Compounds > celastrol
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celastrol and Carcinoma, Non-Small Cell Lung

celastrol has been researched along with Carcinoma, Non-Small Cell Lung in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (63.64)24.3611
2020's4 (36.36)2.80

Authors

AuthorsStudies
Gong, Y; Huang, X; Li, J; Wang, L; Wang, X; Wang, Y; Yang, L; Zhang, L; Zhao, C; Zhao, H; Zhao, Z; Zhu, J1
Wu, J; Xu, T; Ye, F1
Chen, YC; Dai, CH; Du, YJ; Li, J; Tang, XP; Wang, Y; Zhu, LR1
Cao, P; Chang, Y; Chen, F; Fan, Y; Han, B; Han, Y; Huang, L; Li, D; Liu, M; Liu, T; Meng, Y; Nakai, A; Song, Z; Tan, K1
Choi, JW; Jun, HY; Kim, TH; Lee, KK; Lee, YH; Yoon, KH1
Cao, F; Chen, H; Chen, Q; Liu, Q; Peng, B; Uzan, G; Wang, Y; Xu, L; You, J; Zhang, D; Zhang, X1
Kim, SY; Lee, C; Lee, YJ1
Hu, Z; Li, W; Liu, J; Liu, Z; Ma, L; Wen, ZS; Wu, FQ; Zhou, GB1
Fan, XX; He, JX; Leung, EL; Li, N; Liu, L; Wu, JL; Zhou, YL1
Bracco, E; Gisabella, M; Lo Iacono, M; Monica, V; Novello, S; Papotti, M; Saviozzi, S; Scagliotti, GV; Vavalà, T1
Bao, H; Fang, W; Mou, H; Xu, N; Zhao, P; Zheng, Y1

Other Studies

11 other study(ies) available for celastrol and Carcinoma, Non-Small Cell Lung

ArticleYear
Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer.
    Journal of translational medicine, 2022, 11-12, Volume: 20, Issue:1

    Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Mice; Mice, Nude; Reactive Oxygen Species; STAT3 Transcription Factor

2022
Celastrol impairs tumor growth by modulating the CIP2A-GSK3β-MCL-1 axis in gastric cancer cells.
    Aging, 2023, 07-19, Volume: 15, Issue:14

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Stomach Neoplasms; Transcription Factors

2023
Celastrol acts synergistically with afatinib to suppress non-small cell lung cancer cell proliferation by inducing paraptosis.
    Journal of cellular physiology, 2021, Volume: 236, Issue:6

    Topics: Afatinib; Animals; Antineoplastic Combined Chemotherapy Protocols; Calcium; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Humans; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Pentacyclic Triterpenes; Reactive Oxygen Species; Unfolded Protein Response; Xenograft Model Antitumor Assays

2021
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.
    Molecular oncology, 2021, Volume: 15, Issue:8

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Ferroptosis; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mitochondrial Dynamics; Mitophagy; Pentacyclic Triterpenes; Piperazines; Reactive Oxygen Species; Xenograft Model Antitumor Assays

2021
Evaluation of connectivity map-discovered celastrol as a radiosensitizing agent in a murine lung carcinoma model: Feasibility study of diffusion-weighted magnetic resonance imaging.
    PloS one, 2017, Volume: 12, Issue:5

    Topics: A549 Cells; Animals; Carcinoma, Non-Small-Cell Lung; Cell Survival; Chemoradiotherapy; Diffusion Magnetic Resonance Imaging; Drug Screening Assays, Antitumor; Feasibility Studies; Humans; Lung Neoplasms; Male; Mice, Nude; Neoplasm Transplantation; Pentacyclic Triterpenes; Radiation-Sensitizing Agents; Random Allocation; Triterpenes

2017
Celastrol improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance.
    Anti-cancer drugs, 2018, Volume: 29, Issue:8

    Topics: A549 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Random Allocation; Signal Transduction; Triterpenes; Xenograft Model Antitumor Assays

2018
Axl is a novel target of celastrol that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non‑small cell lung cancer cells.
    Molecular medicine reports, 2019, Volume: 19, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Axl Receptor Tyrosine Kinase; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression; Humans; Lung Neoplasms; Mutation; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Triterpenes

2019
Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer.
    Carcinogenesis, 2014, Volume: 35, Issue:4

    Topics: Animals; Autoantigens; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Membrane Proteins; Mice; Pentacyclic Triterpenes; Proteolysis; Triterpenes; Ubiquitination

2014
Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.
    Molecules (Basel, Switzerland), 2014, Mar-21, Volume: 19, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gefitinib; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mitochondria; Pentacyclic Triterpenes; Protein Kinase Inhibitors; Proteolysis; Quinazolines; Signal Transduction; Triterpenes

2014
ATF2 contributes to cisplatin resistance in non-small cell lung cancer and celastrol induces cisplatin resensitization through inhibition of JNK/ATF2 pathway.
    International journal of cancer, 2015, Jun-01, Volume: 136, Issue:11

    Topics: Activating Transcription Factor 2; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; MAP Kinase Signaling System; Middle Aged; Pentacyclic Triterpenes; Prognosis; Triterpenes

2015
Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:5

    Topics: Annexin A5; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cytochromes c; DNA Fragmentation; Down-Regulation; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Medicine, Chinese Traditional; Membrane Potential, Mitochondrial; Mitochondria; Pentacyclic Triterpenes; Propidium; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Triterpenes; Up-Regulation

2011