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cefuroxime and Otitis Media with Effusion

cefuroxime has been researched along with Otitis Media with Effusion in 14 studies

Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
cefuroxime : A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain.

Otitis Media with Effusion: Inflammation of the middle ear with a clear pale yellow-colored transudate.

Research Excerpts

ExcerptRelevanceReference
"In this open, single center study, the concentration of cefuroxime achieved in the serum and middle ear effusion of pediatric acute otitis media patients with purulent effusion was assessed between 2 and 5 h after a single oral dose of 15 mg/kg cefuroxime axetil suspension."9.08Concentration of cefuroxime in middle ear effusion of children with acute otitis media. ( Efthymiopoulos, C; Marr, C; Thorarinsson, H; Thoroddsen, E, 1997)
"This trial compared the efficacy and safety of a 10-day treatment course of cefaclor and cefuroxime axetil in the treatment of acute otitis media with effusion in children who failed therapy with amoxicillin."9.08Comparison of cefaclor and cefuroxime axetil in the treatment of acute otitis media with effusion in children who failed amoxicillin therapy. ( Johns, D; Turik, MA, 1998)
"Two hundred sixty-three pediatric patients from the ages of 3 months to 11 years were enrolled in a randomized, investigator-blinded, multicenter study comparing the clinical and bacteriological efficacies and safety of cefuroxime axetil suspension (CAE) with those of amoxicillin-clavulanate suspension (AMX-CL) in the treatment of acute otitis media with effusion."9.07Comparison of cefuroxime axetil and amoxicillin-clavulanate suspensions in treatment of acute otitis media with effusion in children. ( Aronovitz, G; Bodor, F; Goldfarb, J; McLinn, SE; Moskal, M; Ossi, MJ; Schwartz, R; Self, P, 1994)
"Cefuroxime axetil was evaluated for clinical efficacy and tolerance in the treatment of acute otitis media in children."9.07Cefuroxime axetil in the treatment of acute otitis media in children. ( Beratis, NG; Goumas, PD; Haliotis, FA; Lygatsikas, CG; Spyropoulos, CD; Syrogiannopoulos, GA, 1992)
" The study was undertaken to determine the concentrations of cefuroxime in the blood and middle ear effusions (MEE) of children between 6 and 12 years of age with acute otitis media and chronic OME after a single oral dose administration of cefuroxime axetil, the ester prodrug of cefuroxime."7.68Concentration of cefuroxime in serum and middle ear effusion after single dose treatment with cefuroxime axetil. ( Bluestone, CD; Collins, JJ; Haddad, J; Hart, RW; Isaacson, G; Respler, DS; Yilmaz, HM, 1991)
"In this open, single center study, the concentration of cefuroxime achieved in the serum and middle ear effusion of pediatric acute otitis media patients with purulent effusion was assessed between 2 and 5 h after a single oral dose of 15 mg/kg cefuroxime axetil suspension."5.08Concentration of cefuroxime in middle ear effusion of children with acute otitis media. ( Efthymiopoulos, C; Marr, C; Thorarinsson, H; Thoroddsen, E, 1997)
"This trial compared the efficacy and safety of a 10-day treatment course of cefaclor and cefuroxime axetil in the treatment of acute otitis media with effusion in children who failed therapy with amoxicillin."5.08Comparison of cefaclor and cefuroxime axetil in the treatment of acute otitis media with effusion in children who failed amoxicillin therapy. ( Johns, D; Turik, MA, 1998)
"Two hundred sixty-three pediatric patients from the ages of 3 months to 11 years were enrolled in a randomized, investigator-blinded, multicenter study comparing the clinical and bacteriological efficacies and safety of cefuroxime axetil suspension (CAE) with those of amoxicillin-clavulanate suspension (AMX-CL) in the treatment of acute otitis media with effusion."5.07Comparison of cefuroxime axetil and amoxicillin-clavulanate suspensions in treatment of acute otitis media with effusion in children. ( Aronovitz, G; Bodor, F; Goldfarb, J; McLinn, SE; Moskal, M; Ossi, MJ; Schwartz, R; Self, P, 1994)
"Cefuroxime axetil was evaluated for clinical efficacy and tolerance in the treatment of acute otitis media in children."5.07Cefuroxime axetil in the treatment of acute otitis media in children. ( Beratis, NG; Goumas, PD; Haliotis, FA; Lygatsikas, CG; Spyropoulos, CD; Syrogiannopoulos, GA, 1992)
"Cefuroxime axetil and cefaclor were compared for efficacy in the treatment of acute otitis media with effusion."5.06Treatment of otitis media with cefuroxime axetil. ( Aronovitz, GH, 1988)
"The efficacy of amoxicillin/clavulanate and cefuroxime was determined in a gerbil model of otitis media with a mixed Streptococcus pneumoniae plus Haemophilus influenzae middle ear (ME) infection."3.70Role of Streptococcus pneumoniae and Haemophilus influenzae in the development of acute otitis media and otitis media with effusion in a gerbil model. ( Aguilar, L; Cenjor, C; García-Calvo, G; Giménez, MJ; Nieto, E; Parra, A; Ponte, C; Soriano, F, 2000)
" The study was undertaken to determine the concentrations of cefuroxime in the blood and middle ear effusions (MEE) of children between 6 and 12 years of age with acute otitis media and chronic OME after a single oral dose administration of cefuroxime axetil, the ester prodrug of cefuroxime."3.68Concentration of cefuroxime in serum and middle ear effusion after single dose treatment with cefuroxime axetil. ( Bluestone, CD; Collins, JJ; Haddad, J; Hart, RW; Isaacson, G; Respler, DS; Yilmaz, HM, 1991)
"Disappearance of middle ear effusion is one of the most important outcomes in the treatment of acute otitis media (AOM)."2.72Disappearance of middle ear effusion in acute otitis media monitored daily with tympanometry. ( Jounio-Ervasti, K; Kontiokari, T; Rantala, H; Renko, M; Uhari, M, 2006)
" The serum concentrations of cefuroxime were found to be above the minimal inhibitory concentration (MIC) for penicillin-sensitive Streptococcus pneumoniae for 100% of the dosing interval and 42% of the time for intermediate-resistant strains."2.69Measuring antibiotic levels in otitis media. ( Thoroddsen, E, 1998)
" Although guidelines continue to endorse amoxicillin as the preferred treatment, amoxicillin/clavulanate in high dosage would be the preferred treatment based on the otopathogen mix currently."2.49Otitis media. ( Pichichero, ME, 2013)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's8 (57.14)18.2507
2000's4 (28.57)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pichichero, ME1
Renko, M1
Kontiokari, T1
Jounio-Ervasti, K1
Rantala, H1
Uhari, M1
Jacobs, MR1
Good, CE1
Sellner, T1
Bajaksouzian, S1
Windau, A1
Anon, JB1
McLinn, SE1
Moskal, M1
Goldfarb, J1
Bodor, F1
Aronovitz, G1
Schwartz, R1
Self, P1
Ossi, MJ1
Thoroddsen, E3
Marr, C2
Efthymiopoulos, C1
Thorarinsson, H1
Turik, MA1
Johns, D1
Ponte, C2
Cenjor, C2
Parra, A2
Nieto, E2
García-Calvo, G2
Giménez, MJ2
Aguilar, L2
Soriano, F2
Pessey, JJ1
Gehanno, P1
Dagan, R1
Leibovitz, E1
Machac, J1
Pimentel, JM1
Leblanc, F1
Spandow, O1
Gothefors, L1
Fagerlund, M1
Kristensen, B1
Holm, S1
Syrogiannopoulos, GA1
Goumas, PD1
Haliotis, FA1
Lygatsikas, CG1
Spyropoulos, CD1
Beratis, NG1
Haddad, J1
Isaacson, G1
Respler, DS1
Hart, RW1
Yilmaz, HM1
Collins, JJ1
Bluestone, CD1
Aronovitz, GH1

Reviews

1 review available for cefuroxime and Otitis Media with Effusion

ArticleYear
Otitis media.
    Pediatric clinics of North America, 2013, Volume: 60, Issue:2

    Topics: Age Factors; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bact

2013

Trials

8 trials available for cefuroxime and Otitis Media with Effusion

ArticleYear
Disappearance of middle ear effusion in acute otitis media monitored daily with tympanometry.
    Acta paediatrica (Oslo, Norway : 1992), 2006, Volume: 95, Issue:3

    Topics: Acoustic Impedance Tests; Amoxicillin; Anti-Bacterial Agents; Cefuroxime; Child; Child, Preschool; F

2006
Comparison of cefuroxime axetil and amoxicillin-clavulanate suspensions in treatment of acute otitis media with effusion in children.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:2

    Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Cefuroxime; Child; Child, Preschool; Cla

1994
Concentration of cefuroxime in middle ear effusion of children with acute otitis media.
    The Pediatric infectious disease journal, 1997, Volume: 16, Issue:10

    Topics: Acute Disease; Administration, Oral; Cefuroxime; Cephalosporins; Child, Preschool; Humans; Infant; M

1997
Measuring antibiotic levels in otitis media.
    Ear, nose, & throat journal, 1998, Volume: 77, Issue:6 Suppl

    Topics: Acute Disease; Administration, Oral; Cefuroxime; Cephalosporins; Child, Preschool; Drug Monitoring;

1998
Comparison of cefaclor and cefuroxime axetil in the treatment of acute otitis media with effusion in children who failed amoxicillin therapy.
    Journal of chemotherapy (Florence, Italy), 1998, Volume: 10, Issue:4

    Topics: Administration, Oral; Amoxicillin; Cefaclor; Cefuroxime; Cephalosporins; Child, Preschool; Female; H

1998
Short course therapy with cefuroxime axetil for acute otitis media: results of a randomized multicenter comparison with amoxicillin/clavulanate.
    The Pediatric infectious disease journal, 1999, Volume: 18, Issue:10

    Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Bacterial Infections; Cefuroxime; Ceph

1999
Cefuroxime axetil in the treatment of acute otitis media in children.
    Journal of chemotherapy (Florence, Italy), 1992, Volume: 4, Issue:4

    Topics: Acute Disease; Amoxicillin; Cefuroxime; Child; Child, Preschool; Female; Humans; Male; Otitis Media;

1992
Treatment of otitis media with cefuroxime axetil.
    Southern medical journal, 1988, Volume: 81, Issue:8

    Topics: Acute Disease; Cefaclor; Cefuroxime; Cephalosporins; Child; Child, Preschool; Clinical Trials as Top

1988

Other Studies

5 other studies available for cefuroxime and Otitis Media with Effusion

ArticleYear
Nasopharyngeal carriage of respiratory pathogens in children undergoing pressure equalization tube placement in the era of pneumococcal protein conjugate vaccine use.
    The Laryngoscope, 2007, Volume: 117, Issue:2

    Topics: Adolescent; Anti-Bacterial Agents; Cefuroxime; Cephalosporin Resistance; Child; Child, Preschool; Dr

2007
Antimicrobial treatment of an experimental otitis media caused by a beta-lactamase positive isolate of Haemophilus influenzae.
    The Journal of antimicrobial chemotherapy, 1999, Volume: 44, Issue:1

    Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; beta-Lactamases; Cefuroxime; Cephalosporins;

1999
Lateral sinus thrombosis after untreated otitis media. A clinical problem--again?
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2000, Volume: 257, Issue:1

    Topics: Adolescent; Anticoagulants; Cefadroxil; Cefuroxime; Humans; Lateral Sinus Thrombosis; Magnetic Reson

2000
Role of Streptococcus pneumoniae and Haemophilus influenzae in the development of acute otitis media and otitis media with effusion in a gerbil model.
    The Journal of infectious diseases, 2000, Volume: 181, Issue:2

    Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Animals; Cefuroxime; Cephalosporins; C

2000
Concentration of cefuroxime in serum and middle ear effusion after single dose treatment with cefuroxime axetil.
    The Pediatric infectious disease journal, 1991, Volume: 10, Issue:4

    Topics: Acute Disease; Administration, Oral; Cefuroxime; Child; Chronic Disease; Exudates and Transudates; F

1991