cefteram-pivoxil and Chemical-and-Drug-Induced-Liver-Injury

Topics: Adult; Cefmenoxime; Chemical and Drug Induced Liver Injury; Granuloma; Humans; Male; Skin Transplantation; Ursodeoxycholic Acid

The present study was carried out to examine the effect of single or consecutive administration of T-2588 on liver of male rat injured by the administration of D-galactosamine X HCl. The T-2588 was orally given to hepatic-injured rats at doses of 125 mg/kg and 1,000 mg/kg singly or for consecutive 5 days. A 10 ml/kg dose of the vehicle was orally given to control rats. The results obtained were summarized below. Single administration of T-2588. Twenty-four hours after a single administration of T-2588, the liver taken from control rats apparently indicated galactosamine-induced hepatitis. No drug-related alterations were observed in hepatic functional test, liver weight and histological examinations at either dose of T-2588. Galactosamine-induced hepatitis was not affected by a single administration of T-2588. Consecutive administration of T-2588. Twenty-four hours after a 5-consecutive-day administration of T-2588, galactosamine-induced hepatitis in control rats was restored to the normal state. The cure of galactosamine-induced hepatitis was not affected by a 5-consecutive-day administration of T-2588. The hepatic aldehyde dehydrogenase activity in hepatic-injured rats was not affected by a 5-consecutive-day administration of T-2588.

Topics: Administration, Oral; Aldehyde Dehydrogenase; Animals; Cefmenoxime; Cephalosporins; Chemical and Drug Induced Liver Injury; Liver; Male; Organ Size; Rats; Rats, Inbred Strains