; Down-Regulation; Inflammation; Male; Matrix Metalloproteinase 9; Necroptosis; Neuroprotective Agents; Organ Size; Pentacyclic Triterpenes; Protein Kinases; Rats, Sprague-Dawley; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Subarachnoid Hemorrhage; Survival Analysis; Tight Junctions; Up-Regulation | 2021 |
Topical application of celastrol alleviates atopic dermatitis symptoms mediated through the regulation of thymic stromal lymphopoietin and group 2 innate lymphoid cells.
Topics: Allergens; Animals; Cell Line, Tumor; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Immunity, Innate; Inflammation; Keratinocytes; Lymphocytes; Mice; NF-kappa B; Pentacyclic Triterpenes; Pyroglyphidae; Skin; Thymic Stromal Lymphopoietin | 2021 |
Celastrol reduces IL-1β induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo.
Topics: ADAMTS5 Protein; Aggrecans; Animals; Cell Death; Cell Nucleus; Cell Survival; Collagen Type II; Cyclooxygenase 2; Cytoprotection; Extracellular Matrix; Gene Expression Regulation; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Intervertebral Disc Degeneration; Magnetic Resonance Imaging; Male; NF-kappa B; Nitric Oxide Synthase Type II; Nucleus Pulposus; Oxidative Stress; Pentacyclic Triterpenes; Protein Transport; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta; Triterpenes; Tumor Necrosis Factor-alpha | 2017 |
Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways.
Topics: Animals; Anti-Inflammatory Agents; Diet, High-Fat; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Obesity; Pentacyclic Triterpenes; RAW 264.7 Cells; Signal Transduction; Triterpenes | 2017 |
Pristimerin Inhibits LPS-Triggered Neurotoxicity in BV-2 Microglia Cells Through Modulating IRAK1/TRAF6/TAK1-Mediated NF-κB and AP-1 Signaling Pathways In Vitro.
Topics: Animals; Inflammation; Interleukin-1 Receptor-Associated Kinases; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mice; Microglia; NF-kappa B; Pentacyclic Triterpenes; Signal Transduction; Transcription Factor AP-1; Triterpenes; Tumor Necrosis Factor-alpha | 2018 |
Celastrol reverses palmitic acid (PA)-caused TLR4-MD2 activation-dependent insulin resistance via disrupting MD2-related cellular binding to PA.
Topics: Animals; Diet, High-Fat; Gene Expression Regulation; Humans; Inflammation; Insulin Resistance; Mice, Inbred C57BL; Palmitic Acid; Pentacyclic Triterpenes; Signal Transduction; Toll-Like Receptor 4; Triterpenes | 2018 |
Celastrol attenuates incision-induced inflammation and pain associated with inhibition of the NF-κB signalling pathway via SARM.
Topics: Animals; Armadillo Domain Proteins; Cytokines; Cytoskeletal Proteins; Hyperalgesia; Inflammation; Macrophages; Male; NF-kappa B; Pain; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; Transcription Factor RelA; Triterpenes; Wounds and Injuries | 2018 |
Celastrol alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression.
Topics: Animals; Camphanes; Disease Models, Animal; Fibrosis; Humans; Inflammation; Kidney; Kidney Diseases; Male; Mice, Inbred BALB C; Pentacyclic Triterpenes; Pyrazoles; Receptor, Cannabinoid, CB2; Signal Transduction; Smad3 Protein; Triterpenes; Up-Regulation; Ureteral Obstruction | 2018 |
RETRACTED: Tripterine alleviates LPS-induced inflammatory injury by up-regulation of miR-146a in HaCaT cells.
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Inflammation; Keratinocytes; Lipopolysaccharides; MAP Kinase Kinase 4; MicroRNAs; NF-kappa B; Pentacyclic Triterpenes; Signal Transduction; Triterpenes; Up-Regulation | 2018 |
Effect of celastrol on toll‑like receptor 4‑mediated inflammatory response in free fatty acid‑induced HepG2 cells.
Topics: Animals; Fatty Acids, Nonesterified; Hep G2 Cells; Humans; Inflammation; Non-alcoholic Fatty Liver Disease; Pentacyclic Triterpenes; Rats; Toll-Like Receptor 4; Triglycerides; Triterpenes | 2018 |
Celastrol ameliorates inflammatory pain and modulates HMGB1/NF-κB signaling pathway in dorsal root ganglion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Freund's Adjuvant; Ganglia, Spinal; HMGB1 Protein; Hyperalgesia; Inflammation; Inflammation Mediators; Male; NF-kappa B; Pain; Pentacyclic Triterpenes; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Triterpenes | 2019 |
Celastrol antagonizes high glucose-evoked podocyte injury, inflammation and insulin resistance by restoring the HO-1-mediated autophagy pathway.
Topics: Animals; Autophagy; Cytokines; Diabetic Nephropathies; Gene Expression Regulation, Enzymologic; Glucose; Heme Oxygenase-1; Inflammation; Insulin Resistance; Membrane Proteins; Mice; Pentacyclic Triterpenes; Podocytes; Signal Transduction; Triterpenes | 2018 |
Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Models, Animal; Female; Humans; Inflammation; Interleukin-18; Lipopolysaccharides; Microglia; Neuroprotective Agents; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Pentacyclic Triterpenes; Pyroptosis; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Triterpenes | 2019 |
Celastrol Ameliorates Inflammation in Human Retinal Pigment Epithelial Cells by Suppressing NF-κB Signaling.
Topics: Cells, Cultured; Humans; Inflammation; NF-kappa B; Ophthalmic Solutions; Pentacyclic Triterpenes; Retinal Pigment Epithelium; Signal Transduction; Triterpenes | 2019 |
Inflammation-Targeted Delivery of Celastrol via Neutrophil Membrane-Coated Nanoparticles in the Management of Acute Pancreatitis.
Topics: Amylases; Animals; Cell Membrane; Disease Models, Animal; Inflammation; Interleukin-6; Lung Injury; Male; Molecular Targeted Therapy; Nanoparticles; Neutrophils; Pancreatitis; Particle Size; Pentacyclic Triterpenes; Pharmaceutical Vehicles; Polyesters; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Tissue Distribution; Treatment Outcome; Triterpenes; Tumor Necrosis Factor-alpha | 2019 |
Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions.
Topics: Adipose Tissue, Brown; Animals; Arterial Pressure; Basal Metabolism; Body Weight; Cytokines; Diet, High-Fat; Disease Models, Animal; Eating; Endoplasmic Reticulum Stress; Energy Metabolism; Inflammation; Kidney; Mice; Mice, Knockout; Obesity; Pentacyclic Triterpenes; Receptor, Melanocortin, Type 4; Receptors, Leptin; Sympathetic Nervous System; Triterpenes; Weight Loss | 2019 |
Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis.
Topics: Animals; Arthritis; Biological Availability; Cations; Drug Carriers; Drug Delivery Systems; Drug Liberation; Hyaluronic Acid; Inflammation; Lipids; Liposomes; Male; Mice; Mice, Inbred DBA; Particle Size; Pentacyclic Triterpenes; Rats, Sprague-Dawley; RAW 264.7 Cells; Triterpenes | 2019 |
Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis.
Topics: Animals; Colitis; Cytokines; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Homeostasis; Humans; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Pentacyclic Triterpenes; Superoxide Dismutase; Triterpenes | 2014 |
Pristimerin, a natural anti-tumor triterpenoid, inhibits LPS-induced TNF-α and IL-8 production through down-regulation of ROS-related classical NF-κB pathway in THP-1 cells.
Topics: Antineoplastic Agents; Cells, Cultured; Down-Regulation; Humans; I-kappa B Kinase; I-kappa B Proteins; Inflammation; Interleukin-8; Lipopolysaccharides; NF-kappa B; NF-KappaB Inhibitor alpha; Pentacyclic Triterpenes; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Transcription Factor RelA; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmune Diseases; Cell Differentiation; Chemotaxis; Disease Models, Animal; Drugs, Chinese Herbal; Inflammation; Pentacyclic Triterpenes; Rats; T-Lymphocytes, Regulatory; Th17 Cells; Triterpenes | 2015 |
Celastrol inhibits inflammatory stimuli-induced neutrophil extracellular trap formation.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Extracellular Traps; Humans; I-kappa B Proteins; Immunoglobulin G; Inflammation; Intracellular Signaling Peptides and Proteins; Lupus Erythematosus, Systemic; MAP Kinase Kinase Kinases; Neutrophils; NF-KappaB Inhibitor alpha; Ovalbumin; Pentacyclic Triterpenes; Phosphorylation; Protein-Tyrosine Kinases; Respiratory Burst; Syk Kinase; Tripterygium; Triterpenes; Tumor Necrosis Factor-alpha | 2015 |
Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells.
Topics: Antimycin A; Cell Line; Glucose; Glucose Transporter Type 4; Humans; Inflammation; Insulin; Insulin Resistance; Mitochondria; Muscle Cells; Muscle, Skeletal; NF-kappa B; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Phosphorylation; Protective Agents; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction; Triterpenes | 2015 |
Inhibition of inflammation with celastrol fails to improve muscle function in dysferlin-deficient A/J mice.
Topics: Analysis of Variance; Animals; Body Weight; Cytokines; Disease Models, Animal; Dysferlin; Echocardiography; Female; Gene Expression Regulation; In Vitro Techniques; Inflammation; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Strength; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Pentacyclic Triterpenes; Triterpenes | 2015 |
Celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation.
Topics: Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Inflammation; Light; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Neuroprotective Agents; Opsins; Oxidative Stress; Pentacyclic Triterpenes; Retinal Degeneration; Rhodopsin; Triterpenes | 2016 |
Celastrol inhibits IL-1β-induced inflammation in orbital fibroblasts through the suppression of NF-κB activity.
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Survival; Cyclooxygenase 2; Dinoprostone; Enzyme Activation; Female; Fibroblasts; Gene Expression; Graves Disease; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Interleukin-8; Male; NF-kappa B; Pentacyclic Triterpenes; Signal Transduction; Triterpenes | 2016 |
Celastrol and Its Role in Controlling Chronic Diseases.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Autoimmune Diseases; Chronic Disease; Humans; Inflammation; Pentacyclic Triterpenes; Signal Transduction; Triterpenes | 2016 |
Celastrol attenuates mitochondrial dysfunction and inflammation in palmitate-mediated insulin resistance in C3A hepatocytes.
Topics: Biological Transport; Cell Survival; Cytokines; Cytoprotection; Fatty Acids; Glucose; Hepatocytes; Humans; Inflammation; Insulin; Insulin Resistance; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Mitochondria; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Palmitates; Pentacyclic Triterpenes; Signal Transduction; Triterpenes | 2017 |
Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1.
Topics: Animals; Blood Pressure; Cells, Cultured; Cytokines; Enzyme Activation; Fructose; Heme Oxygenase (Decyclizing); Hypertension; Inflammation; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Triterpenes | 2010 |
Tunable physiologic interactions of adhesion molecules for inflamed cell-selective drug delivery.
Topics: Cell Adhesion; Cell Adhesion Molecules; Cell Line; Drug Delivery Systems; Endothelium; Flow Cytometry; Humans; Inflammation; Integrins; Intercellular Adhesion Molecule-1; Liposomes; Monocytes; Pentacyclic Triterpenes; Reverse Transcriptase Polymerase Chain Reaction; Triterpenes | 2011 |
Modulation of inflammatory signaling and cytokine release from microglia by celastrol incorporated into dendrimer nanocarriers.
Topics: Anti-Inflammatory Agents; Cell Line; Cell Survival; Cytokines; Dendrimers; Drug Carriers; Humans; Inflammation; Lipopolysaccharides; Microglia; NF-kappa B; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Signal Transduction; Tripterygium; Triterpenes | 2012 |
Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Benzoquinones; Cell Line; Cell Membrane; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Hydroxamic Acids; Inflammation; Inhibitory Concentration 50; Lipopolysaccharides; Mice; Microscopy, Confocal; Monocytes; Pentacyclic Triterpenes; Peptide Hydrolases; Recombinant Proteins; Sulfonamides; Triterpenes; Tumor Necrosis Factor-alpha | 2012 |
Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk.
Topics: 3T3 Cells; Acid Phosphatase; Animals; Arthritis; Autoimmune Diseases; Bone and Bones; Celastrus; Cell Line; Fibroblasts; Immune System; Inflammation; Isoenzymes; Macrophages; Mice; Pentacyclic Triterpenes; Plant Extracts; Rats; Rats, Inbred Lew; Synovial Membrane; Tartrate-Resistant Acid Phosphatase; Triterpenes | 2012 |
Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Carbonates; Cell Line; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Humans; Inflammation; Lactones; Male; Mice; Pentacyclic Triterpenes; Phenanthrenes; Phytotherapy; Pyridines; Rats; Tripterygium; Triterpenes | 2012 |
[The experimental study on the inhibitory effect of tripterine on airway inflammation in asthmatic mice].
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Eosinophils; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NIH 3T3 Cells; Pentacyclic Triterpenes; Random Allocation; Stem Cell Factor; Tripterygium; Triterpenes | 2004 |
Celastrol inhibits pro-inflammatory cytokine secretion in Crohn's disease biopsies.
Topics: Cell Line; Cell Survival; Cells, Cultured; Colon; Crohn Disease; Cytokines; Humans; Inflammation; Lipopolysaccharides; Monocytes; Pentacyclic Triterpenes; Receptors, Glucocorticoid; Triterpenes | 2004 |
Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; DNA-Binding Proteins; Female; Gene Expression; Genes, Reporter; HeLa Cells; Humans; I-kappa B Kinase; Inflammation; Jurkat Cells; Mice; Mice, Nude; Neoplasms, Experimental; NF-kappa B; Pentacyclic Triterpenes; Phosphorylation; Triterpenes | 2006 |
Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells.
Topics: Animals; Cell Line; Cytokines; Gene Expression Regulation, Enzymologic; Inflammation; Inflammation Mediators; Mice; Microglia; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Pentacyclic Triterpenes; RNA, Messenger; Signal Transduction; Transcription, Genetic; Triterpenes | 2007 |