celastrol has been researched along with Hepatocellular Carcinoma in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 10 (47.62) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, K; Fang, M; Guo, K; He, F; Huang, J; Li, B; Lin, Z; Liu, S; Wu, Q; Wu, Z; Yao, J; Zeng, J | 1 |
| Chen, J; Chen, X; Fang, M; Li, M; Li, Z; Liu, W; Qin, J; Qiu, Y; Wang, S; Wu, Z; Xia, Y; Yuan, Q | 1 |
| Lin, Y; Liu, J; Wang, X; Xu, W; Xu, X; Zhang, X; Zheng, Y | 1 |
| Chen, SR; Cheng, YC; Ding, MY; Li, ZQ; Shan, YM; Sun, YW; Wang, Y; Wang, YQ; Xu, J; Zhang, GX | 1 |
| Chen, X; Hu, J; Hu, X; Qiu, Z; Yuan, M; Zheng, G | 1 |
| El-Ahwany, E; El-Kader, EMA; Ghanim, AMH; Saber, S | 1 |
| Chen-Fang, L; Chih-Hsien, C; Hong-Shiue, C; Kun-Ming, C; Ting-Jung, W; Wei-Chen, L | 1 |
| Cao, Y; Chen, Y; Cheng, J; Chu, F; Ding, X; Du, S; Durojaye, OA; Gao, X; Li, Y; Liu, X; Shi, X; Song, X; Su, Z; Wang, D; Wang, F; Wang, J; Wang, T; Zeng, W | 1 |
| Chen, B; Chen, J; Chen, X; Huang, S; Li, J; Peng, B; Tang, Y; Zheng, Y; Zhong, X; Zou, X | 1 |
| Chen, HB; Shen, B; Wu, MH; Zhou, HG | 1 |
| Hsu, SP; Lee, JC; Lin, CK; Tseng, CK; Wu, YH; Young, KC | 1 |
| Fang, S; He, B; Liu, Z; Ma, L; Peng, L | 1 |
| Chen, Z; Kong, LC; Wei, P; Wu, SS; Xu, J; Zhang, R | 1 |
| Jiang, HL; Jin, JZ; Liang, J; Lin, GF; Ma, DY; Wu, D; Xu, D; Yu, H | 1 |
| Li, H; Li, Y; Liu, D; Liu, J; Sun, H | 1 |
| Han, LZ; Jin, X; Lee, JJ; Liang, H; Ma, J; Mi, C; Shi, H | 1 |
| Chua, MS; So, S; Sun, CK; Wang, X; Wei, W; Wu, S; Yan, X; Yang, X | 1 |
| He, W; Li, PP; Lu, JT; Song, SS; Wei, W; Yuan, PF | 1 |
| Chang, W; He, W; Li, PP; Lu, JT; Song, SS; Wei, W; Yuan, PF | 1 |
| Goh, JN; Kannaiyan, R; Khin, E; Kumar, AP; Li, F; Luk, JM; Rajendran, P; Sethi, G; Shanmugam, MK; Tergaonkar, V; Wang, W; Wong, KF | 1 |
| Ding, WJ; He, LJ; He, QJ; Huang, P; Liao, SD; Lu, W; Yang, B; Yang, W; Zheng, L; Zhu, H | 1 |
21 other study(ies) available for celastrol and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Design; Humans; Hydrazines; Kaplan-Meier Estimate; Liver Neoplasms; Mice; Molecular Docking Simulation; Nuclear Receptor Subfamily 4, Group A, Member 1; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2020 |
Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Humans; Indoles; Liver Neoplasms; Molecular Targeted Therapy; Nuclear Receptor Subfamily 4, Group A, Member 1; Pentacyclic Triterpenes; Structure-Activity Relationship | 2022 |
Hepatoma-targeting and reactive oxygen species-responsive chitosan-based polymeric micelles for delivery of celastrol.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Chitosan; Drug Carriers; Humans; Liver Neoplasms; Micelles; Polymers; Reactive Oxygen Species; Tumor Microenvironment | 2023 |
Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β.
Topics: Animals; Carcinoma, Hepatocellular; Heat-Shock Proteins; Hepacivirus; Hepatitis C; HSP90 Heat-Shock Proteins; Inflammation; Liver Neoplasms; Mice; NLR Family, Pyrin Domain-Containing 3 Protein | 2023 |
Celastrol-Loaded Galactosylated Liposomes Effectively Inhibit AKT/c-Met-Triggered Rapid Hepatocarcinogenesis in Mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Survival; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Galactose; Hep G2 Cells; Humans; Liposomes; Liver Neoplasms; Mice; Particle Size; Pentacyclic Triterpenes; Phosphatidylethanolamines; Polyethylene Glycols; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Solubility; Transfection; Treatment Outcome | 2020 |
Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; I-kappa B Kinase; Inflammasomes; Liver Neoplasms; Male; Metformin; Mice; Mice, Inbred BALB C; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Pentacyclic Triterpenes; Signal Transduction; Triterpenes | 2020 |
Potential Anticancer Effect of Celastrol on Hepatocellular Carcinoma by Suppressing CXCR4-related Signal and Impeding Tumor Growth in Vivo.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Humans; Liver Neoplasms; Mice; Pentacyclic Triterpenes; Receptors, CXCR4; Signal Transduction; Triterpenes | 2020 |
Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells.
Topics: Biotin; Carcinoma, Hepatocellular; Catalytic Domain; Cell Movement; Cytoskeletal Proteins; Disease Progression; HEK293 Cells; Hep G2 Cells; Humans; Liver Neoplasms; Medicine, Chinese Traditional; Molecular Docking Simulation; Neoplasm Invasiveness; Neoplasm Metastasis; Pentacyclic Triterpenes; Phosphorylation; rho-Associated Kinases; Triterpenes; Wound Healing | 2020 |
Pristimerin synergistically sensitizes conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells to sorafenib through endoplasmic reticulum stress and ROS generation by modulating Akt/FoxO1/p27
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Survival; Cyclin-Dependent Kinase Inhibitor p27; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Forkhead Box Protein O1; Human Umbilical Vein Endothelial Cells; Humans; Liver Neoplasms; Middle Aged; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Sorafenib; Tumor Cells, Cultured | 2021 |
Celastrol induces caspase-dependent apoptosis of hepatocellular carcinoma cells by suppression of mammalian target of rapamycin.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Pentacyclic Triterpenes; Sirolimus; TOR Serine-Threonine Kinases | 2021 |
Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells.
Topics: Antiviral Agents; Carcinoma, Hepatocellular; DNA Replication; Heme Oxygenase-1; Hepacivirus; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; NF-E2-Related Factor 2; Pentacyclic Triterpenes; Replicon; Signal Transduction; Transcriptional Activation; Triterpenes; Up-Regulation; Viral Nonstructural Proteins; Virus Replication | 2017 |
Celastrol downregulates E2F1 to induce growth inhibitory effects in hepatocellular carcinoma HepG2 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Pentacyclic Triterpenes; RNA, Small Interfering; Signal Transduction; Triterpenes | 2017 |
Celastrol Enhances the Anti-Liver Cancer Activity of Sorafenib.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Mice; Mice, Inbred C57BL; Pentacyclic Triterpenes; Signal Transduction; Sorafenib; Triterpenes; Xenograft Model Antitumor Assays | 2019 |
Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Synergism; Humans; Indoles; Liver Neoplasms; Male; Mice; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-met; Sulfones; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
miR-224 is critical for celastrol-induced inhibition of migration and invasion of hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Movement; Cell Survival; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MicroRNAs; Neoplasm Invasiveness; NF-kappa B; Pentacyclic Triterpenes; Real-Time Polymerase Chain Reaction; Triterpenes | 2013 |
Celastrol inhibits the HIF-1α pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Liver Neoplasms, Experimental; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Pentacyclic Triterpenes; Phosphorylation; Proteolysis; Triterpenes; Xenograft Model Antitumor Assays | 2014 |
Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Pentacyclic Triterpenes; Signal Transduction; Triterpenes; Xenograft Model Antitumor Assays | 2014 |
Celastrol induces mitochondria-mediated apoptosis in hepatocellular carcinoma Bel-7402 cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Cytochromes c; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mitochondria, Liver; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tripterygium; Triterpenes; Tumor Cells, Cultured | 2015 |
Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms.
Topics: Animals; Antineoplastic Agents; bcl-2-Associated X Protein; bcl-X Protein; Carcinogenesis; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Cytochromes c; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Liver; Liver Neoplasms; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitochondria; Pentacyclic Triterpenes; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Triterpenes; Tumor Suppressor Protein p53 | 2016 |
Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Female; Gene Expression Regulation; Humans; In Vitro Techniques; Janus Kinase 2; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Pentacyclic Triterpenes; Signal Transduction; STAT3 Transcription Factor; Tetrazolium Salts; Thiazoles; Triterpenes; Vanadates | 2012 |
Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells.
Topics: Apoptosis; Biphenyl Compounds; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Drug Synergism; Endoplasmic Reticulum Stress; Humans; Immunoprecipitation; Membrane Potential, Mitochondrial; Nitrophenols; Pentacyclic Triterpenes; Piperazines; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sulfonamides; Triterpenes | 2012 |