celastrol has been researched along with Disease Models, Animal in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (2.67) | 29.6817 |
| 2010's | 48 (64.00) | 24.3611 |
| 2020's | 25 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Astry, B; Moudgil, KD; Nanjundaiah, SM; Venkatesha, SH; Yu, H | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Chen, S; Qiu, F; Wang, Z; Xi, L; Zhao, Y; Zheng, Y | 1 |
| Guo, B; Qin, L; Su, Z; Wang, B; Zhang, C; Zhang, W; Zhao, M; Zheng, R | 1 |
| Guo, B; Hu, Z; Liu, J; Qin, L; Su, Z; Wang, B; Yang, X; Zhang, C; Zhang, W; Zhao, M; Zheng, R | 1 |
| Chen, X; Li, B; Li, HJ; Li, W; Li, X; Liu, L; Lu, Y; Sun, XY; Ze, K; Zhou, YQ | 1 |
| Chen, D; Chen, Q; Fan, H; Guo, C; Guo, H; Hou, X; Liu, H; Mu, X; Su, Y; Wang, G; Xu, H; Yu, C; Zhao, F; Zhao, Y | 1 |
| Gao, W; Jiang, M; Liu, X; Liu, Y; Wu, X; Wu, Y; Xin, J; Yang, T | 1 |
| Ahmed Abdi, B; Arora, R; Biernaskie, J; Carter, DE; Chitturi, P; Leask, A; Nguyen, J; Sinha, S; Stratton, RJ; Xu, S | 1 |
| Jin, H; Sun, K; Xing, Y; Yu, F; Zhao, W; Zheng, X | 1 |
| Fan, N; Luo, D; Nie, H; Rong, J; Wang, Y; Zhang, Z; Zhao, J | 1 |
| Morgese, MG; Schiavone, S; Trabace, L; Tucci, P | 1 |
| Bi, Y; Jia, J; Liu, Y; Ren, Z; Tan, Y; Yu, M; Yu, X; Zhang, Q; Zhao, Q; Zhong, J | 1 |
| Benedict, B; Hulleman, E; Kaspers, GJL; Koster, J; Meel, MH; Metselaar, DS; Waranecki, P | 1 |
| Li, J; Li, L; Liang, Y; Liao, H; Lin, L; Peng, X; Wang, J; Yin, Y | 1 |
| Chen, S; He, J; Jiang, X; Liu, M; Lu, W; Ye, X; Yi, C; Zhang, Q | 1 |
| Chen, X; Hu, J; Hu, X; Qiu, Z; Yuan, M; Zheng, G | 1 |
| Ahn, KS; Alharbi, SA; Arfuso, F; Chinnathambi, A; Sethi, G; Shair, OH; Tang, FR; Wang, H | 1 |
| Li, RX; Qian, ZQ; Yang, HR; Zhu, BJ | 1 |
| Abd El-Kader, EM; El-Saeed, B; El-Shamy, R; Ezzat, D; Mostafa, A; Saber, S; Sharaf, H; Shata, A | 1 |
| Ji, Y; Jin, T; Jin, YY; Liu, XM; Ma, BJ; Ma, K; Wu, D; Wu, SY; Wu, T; Xu, JT | 1 |
| Abu Bakar, MH; Lee, LK; Shariff, KA; Tan, JS | 1 |
| Fan, X; Fu, C; Hou, Z; Li, Y; Nie, Y; Tong, X; Xie, H; Yan, M; Zhang, H; Zhang, M | 1 |
| Kikuchi, N; Kurosawa, R; Miyata, S; Nakata, T; Nogi, M; Omura, J; Satoh, K; Satoh, T; Shimokawa, H; Shindo, T; Siddique, MAH; Sunamura, S; Takeuchi, Y | 1 |
| Chen, Q; Chen, X; Lin, C; Liu, T; Ren, L; Shan, W; Yang, Q; Zhang, H; Zhang, L; Zhang, X; Zheng, H | 1 |
| Chi, H; Li, J; Lin, N; Liu, Y; Meng, Y; Tian, C; Wang, J; Yang, J; Zhu, C; Zhu, Y | 1 |
| Chen, M; Fei, H; Huang, H; Li, M; Liu, M; Luo, W; Luo, Y; Peng, Z; Wang, H; Yang, J | 1 |
| Cho, I; Cho, YY; Kang, HC; Kim, KB; Kwack, SJ; Lee, HS; Lee, JK; Lee, JY; Seok, JK; Yang, G | 1 |
| Deng, CF; Gong, YZ; Liao, DF; Liu, LP; Qin, L; Shi, YN; Shi, Z; Yan, JY; Zhao, TJ | 1 |
| Alitongbieke, G; Cai, L; Chen, H; Chen, X; Chong, S; Diaz-Meco, MT; Fang, H; Hu, M; Jiang, F; Lin, X; Liu, J; Luo, Q; Moscat, J; Su, Y; Wang, Z; Xie, L; Xu, C; Yang, S; Ye, X; Zhang, D; Zhang, F; Zhang, XK; Zhou, H; Zhou, Y | 1 |
| Wang, Y; Wei, Y | 1 |
| Hou, Y; Song, X; Wang, P; Yin, J; Yin, Y | 1 |
| Divya, T; Sudhandiran, G; Velavan, B | 1 |
| Caprioli, J; Gu, L; Kwong, JMK; Piri, N; Yadegari, D; Yu, F | 1 |
| Cao, F; Hu, X; Jiang, M; Jin, M; Liu, X; Wang, Y; Xu, F; Xu, L; Zhang, D | 1 |
| Cao, X; He, QH; Li, GQ; Li, SJ; Li, Y; Tang, M; Xu, GL; Zhang, K; Zhang, KQ; Zheng, QY | 1 |
| Guo, L; Li, J; Li, Q; Luo, X; Wang, Y; Wu, G; Xi, J | 1 |
| Ding, G; Huang, S; Jia, Z; Meng, X; Xu, M; Yu, X; Zhang, A; Zhang, X; Zhang, Y | 1 |
| Gualtieri, F; Hunt, CR; Keck, M; Pandita, TK; Potschka, H; von Rüden, EL; Wolf, F | 1 |
| Dai, W; Li, C; Teng, H; Wang, B; Wang, J; Wang, X | 1 |
| Bao, WM; Cheng, Y; Gonzalez, FJ; Hu, DD; Hu, JP; Jiang, T; Li, F; Liu, F; Tang, YM; Xiao, XR; Yang, JH; Zhao, Q | 1 |
| Cao, X; Deng, L; Tu, H; Zhang, ZR; Zhou, X | 1 |
| Jiang, N; Li, C; Lin, J; Peng, X; Sun, Q; Wang, Q; Xu, Q; Zhao, G | 1 |
| Berglund, ED; Cui, H; Davis, KC; Grobe, JL; Jiang, J; Morgan, DA; Rahmouni, K; Saito, K; Singh, U; Toth, BA | 1 |
| Lin, Z; Liu, Z; Meng, S; Sun, L; Wang, L; Wang, Z; Xi, L; Zheng, Y | 1 |
| Jiang, HL; Jin, JZ; Liang, J; Lin, GF; Ma, DY; Wu, D; Xu, D; Yu, H | 1 |
| Arreaza-Rubín, G; Duclos, SK; Grant, CW; Guberski, DL; Moran-Paul, CM; Spain, LM | 1 |
| Gao, S; Hao, J; Huang, H; Ji, W; Ren, H; Zhao, X | 1 |
| Choi, J; Dhandapani, KM; Eroglu, B; Kimbler, DE; Mivechi, NF; Moskophidis, D; Pang, J; Yanasak, N | 1 |
| Cui, J; Li, H; Wang, H | 1 |
| Fu, J; Li, Y; Lin, D; Qiu, Y; Ren, J; Yang, L; Zhu, C | 1 |
| Anamalai, M; Deshmukh, S; Kaushal, S; Mishra, R; Patel, J; Sharma, S; Simpson, D; Singh, IS; Walker, BL; Zampino, M | 1 |
| Astry, B; Moudgil, KD; Nanjundaiah, SM; Tong, L; Venkatesha, SH; Yu, H | 1 |
| Astry, B; Christensen-Quick, A; Frieman, MB; Garzino-Demo, A; Laurence, A; Moudgil, KD; O'Shea, JJ; Venkatesha, SH | 1 |
| Cao, FF; Cao, L; Peng, B; Shen, YF; Uzan, G; Wang, Y; Xu, LM; Zhang, DH; Zhang, X | 1 |
| Bekerman, V; Caprioli, J; Gu, L; Kwong, JM; Kyung, H; Piri, N; Yadegari, D | 1 |
| Dong, JN; Gong, JF; Gu, LL; Li, JS; Li, N; Li, Y; Shi, P; Sun, Y; Wang, HG; Zhao, J; Zhu, WM; Zuo, LG | 1 |
| Ampong, B; Benny Klimek, ME; Dillingham, BC; Gallardo, E; Gernapudi, R; Gordish-Dressman, H; Jordan, S; Nagaraju, K; Rayavarapu, S; Spurney, CF; Van der Meulen, JH | 1 |
| Cao, C; Li, M; Lu, C; Pei, E; Tang, T; Uzan, G; Wang, S; Xu, J; Ye, M; Yu, X; Zhang, X; Zhi, K; Zuo, K | 1 |
| Berdel, WE; Coulibaly, A; Dassé, E; Frampton, J; Jakobs, A; Jose, J; Klempnauer, KH; Müller-Tidow, C; Schlenke, P; Schmidt, TJ; Schomburg, C; Steinmann, S; Trentmann, A; Uttarkar, S | 1 |
| Bian, M; Chen, Y; Cui, J; Du, X; Wang, P; Wang, W; Zhang, T; Zhu, W | 1 |
| Cai, F; Liu, L; Liu, X; Yang, A; Zhang, Y | 1 |
| Chai, Y; Dai, W; Duan, G; Fan, G; Gonzalez, FJ; Gu, X; Lu, F; Qi, Y; Wang, R; Ye, J | 1 |
| Chen, LM; Cui, ZJ; Guan, Y; Han, LP; Li, CJ; Sun, B | 1 |
| Chen, LM; Guan, Y; Han, LP; Li, CJ; Ma, ZJ; Sun, B; Xie, Y | 1 |
| Jin, Y; Lu, J; Ma, S; Shuang, G; Wang, Y; Zhao, D | 1 |
| Cheng, M; Song, Y; Tu, L; Wang, L; Wu, G; Zhang, C; Zhang, L | 1 |
| Astry, B; Dudics, S; Moudgil, KD; Venkatesha, SH | 1 |
| Hsieh, CL; Hsu, YC; Lee, JC; Lin, CK; Tseng, CK; Wu, YH; Yu, JS | 1 |
| El-Awady, MS; El-Kashef, HA; El-Tanbouly, GS; Megahed, NA; Salem, HA | 1 |
| But, PP; Ge, W; He, MF; Jiang, R; Liu, L; Shaw, PC; Wu, LW | 1 |
| Jeoung, D; Kim, DY; Park, JW; Ro, JY | 1 |
| Ait-Ghezala, G; Bachmeier, C; Beaulieu-Abdelahad, D; Ganey, NJ; Laporte, V; March, A; Mullan, MJ; Paris, D; Patel, NS | 1 |
| Cascão, R; Figueiredo, N; Fonseca, JE; Gupta, V; Moita, LF; Neves-Costa, A; Raquel, H; Vidal, B | 1 |
| Moudgil, KD; Venkatesha, SH; Yu, H | 1 |
1 review(s) available for celastrol and Disease Models, Animal
| Article | Year |
|---|---|
Control of autoimmune inflammation by celastrol, a natural triterpenoid.
Topics: Animals; Autoimmune Diseases; Autoimmunity; Biological Products; Cell Adhesion Molecules; Cell Communication; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Humans; Immunomodulation; Inflammation; Pentacyclic Triterpenes; Signal Transduction; T-Lymphocyte Subsets; Triterpenes | 2016 |
74 other study(ies) available for celastrol and Disease Models, Animal
| Article | Year |
|---|---|
Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Celastrus; Cell Movement; Chemokines; Cytokines; Disease Models, Animal; Flow Cytometry; Male; Pentacyclic Triterpenes; Rats; Rats, Inbred Lew; Receptors, Chemokine; Spleen; Triterpenes | 2012 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Celastrol Niosome Hydrogel Has Anti-Inflammatory Effect on Skin Keratinocytes and Circulation without Systemic Drug Exposure in Psoriasis Mice.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Hydrogels; Keratinocytes; Liposomes; Mice; Mice, Inbred BALB C; Pentacyclic Triterpenes; Psoriasis; Skin | 2021 |
The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease.
Topics: Animals; Caspase 1; Disease Models, Animal; Mice; Mice, Inbred C57BL; Neuroprotective Agents; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Pentacyclic Triterpenes | 2021 |
Celastrol prevents high-fat diet-induced obesity by promoting white adipose tissue browning.
Topics: Adipose Tissue, White; Analysis of Variance; Animals; Diet, High-Fat; Disease Models, Animal; Maillard Reaction; Mice; Mice, Knockout; Obesity; Pentacyclic Triterpenes | 2021 |
Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells.
Topics: Animals; Disease Models, Animal; Female; Gels; Imiquimod; Interleukin-23; Langerhans Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pentacyclic Triterpenes; Psoriasis; Tripterygium | 2022 |
Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cell Survival; Chemistry, Pharmaceutical; Dextran Sulfate; Disease Models, Animal; Drug Carriers; Drug Liberation; Matrix Metalloproteinase 2; Mice; Micelles; Nanoparticles; Particle Size; Pentacyclic Triterpenes; Random Allocation; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Surface Properties | 2022 |
Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model.
Topics: Animals; Disease Models, Animal; Liver; Mice; Reperfusion Injury; Transcriptome | 2023 |
Topics: Animals; Bleomycin; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Mice; Scleroderma, Systemic; Skin; Skin Diseases; Transcription Factors; Tripterygium | 2023 |
Combination Therapy with Resveratrol and Celastrol Using Folic Acid-Functionalized Exosomes Enhances the Therapeutic Efficacy of Sepsis.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Exosomes; Folic Acid; Lipopolysaccharides; Mice; Pentacyclic Triterpenes; Resveratrol; Sepsis | 2023 |
Celastrol-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Ethylene Glycols; Gastrointestinal Tract; Inflammation; Insulin Resistance; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Obesity; Particle Size; Pentacyclic Triterpenes; Polyesters; Triterpenes | 2019 |
Early Celastrol Administration Prevents Ketamine-Induced Psychotic-Like Behavioral Dysfunctions, Oxidative Stress and IL-10 Reduction in The Cerebellum of Adult Mice.
Topics: Animals; Cerebellum; Disease Models, Animal; Interleukin-10; Ketamine; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Parvalbumins; Pentacyclic Triterpenes; Psychotic Disorders; Reactive Oxygen Species; Triterpenes | 2019 |
Pristimerin suppresses colorectal cancer through inhibiting inflammatory responses and Wnt/β-catenin signaling.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; HCT116 Cells; HT29 Cells; Humans; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Pentacyclic Triterpenes; Triterpenes; Wnt Signaling Pathway | 2020 |
Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin.
Topics: Adolescent; Animals; Carboplatin; Cell Line, Tumor; Cell Survival; Child; Child, Preschool; Cross-Linking Reagents; Disease Models, Animal; DNA Damage; Drug Resistance, Neoplasm; Fanconi Anemia Complementation Group D2 Protein; Female; Glioma; Humans; Male; Mice; Neoplasm Grading; Pentacyclic Triterpenes; Proteolysis; Triterpenes; Xenograft Model Antitumor Assays | 2019 |
Preventive effects of "ovalbumin-conjugated celastrol-loaded nanomicelles'' in a mouse model of ovalbumin-induced allergic airway inflammation.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophils; Female; Histamine Release; Immunoglobulin E; Immunoglobulin G; Lung; Mice, Inbred BALB C; Micelles; Nanostructures; Ovalbumin; Pentacyclic Triterpenes; Triterpenes | 2020 |
Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrestin; Bleomycin; Calcium; Disease Models, Animal; Drug Evaluation, Preclinical; Fibrosis; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Pentacyclic Triterpenes; RAW 264.7 Cells; Receptor, Cannabinoid, CB2; Scleroderma, Systemic; Triterpenes | 2020 |
Celastrol-Loaded Galactosylated Liposomes Effectively Inhibit AKT/c-Met-Triggered Rapid Hepatocarcinogenesis in Mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Survival; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Galactose; Hep G2 Cells; Humans; Liposomes; Liver Neoplasms; Mice; Particle Size; Pentacyclic Triterpenes; Phosphatidylethanolamines; Polyethylene Glycols; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Solubility; Transfection; Treatment Outcome | 2020 |
Celastrol Alleviates Gamma Irradiation-Induced Damage by Modulating Diverse Inflammatory Mediators.
Topics: Animals; Cell Line; Cell Proliferation; Cell Survival; Disease Models, Animal; Fibroblasts; Foreskin; Gamma Rays; Glutathione; Humans; Interleukin-1beta; Interleukin-6; Keratinocytes; Male; Mice; Oxidative Stress; Pentacyclic Triterpenes; Radiation-Protective Agents; Triterpenes; Tumor Necrosis Factor-alpha | 2020 |
Tripterine: A Potential Anti-Allergic Compound.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Calcimycin; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Histamine Release; Humans; Male; Mast Cells; Mice, Inbred BALB C; NF-kappa B; p-Methoxy-N-methylphenethylamine; Pentacyclic Triterpenes; Rats; Rhinitis, Allergic; Tetradecanoylphorbol Acetate; Triterpenes | 2021 |
Celastrol augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Drug Therapy, Combination; Furans; Heterocyclic Compounds, 4 or More Rings; HSP90 Heat-Shock Proteins; Indenes; Inflammasomes; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Pentacyclic Triterpenes; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Triterpenes | 2020 |
Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Disease Models, Animal; Hydrogen-Ion Concentration; Injections, Intra-Articular; Male; Nanomedicine; Nanoparticles; Osteoarthritis, Knee; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Silicon Dioxide; Triterpenes | 2020 |
Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Inflammation Mediators; Insulin Resistance; Macrophage Activation; Macrophages; Male; Mitochondria, Muscle; Muscle, Skeletal; Obesity; Organelle Biogenesis; Panniculitis; Pentacyclic Triterpenes; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1 | 2020 |
Celastrol slows the progression of early diabetic nephropathy in rats via the PI3K/AKT pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Kidney Glomerulus; Male; Molecular Structure; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Podocytes; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Streptozocin | 2020 |
Identification of Celastrol as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension and Right Ventricular Failure Through Suppression of Bsg (Basigin)/CyPA (Cyclophilin A).
Topics: Animals; Antihypertensive Agents; Basigin; Cyclophilin A; Disease Models, Animal; Humans; Hypoxia; Indoles; Mice; Mice, Transgenic; Myocytes, Cardiac; Pentacyclic Triterpenes; Pulmonary Arterial Hypertension; Pyrroles; Rats; Triterpenes; Ventricular Dysfunction, Right | 2021 |
Tubule-specific protein nanocages potentiate targeted renal fibrosis therapy.
Topics: Animals; Apoptosis; Cell Line; Disease Models, Animal; Epithelial Cells; Fibrosis; Kidney; Kidney Tubules; Male; Mice; Mice, Inbred BALB C; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Ureteral Obstruction | 2021 |
Celastrol alleviates comorbid obesity and depression by directly binding amygdala HnRNPA1 in a mouse model.
Topics: Amygdala; Animals; Comorbidity; Depression; Disease Models, Animal; Heterogeneous Nuclear Ribonucleoprotein A1; Mice; Obesity; Pentacyclic Triterpenes | 2021 |
Lipidomic Profiling of Ipsilateral Brain and Plasma after Celastrol Post-Treatment in Transient Middle Cerebral Artery Occlusion Mice Model.
Topics: Animals; Brain; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Lipidomics; Lipids; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Pentacyclic Triterpenes; Reperfusion Injury | 2021 |
Topical application of celastrol alleviates atopic dermatitis symptoms mediated through the regulation of thymic stromal lymphopoietin and group 2 innate lymphoid cells.
Topics: Allergens; Animals; Cell Line, Tumor; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Immunity, Innate; Inflammation; Keratinocytes; Lymphocytes; Mice; NF-kappa B; Pentacyclic Triterpenes; Pyroglyphidae; Skin; Thymic Stromal Lymphopoietin | 2021 |
Celastrol ameliorates vascular neointimal hyperplasia through Wnt5a-involved autophagy.
Topics: Animals; Autophagy; Cells, Cultured; Disease Models, Animal; Femoral Artery; Humans; Hyperplasia; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Pentacyclic Triterpenes; Signal Transduction; TOR Serine-Threonine Kinases; Wnt-5a Protein; Wound Healing | 2021 |
Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Autophagy; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Genotype; HEK293 Cells; HeLa Cells; Hep G2 Cells; Humans; Ligands; Male; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Mitophagy; Nuclear Receptor Subfamily 4, Group A, Member 1; Pentacyclic Triterpenes; Phenotype; Protein Binding; Protein Interaction Domains and Motifs; RNA Interference; Sequestosome-1 Protein; Signal Transduction; TNF Receptor-Associated Factor 2; Transfection; Triterpenes; Ubiquitination | 2017 |
Celastrol attenuates impairments associated with lipopolysaccharide-induced acute respiratory distress syndrome (ARDS) in rats.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Humans; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Medicine, Chinese Traditional; NF-kappa B; Pentacyclic Triterpenes; Rats; Rats, Wistar; Respiratory Distress Syndrome; Triterpenes | 2017 |
Optimization on biodistribution and antitumor activity of tripterine using polymeric nanoparticles through RES saturation.
Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Male; Mice; Mice, Inbred BALB C; Mononuclear Phagocyte System; Nanoparticles; Particle Size; Pentacyclic Triterpenes; Polymers; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Tissue Distribution; Triterpenes | 2017 |
Regulation of Transforming Growth Factor-β/Smad-mediated Epithelial-Mesenchymal Transition by Celastrol Provides Protection against Bleomycin-induced Pulmonary Fibrosis.
Topics: A549 Cells; Animals; Bleomycin; Cadherins; Disease Models, Animal; Drugs, Chinese Herbal; Epithelial Cells; Epithelial-Mesenchymal Transition; Humans; Lung; Male; Pentacyclic Triterpenes; Pulmonary Fibrosis; Rats; Rats, Wistar; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Tripterygium; Triterpenes | 2018 |
The effect of celastrol on the ocular hypertension-induced degeneration of retinal ganglion cells.
Topics: Animals; Cell Survival; Disease Models, Animal; Nerve Degeneration; Neuroprotection; Neuroprotective Agents; Ocular Hypertension; Pentacyclic Triterpenes; Rats; Retinal Ganglion Cells; Treatment Outcome; Triterpenes | 2018 |
Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization.
Topics: Aged; Animals; Apoptosis; Brain Infarction; Brain Injuries; Brain Ischemia; Cell Polarity; Coculture Techniques; Disease Models, Animal; Female; Humans; Interleukin-1 Receptor-Like 1 Protein; Interleukin-3; Macrophages; Male; Microglia; Middle Aged; Neuroprotective Agents; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Recovery of Function; Sensory Gating; Stroke; Triterpenes | 2018 |
Celastrol alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression.
Topics: Animals; Camphanes; Disease Models, Animal; Fibrosis; Humans; Inflammation; Kidney; Kidney Diseases; Male; Mice, Inbred BALB C; Pentacyclic Triterpenes; Pyrazoles; Receptor, Cannabinoid, CB2; Signal Transduction; Smad3 Protein; Triterpenes; Up-Regulation; Ureteral Obstruction | 2018 |
Celastrol inhibits glucocorticoid‑induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways.
Topics: Animals; Body Weight; Calcium; Cell Differentiation; Collagen Type I; Disease Models, Animal; Gene Expression Regulation; Glucocorticoids; Humans; Male; Oncogene Protein v-akt; Osteocalcin; Osteoporosis; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Rats; Tartrate-Resistant Acid Phosphatase; Triterpenes; Wnt Signaling Pathway | 2018 |
Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-κB and improving mitochondrial function.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Biopsy; Cell Line; Cisplatin; Disease Models, Animal; Kidney; Male; Mice; Mitochondria; NF-kappa B; Oxygen Consumption; Pentacyclic Triterpenes; Protective Agents; Reactive Oxygen Species; Signal Transduction; Triterpenes | 2018 |
Genetic and Pharmacological Targeting of Heat Shock Protein 70 in the Mouse Amygdala-Kindling Model.
Topics: Amygdala; Animals; Disease Models, Animal; Drug Delivery Systems; Gene Targeting; HSP70 Heat-Shock Proteins; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentacyclic Triterpenes; Random Allocation; Triterpenes | 2019 |
Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Models, Animal; Female; Humans; Inflammation; Interleukin-18; Lipopolysaccharides; Microglia; Neuroprotective Agents; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Pentacyclic Triterpenes; Pyroptosis; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Triterpenes | 2019 |
Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling.
Topics: 1-Naphthylisothiocyanate; Adult; Animals; Cholestasis, Intrahepatic; Disease Models, Animal; Female; Gene Expression Profiling; Humans; Male; Metabolomics; Mice; Middle Aged; Pentacyclic Triterpenes; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sirtuin 1; Thioacetamide; Treatment Outcome; Triterpenes | 2019 |
Inflammation-Targeted Delivery of Celastrol via Neutrophil Membrane-Coated Nanoparticles in the Management of Acute Pancreatitis.
Topics: Amylases; Animals; Cell Membrane; Disease Models, Animal; Inflammation; Interleukin-6; Lung Injury; Male; Molecular Targeted Therapy; Nanoparticles; Neutrophils; Pancreatitis; Particle Size; Pentacyclic Triterpenes; Pharmaceutical Vehicles; Polyesters; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Tissue Distribution; Treatment Outcome; Triterpenes; Tumor Necrosis Factor-alpha | 2019 |
Celastrol ameliorates Aspergillus fumigatus keratitis via inhibiting LOX-1.
Topics: Animals; Anti-Inflammatory Agents; Aspergillosis; Aspergillus fumigatus; Cells, Cultured; Cornea; Disease Models, Animal; Female; Humans; Keratitis; Macrophages, Peritoneal; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Pentacyclic Triterpenes; Primary Cell Culture; Scavenger Receptors, Class E; Triterpenes | 2019 |
Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions.
Topics: Adipose Tissue, Brown; Animals; Arterial Pressure; Basal Metabolism; Body Weight; Cytokines; Diet, High-Fat; Disease Models, Animal; Eating; Endoplasmic Reticulum Stress; Energy Metabolism; Inflammation; Kidney; Mice; Mice, Knockout; Obesity; Pentacyclic Triterpenes; Receptor, Melanocortin, Type 4; Receptors, Leptin; Sympathetic Nervous System; Triterpenes; Weight Loss | 2019 |
Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Biomarkers; Cholesterol; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Female; Hexoses; Imiquimod; Interferon Inducers; Interleukins; Liposomes; Mice; Mice, Inbred C57BL; Pentacyclic Triterpenes; Plant Extracts; Psoriasis; Skin; Spleen; Tripterygium; Triterpenes | 2019 |
Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Synergism; Humans; Indoles; Liver Neoplasms; Male; Mice; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-met; Sulfones; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Testing agents for prevention or reversal of type 1 diabetes in rodents.
Topics: Animals; Antibodies; Blood Glucose; CD3 Complex; Diabetes Mellitus, Type 1; Disease Models, Animal; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Mice; Mice, Inbred NOD; Pentacyclic Triterpenes; Rats; Remission Induction; Triterpenes | 2013 |
Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Humans; Male; Mice; Pancreatic Neoplasms; Pentacyclic Triterpenes; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury.
Topics: Animals; Brain; Brain Injuries; Disease Models, Animal; Gene Expression Regulation; HSP110 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Immunoblotting; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiplex Polymerase Chain Reaction; Oligonucleotide Array Sequence Analysis; Oximes; Pentacyclic Triterpenes; Piperidines; Reactive Oxygen Species; Triterpenes; Tumor Suppressor Protein p53 | 2014 |
[Protective effect of celastrol on allergic rhinitis in rats].
Topics: Animals; Disease Models, Animal; Glutamate-Cysteine Ligase; Male; Nasal Mucosa; NF-E2-Related Factor 2; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic; Triterpenes | 2014 |
Celastrol attenuates inflammatory and neuropathic pain mediated by cannabinoid receptor type 2.
Topics: Analgesics; Animals; Camphanes; Carrageenan; Disease Models, Animal; Edema; Hyperalgesia; Interleukin-1beta; Interleukin-6; Mice; Mice, Inbred C57BL; Neuralgia; Pentacyclic Triterpenes; Pyrazoles; Receptor, Cannabinoid, CB2; Signal Transduction; Spinal Cord Injuries; Tripterygium; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death.
Topics: Animals; Apoptosis; Cardiomyopathies; Cell Line, Tumor; Cell Survival; Disease Models, Animal; DNA-Binding Proteins; Doxorubicin; GATA4 Transcription Factor; Gene Expression; Heat Shock Transcription Factors; Heat-Shock Proteins; Humans; Interleukin-1beta; Interleukin-6; Liver; Liver Failure; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Pentacyclic Triterpenes; Thioacetamide; Transcription Factors; Triterpenes; Tumor Necrosis Factor-alpha | 2015 |
Pristimerin, a naturally occurring triterpenoid, protects against autoimmune arthritis by modulating the cellular and soluble immune mediators of inflammation and tissue damage.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Autoimmune Diseases; Bone Remodeling; Cytokines; Disease Models, Animal; Disease Progression; Inflammation Mediators; Lymphocyte Count; Male; Matrix Metalloproteinase 9; Nuclear Receptor Subfamily 1, Group F, Member 3; Pentacyclic Triterpenes; Rats; STAT3 Transcription Factor; Synovial Membrane; T-Lymphocyte Subsets; Triterpenes | 2014 |
Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmune Diseases; Cell Differentiation; Chemotaxis; Disease Models, Animal; Drugs, Chinese Herbal; Inflammation; Pentacyclic Triterpenes; Rats; T-Lymphocytes, Regulatory; Th17 Cells; Triterpenes | 2015 |
Celastrol Ameliorates EAE Induction by Suppressing Pathogenic T Cell Responses in the Peripheral and Central Nervous Systems.
Topics: Animals; Bone Marrow Cells; Central Nervous System; Dendritic Cells; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Multiple Sclerosis; NF-kappa B; Pentacyclic Triterpenes; Peripheral Nervous System; Th17 Cells; Triterpenes | 2015 |
Celastrol supports survival of retinal ganglion cells injured by optic nerve crush.
Topics: Animals; Body Weight; Cell Count; Cell Survival; Disease Models, Animal; DNA-Binding Proteins; Down-Regulation; Heat Shock Transcription Factors; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); HSP70 Heat-Shock Proteins; Nerve Crush; Neuroprotective Agents; Optic Nerve; Optic Nerve Injuries; Pentacyclic Triterpenes; Rats; Retinal Ganglion Cells; Transcription Factors; Triterpenes; Tumor Necrosis Factor-alpha | 2015 |
Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Blotting, Western; Colon; Crohn Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Interleukin-10; Mice, Inbred C57BL; Mice, Knockout; Pentacyclic Triterpenes; Peroxidase; Real-Time Polymerase Chain Reaction; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes | 2015 |
Inhibition of inflammation with celastrol fails to improve muscle function in dysferlin-deficient A/J mice.
Topics: Analysis of Variance; Animals; Body Weight; Cytokines; Disease Models, Animal; Dysferlin; Echocardiography; Female; Gene Expression Regulation; In Vitro Techniques; Inflammation; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Strength; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Pentacyclic Triterpenes; Triterpenes | 2015 |
Tripterine treatment improves endothelial progenitor cell function via integrin-linked kinase.
Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelial Progenitor Cells; Gene Expression Regulation; Lipoproteins, LDL; Mice; Pentacyclic Triterpenes; Protein Serine-Threonine Kinases; Triterpenes | 2015 |
Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.
Topics: Animals; Cell Differentiation; Cell Proliferation; Chickens; Disease Models, Animal; E1A-Associated p300 Protein; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Mice, Inbred C57BL; Molecular Targeted Therapy; Myeloid Cells; Pentacyclic Triterpenes; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-myb; Small Molecule Libraries; Triterpenes | 2016 |
Celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation.
Topics: Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Inflammation; Light; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Neuroprotective Agents; Opsins; Oxidative Stress; Pentacyclic Triterpenes; Retinal Degeneration; Rhodopsin; Triterpenes | 2016 |
Celastrol, an NF-κB inhibitor, ameliorates hypercalciuria and articular cartilage lesions in a mouse model of secondary osteoporosis.
Topics: Adipose Tissue; Animals; Body Weight; Cartilage, Articular; Disease Models, Animal; Disease Progression; Hypercalciuria; Leptin; Lipid Metabolism; Male; Mice, Inbred C57BL; Molecular Targeted Therapy; NF-kappa B; Osteoporosis; Parathyroid Hormone; Pentacyclic Triterpenes; Triterpenes | 2016 |
A lipidomics investigation into the intervention of celastrol in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Colitis; Dextran Sulfate; Disease Models, Animal; Gene Expression; Lipid Metabolism; Lipids; Male; Metabolomics; Mice; Pentacyclic Triterpenes; Stearoyl-CoA Desaturase; Triterpenes | 2016 |
Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway.
Topics: Aged; AMP-Activated Protein Kinases; Animals; Biomarkers; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Humans; Male; Middle Aged; Mitochondria; Muscle, Skeletal; Oxidative Stress; Pentacyclic Triterpenes; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Signal Transduction; Sirtuin 3; Superoxide Dismutase; Triterpenes | 2016 |
Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats.
Topics: Animals; Anti-Inflammatory Agents; Cytoprotection; Diabetes Mellitus, Type 2; Disease Models, Animal; Interleukin-1beta; Liver; Liver Diseases; Male; Myeloid Differentiation Factor 88; NF-kappa B; Pentacyclic Triterpenes; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4; Triterpenes; Tumor Necrosis Factor-alpha | 2016 |
Pristimerin attenuates ovalbumin-induced allergic airway inflammation in mice.
Topics: Animals; Asthma; Cytokines; Disease Models, Animal; Immunoglobulin E; Mice; Mice, Inbred BALB C; Ovalbumin; Pentacyclic Triterpenes; Triterpenes | 2016 |
Celastrol-Induced Suppression of the MiR-21/ERK Signalling Pathway Attenuates Cardiac Fibrosis and Dysfunction.
Topics: Actins; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cell Survival; Collagen; Disease Models, Animal; Down-Regulation; Fibrosis; Heart Ventricles; Male; MAP Kinase Signaling System; Mice; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; Natriuretic Peptide, Brain; Pentacyclic Triterpenes; Phosphorylation; Transforming Growth Factor beta1; Triterpenes; Up-Regulation | 2016 |
Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses.
Topics: Animals; Animals, Suckling; Antiviral Agents; Dengue; Dengue Virus; Disease Models, Animal; DNA Replication; Interferon Type I; Interferon-alpha; Mice; Mice, Inbred ICR; Pentacyclic Triterpenes; RNA Interference; Survival Analysis; Transcriptional Activation; Triterpenes; Up-Regulation; Virus Replication | 2017 |
The NF-κB inhibitor celastrol attenuates acute hepatic dysfunction induced by cecal ligation and puncture in rats.
Topics: Animals; Anti-Inflammatory Agents; Cecum; Disease Models, Animal; Gene Expression Regulation; Interleukin-10; Interleukin-6; Liver Diseases; Male; NF-kappa B; Pentacyclic Triterpenes; Rats; Toll-Like Receptor 4; Triterpenes | 2017 |
Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Diterpenes; Drugs, Chinese Herbal; Embryo, Nonmammalian; Epoxy Compounds; Neovascularization, Physiologic; Pentacyclic Triterpenes; Phenanthrenes; Plant Roots; Reverse Transcriptase Polymerase Chain Reaction; Terpenes; Tripterygium; Triterpenes; Zebrafish | 2009 |
Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Lung; Matrix Metalloproteinases; Mice; Ovalbumin; Pentacyclic Triterpenes; RNA, Messenger; Specific Pathogen-Free Organisms; Triterpenes | 2009 |
Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Aspartic Acid Endopeptidases; Brain; Carcinogens; Cell Cycle Proteins; Cell Line, Transformed; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; HSP90 Heat-Shock Proteins; Humans; Mice; Mice, Transgenic; Molecular Chaperones; Pentacyclic Triterpenes; Phorbol Esters; Presenilin-1; Signal Transduction; Transfection; Triterpenes | 2010 |
Effective treatment of rat adjuvant-induced arthritis by celastrol.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Differentiation; Cell Line; Digoxin; Disease Models, Animal; Female; Humans; Interleukin-1beta; Joints; Pentacyclic Triterpenes; Rats; Rats, Wistar; Th17 Cells; Triterpenes | 2012 |
Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of Celastrus-derived Celastrol.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Bacterial Proteins; Celastrus; Cell Proliferation; Chaperonin 60; Disease Models, Animal; Gene Expression Profiling; Humans; Immunity; Inflammation Mediators; Medicine, Chinese Traditional; Oligonucleotide Array Sequence Analysis; Pentacyclic Triterpenes; Rats; Rats, Inbred Lew; Signal Transduction; Triterpenes | 2012 |