cefuzonam and Urinary-Tract-Infections

Cefuzonam (L-105, CZON), a new parenteral cephalosporin, was evaluated for its efficacy and safety in 22 children with bacterial infections (Table 1). The results obtained are summarized below. MICs of CZON to 26 strains of isolated organisms are shown in Table 2. MICs to all 14 strains of Haemophilus influenzae and 6 strains of Streptococcus pneumoniae were less than 0.05 microgram/ml. The MIC to 2 strains of Staphylococcus aureus was 0.39 microgram/ml and that to another was 0.78 microgram/ml. Two strains of Escherichia coli showed MICs of less than 0.05 and 0.10 microgram/ml, respectively. The MIC to 1 strain of Enterococcus faecalis was 6.25 micrograms/ml. The CZON was administered in 3 or 4 divided doses at a daily dosage ranging from 58.5 to 85.7 mg/kg by 30-minute drip infusion or intravenous injection to 22 patients (9 cases of pneumonia, 9 cases of tonsillitis, 2 cases of bronchitis, 1 case each of suppurative parotitis and acute pyelonephritis) and the following clinical results were obtained; excellent: 12 cases; good: 7 cases; fair: 3 cases. The overall efficacy rate was 86% (Table 4). Diarrhea was observed in four patients, and was resolved with or without discontinuation of the medication within a week. Anemia was noted in 2 cases. Leucopenia and neutropenia was observed in 1 case. There were a moderate rises in S-GOT and S-GPT activities in 1 patient (Table 4), and they necessitated the cessation of the CZON therapy. The S-GOT and S-GPT activities became normal after the drug treatment was stopped.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Age Factors; Bacteria; Ceftizoxime; Cephalosporins; Child; Child, Preschool; Drug Evaluation; Drug Resistance, Microbial; Female; Humans; Infant; Male; Respiratory Tract Infections; Urinary Tract Infections

Cefuzonam (L-105, CZON) was given intravenously to 20 pediatric patients with the following acute bacterial infections: 13 of bronchopneumonia and 1 each of tonsillitis, purulent cervical lymphadenitis and acute tonsillitis, laryngitis, bronchitis, pyothorax, purulent meningitis complicated with septic arthritis, and urinary tract infection. Good clinical responses were obtained in all of the 20 patients and bacterial eradication of all 16 strains. No side effect was observed except 3 cases of slight elevation of transaminase, and 1 case each of soft stool and eosinophilia. From the above clinical results, it appears that CZON is a useful antibiotic for the treatment of pediatric patients with various kinds of bacterial infections.

Topics: Acute Disease; Arthritis, Infectious; Bacterial Infections; Bronchitis; Ceftizoxime; Cephalosporins; Child; Child, Preschool; Drug Evaluation; Empyema; Female; Humans; Infant; Laryngitis; Male; Meningitis; Pneumonia; Tonsillitis; Urinary Tract Infections

Cefuzoname (CZON), a new semisynthetic cephalospolin antibiotic, was administered intravenously at a dose of 1.0 g twice a day for 14 days to 20 patients with complicated urinary tract infections and the therapeutic efficacy of the drug and safety were evaluated. The results obtained were summarized as follows: 1. After 5 days, clinical results were excellent in 7, moderate in 3 and poor in 9 cases. The overall effectiveness rate was 52.6%. Bacteriologically, 24 out of 32 isolated strains were susceptible to this drug, but 8 strains were found to be resistant. 2. After treatment, clinical results were excellent in 6, moderate in 3 and poor in 10 cases. The overall effectiveness was 47.4%. In bacteriological results of 32 isolated strains, 26 strains were eradicated and 6 strains persisted. 3. Among 20 cases treated none showed subjective or objective symptoms of side effects. Noted as clinical laboratory test abnormalities were eosinophilia in 1 case after 5 days, increase of S-GOT, gamma-GTP, and K in 1 case, and increase of S-creatinine in 1 case at the termination of treatment. All of these abnormalities were mild and normal values were restored soon after at the termination of the treatment.

Topics: Adult; Aged; Bacteria; Ceftizoxime; Cephalosporins; Drug Resistance, Microbial; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Urinary Tract Infections

A multi-center open study was conducted to investigate cefuzonam (L-105, CZON), a newly developed cephalosporin from pharmacokinetic, bacteriological and clinical aspects, in the pediatric field with the participation of 17 institutions and their related facilities. The results are summarized as follows. Serum concentrations and urinary excretion. The pharmacokinetics in pediatric patients was investigated with a dose of 20 mg/kg, via one shot intravenous injection or intravenous drip infusion over 1 hour. The results were nearly the same as those in adult patients. Mean serum concentrations 5 minutes after one shot intravenous injections were: 52.8 micrograms/ml with the dosage of 10 mg/kg, 135 micrograms/ml with 20 mg/kg, and 317 micrograms/ml with 40 mg/kg, and T1/2 beta's for the 3 dosages were 1.07 hours, 0.91 hour, and 1.01 hours, respectively. With 1-hour intravenous drip infusion, mean serum concentrations at the end of infusion were: 22.4 micrograms/ml with 10 mg/kg, 46.3 micrograms/ml with 20 mg/kg, 72.5 micrograms/ml with 40 mg/kg, and 69.2 micrograms/ml with 50 mg/kg, and T1/2 beta's for these dosages were 1.31 hours, 1.45 hours, 0.84 hour, and 0.66 hour, respectively. In 6 hours after administration of CZON, urinary excretion rates were 43.5-51.4% for one shot intravenous injections of 10-40 mg/kg, and 42.7-58.6% for 10-50 mg/kg drip infusions. Concentrations in cerebrospinal fluid Penetrations into cerebrospinal fluids in patients with purulent meningitis achieved levels of 2.80-6.40 micrograms/ml with the administration of CZON at 100 mg/kg in acute cases of within 6 days after onset. When the administration of the drug was done at the earlier stage, the greater penetration occurred. However, rates of penetration were 3.10% to 5.03% within 4 days after a drug administration, thus, the penetration was not thought to be as good as other beta-lactam agents which achieve higher penetration rates. Clinical results Of 407 cases treated with CZON, 18 cases were excluded from the statistical analysis. The remaining 389 cases plus 8 cases each of which had 2 complicated diseases, with a total of 397, were statistically analyzed for the clinical effectiveness of this drug against various infections. The efficacy was evaluated as "good" or "excellent" in 248 out of 266 cases from which pathogens were isolated, for an efficacy rate of 93.2%. The efficacy rate was 88.5% for 131 cases for which pathogens were unidentified, thus no statistically significa

Topics: Ceftizoxime; Cephalosporins; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Injections, Intravenous; Kinetics; Male; Meningitis; Pneumonia; Urinary Tract Infections

A new member of injectable cephem antibiotics, cefuzonam (L-105, CZON) was administered in the treatment of 11 chronic complicated urinary tract infections (CC-UTI) which were considered to be for indications of long-term chemotherapy. The results obtained are summarized as follows. Responses in 6 cases out of 9, 66.7%, were evaluated as excellent or moderate by the criteria of the Japan UTI committee at fifth day's judgement. At the end of the treatment, however, only 3 out of 8, 37.5% were determined to be effective. The apparent decrease in the efficacy of the drug after the longer treatment period was caused by replacements of susceptible bacteria with resistant strains. Side reactions were observed in 2 cases, one was diarrhea and the other was chill and fever. In these cases, the administration of the drug was discontinued, and the conditions returned to normal within a few days. In laboratory tests, a slight decrease of thrombocyte was observed in 1 case. The CZON was very effective against infections caused by susceptible bacteria. No differences between CZON and other related compounds were found with regard to safety, hence it was estimated that the drug was highly useful for a long-term treatment on infections caused by susceptible strains to CZON.

Topics: Adult; Aged; Ceftizoxime; Cephalosporins; Chronic Disease; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Urinary Tract Infections