cefsulodin and Otitis-Media

Topics: Adult; Cefsulodin; Cephalosporins; Chronic Disease; Clinical Trials as Topic; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Otitis Media; Otorhinolaryngologic Diseases; Pseudomonas Infections

Pharmacokinetics and clinical studies on cefsulodin (CFS) were conducted in neonates. 1. MIC's of CFS, sulbenicillin and gentamicin (GM) were determined using 7 strains of Pseudomonas aeruginosa clinically isolated from neonates and maintained as stock cultures. CFS was found to be nearly as active as GM. 2. When CFS 20 mg/kg was administered to a 12-day-old neonate by intravenous bolus injection, serum concentrations were 8.7 micrograms/ml before administration and 51.7 micrograms/ml at 30 minutes, 44.4 micrograms/ml at 1 hour, 38.6 micrograms/ml at 2 hours and 11.1 micrograms/ml at 6 hours after administration. The half-life was 2.5 hours. 3. CFS was administered alone or combination with other drugs to 3 neonates. The drug was clinically effective in 2 cases and slightly effective in another. Bacteriologically, one case was rated as decreased, another as replaced, and the remaining one as unchanged. 4. Neither side effects nor abnormal laboratory values attributable to CFS were found.

Topics: Cefsulodin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Male; Otitis Media; Pneumonia; Pseudomonas aeruginosa

The clinical evaluation for cefsulodin (CFS) against P. aeruginosa was studied in postoperative infections of chronic otitis media by means of washing the middle ear with the drug, and the following results were obtained; CFS treatment was given to 5 cases, and the clinical responses were excellent in 4 and good in 1 case. P. aeruginosa in otorrhea was eradicated within several days, and otorrhea disappeared in all the cases. No side effect was observed in all cases.

Topics: Administration, Topical; Adolescent; Adult; Aged; Cefsulodin; Cephalosporins; Drug Evaluation; Female; Humans; Male; Otitis Media; Postoperative Complications; Pseudomonas Infections

The pharmacokinetics of cefsulodin in the fluids of the ear and eye as well as in serum were studied after intramuscular administration of 200 and 400 mg/kg to eight groups of six guinea pigs. A retention of cefsulodin in the inner ear-similar to that of the aminoglycoside antibiotics - was observed. As the measured perilymph concentrations of cefsulodin and gentamicin are comparable on a weight for weight basis and as the clinical dosage of cefsulodin is much higher than that of gentamicin, the perilymph concentrations of cefsulodin reached in man are probably much higher than those of gentamicin. The results obtained are compared to those of mezlocillin, azlocillin and fosfomycin, Finally, the importance of the cefsulodin perilymph concentrations in the treatment and prophylaxis of infectious inner ear complications due to the most common pathogens of chronic otitis media as well as in the treatment of certain eye infections is discussed.

Topics: Animals; Aqueous Humor; Cefsulodin; Cephalosporins; Guinea Pigs; Injections, Intramuscular; Otitis Media; Perilymph

Topics: Adolescent; Adult; Aged; Cefsulodin; Cephalosporins; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Otitis Media; Pseudomonas Infections; Suppuration

Topics: Adolescent; Adult; Cefsulodin; Cephalosporins; Child; Drug Evaluation; Humans; Infusions, Parenteral; Male; Middle Aged; Otitis Media; Pseudomonas Infections; Suppuration

The clinical effect of cefsulodin (CFS) on Pseudomonas species infections in otorhinolaryngologic field was studied in 10 patients. The overall clinical effectiveness was 80% (excellent 4, good 4, poor 2). The bacteriological response of CFS against Pseudomonas species was evaluated from 11 strains. Eradication rate of Pseudomonas species was 82%. In 1 case, body temperature was rised after injection. No abnormal laboratory findings, relating to the drug, were observed after treatment.

Topics: Adult; Cefsulodin; Cephalosporins; Child; Drug Evaluation; Female; Humans; Male; Middle Aged; Otitis Media; Pseudomonas Infections

The clinical effect of cefsulodin (CFS) on Pseudomonas aeruginosa infections in otorhinolaryngology was studied in 10 patients. The overall clinical effectiveness was 80% (excellent 2, good 6, poor 2). Eradication rates of P. aeruginosa was 60%. No side effect and positive skin test were found in any cases. Examination of laboratory data before and after the administration revealed no abnormal findings in every cases.

Topics: Adult; Aged; Cefsulodin; Cephalosporins; Chronic Disease; Drug Evaluation; Female; Humans; Male; Middle Aged; Otitis Media; Pseudomonas Infections; Surgical Wound Infection

Clinical evaluation of cefsulodin (CFS) in treatment of infection in otorhinolaryngologic field was carried out and the following result was obtained. 1. Daily 1 to 5 gram of CFS was administered in divided dose to 9 cases of chronic purulent middle ear infection and postoperative wound infection. Clinical effectiveness was excellent, good and fair in 1, 2 and 5 cases, respectively. 2. No side effect as well as abnormal change of laboratory finding was observed. As for ototoxicity to be the most concerned matter of physicians, CFS seems to have no special problem. Thus, CFS is considered to be the useful drug for the treatment of chronic purulent middle ear infection and postoperative wound infection caused by P. aeruginosa in the field of otorhinolaryngology, and synergistic clinical effect will be expected by the combination therapy with other antibiotics or local administration of CFS.

Topics: Cefsulodin; Cephalosporins; Chronic Disease; Drug Evaluation; Female; Humans; Male; Otitis Media; Pseudomonas Infections; Surgical Wound Infection