ceftiofur and Lung-Diseases--Obstructive

Scintigraphical analysis of the ratio of inhalation (I) to perfusion (Q) was designed to determine whether chronic pulmonary disease in horses induced mismatches in I/Q and to assess whether medical treatment would restore an I/Q distribution pattern identical to that of control horses. In addition, the results of the I/Q analysis were correlated with the alveolar-arterial PO2 difference (AaDO2). The I/Q matching found in a group of control horses was compared with the I/Q analysis of a group of diseased horses before and after their clinical signs had been treated. The analysis indicated that there was mismatching between I and Q before they were treated. The treatment improved the diseased horses, pulmonary function but there was still heterogeneity in the I/Q distribution after they had been treated. The I/Q analysis parameters were well correlated with the ratio of ventilation (VA) and pulmonary blood flow (Q), evaluated by the determination of AaDO2.

Topics: Aerosols; Animals; Anti-Inflammatory Agents; Blood Gas Analysis; Cephalosporins; Horse Diseases; Horses; Lung Diseases, Obstructive; Prednisolone; Radionuclide Imaging; Radiopharmaceuticals; Reference Values; Severity of Illness Index; Technetium Tc 99m Aggregated Albumin; Ventilation-Perfusion Ratio