celastrol has been researched along with Arthritis, Rheumatoid in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 16 (59.26) | 24.3611 |
| 2020's | 11 (40.74) | 2.80 |
| Authors | Studies |
|---|---|
| Astry, B; Moudgil, KD; Nanjundaiah, SM; Venkatesha, SH; Yu, H | 1 |
| Huang, C; Ran, Y; Su, M; Wang, Y; Yin, Z; Zhao, X | 1 |
| Chen, D; Chen, Q; Fan, H; Guo, C; Guo, H; Hou, X; Liu, H; Mu, X; Su, Y; Wang, G; Xu, H; Yu, C; Zhao, F; Zhao, Y | 1 |
| Hou, G; Jing, M; Li, J; Liu, J; Sun, H; Sun, M; Wang, C; Wang, Q; Xin, W; Yang, J; Zhang, L | 1 |
| Cai, BL; Huang, F; Lin, N; Mao, X; Su, XH; Wang, JR; Wang, KX; Wu, AG; Zhang, YG | 1 |
| Cao, M; Chen, D; Diao, N; Geng, H; Guo, C; Kong, M; Wang, W; Zhang, D | 1 |
| Chen, DY; Hsu, TC; Huang, CL; Lin, JW; Tzang, BS; Tzang, CC | 1 |
| Deng, C; Gong, T; Xiao, Y; Zhang, P; Zhang, Z | 1 |
| Dai, E; Song, X; Zhang, Y | 1 |
| Erqin, D; Hongtao, D; Lei, W; Ningning, Y; Xinqiang, S; Yu, Z | 1 |
| An, L; Jin, L; Li, J; Li, Z; Shi, L; Shuai, X; Wang, L; Wang, Y | 1 |
| Deng, C; Gong, T; He, K; He, P; Lei, G; Sun, X; Zhang, Q; Zhang, Z; Zhou, B | 1 |
| Hou, G; Jing, M; Liu, J; Sun, Y; Wang, C; Wang, M; Xin, W; Xu, S; Yan, W; Yang, J; Zhang, L | 1 |
| Dudics, S; Moudgil, KD; Venkatesha, SH | 1 |
| Kang, Q; Liu, J; Liu, X; Liu, XY; Mo, NL; Wang, YJ; Wu, Q; Zhao, Y | 1 |
| Chan, Y; Chan, YL; Chellappan, DK; Collet, T; Dua, K; Gupta, G; Hansbro, N; Hansbro, PM; Hsu, A; Madheswaran, T; Ng, SW; Oliver, BG; Panneerselvam, J; Wark, P; Zeeshan, F | 1 |
| Dai, E; Du, H; Song, X; Wang, L; Zhang, Y | 1 |
| Chen, L; Chen, X; Wang, Y; Wei, X; Wu, G; Xu, Z | 1 |
| Guo, S; Hisamitsu, T; Li, G; Liu, D; Liu, Y; Qian, Y; Sunagawa, M; Zhang, H; Zhang, Y | 1 |
| Guo, SY; Hisamitsu, T; Li, GQ; Liu, D; Liu, YQ; Qian, YY; Sunagawa, M; Zhang, Y; Zhu, YD | 1 |
| Feng, X; Gan, K; Tan, W; Wang, F; Xu, L; Zhang, M; Zhang, Q | 1 |
| Astry, B; Christensen-Quick, A; Frieman, MB; Garzino-Demo, A; Laurence, A; Moudgil, KD; O'Shea, JJ; Venkatesha, SH | 1 |
| Hearth-Holmes, MP; Klassen, LW; Koehn, CD; Li, S; Mikuls, TR; O'Dell, JR; Su, K; Thiele, GM; Yu, Y; Yue, Y; Zhang, Z | 1 |
| Dai, GL; Fu, HY; Ju, WZ; Li, CY; Liu, SJ; Sun, BT; Tan, HS; Wu, L | 1 |
| Cascão, R; Fonseca, JE; Lopes, IP; Moita, LF; Paisana, E; Rino, J; Vidal, B | 1 |
| Moudgil, KD; Venkatesha, SH; Yu, H | 1 |
| Guo, SY; Hisamitsu, T; Li, GQ; Liu, D; Liu, YQ; Qian, YY; Sunagawa, M; Zhang, H; Zhang, Y | 1 |
2 review(s) available for celastrol and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review).
Topics: Arthritis, Rheumatoid; Chemokines; Cyclooxygenase 2; Diterpenes; Epoxy Compounds; Humans; NF-kappa B; Pentacyclic Triterpenes; Phenanthrenes; Signal Transduction; Toll-Like Receptor 4; Tripterygium; Triterpenes | 2020 |
Molecular modulators of celastrol as the keystones for its diverse pharmacological activities.
Topics: Animals; Arthritis, Rheumatoid; Biological Products; Drug Discovery; Humans; Inflammation; Metabolic Diseases; Pentacyclic Triterpenes; Plants, Medicinal; Tripterygium; Triterpenes | 2019 |
25 other study(ies) available for celastrol and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Celastrus; Cell Movement; Chemokines; Cytokines; Disease Models, Animal; Flow Cytometry; Male; Pentacyclic Triterpenes; Rats; Rats, Inbred Lew; Receptors, Chemokine; Spleen; Triterpenes | 2012 |
Reactive Oxygen Species-Responsive Celastrol-Loaded : Bilirubin Nanoparticles for the Treatment of Rheumatoid Arthritis.
Topics: Animals; Arthritis, Rheumatoid; Bilirubin; Nanoparticles; Pentacyclic Triterpenes; Rats; Reactive Oxygen Species | 2021 |
Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cell Survival; Chemistry, Pharmaceutical; Dextran Sulfate; Disease Models, Animal; Drug Carriers; Drug Liberation; Matrix Metalloproteinase 2; Mice; Micelles; Nanoparticles; Particle Size; Pentacyclic Triterpenes; Random Allocation; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Surface Properties | 2022 |
Celastrol inhibits rheumatoid arthritis by inducing autophagy via inhibition of the PI3K/AKT/mTOR signaling pathway.
Topics: Animals; Arthritis, Rheumatoid; Autophagy; Beclin-1; Cell Proliferation; Collagen Type II; Cytokines; Deoxyuridine; Eosine Yellowish-(YS); Hematoxylin; Mice; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinones; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2022 |
[In vitro "benefit-risk" evaluation and network regulation mechanism of Colquhounia Root Tablets and its key material basis].
Topics: Animals; Arthritis, Rheumatoid; Cytokines; Diabetic Nephropathies; Drugs, Chinese Herbal; Glomerulonephritis, Membranous; Humans; Mice; Molecular Docking Simulation; Tablets | 2022 |
Achyranthes polysaccharide based dual-responsive nano-delivery system for treatment of rheumatoid arthritis.
Topics: Achyranthes; Arthritis, Rheumatoid; Nanoparticle Drug Delivery System; Nanoparticles; Polysaccharides | 2023 |
Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages.
Topics: Arthritis, Rheumatoid; Cytokines; Humans; Inflammasomes; Macrophages; NLR Family, Pyrin Domain-Containing 3 Protein; Parvovirus B19, Human | 2023 |
An effective and safe treatment strategy for rheumatoid arthritis based on human serum albumin and Kolliphor
Topics: Animals; Arthritis, Rheumatoid; Drug Carriers; Drug Delivery Systems; Humans; Male; Mice; Nanoparticles; Pentacyclic Triterpenes; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Serum Albumin, Human; Stearates; Triterpenes | 2019 |
Potential mechanisms of action of celastrol against rheumatoid arthritis: Transcriptomic and proteomic analysis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cells, Cultured; Chromatography, Liquid; Gene Expression Regulation; Gene Ontology; High-Throughput Nucleotide Sequencing; Humans; Models, Molecular; Molecular Docking Simulation; Pentacyclic Triterpenes; Proteomics; RNA, Messenger; Spectrometry, Mass, Electrospray Ionization; Synoviocytes; Tandem Mass Spectrometry; Transcriptome; Triterpenes | 2020 |
Inflammation-Targeted Celastrol Nanodrug Attenuates Collagen-Induced Arthritis through NF-κB and Notch1 Pathways.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Inflammation; NF-kappa B; Pentacyclic Triterpenes | 2020 |
Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis.
Topics: Animals; Apoptosis; Arthritis, Rheumatoid; Bone and Bones; Endocytosis; Female; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Joints; Lipopolysaccharides; Macrophages; Mice, Inbred C57BL; Nanoparticles; Oligopeptides; Osteoclasts; Pentacyclic Triterpenes; Rats; Synovial Membrane; Tissue Distribution; Triterpenes; X-Ray Microtomography | 2021 |
Celastrol inhibits rheumatoid arthritis through the ROS-NF-κB-NLRP3 inflammasome axis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Humans; Inflammasomes; Male; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Pentacyclic Triterpenes; Rats; Reactive Oxygen Species; Signal Transduction; THP-1 Cells | 2021 |
The Micro-RNA Expression Profiles of Autoimmune Arthritis Reveal Novel Biomarkers of the Disease and Therapeutic Response.
Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Cells, Cultured; Male; Medicine, Chinese Traditional; MicroRNAs; Pentacyclic Triterpenes; Rats; Triterpenes | 2018 |
Transdermal delivery system of nanostructured lipid carriers loaded with Celastrol and Indomethacin: optimization, characterization and efficacy evaluation for rheumatoid arthritis.
Topics: Administration, Cutaneous; Animals; Arthritis, Rheumatoid; beta-Endorphin; Drug Carriers; Drug Liberation; Indomethacin; Interleukin-1beta; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Skin Absorption; Substance P; Triterpenes; Tumor Necrosis Factor-alpha | 2018 |
Mechanism of action of celastrol against rheumatoid arthritis: A network pharmacology analysis.
Topics: Arthritis, Rheumatoid; Cell Death; Computational Biology; Connective Tissue Diseases; Drug Discovery; Humans; Macrophages; Molecular Docking Simulation; Neoplasms; Organogenesis; Pentacyclic Triterpenes; Pharmacology; Signal Transduction; Th1 Cells; Th2 Cells; Triterpenes | 2019 |
Celastrol induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; bcl-2-Associated X Protein; Caspases; Cell Cycle Checkpoints; Cell Line; Cell Survival; DNA Damage; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fibroblasts; Humans; Pentacyclic Triterpenes; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; Synovial Membrane; Tripterygium; Triterpenes | 2013 |
Celastrol inhibits lipopolysaccharide-stimulated rheumatoid fibroblast-like synoviocyte invasion through suppression of TLR4/NF-κB-mediated matrix metalloproteinase-9 expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Cycle; Cell Movement; Cell Survival; Collagen Type II; Female; Gene Expression Regulation; Humans; Joint Capsule; Lipopolysaccharides; Matrix Metalloproteinase 9; NF-kappa B; Pentacyclic Triterpenes; Primary Cell Culture; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4; Triterpenes | 2013 |
Anti-invasive effects of celastrol in hypoxia-induced fibroblast-like synoviocyte through suppressing of HIF-1α/CXCR4 signaling pathway.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cell Cycle; Cell Movement; Cell Survival; Cells, Cultured; Fibroblasts; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Pentacyclic Triterpenes; Receptors, CXCR4; RNA, Small Interfering; Synovial Membrane; Triterpenes | 2013 |
Celastrol attenuates bone erosion in collagen-Induced arthritis mice and inhibits osteoclast differentiation and function in RANKL-induced RAW264.7.
Topics: Acid Phosphatase; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Resorption; Cell Differentiation; Cell Line; Gene Expression Regulation; Humans; Isoenzymes; Joints; Medicine, Chinese Traditional; Mice; Mice, Inbred Strains; Osteoclasts; Pentacyclic Triterpenes; RANK Ligand; Tartrate-Resistant Acid Phosphatase; Transcriptional Activation; Tripterygium; Triterpenes | 2015 |
Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmune Diseases; Cell Differentiation; Chemotaxis; Disease Models, Animal; Drugs, Chinese Herbal; Inflammation; Pentacyclic Triterpenes; Rats; T-Lymphocytes, Regulatory; Th17 Cells; Triterpenes | 2015 |
Celastrol inhibits inflammatory stimuli-induced neutrophil extracellular trap formation.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Extracellular Traps; Humans; I-kappa B Proteins; Immunoglobulin G; Inflammation; Intracellular Signaling Peptides and Proteins; Lupus Erythematosus, Systemic; MAP Kinase Kinase Kinases; Neutrophils; NF-KappaB Inhibitor alpha; Ovalbumin; Pentacyclic Triterpenes; Phosphorylation; Protein-Tyrosine Kinases; Respiratory Burst; Syk Kinase; Tripterygium; Triterpenes; Tumor Necrosis Factor-alpha | 2015 |
[Study on biomarker of Tripterygium wilfordii in treatment of rheumatoid arthritis based on PK/PD].
Topics: Animals; Arthritis, Rheumatoid; Biomarkers; Female; Interleukin-17; Interleukin-6; Pentacyclic Triterpenes; Phytotherapy; Rats; Rats, Sprague-Dawley; Tripterygium; Triterpenes | 2015 |
Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Count; Female; Gene Expression; Humans; Injections, Intraperitoneal; Interleukin-1beta; Macrophages; Pentacyclic Triterpenes; Rats; Rats, Wistar; Synovial Membrane; Treatment Outcome; Triterpenes; Tumor Necrosis Factor-alpha | 2015 |
Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of Celastrus-derived Celastrol.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Bacterial Proteins; Celastrus; Cell Proliferation; Chaperonin 60; Disease Models, Animal; Gene Expression Profiling; Humans; Immunity; Inflammation Mediators; Medicine, Chinese Traditional; Oligonucleotide Array Sequence Analysis; Pentacyclic Triterpenes; Rats; Rats, Inbred Lew; Signal Transduction; Triterpenes | 2012 |
Celastrol inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and invasion through suppression of NF-κB-mediated matrix metalloproteinase-9 expression.
Topics: Arthritis, Rheumatoid; Cell Movement; Cells, Cultured; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-17; Matrix Metalloproteinase 9; Molecular Structure; NF-kappa B; Pentacyclic Triterpenes; Real-Time Polymerase Chain Reaction; RNA Folding; RNA, Messenger; Synovial Fluid; Triterpenes | 2012 |