celastrol has been researched along with Breast Cancer in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 17 (70.83) | 24.3611 |
| 2020's | 6 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Feng, Y; Fu, X; Li, Z; Lin, F; Lv, J; Mao, Q; Mou, Y; Wang, S; Yang, Y; Zhang, B; Zhang, L; Zhang, P; Zhao, J | 1 |
| Law, S; Leung, AW; Xu, C | 1 |
| Ao, H; Guo, Y; Han, M; Huang, T; Shen, Y; Wang, X; Wang, Y | 1 |
| Cui, J; Gong, T; Hu, Q; Huang, J; Liu, X; Lu, W; Ma, H; Pu, J; Wang, W; Wu, Y | 1 |
| Wang, J | 1 |
| Liu, C; Shu, Y; Tang, L; Wang, L; Yao, C | 1 |
| Hong, Y; Hu, F; Huang, X; Liu, X; Meng, T; Tan, Y; Yang, X; Yuan, H; Zhao, Y; Zhu, Y | 1 |
| Cheng, S; Honggang, L; Liang, G; Wu, H; Yang, Y | 1 |
| Cha, EY; Lee, JS; Lee, MS; Lee, Y; Na, J; Park, JB; Sul, JY | 1 |
| An, N; Kaijzel, EL; Löwik, CW; Mezzanotte, L; Mol, IM | 1 |
| Choi, KS; Jeong, SA; Kim, JY; Kim, YS; Kwon, YJ; Lee, AR; Yoon, MJ | 1 |
| Han, LZ; Jin, X; Lee, JJ; Ma, J; Mi, C; Shi, H | 1 |
| Chen, X; Cheng, X; Deshmukh, RR; Dou, QP; Ji, W; Long, J; Lu, L; Shi, W; Zeng, G; Zhang, Y | 1 |
| Jeengar, MK; Naidu, VG; Reddy, GB; Reddy, VS; Shrivastava, S | 1 |
| Cao, F; Cao, L; Peng, B; Shen, Y; Uzan, G; Wang, Y; Yang, C; Zhang, D; Zhang, X | 1 |
| Aggarwal, BB; Chaturvedi, MM; Cho, SG; Kannappan, R; Liu, M; Prasad, S; Sung, B; Yadav, VR | 1 |
| Jang, SW; Jang, SY; Ko, J | 1 |
| Bailey, TA; Band, H; Band, V; Clubb, RJ; Duan, L; Natarajan, A; Nyong, AM; Ortega-Cava, C; Raja, SM; Reddi, AL; Williams, SH; Zhao, X | 1 |
| Kim, JY; Lee, BW; Lee, JH; Lee, MK; Park, KH; Seo, KI; Shim, KH; Yang, HS | 1 |
| Jang, SW; Kang, H; Kim, Y; Ko, J | 1 |
| Jiang, ZZ; Li, H; Mu, XM; Shi, W; Sun, LX; Wang, YR; Zhang, LY | 1 |
| Kim, HS; Kim, JH; Kim, N; Kim, SJ; Lee, JO; Lee, SK; Moon, JW; Park, SH; Sha, J; You, GY | 1 |
| Cha, EY; Diep, TT; Kim, JR; Lee, JS; Lee, MS; Thuong, PT; Yoon, IS | 1 |
| Chan, ML; Chang, FR; Chen, WY; Tsai, CY; Wu, CC; Wu, YC | 1 |
24 other study(ies) available for celastrol and Breast Cancer
| Article | Year |
|---|---|
Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Oxazoles; Pentacyclic Triterpenes; Pyrazines; Structure-Activity Relationship; Zebrafish | 2022 |
Folic acid-modified celastrol nanoparticles: synthesis, characterization, anticancer activity in 2D and 3D breast cancer models.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Capsules; Cell Survival; Drug Stability; Folate Receptors, GPI-Anchored; Folic Acid; Gold; Humans; MCF-7 Cells; Metal Nanoparticles; Molecular Structure; Particle Size; Pentacyclic Triterpenes; Polymers; Solubility; Spheroids, Cellular; Triterpenes | 2020 |
Preparation of high drug-loading celastrol nanosuspensions and their anti-breast cancer activities in vitro and in vivo.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Female; Humans; Mice; Mice, Inbred BALB C; Nanostructures; Particle Size; Pentacyclic Triterpenes; Temperature; Transplantation, Heterologous; Triterpenes | 2020 |
A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Dose-Response Relationship, Drug; Estrogen Receptor alpha; Female; HEK293 Cells; Humans; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; Mutation; Pentacyclic Triterpenes; Protein Structure, Secondary; Xanthones | 2021 |
Tripterine and miR-184 show synergy to suppress breast cancer progression.
Topics: Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Synergism; Female; Humans; MicroRNAs; Pentacyclic Triterpenes | 2021 |
The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Breast Neoplasms; Drug Synergism; Female; Humans; MCF-7 Cells; Mice; Pentacyclic Triterpenes; Tamoxifen; Xenograft Model Antitumor Assays | 2021 |
Simultaneous targeting therapy for lung metastasis and breast tumor by blocking the NF-κB signaling pathway using Celastrol-loaded micelles.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Integrin alphaVbeta3; Lung Neoplasms; Mice; Mice, Inbred BALB C; Micelles; Neoplasm Metastasis; NF-kappa B; Pentacyclic Triterpenes; Signal Transduction; Thyroxine; Triterpenes | 2018 |
Celastrol inhibits cancer metastasis by suppressing M2-like polarization of macrophages.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Female; Interleukin-13; Lectins, C-Type; Macrophages; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Pentacyclic Triterpenes; RAW 264.7 Cells; Receptors, Cell Surface; Tripterygium; Triterpenes | 2018 |
Combination of pristimerin and paclitaxel additively induces autophagy in human breast cancer cells via ERK1/2 regulation.
Topics: Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Synergism; Female; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Paclitaxel; Pentacyclic Triterpenes; Triterpenes | 2018 |
A new multicolor bioluminescence imaging platform to investigate NF-κB activity and apoptosis in human breast cancer cells.
Topics: Animals; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 7; Cell Line, Tumor; Chemoprevention; Female; Genetic Vectors; Humans; Imaging, Three-Dimensional; Lentivirus; Luminescence; Mice; NF-kappa B; Pentacyclic Triterpenes; Promoter Regions, Genetic; Time Factors; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Release of Ca2+ from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells.
Topics: Apoptosis; Breast Neoplasms; Calcium; Cell Line, Tumor; Colonic Neoplasms; Endoplasmic Reticulum; Female; Humans; MCF-7 Cells; Mitochondria; Pentacyclic Triterpenes; Transfection; Triterpenes | 2014 |
Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Movement; Down-Regulation; Drug Screening Assays, Antitumor; Female; Gene Expression; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Pentacyclic Triterpenes; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Tumor necrosis factor-α sensitizes breast cancer cells to natural products with proteasome-inhibitory activity leading to apoptosis.
Topics: Apoptosis; Biological Products; Blotting, Western; Breast Neoplasms; Caspase 3; Caspase 9; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Microscopy, Fluorescence; Pentacyclic Triterpenes; Proteasome Endopeptidase Complex; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Triterpenes; Tumor Necrosis Factor-alpha; Withanolides; X-Linked Inhibitor of Apoptosis Protein | 2014 |
Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways.
Topics: Apoptosis; Breast Neoplasms; Cell Survival; MCF-7 Cells; Mitochondria; Oxidative Stress; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Triterpenes | 2015 |
Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol.
Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MCF-7 Cells; MicroRNAs; NF-kappa B; Pentacyclic Triterpenes; Prostatic Neoplasms; Signal Transduction; Triterpenes | 2015 |
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
Topics: Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Colonic Neoplasms; Down-Regulation; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Neoplasm Invasiveness; NF-kappa B; Organ Specificity; Pancreatic Neoplasms; Pentacyclic Triterpenes; Protein Processing, Post-Translational; Receptors, CXCR4; Triterpenes; Tumor Necrosis Factor-alpha | 2010 |
Celastrol inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor α.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cyclin D1; Cytoplasm; Estrogen Receptor alpha; Female; Humans; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-myb; Receptors, Estrogen; RNA, Messenger; Triterpenes | 2011 |
Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Female; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Lapatinib; Mice; Mice, SCID; Pentacyclic Triterpenes; Quinazolines; Receptor, ErbB-2; Signal Transduction; Trastuzumab; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells.
Topics: Actins; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Breast Neoplasms; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cytochromes c; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Structure; Pentacyclic Triterpenes; Tripterygium; Triterpenes | 2011 |
Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Enzymologic; Humans; I-kappa B Kinase; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Medicine, Chinese Traditional; Neoplasm Invasiveness; NF-kappa B; Pentacyclic Triterpenes; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate; Triterpenes | 2011 |
Pristimerin inhibits breast cancer cell migration by up- regulating regulator of G protein signaling 4 expression.
Topics: Actins; Analysis of Variance; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chymases; Dose-Response Relationship, Drug; Female; Humans; Leupeptins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Pentacyclic Triterpenes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Random Allocation; RGS Proteins; RNA Interference; Triterpenes; Tumor Burden; Up-Regulation | 2012 |
Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Female; G1 Phase Cell Cycle Checkpoints; HCT116 Cells; Humans; MCF-7 Cells; Pentacyclic Triterpenes; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase C; Protein Serine-Threonine Kinases; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction; Triterpenes; Tumor Suppressor Protein p53 | 2013 |
Anticancer activity of pristimerin in epidermal growth factor receptor 2-positive SKBR3 human breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Movement; Cell Proliferation; Fatty Acid Synthase, Type I; Humans; Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Plant Extracts; Plant Roots; Poly(ADP-ribose) Polymerases; Receptor, ErbB-2; RNA, Messenger; Salacia; TOR Serine-Threonine Kinases; Triterpenes; Wound Healing | 2013 |
Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase Inhibitors; Caspases; Cytochromes c; Female; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Triterpenes; Tumor Cells, Cultured | 2005 |